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Aliases for MAGOHB Gene

Aliases for MAGOHB Gene

  • Mago Homolog B, Exon Junction Complex Core Component 2 3 5
  • Mago-Nashi Homolog B (Drosophila) 2
  • Protein Mago Nashi Homolog 2 3
  • Mago-Nashi Homolog B 3
  • MAGOH2 4
  • Magoh 3
  • MGN2 3
  • Mago 3

External Ids for MAGOHB Gene

Previous GeneCards Identifiers for MAGOHB Gene

  • GC12M010652
  • GC12M010756
  • GC12M010485
  • GC12M010653
  • GC12M010821
  • GC12M011023
  • GC12M011327
  • GC12M011545
  • GC12M011736

Summaries for MAGOHB Gene

GeneCards Summary for MAGOHB Gene

MAGOHB (Mago Homolog B, Exon Junction Complex Core Component) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Termination and Gene Expression. An important paralog of this gene is MAGOH.

UniProtKB/Swiss-Prot for MAGOHB Gene

  • Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway.

Additional gene information for MAGOHB Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGOHB Gene

Genomics for MAGOHB Gene

GeneHancer (GH) Regulatory Elements for MAGOHB Gene

Promoters and enhancers for MAGOHB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I010611 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.3 278 2.9 HDGF SMAD1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 MAGOHB ENSG00000213443 KLRA1P EIF2S3B TAS2R43 TAS2R50 ENSG00000257027 ENSG00000256682 STYK1 CLEC2D
GH12I010384 Promoter/Enhancer 1.7 EPDnew FANTOM5 ENCODE dbSUPER 37.1 +226.2 226185 5.1 FOXA2 ZSCAN4 FEZF1 ZEB1 GTF3C2 FOS ZNF362 YY2 CEBPB ZNF662 KLRK1 GC12P010386 TAS2R19 TAS2R31 TAS2R14 TAS2R10 KLRA1P TAS2R15P MAGOHB TAS2R20
GH12I010715 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.5 -106.5 -106471 8.8 CLOCK FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 YBX3 KLRA1P TAS2R20 TAS2R31 TAS2R43 MAGOHB TAS2R14 TAS2R50 TAS2R15P TAS2R10
GH12I010673 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 15.1 -60.5 -60520 1.5 SIN3A ZNF2 TCF12 GLIS2 ZNF207 ZNF143 RUNX3 SP3 YY2 REST STYK1 KLRA1P MAGOHB TAS2R20 TAS2R14 LOC101928100 GC12P010619
GH12I010391 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +218.8 218840 7.4 FOXA2 SMAD1 ARID4B SIN3A FEZF1 ATF7 RUNX3 DEK JUNB REST KLRK1 KLRA1P KLRC3 KLRC4 KLRC2 LOC101928100 TAS2R31 TAS2R20 MAGOHB TAS2R10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAGOHB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAGOHB gene promoter:

Genomic Locations for MAGOHB Gene

Genomic Locations for MAGOHB Gene
chr12:10,603,765-10,613,623
(GRCh38/hg38)
Size:
9,859 bases
Orientation:
Minus strand
chr12:10,756,364-10,766,222
(GRCh37/hg19)

Genomic View for MAGOHB Gene

Genes around MAGOHB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGOHB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGOHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGOHB Gene

Proteins for MAGOHB Gene

  • Protein details for MAGOHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A72-MGN2_HUMAN
    Recommended name:
    Protein mago nashi homolog 2
    Protein Accession:
    Q96A72

    Protein attributes for MAGOHB Gene

    Size:
    148 amino acids
    Molecular mass:
    17276 Da
    Quaternary structure:
    • Interacts with RBM8A and is part of the exon junction complex (EJC).

    Three dimensional structures from OCA and Proteopedia for MAGOHB Gene

neXtProt entry for MAGOHB Gene

Post-translational modifications for MAGOHB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAGOHB Gene

Domains & Families for MAGOHB Gene

Gene Families for MAGOHB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGOHB Gene

Suggested Antigen Peptide Sequences for MAGOHB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A72

UniProtKB/Swiss-Prot:

MGN2_HUMAN :
  • Belongs to the mago nashi family.
Family:
  • Belongs to the mago nashi family.
genes like me logo Genes that share domains with MAGOHB: view

Function for MAGOHB Gene

Molecular function for MAGOHB Gene

UniProtKB/Swiss-Prot Function:
Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway.

