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This gene produces a precursor transcript from which a long non-coding RNA is derived by RNase P cleavage of a tRNA-like small ncRNA (known as mascRNA) from its 3' end. The resultant mature transcript lacks a canonical poly(A) tail but is instead stabilized by a 3' triple helical structure. This transcript is retained in the nucleus where it is thought to form molecular scaffolds for ribonucleoprotein complexes. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer metastasis and cell migration, and it is involved in cell cycle regulation. Its upregulation in multiple cancerous tissues has been associated with the proliferation and metastasis of tumor cells. [provided by RefSeq, Mar 2015]
MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with MALAT1 include Hyperglycemia and Leukemia, Acute Monocytic.
GO ID | Qualified GO term | Evidence | PubMed IDs |
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GO:0005634 | nucleus | IDA | 23985560 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0071456 | cellular response to hypoxia | IMP | 29605300 |
GO:0110024 | positive regulation of cardiac muscle myoblast proliferation | IMP | 29605300 |
GO:2000147 | positive regulation of cell motility | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Platinum compounds | Pharma | 0 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000772640_9606 | lncRNA | 572 | 4 |
Ensembl: ENST00000616527 (view in UCSC) , LncBook: HSALNT0176821, LNCipedia: MALAT1:31, NONCODE: NONHSAT159248.1, |
URS0000762AC3_9606 | lncRNA | 480 | 4 |
Ensembl: ENST00000544868 (view in UCSC) , LncBook: HSALNT0176804, LNCipedia: MALAT1:21, NONCODE: NONHSAT159244.1, |
URS0000788907_9606 | lncRNA | 394 | 4 |
Ensembl: ENST00000617791 (view in UCSC) , LncBook: HSALNT0176803, LNCipedia: MALAT1:22, NONCODE: NONHSAT159243.1, |
URS0000781278_9606 | lncRNA | 353 | 4 |
Ensembl: ENST00000610481 (view in UCSC) , LncBook: HSALNT0176817, LNCipedia: MALAT1:29, NONCODE: NONHSAT159246.1, |
URS00007632D8_9606 | lncRNA | 352 | 4 |
Ensembl: ENST00000620902 (view in UCSC) , LncBook: HSALNT0176802, LNCipedia: MALAT1:20, NONCODE: NONHSAT159242.1, |
Disorder | Aliases | PubMed IDs |
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hyperglycemia |
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leukemia, acute monocytic |
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histiocytoid hemangioma |
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ovarian endometrial cancer |
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fibroma |
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