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This gene produces a precursor transcript from which a long non-coding RNA is derived by RNase P cleavage of a tRNA-like small ncRNA (known as mascRNA) from its 3' end. The resultant mature transcript lacks a canonical poly(A) tail but is instead stabilized by a 3' triple helical structure. This transcript is retained in the nucleus where it is thought to form molecular scaffol... See more...
Aliases for MALAT1 Gene
Subcategory (RNA class) for MALAT1 Gene
lncRNA
Number of RNA Genes sources:
5 / 17
Aliases for MALAT1 Gene
- Metastasis Associated Lung Adenocarcinoma Transcript 1 2 3 5
- MALAT1 2 5 165
- Metastasis Associated Lung Adenocarcinoma Transcript 1 (Non-Protein Coding) 2 3
- Nuclear Paraspeckle Assembly Transcript 2 (Non-Protein Coding) 2 3
- Long Intergenic Non-Protein Coding RNA 47 2 3
- Nuclear Enriched Abundant Transcript 2 2 3
- NCRNA00047 2 3
- Hepcarcin 2 3
- LINC00047 2 3
- NEAT2 2 3
External Ids for MALAT1 Gene
- HGNC: 29665
- Entrez Gene: 378938
- Ensembl: ENSG00000251562
- OMIM: 607924
Previous GeneCards Identifiers for MALAT1 Gene
- GC11P065032
- GC11U900628
- GC11P065266
- GC11P061592
- GC11P065497
- GC11P065562
- GC11P065621
Summaries for MALAT1 Gene
-
This gene produces a precursor transcript from which a long non-coding RNA is derived by RNase P cleavage of a tRNA-like small ncRNA (known as mascRNA) from its 3' end. The resultant mature transcript lacks a canonical poly(A) tail but is instead stabilized by a 3' triple helical structure. This transcript is retained in the nucleus where it is thought to form molecular scaffolds for ribonucleoprotein complexes. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer metastasis and cell migration, and it is involved in cell cycle regulation. Its upregulation in multiple cancerous tissues has been associated with the proliferation and metastasis of tumor cells. [provided by RefSeq, Mar 2015]
GeneCards Summary for MALAT1 Gene
MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with MALAT1 include Hyperglycemia and Leukemia, Acute Monocytic.
Rfam classification for MALAT1 Gene
Additional gene information for MALAT1 Gene
- HGNC(29665)
- Entrez Gene(378938)
- Ensembl(ENSG00000251562)
- OMIM(607924)
- Open Targets Platform(ENSG00000251562)
- Monarch Initiative
- Search for MALAT1 at DataMed
- Search for MALAT1 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for MALAT1 Gene
Genomics for MALAT1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MALAT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MALAT1 on the GeneHancer Hub at the UCSC Golden Path
- Top Transcription factor binding sites by QIAGEN in the MALAT1 gene promoter:
-
- CBF(2)
- CREB
- deltaCREB
- FOXO1
- FOXO1a
- NF-Y
- Nkx2-5
- SREBP-1a
- SREBP-1b
- SREBP-1c
Genomic Locations for MALAT1 Gene
Genomic Locations for MALAT1 Gene
- chr11:65,496,267-65,509,085
- (GRCh38/hg38)
- Size:
- 12,819 bases
- Orientation:
- Plus strand
- chr11:65,265,233-65,273,940
- (GRCh37/hg19)
- Size:
- 8,708 bases
- Orientation:
- Plus strand
Genomic View for MALAT1 Gene
Genes around MALAT1 on UCSC Golden Path with GeneCards custom track
MALAT1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 11q13.1 by HGNC
- 11q13.1 by Entrez Gene
- 11q13.1 by Ensembl
MALAT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MALAT1 Gene
Proteins for MALAT1 Gene
Post-translational modifications for MALAT1 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MALAT1
- Origene Custom Protein Services for MALAT1
No data available for DME Specific Peptides for MALAT1 Gene
Domains & Families for MALAT1 Gene
Gene Families for MALAT1 Gene
Suggested Antigen Peptide Sequences for MALAT1 Gene
- GenScript: Design optimal peptide antigens:
-
- Metastasis-associated lung adenocarcinoma transcript 1 (MALAT_HUMAN)
No data available for Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MALAT1 Gene
Function for MALAT1 Gene
Phenotypes From GWAS Catalog for MALAT1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MALAT1 - Select products 50% OFF >
- * MALAT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MALAT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MALAT1
miRNA for MALAT1 Gene
- miRTarBase miRNAs that target MALAT1
-
- hsa-miR-9-5p (MIRT054196)
- hsa-miR-200c-3p (MIRT731897)
- hsa-miR-22-3p (MIRT732335)
- hsa-miR-23c (MIRT732955)
- hsa-miR-202-3p (MIRT733621)
- hsa-miR-1297 (MIRT734145)
- hsa-miR-204-5p (MIRT734472)
- hsa-miR-375 (MIRT734845)
- hsa-miR-146b-5p (MIRT735285)
- hsa-miR-200a-3p (MIRT735329)
- hsa-miR-200b-3p (MIRT735330)
- hsa-miR-141-3p (MIRT735331)
- hsa-miR-429 (MIRT735332)
miRNA Products
Inhibitory RNA Products
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MALAT1
Clone Products
- Applied Biological Materials (abm): Clones for MALAT1 - Select products 50% OFF >
- * MALAT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MALAT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MALAT1
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MALAT1 Gene
Localization for MALAT1 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 23985560 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MALAT1 Gene
Pathways & Interactions for MALAT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0071456 | cellular response to hypoxia | IMP | 29605300 |
