Aliases for MALT1 Gene
Aliases for MALT1 Gene
External Ids for MALT1 Gene
- HGNC: 6819
- Entrez Gene: 10892
- Ensembl: ENSG00000172175
- OMIM: 604860
- UniProtKB: Q9UDY8
Previous HGNC Symbols for MALT1 Gene
- MLT
Previous GeneCards Identifiers for MALT1 Gene
- GC18P056267
- GC18P056123
- GC18P054487
- GC18P054489
- GC18P056339
- GC18P053046
Summaries for MALT1 Gene
-
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MALT1 Gene
MALT1 (MALT1 Paracaspase) is a Protein Coding gene. Diseases associated with MALT1 include Immunodeficiency 12 and Lymphoma, Mucosa-Associated Lymphoid Type. Among its related pathways are CLEC7A (Dectin-1) signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and peptidase activity.
UniProtKB/Swiss-Prot for MALT1 Gene
-
Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.
-
Aminopeptidases catalyze the removal of amino acids from the amino terminus of proteins and peptides. They express different substrate specificities - for example, leucyl aminopeptidase preferentially cleaves leucine residues.
Additional gene information for MALT1 Gene
- Monarch Initiative
- Search for MALT1 at DataMed
- Search for MALT1 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MALT1 Gene
Genomics for MALT1 Gene
GeneHancer (GH) Regulatory Elements for MALT1 Gene
Promoters and enhancers for MALT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MALT1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MALT1 Gene
Genomic Locations for MALT1 Gene
- chr18:58,671,386-58,754,477
- (GRCh38/hg38)
- Size:
- 83,092 bases
- Orientation:
- Plus strand
- chr18:56,338,618-56,417,371
- (GRCh37/hg19)
Genomic View for MALT1 Gene
Genes around MALT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q21.32 by Ensembl
- 18q21.32 by Entrez Gene
- 18q21.32 by HGNC
MALT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MALT1 Gene
Proteins for MALT1 Gene
-
Protein details for MALT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UDY8-MALT1_HUMAN
- Recommended name:
- Mucosa-associated lymphoid tissue lymphoma translocation protein 1
- Protein Accession:
- Q9UDY8
- Q9NTB7
- Q9ULX4
Protein attributes for MALT1 Gene
- Size:
- 824 amino acids
- Molecular mass:
- 92272 Da
- Quaternary structure:
-
- Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6 (PubMed:15125833). Forms a complex with CARD14 and BCL10; resulting in the formation of a CBM (CARD14-BCL10-MALT1) complex (PubMed:27113748). Interacts with BCL10; as part of a CBM (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation (PubMed:28628108).
Three dimensional structures from OCA and Proteopedia for MALT1 Gene
Protein Expression for MALT1 Gene
Post-translational modifications for MALT1 Gene
Other Protein References for MALT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MALT1 (MALT1)
- Novus Biologicals Antibodies for MALT1
-
Abcam antibodies for MALT1
- Invitrogen Antibodies for MALT1
- antibodies-online: Search results for 194 available MALT1 Antibodies ranked by validation data
- Compare Top MALT1 Antibodies
-
Recommended
- 12 IF (p) Antibodies (anti-rat)
- 25 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-mouse)
- 26 WB Antibodies (anti-mouse)
- 1 IF Antibody (anti-human)
- 1 Func Antibody (anti-human)
- 2 FACS Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 134 WB Antibodies (anti-human)
- GeneTex MALT1 antibody for MALT1
-
Custom Antibody ServicesProSci Antibodies for MALT1
-
Santa Cruz Biotechnology (SCBT) Antibodies for MALT1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MALT1
- Origene Custom Protein Services for MALT1
- Search GeneTex for Proteins for MALT1
-
Abcam proteins for MALT1
Assay Products
No data available for DME Specific Peptides for MALT1 Gene
Domains & Families for MALT1 Gene
Gene Families for MALT1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for MALT1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MALT1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UDY8- Family:
-
- Belongs to the peptidase C14B family.
Function for MALT1 Gene
Molecular function for MALT1 Gene
- GENATLAS Biochemistry:
- mucosa associated lymphoid tissue rearranged with API2 in the t(11;18)(q21;q21) in extranodal marginal zone B-cell lymphomas,in low-grade B cell lymphoma of mucosa associated lymphoid tissue
- UniProtKB/Swiss-Prot Function:
- Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.
