Aliases for MALRD1 Gene
External Ids for MALRD1 Gene
Previous HGNC Symbols for MALRD1 Gene
Previous GeneCards Identifiers for MALRD1 Gene
This gene encodes a conserved protein that features multiple MAM (meprin-A5-protein tyrosine phosphatase mu) and LDLR A2 (low density lipoprotein receptor A2) domains. Expression of this gene is enriched in the small intestine and is upregulated during differentiation of a human cell line that exhibits properties of intestinal epithelial cells. The encoded protein has been shown to modulate production of FGF19 in a human intestinal cell line and may regulate bile acid metabolism in the liver. A synergistic interaction between an allele of this gene and the APOE E4 allele is associated with an elevated risk of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2017]
GeneCards Summary for MALRD1 Gene
MALRD1 (MAM And LDL Receptor Class A Domain Containing 1) is a Protein Coding gene. Diseases associated with MALRD1 include Allergic Urticaria and Alzheimer Disease. An important paralog of this gene is MAMDC4.
UniProtKB/Swiss-Prot Summary for MALRD1 Gene
Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.