Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAN1A1 Gene

Aliases for MAN1A1 Gene

  • Mannosidase Alpha Class 1A Member 1 2 3 4 5
  • Processing Alpha-1,2-Mannosidase IA 3 4
  • Alpha-1,2-Mannosidase IA 3 4
  • Man(9)-Alpha-Mannosidase 3 4
  • Man9-Mannosidase 3 4
  • Mannosyl-Oligosaccharide 1,2-Alpha-Mannosidase IA 3
  • Mannosidase, Alpha, Class 1A, Member 1 2
  • EC 4
  • HUMM3 3
  • HUMM9 3
  • MAN9 3

External Ids for MAN1A1 Gene

Previous GeneCards Identifiers for MAN1A1 Gene

  • GC06M119456
  • GC06M119479
  • GC06M119540
  • GC06M117081

Summaries for MAN1A1 Gene

Entrez Gene Summary for MAN1A1 Gene

  • This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]

GeneCards Summary for MAN1A1 Gene

MAN1A1 (Mannosidase Alpha Class 1A Member 1) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and N-Glycan biosynthesis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and mannosidase activity. An important paralog of this gene is MAN1A2.

UniProtKB/Swiss-Prot for MAN1A1 Gene

  • Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).

Gene Wiki entry for MAN1A1 Gene

Additional gene information for MAN1A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAN1A1 Gene

Genomics for MAN1A1 Gene

GeneHancer (GH) Regulatory Elements for MAN1A1 Gene

Promoters and enhancers for MAN1A1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J119351 Enhancer 0.6 Ensembl dbSUPER 650.7 -0.4 -368 0.4 AFF1 CBX8 GTF2E2 GC06P119350 MAN1A1 RPL13AP15 PIR44683
GH06J119311 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.9 +37.6 37624 5.2 HDGF PKNOX1 SMAD1 ARNT ZNF766 ZNF207 ZNF592 MEF2D SMARCA4 NBN MAN1A1 MCM9 RPL13AP15 RNU6-194P GC06M119272
GH06J119307 Enhancer 1.5 Ensembl ENCODE dbSUPER 11.3 +42.8 42770 2.6 PKNOX1 FOXA2 ARNT ARID4B FEZF1 ZNF2 YY1 ZNF766 E2F8 FOS MCM9 MAN1A1 RPL13AP15 RNU6-194P GC06M119272
GH06J119310 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.3 +40.9 40860 0.9 BRD4 HDAC1 ASH1L ZNF644 FOSL1 CTBP1 POLR2A ZNF138 FOXK2 SMARCE1 MAN1A1 MCM9 RNU6-194P GC06M119272
GH06J119626 Enhancer 1.4 Ensembl ENCODE dbSUPER 8.7 -276.5 -276464 2.6 PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 ATF7 CAVIN1 GC06P119628 MCM9 MAN1A1 LOC285762
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAN1A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAN1A1 gene promoter:
  • Pax-2
  • Sp1
  • Pax-2a
  • NRF-2
  • C/EBPbeta
  • AhR
  • POU2F1a
  • POU2F1
  • STAT5B
  • E47

Genomic Locations for MAN1A1 Gene

Genomic Locations for MAN1A1 Gene
174,433 bases
Minus strand
172,553 bases
Minus strand

Genomic View for MAN1A1 Gene

Genes around MAN1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAN1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAN1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAN1A1 Gene

Proteins for MAN1A1 Gene

  • Protein details for MAN1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
    Protein Accession:
    Secondary Accessions:
    • E7EU32
    • Q6P052
    • Q9NU44
    • Q9UJI3

    Protein attributes for MAN1A1 Gene

    653 amino acids
    Molecular mass:
    72969 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAN1A1 Gene


neXtProt entry for MAN1A1 Gene

Post-translational modifications for MAN1A1 Gene

  • Glycosylation at isoforms=513
  • Modification sites at PhosphoSitePlus

Other Protein References for MAN1A1 Gene

No data available for DME Specific Peptides for MAN1A1 Gene

Domains & Families for MAN1A1 Gene

Gene Families for MAN1A1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MAN1A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 47 family.
  • Belongs to the glycosyl hydrolase 47 family.
genes like me logo Genes that share domains with MAN1A1: view

Function for MAN1A1 Gene

Molecular function for MAN1A1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by both 1-deoxymannojirimycin and kifunensine.
GENATLAS Biochemistry:
mannosyl-oligo saccharide alpha-1,2-mannosidase,class 1A,member 1,membrane type,expressed in kidney,located in endoplasmic reticulum,involved in processing of Asp-linked (N) glycans

Enzyme Numbers (IUBMB) for MAN1A1 Gene

Phenotypes From GWAS Catalog for MAN1A1 Gene

Gene Ontology (GO) - Molecular Function for MAN1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity TAS --
GO:0005509 calcium ion binding TAS,IEA --
GO:0015923 mannosidase activity TAS 8223597
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MAN1A1: view
genes like me logo Genes that share phenotypes with MAN1A1: view

Animal Model Products

CRISPR Products

miRNA for MAN1A1 Gene

miRTarBase miRNAs that target MAN1A1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAN1A1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAN1A1 Gene

Localization for MAN1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAN1A1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAN1A1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
cytosol 5
golgi apparatus 5
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAN1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum TAS 8223597
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005794 Golgi apparatus IEA,IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MAN1A1: view

Pathways & Interactions for MAN1A1 Gene

genes like me logo Genes that share pathways with MAN1A1: view

UniProtKB/Swiss-Prot P33908-MA1A1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for MAN1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006491 N-glycan processing IBA --
GO:0008152 metabolic process IEA --
GO:1904381 Golgi apparatus mannose trimming TAS --
genes like me logo Genes that share ontologies with MAN1A1: view