Enzyme Numbers (IUBMB) for MALT1 Gene
Phenotypes From GWAS Catalog for MALT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IEA | -- |
| GO:0004197 | cysteine-type endopeptidase activity | IEA,NAS | 11090634 |
| GO:0004842 | ubiquitin-protein transferase activity | IDA | 14695475 |
| GO:0004871 | signal transducer activity | IMP,HMP | 12761501 |
| GO:0005515 | protein binding | IPI | 14695475 |
Phenotypes for MALT1 Gene
- MGI mutant phenotypes for MALT1:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for MALT1:
Animal Model Products
-
Taconic Biosciences Mouse Models for MALT1
- Cyagen custom Knockout/knockin (KOKI) mouse models for MALT1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MALT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MALT1 gene
- Search ViGene Biosciences for MALT1
CRISPR Products
-
OriGene CRISPR knockouts for MALT1
- genomics-online: gRNA clones - Search results for 82 available MALT1 gene related products
- Overview of 82 available MALT1 gene related products
- Applied Biological Materials CRISPR for MALT1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MALT1
- GenScript: Design CRISPR guide RNA sequences for MALT1
miRNA for MALT1 Gene
- miRTarBase miRNAs that target MALT1
-
- hsa-mir-21-5p (MIRT030793)
- hsa-mir-142-3p (MIRT488793)
- hsa-mir-6073 (MIRT488794)
- hsa-mir-548au-3p (MIRT488795)
- hsa-mir-3148 (MIRT488796)
- hsa-mir-6124 (MIRT488797)
- hsa-mir-605-3p (MIRT488798)
- hsa-mir-6849-5p (MIRT488799)
- hsa-mir-3681-5p (MIRT488800)
- hsa-mir-449c-5p (MIRT488801)
- hsa-mir-34b-5p (MIRT488802)
- hsa-mir-2682-5p (MIRT488803)
- hsa-mir-429 (MIRT488804)
- hsa-mir-200c-3p (MIRT488805)
- hsa-mir-200b-3p (MIRT488806)
- hsa-mir-3714 (MIRT488807)
- hsa-mir-4762-3p (MIRT529413)
- hsa-mir-3192-3p (MIRT529414)
- hsa-mir-4777-3p (MIRT529415)
- hsa-mir-668-3p (MIRT529416)
- hsa-mir-875-5p (MIRT529417)
- hsa-mir-200a-3p (MIRT529418)
- hsa-mir-141-3p (MIRT529419)
- hsa-mir-96-5p (MIRT529420)
- hsa-mir-1271-5p (MIRT529421)
- hsa-mir-182-5p (MIRT529422)
- hsa-mir-7150 (MIRT529423)
- hsa-mir-548aw (MIRT529424)
- hsa-mir-4473 (MIRT529425)
- hsa-mir-4671-3p (MIRT529426)
- hsa-mir-4775 (MIRT529427)
- hsa-mir-6740-5p (MIRT529428)
- hsa-mir-19b-3p (MIRT529429)
- hsa-mir-19a-3p (MIRT529430)
- hsa-mir-1468-3p (MIRT529431)
- hsa-mir-548x-5p (MIRT529432)
- hsa-mir-548g-5p (MIRT529433)
- hsa-mir-548f-5p (MIRT529434)
- hsa-mir-548aj-5p (MIRT529435)
- hsa-mir-4735-5p (MIRT529436)
- hsa-mir-3613-3p (MIRT529437)
- hsa-mir-648 (MIRT529438)
- hsa-mir-520f-3p (MIRT529439)
- hsa-mir-302c-3p (MIRT529440)
- hsa-mir-512-3p (MIRT529441)
- hsa-mir-590-3p (MIRT529442)
- hsa-mir-33a-3p (MIRT529443)
- hsa-mir-409-3p (MIRT529444)
- hsa-mir-26a-5p (MIRT732676)
- hsa-mir-181d-5p (MIRT734325)
miRNA Products
- Search ViGene Biosciences for MALT1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MALT1
- Browse OriGene Inhibitory RNA Products For MALT1
- genomics-online: shRNA clones - Search results for 82 available MALT1 gene related products
- Overview of 82 available MALT1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MALT1 gene
Clone Products
- Sino Biological Human cDNA Clone for MALT1
- VectorBuilder custom plasmid, inducible vectors for MALT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MALT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MALT1
- Applied Biological Materials Clones for MALT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MALT1
-
ViGene Biosciences adenoviral particle packaged cDNA for MALT1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MALT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MALT1 gene
No data available for Transcription Factor Targets and HOMER Transcription for MALT1 Gene
Localization for MALT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MALT1 Gene
- Cytoplasm, perinuclear region. Nucleus. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoli (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | IEA,IDA | 16123224 |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 16123224 |
| GO:0005829 | cytosol | IDA,TAS | -- |
Pathways & Interactions for MALT1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | B cell receptor signaling pathway (KEGG) | ||
| 2 | T cell receptor signaling pathway | ||
| 3 | CLEC7A (Dectin-1) signaling | ||
| 4 | B Cell Receptor Signaling Pathway (sino) | ||
| 5 | TCR Signaling (Qiagen) |
.68
|
|
Pathways by source for MALT1 Gene
3 Sino Biological pathways for MALT1 Gene
7 BioSystems pathways for MALT1 Gene
13 Reactome pathways for MALT1 Gene
4 KEGG pathways for MALT1 Gene
1 GeneGo (Thomson Reuters) pathway for MALT1 Gene
1 R&D Systems pathway for MALT1 Gene
5 Qiagen pathways for MALT1 Gene
2 Cell Signaling Technology pathways for MALT1 Gene
Interacting Proteins for MALT1 Gene
Selected Interacting proteins:
Q9UDY8-MALT1_HUMAN
ENSP00000319279
for MALT1 Gene via
MINT
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001923 | B-1 B cell differentiation | IEA | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002237 | response to molecule of bacterial origin | IEA | -- |
| GO:0002726 | positive regulation of T cell cytokine production | IMP | 15125833 |
| GO:0006508 | proteolysis | IDA,IEA | 18223652 |
Transcripts for MALT1 Gene
mRNA/cDNA for MALT1 Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (132) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MALT1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MALT1
- genomics-online: gRNA clones - Search results for 82 available MALT1 gene related products
