Aliases for MALAT1 Gene
Subcategory (RNA class) for MALAT1 Gene
non-coding RNA
Quality Score for this RNA gene is
13
Aliases for MALAT1 Gene
- Metastasis Associated Lung Adenocarcinoma Transcript 1 (Non-Protein Coding) 2 3 5
- Nuclear Paraspeckle Assembly Transcript 2 (Non-Protein Coding) 2 3
- Long Intergenic Non-Protein Coding RNA 47 2 3
- Nuclear Enriched Abundant Transcript 2 2 3
- Hepcarcin 2 3
- Metastasis Associated In Lung Adenocarcinoma Transcript 1 2
- Non-Protein Coding RNA 47 2
External Ids for MALAT1 Gene
- HGNC: 29665
- Entrez Gene: 378938
- Ensembl: ENSG00000251562
- OMIM: 607924
Previous GeneCards Identifiers for MALAT1 Gene
- GC11P065032
- GC11U900628
- GC11P065266
- GC11P061592
Summaries for MALAT1 Gene
-
This gene produces a precursor transcript from which a long non-coding RNA is derived by RNase P cleavage of a tRNA-like small ncRNA (known as mascRNA) from its 3' end. The resultant mature transcript lacks a canonical poly(A) tail but is instead stabilized by a 3' triple helical structure. This transcript is retained in the nucleus where it is thought to form molecular scaffolds for ribonucleoprotein complexes. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer metastasis and cell migration, and it is involved in cell cycle regulation. Its upregulation in multiple cancerous tissues has been associated with the proliferation and metastasis of tumor cells. [provided by RefSeq, Mar 2015]
GeneCards Summary for MALAT1 Gene
MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MALAT1 include Undifferentiated Embryonal Sarcoma Of The Liver and Lung Cancer.
Additional gene information for MALAT1 Gene
- Monarch Initiative
- Search for MALAT1 at DataMed
- Search for MALAT1 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MALAT1 Gene
Genomics for MALAT1 Gene
GeneHancer (GH) Regulatory Elements for MALAT1 Gene
Promoters and enhancers for MALAT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MALAT1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MALAT1 Gene
Genomic Locations for MALAT1 Gene
- chr11:65,497,762-65,506,516
- (GRCh38/hg38)
- Size:
- 8,755 bases
- Orientation:
- Plus strand
- chr11:65,265,233-65,273,940
- (GRCh37/hg19)
Genomic View for MALAT1 Gene
Genes around MALAT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
MALAT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MALAT1 Gene
Proteins for MALAT1 Gene
Post-translational modifications for MALAT1 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MALAT1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MALAT1
- Origene Custom Protein Services for MALAT1
- Search GeneTex for Proteins for MALAT1
Assay Products
No data available for DME Specific Peptides for MALAT1 Gene
Domains & Families for MALAT1 Gene
Gene Families for MALAT1 Gene
Suggested Antigen Peptide Sequences for MALAT1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains and UniProtKB/Swiss-Prot for MALAT1 Gene
Function for MALAT1 Gene
Phenotypes From GWAS Catalog for MALAT1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MALAT1
-
- Search ViGene Biosciences for MALAT1
CRISPR Products
- Browse CRISPR knockouts for MALAT1
- genomics-online: gRNA clones - Search results for available MALAT1 gene related products
- Applied Biological Materials CRISPR for MALAT1
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA for MALAT1 Gene
- miRTarBase miRNAs that target MALAT1
-
- hsa-mir-9-5p (MIRT054196)
- hsa-mir-200c-3p (MIRT731897)
- hsa-mir-22-3p (MIRT732335)
- hsa-mir-23c (MIRT732955)
- hsa-mir-202-3p (MIRT733621)
- hsa-mir-1297 (MIRT734145)
- hsa-mir-204-5p (MIRT734472)
- hsa-mir-375 (MIRT734845)
- hsa-mir-146b-5p (MIRT735285)
- hsa-mir-200a-3p (MIRT735329)
- hsa-mir-200b-3p (MIRT735330)
- hsa-mir-141-3p (MIRT735331)
- hsa-mir-429 (MIRT735332)
miRNA Products
- Search ViGene Biosciences for MALAT1
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for available MALAT1 gene related products
- Search ViGene Biosciences for MALAT1
Clone Products
- GenScript: Custom all cDNA clones Services for MALAT1
- VectorBuilder custom plasmid, inducible vectors for MALAT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MALAT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MALAT1 gene related products
- orf clones - Search results for available MALAT1 gene related products
- Applied Biological Materials Clones for MALAT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MALAT1 Gene
Localization for MALAT1 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 2 |
| extracellular | 2 |
| nucleus | 2 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MALAT1 Gene
Drugs & Compounds for MALAT1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Platinum compounds | Pharma | 0 |
Transcripts for MALAT1 Gene
mRNA/cDNA for MALAT1 Gene
- (18) Additional mRNA sequences :
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MALAT1 Gene
CRISPR Products
- Browse CRISPR knockouts for MALAT1