No data available for SIGNOR curated interactions for MAN1A1 Gene

Drugs & Compounds for MAN1A1 Gene

(4) Drugs for MAN1A1 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
calcium Approved Nutra 0
mannose Investigational Pharma 0
swainsonine Pharma 0

(1) Additional Compounds for MAN1A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAN1A1: view

Transcripts for MAN1A1 Gene

mRNA/cDNA for MAN1A1 Gene

Unigene Clusters for MAN1A1 Gene

Mannosidase, alpha, class 1A, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAN1A1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAN1A1 Gene

No ASD Table

Relevant External Links for MAN1A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAN1A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAN1A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAN1A1 Gene

This gene is overexpressed in Liver (x4.8).

Protein differential expression in normal tissues from HIPED for MAN1A1 Gene

This gene is overexpressed in Serum (40.0) and Urine (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAN1A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAN1A1 Gene:


SOURCE GeneReport for Unigene cluster for MAN1A1 Gene:


Evidence on tissue expression from TISSUES for MAN1A1 Gene

  • Kidney(4.5)
  • Liver(2.9)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with MAN1A1: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAN1A1 Gene

Orthologs for MAN1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAN1A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAN1A1 34 33
  • 99.69 (n)
(Canis familiaris)
Mammalia MAN1A1 34 33
  • 90.62 (n)
(Bos Taurus)
Mammalia LOC530027 33
  • 90.14 (n)
MAN1A1 34
  • 89 (a)
(Mus musculus)
Mammalia Man1a 16 34 33
  • 87.85 (n)
(Ornithorhynchus anatinus)
Mammalia MAN1A1 34
  • 87 (a)
(Rattus norvegicus)
Mammalia Man1a1 33
  • 86.98 (n)
(Monodelphis domestica)
Mammalia MAN1A1 34
  • 81 (a)
(Gallus gallus)
Aves MAN1A1 34 33
  • 79.35 (n)
(Anolis carolinensis)
Reptilia MAN1A1 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia man1a1 33
  • 74.8 (n)
Str.7245 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.34275 33
(Danio rerio)
Actinopterygii man1a1 34 33
  • 68.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta alpha-Man-I 34 35
  • 42 (a)
CG31202 34
  • 37 (a)
(Caenorhabditis elegans)
Secernentea D2030.1 35 33
  • 54.08 (n)
C52E4.5 35
  • 50 (a)
mans-1 34
  • 47 (a)
mans-2 34
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MNS1 34
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MNS2 33
  • 51.44 (n)
(Oryza sativa)
Liliopsida Os04g0606400 33
  • 50.68 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
Species where no ortholog for MAN1A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAN1A1 Gene

Gene Tree for MAN1A1 (if available)
Gene Tree for MAN1A1 (if available)
Evolutionary constrained regions (ECRs) for MAN1A1: view image

Paralogs for MAN1A1 Gene

Paralogs for MAN1A1 Gene

(4) SIMAP similar genes for MAN1A1 Gene using alignment to 2 proteins:

  • Q6P052_HUMAN Pseudogenes for MAN1A1 Gene

genes like me logo Genes that share paralogs with MAN1A1: view

Variants for MAN1A1 Gene

Sequence variations from dbSNP and Humsavar for MAN1A1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000030516 -- 119,183,318(-) G/A/C genic_downstream_transcript_variant, intron_variant
rs1000036175 -- 119,347,039(-) A/G intron_variant
rs1000057705 -- 119,184,770(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000062277 -- 119,223,178(-) G/T intron_variant
rs1000069482 -- 119,347,947(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAN1A1 Gene

Variant ID Type Subtype PubMed ID
dgv1827e212 CNV loss 25503493
esv2507819 CNV deletion 19546169
esv2540099 CNV deletion 19546169
esv2732626 CNV deletion 23290073
esv2732627 CNV deletion 23290073
esv2732629 CNV deletion 23290073
esv3540366 CNV deletion 23714750
esv3571375 CNV loss 25503493
esv3610536 CNV loss 21293372
esv3610537 OTHER inversion 21293372
esv3610538 OTHER inversion 21293372
esv3610540 CNV gain 21293372
esv3610542 CNV loss 21293372
esv3610543 CNV loss 21293372
nsv1016699 CNV loss 25217958
nsv1034992 CNV loss 25217958
nsv522725 CNV loss 19592680
nsv955931 CNV insertion 24416366
nsv969440 CNV duplication 23825009

Variation tolerance for MAN1A1 Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAN1A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAN1A1 Gene

Disorders for MAN1A1 Gene

Additional Disease Information for MAN1A1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MAN1A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAN1A1 Gene

Publications for MAN1A1 Gene

  1. Molecular cloning and primary structure of Man9-mannosidase from human kidney. (PMID: 8223597) Bause E … Schmidt B (European journal of biochemistry 1993) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Man9-mannosidase from pig liver is a type-II membrane protein that resides in the endoplasmic reticulum. cDNA cloning and expression of the enzyme in COS 1 cells. (PMID: 9219526) Bieberich E … Bause E (European journal of biochemistry 1997) 3 22 58
  5. Man9-mannosidase from human kidney is expressed in COS cells as a Golgi-resident type II transmembrane N-glycoprotein. (PMID: 7588811) Bieberich E … Bause E (European journal of biochemistry 1995) 3 22 58

Products for MAN1A1 Gene

Sources for MAN1A1 Gene

Loading form....