- Overview of 82 available MALT1 gene related products
- Applied Biological Materials CRISPR for MALT1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MALT1
- GenScript: Design CRISPR guide RNA sequences for MALT1
miRNA Products
- Search ViGene Biosciences for MALT1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MALT1
- Browse OriGene Inhibitory RNA Products For MALT1
- genomics-online: shRNA clones - Search results for 82 available MALT1 gene related products
- Overview of 82 available MALT1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MALT1 gene
Clone Products
- Sino Biological Human cDNA Clone for MALT1
- VectorBuilder custom plasmid, inducible vectors for MALT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MALT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MALT1
- Applied Biological Materials Clones for MALT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MALT1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Lymph node (15.8), Breast (14.1), Blymphocyte (8.2), Peripheral blood mononuclear cells (7.6), and Lung (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MALT1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MALT1 Gene:
MALT1SOURCE GeneReport for Unigene cluster for MALT1 Gene:
Hs.601217mRNA Expression by UniProt/SwissProt for MALT1 Gene:
Q9UDY8-MALT1_HUMAN
Tissue specificity:
Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
Evidence on tissue expression from TISSUES for MALT1 Gene
- Kidney(4.2)
- Blood(2.7)
- Lymph node(2.4)
- Stomach(2.4)
- Intestine(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MALT1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- immune
- integumentary
- lymphatic
- nervous
- respiratory
Regions:
Head and neck:
- brain
- head
Thorax:
- esophagus
- lung
Abdomen:
- intestine
- large intestine
- stomach
Pelvis:
- rectum
General:
- blood
- bone marrow
- skin
- sweat gland
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for MALT1
- genomics-online: primer clones - Search results for 82 available MALT1 gene related products
- Overview of 82 available MALT1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for MALT1 Gene
Orthologs for MALT1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MALT1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MALT1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MALT1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Malt1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Malt1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | MALT1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC426852 33 |
|
||
| MALT1 34 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | MALT1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | malt1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | malt1b 33 34 |
|
||
| malt1 33 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | F22D3.6 35 33 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1584 34 |
|
OneToOne |
- Species where no ortholog for MALT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MALT1 Gene
No data available for Paralogs for MALT1 Gene
Variants for MALT1 Gene
| SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs149988025 | uncertain-significance, Immunodeficiency 12 | 58,709,405(+) | A/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs200919386 | likely-benign, Immunodeficiency 12 | 58,700,600(+) | C/T | intron_variant | |
| rs35533328 | likely-benign, Immunodeficiency 12 | 58,745,675(+) | A/G | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs35575273 | benign, Immunodeficiency 12 | 58,733,473(+) | A/T | 3_prime_UTR_variant, coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
| rs398123058 | pathogenic, Immunodeficiency 12, Immunodeficiency 12 (IMD12) [MIM:615468] | 58,681,226(+) | G/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2447858 | CNV | deletion | 19546169 |
| esv3583096 | CNV | loss | 25503493 |
| esv3583097 | CNV | loss | 25503493 |
| nsv1126485 | CNV | deletion | 24896259 |
| nsv519742 | CNV | loss | 19592680 |
| nsv524760 | CNV | loss | 19592680 |
| nsv577050 | CNV | loss | 21841781 |
| nsv819829 | CNV | loss | 19587683 |
| nsv820257 | CNV | loss | 19587683 |
Residual Variation Intolerance Score:
42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.22;
40.00% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MALT1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MALT1 Gene
Disorders for MALT1 Gene
(19) MalaCards diseases for MALT1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency 12 |
|
|
| lymphoma, mucosa-associated lymphoid type |
|
|
| lymphoma |
|
|
| b-cell lymphomas |
|
|
| marginal zone b-cell lymphoma |
|
|
Search MALT1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MALT1_HUMAN- Immunodeficiency 12 (IMD12) [MIM:615468]: A primary immunodeficiency characterized by onset in infancy of recurrent bacterial and candidal infections resulting in bronchiectasis and growth delay. Manifestations include mastoiditis, aphthous ulcers, cheilitis, gingivitis, esophagitis, gastritis, duodenitis, and meningitis. Levels of absolute lymphocytes and serum immunoglobulins are normal, but specific antibody titers are low despite immunization, and T-cells show impaired proliferative responses to mitogens. {ECO:0000269 PubMed:23727036}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. {ECO:0000269 PubMed:10339464, ECO:0000269 PubMed:10523859, ECO:0000269 PubMed:10702396, ECO:0000269 PubMed:11090634}.