Gene Ontology (GO) - Molecular Function for MAGOHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22681889
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MAGOHB: view
genes like me logo Genes that share phenotypes with MAGOHB: view

Animal Model Products

CRISPR Products

miRNA for MAGOHB Gene

miRTarBase miRNAs that target MAGOHB

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGOHB Gene

Localization for MAGOHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGOHB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGOHB gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MAGOHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0035145 exon-exon junction complex IDA 23917022
GO:0043025 neuronal cell body IEA --
GO:0071013 catalytic step 2 spliceosome IBA --
genes like me logo Genes that share ontologies with MAGOHB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAGOHB Gene

Pathways & Interactions for MAGOHB Gene

genes like me logo Genes that share pathways with MAGOHB: view

Gene Ontology (GO) - Biological Process for MAGOHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing IEA --
GO:0006405 RNA export from nucleus TAS --
genes like me logo Genes that share ontologies with MAGOHB: view

No data available for SIGNOR curated interactions for MAGOHB Gene

Drugs & Compounds for MAGOHB Gene

No Compound Related Data Available

Transcripts for MAGOHB Gene

Unigene Clusters for MAGOHB Gene

Mago-nashi homolog B (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGOHB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - - - - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for MAGOHB Gene

GeneLoc Exon Structure for
MAGOHB
ECgene alternative splicing isoforms for
MAGOHB

Expression for MAGOHB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGOHB Gene

Protein differential expression in normal tissues from HIPED for MAGOHB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.5) and Nasal epithelium (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAGOHB Gene



Protein tissue co-expression partners for MAGOHB Gene

NURSA nuclear receptor signaling pathways regulating expression of MAGOHB Gene:

MAGOHB

SOURCE GeneReport for Unigene cluster for MAGOHB Gene:

Hs.104650

mRNA Expression by UniProt/SwissProt for MAGOHB Gene:

Q96A72-MGN2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for MAGOHB Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with MAGOHB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGOHB Gene

Orthologs for MAGOHB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAGOHB Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MAGOHB 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAGOHB 33 34
  • 99.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 99 (a)
ManyToMany
-- 34
  • 98 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia MAGOHB 33 34
  • 94.82 (n)
mouse
(Mus musculus)
Mammalia Magohb 33 16 34
  • 91.22 (n)
rat
(Rattus norvegicus)
Mammalia Magohb 33
  • 90.54 (n)
chicken
(Gallus gallus)
Aves MAGOH 34
  • 99 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 99 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia magoh 33
  • 83.33 (n)
zebrafish
(Danio rerio)
Actinopterygii magoh 33 34
  • 78.62 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010755 33
  • 72.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta mago 33 34
  • 70.57 (n)
worm
(Caenorhabditis elegans)
Secernentea mag-1 33 34
  • 65.75 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MAGO 33
  • 65.52 (n)
rice
(Oryza sativa)
Liliopsida Os12g0287200 33
  • 65.98 (n)
Os.12841 33
bread mold
(Neurospora crassa)
Ascomycetes NCU04405 33
  • 62.61 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mnh1 33
  • 57.87 (n)
Species where no ortholog for MAGOHB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAGOHB Gene

ENSEMBL:
Gene Tree for MAGOHB (if available)
TreeFam:
Gene Tree for MAGOHB (if available)

Paralogs for MAGOHB Gene

Paralogs for MAGOHB Gene

(1) SIMAP similar genes for MAGOHB Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for MAGOHB Gene

genes like me logo Genes that share paralogs with MAGOHB: view

Variants for MAGOHB Gene

Sequence variations from dbSNP and Humsavar for MAGOHB Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
VAR_036431 A breast cancer sample p.Glu119Lys
rs1000139915 -- 10,615,058(-) C/G upstream_transcript_variant
rs1000426790 -- 10,614,576(-) G/A upstream_transcript_variant
rs1000835038 -- 10,610,146(-) C/T intron_variant
rs1000990070 -- 10,610,454(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAGOHB Gene

Variant ID Type Subtype PubMed ID
nsv516351 CNV loss 19592680
nsv832329 CNV gain 17160897

Variation tolerance for MAGOHB Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGOHB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGOHB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGOHB Gene

Disorders for MAGOHB Gene

Additional Disease Information for MAGOHB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MAGOHB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGOHB Gene

Publications for MAGOHB Gene

  1. Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay. (PMID: 23917022) Singh KK … Gehring NH (RNA biology 2013) 2 3 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58

Products for MAGOHB Gene

Sources for MAGOHB Gene

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