| GO:0110024 | positive regulation of cardiac muscle myoblast proliferation | IMP | 29605300 |
| GO:2000147 | positive regulation of cell motility | IEA | -- |
No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MALAT1 Gene
Drugs & Compounds for MALAT1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Platinum compounds | Pharma | 0 |
Transcripts for MALAT1 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MALAT1 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS0000772640_9606 | lncRNA | 572 | 4 |
Ensembl: ENST00000616527 (view in UCSC) , LncBook: HSALNT0176821, LNCipedia: MALAT1:31, NONCODE: NONHSAT159248.1, |
| URS0000762AC3_9606 | lncRNA | 480 | 4 |
Ensembl: ENST00000544868 (view in UCSC) , LncBook: HSALNT0176804, LNCipedia: MALAT1:21, NONCODE: NONHSAT159244.1, |
| URS0000788907_9606 | lncRNA | 394 | 4 |
Ensembl: ENST00000617791 (view in UCSC) , LncBook: HSALNT0176803, LNCipedia: MALAT1:22, NONCODE: NONHSAT159243.1, |
| URS0000781278_9606 | lncRNA | 353 | 4 |
Ensembl: ENST00000610481 (view in UCSC) , LncBook: HSALNT0176817, LNCipedia: MALAT1:29, NONCODE: NONHSAT159246.1, |
| URS00007632D8_9606 | lncRNA | 352 | 4 |
Ensembl: ENST00000620902 (view in UCSC) , LncBook: HSALNT0176802, LNCipedia: MALAT1:20, NONCODE: NONHSAT159242.1, |
MALAT1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MALAT1 Gene
- 14 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MALAT1 - Select products 50% OFF >
- * MALAT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MALAT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MALAT1
miRNA Products
Inhibitory RNA Products
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MALAT1
Clone Products
- Applied Biological Materials (abm): Clones for MALAT1 - Select products 50% OFF >
- * MALAT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MALAT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MALAT1
Relevant External Links for MALAT1 Gene
- GeneLoc Exon Structure for
- MALAT1
Expression for MALAT1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MALAT1
SOURCE GeneReport for Unigene cluster for MALAT1 Gene:
Hs.621695Evidence on tissue expression from TISSUES for MALAT1 Gene
- Nervous system(2.7)
- Skin(2.5)
- Heart(2.4)
- Muscle(2.3)
- Blood(2.2)
Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MALAT1 Gene
Orthologs for MALAT1 Gene
No data available for Orthologs for MALAT1 Gene
Paralogs for MALAT1 Gene
No data available for Paralogs for MALAT1 Gene
Variants for MALAT1 Gene
Additional Variant Information for MALAT1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MALAT1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MALAT1 Gene
Disorders for MALAT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hyperglycemia |
|
|
| leukemia, acute monocytic |
|
|
| histiocytoid hemangioma |
|
|
| ovarian endometrial cancer |
|
|
| fibroma |
|
Search MALAT1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MALAT1
No data available for UniProtKB/Swiss-Prot and Genatlas for MALAT1 Gene
Publications for MALAT1 Gene
- Disrupting MALAT1/miR-200c sponge decreases invasion and migration in endometrioid endometrial carcinoma. (PMID: 27693631) Li Q … Jiang Q (Cancer letters 2016) 2 3
- MALAT-1, a non protein-coding RNA is upregulated in the cerebellum, hippocampus and brain stem of human alcoholics. (PMID: 22560368) Kryger R … Jaquet V (Alcohol (Fayetteville, N.Y.) 2012) 2 3
- MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. (PMID: 12970751) Ji P … Müller-Tidow C (Oncogene 2003) 2 3
- Association of lncRNA polymorphisms with triglyceride and total cholesterol levels among myocardial infarction patients in Chinese population. (PMID: 30898706) Li Y … Zhang Y (Gene 2020) 3
- Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 cooperates with enhancer of zeste homolog 2 to promote hepatocellular carcinoma development by modulating the microRNA-22/Snail family transcriptional repressor 1 axis. (PMID: 32129914) Chen S … Li H (Cancer science 2020) 3
ExternalLinks
Products for MALAT1 Gene
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- Custom Assay Services
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- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for MALAT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Addgene plasmids for MALAT1
- antibodies-online: Search results for available MALAT1 related products ranked by validation data
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- antibodies-online: Search results for available MALAT1 related products ranked by validation data
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for MALAT1
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Sources for MALAT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
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- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
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- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
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- (128) SNPedia
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- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
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- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (171) SRPDB
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- (178) MirGeneDB