Additional Disease Information for MALT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for MALT1 Gene
Publications for MALT1 Gene
- Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. (PMID: 11090634) Uren AG … Dixit VM (Molecular cell 2000) 2 3 4 22 58
- The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. (PMID: 10339464) Dierlamm J … Marynen P (Blood 1999) 2 3 4 22 58
- A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. (PMID: 10523859) Akagi T … Seto M (Oncogene 1999) 2 3 4 22 58
- Germline variations of the MALT1 gene as risk factors in the development of primary gastric B-cell lymphoma. (PMID: 19394813) Hellmig S … Schreiber S (European journal of cancer (Oxford, England : 1990) 2009) 3 22 44 58
- MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10. (PMID: 16123224) Nakagawa M … Seto M (Blood 2005) 3 4 22 58
Products for MALT1 Gene
- R&D Systems Antibodies for MALT1 (MALT1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for MALT1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MALT1
- Origene Custom Protein Services for MALT1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MALT1
- Browse OriGene Inhibitory RNA Products For MALT1
- OriGene qPCR primer pairs for MALT1
- OriGene CRISPR knockouts for MALT1
- OriGene ORF clones in human for MALT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MALT1
- GenScript: Next-day shipping of latest version cDNA ORF clones for MALT1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for MALT1
- GenScript Custom Assay Services for MALT1
- GenScript Custom overexpressing Cell Line Services for MALT1
- GenScript: Design CRISPR guide RNA sequences for MALT1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MALT1
- Sino Biological Human cDNA Clone for MALT1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for MALT1
- Novus Biologicals lysates and proteins for MALT1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MALT1
- Abcam proteins for MALT1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for MALT1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for MALT1
- Cyagen custom Knockout/knockin (KOKI) mouse models for MALT1
- VectorBuilder custom plasmid, inducible vectors for MALT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MALT1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MALT1
- antibodies-online: Search results for 194 available MALT1 Antibodies ranked by validation data
- Compare Top MALT1 Antibodies
- Recommended
- 134 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 26 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 25 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Search results for available MALT1 related products ranked by validation data
- antibodies-online: Search results for 6 available MALT1 Proteins ranked by validation data
- Compare Top MALT1 Proteins
- GeneTex MALT1 antibody for MALT1
- Search GeneTex for Proteins for MALT1
- ViGene Biosciences adenoviral particle packaged cDNA for MALT1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MALT1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MALT1 gene
- Search ViGene Biosciences for MALT1
- Santa Cruz Biotechnology (SCBT) Antibodies for MALT1
- Search Santa Cruz Biotechnology (SCBT) for MALT1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MALT1
- Horizon Cell Lines for MALT1
- genomics-online: cdna clones - Search results for 82 available MALT1 gene related products
- Overview of 82 available MALT1 gene related products
- orf clones - Search results for 82 available MALT1 gene related products
- Overview of 82 available MALT1 gene related products
- genomics-online: gRNA clones - Search results for 82 available MALT1 gene related products
- Overview of 82 available MALT1 gene related products
- genomics-online: primer clones - Search results for 82 available MALT1 gene related products
- Overview of 82 available MALT1 gene related products
- genomics-online: shRNA clones - Search results for 82 available MALT1 gene related products
- Overview of 82 available MALT1 gene related products
Sources for MALT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
