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MAML3 (Mastermind Like Transcriptional Coactivator 3) is a Protein Coding gene. Diseases associated with MAML3 include Schneiderian Carcinoma and Ossifying Fibromyxoid Tumor. Among its related pathways are Signaling by GPCR and Pre-NOTCH Expression and Processing. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is MAML1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003713 | transcription coactivator activity | IBA,IDA | 12370315 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 12370315 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0016607 | nuclear speck | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by NOTCH1 | ||
2 | Notch Signaling Pathway (WikiPathways) | ||
3 | Pre-NOTCH Expression and Processing | ||
4 | HIV Life Cycle |
.45
|
|
5 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
GO:0007219 | Notch signaling pathway | TAS | -- |
GO:0007221 | positive regulation of transcription of Notch receptor target | IBA,TAS | -- |
GO:0045747 | positive regulation of Notch signaling pathway | TAS | -- |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 12370315 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MAML3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MAML3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MAML3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Maml3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Maml3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | MAML3 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MAML3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MAML3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MAML3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | maml3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC101886283 30 |
|
||
maml3 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
770352 | Benign: not provided | 139,889,909(-) | T/TTGC | INFRAME_INSERTION |
Disorder | Aliases | PubMed IDs |
---|---|---|
schneiderian carcinoma |
|
|
ossifying fibromyxoid tumor |
|
|
kidney clear cell sarcoma |
|
|
cellular schwannoma |
|
|
spindle cell rhabdomyosarcoma |
|
|