- genomics-online: gRNA clones - Search results for available MALAT1 gene related products
- Applied Biological Materials CRISPR for MALAT1
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for MALAT1
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for available MALAT1 gene related products
- Search ViGene Biosciences for MALAT1
Clone Products
- GenScript: Custom all cDNA clones Services for MALAT1
- VectorBuilder custom plasmid, inducible vectors for MALAT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MALAT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MALAT1 gene related products
- orf clones - Search results for available MALAT1 gene related products
- Applied Biological Materials Clones for MALAT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MALAT1 Gene
NURSA nuclear receptor signaling pathways regulating expression of MALAT1 Gene:
MALAT1SOURCE GeneReport for Unigene cluster for MALAT1 Gene:
Hs.621695Evidence on tissue expression from TISSUES for MALAT1 Gene
- Nervous system(2.2)
- Heart(2)
Primer Products
- genomics-online: primer clones - Search results for available MALAT1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MALAT1 Gene
Orthologs for MALAT1 Gene
No data available for Orthologs for MALAT1 Gene
Paralogs for MALAT1 Gene
No data available for Paralogs for MALAT1 Gene
Variants for MALAT1 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000379526 | -- | 65,499,088(+) | G/A | non_coding_transcript_variant | |
| rs1000567968 | -- | 65,499,663(+) | A/G | non_coding_transcript_variant | |
| rs1000803626 | -- | 65,503,861(+) | G/A | non_coding_transcript_variant | |
| rs1001077875 | -- | 65,504,195(+) | CC/C | non_coding_transcript_variant | |
| rs1001130007 | -- | 65,504,084(+) | A/G | non_coding_transcript_variant |
Additional Variant Information for MALAT1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MALAT1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MALAT1 Gene
Disorders for MALAT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| undifferentiated embryonal sarcoma of the liver |
|
|
| lung cancer |
|
|
| embryonal sarcoma |
|
|
| xanthinuria |
|
|
Search MALAT1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MALAT1
No data available for UniProtKB/Swiss-Prot and Genatlas for MALAT1 Gene
Publications for MALAT1 Gene
- Disrupting MALAT1/miR-200c sponge decreases invasion and migration in endometrioid endometrial carcinoma. (PMID: 27693631) Li Q … Jiang Q (Cancer letters 2016) 2 3 58
- MALAT-1, a non protein-coding RNA is upregulated in the cerebellum, hippocampus and brain stem of human alcoholics. (PMID: 22560368) Kryger R … Jaquet V (Alcohol (Fayetteville, N.Y.) 2012) 2 3 58
- MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. (PMID: 12970751) Ji P … Müller-Tidow C (Oncogene 2003) 2 3 58
- Long non-coding RNA MALAT1 promotes oral squamous cell carcinoma development via microRNA-125b/STAT3 axis. (PMID: 28926115) Chang SM … Hu WW (Journal of cellular physiology 2018) 3 58
- Association analyses of genetic variants in long non-coding RNA MALAT1 with breast cancer susceptibility and mRNA expression of MALAT1 in Chinese Han population. (PMID: 29146194) Peng R … Song C (Gene 2018) 3 58
Products for MALAT1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MALAT1
- Origene Custom Protein Services for MALAT1
- Browse OriGene Inhibitory RNA Products For MALAT1
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for MALAT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MALAT1
- GenScript: Custom all cDNA clones Services for MALAT1
- GenScript Custom Purified and Recombinant Proteins Services for MALAT1
- GenScript Custom Assay Services for MALAT1
- GenScript Custom overexpressing Cell Line Services for MALAT1
- Browse GenScript CRISPR for MALAT1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MALAT1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MALAT1
- VectorBuilder custom plasmid, inducible vectors for MALAT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MALAT1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available MALAT1 related products ranked by validation data
- antibodies-online: Search results for available MALAT1 related products ranked by validation data
- antibodies-online: Search results for available MALAT1 related products ranked by validation data
- Search GeneTex for Antibodies for MALAT1
- Search GeneTex for Proteins for MALAT1
- Search ViGene Biosciences for MALAT1
- genomics-online: cdna clones - Search results for available MALAT1 gene related products
- orf clones - Search results for available MALAT1 gene related products
- genomics-online: gRNA clones - Search results for available MALAT1 gene related products
- genomics-online: primer clones - Search results for available MALAT1 gene related products
- genomics-online: shRNA clones - Search results for available MALAT1 gene related products
Sources for MALAT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems