Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [pr... See more...

Aliases for MAGOH Gene

Aliases for MAGOH Gene

  • Mago Homolog, Exon Junction Complex Subunit 2 3 5
  • Mago Homolog, Exon Junction Complex Core Component 2 3
  • Protein Mago Nashi Homolog 3 4
  • MAGOHA 3 4
  • Mago-Nashi (Drosophila) Homolog, Proliferation-Associated 2
  • Mago-Nashi Homolog, Proliferation-Associated (Drosophila) 2
  • Mago-Nashi Homolog, Proliferation-Associated 3
  • MAGOH1 3

External Ids for MAGOH Gene

Previous GeneCards Identifiers for MAGOH Gene

  • GC01M053327
  • GC01M052581
  • GC01M053051
  • GC01M053062
  • GC01M053404
  • GC01M053465
  • GC01M053692
  • GC01M051808

Summaries for MAGOH Gene

Entrez Gene Summary for MAGOH Gene

  • Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGOH Gene

MAGOH (Mago Homolog, Exon Junction Complex Subunit) is a Protein Coding gene. Diseases associated with MAGOH include Metaphyseal Chondrodysplasia, Schmid Type and Primary Autosomal Recessive Microcephaly. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm. An important paralog of this gene is MAGOHB.

UniProtKB/Swiss-Prot Summary for MAGOH Gene

  • Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638). Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway (PubMed:23917022). The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.

Gene Wiki entry for MAGOH Gene

Additional gene information for MAGOH Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAGOH Gene

Genomics for MAGOH Gene

GeneHancer (GH) Regulatory Elements for MAGOH Gene

Promoters and enhancers for MAGOH Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAGOH on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAGOH

Top Transcription factor binding sites by QIAGEN in the MAGOH gene promoter:
  • COMP1
  • CUTL1
  • E47
  • FOXO3
  • FOXO3a
  • FOXO3b
  • Hand1
  • SRF
  • SRF (504 AA)
  • XBP-1

Genomic Locations for MAGOH Gene

Genomic Locations for MAGOH Gene
chr1:53,226,892-53,238,610
(GRCh38/hg38)
Size:
11,719 bases
Orientation:
Minus strand
chr1:53,692,564-53,704,282
(GRCh37/hg19)
Size:
11,719 bases
Orientation:
Minus strand

Genomic View for MAGOH Gene

Genes around MAGOH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGOH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGOH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGOH Gene

Proteins for MAGOH Gene

  • Protein details for MAGOH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61326-MGN_HUMAN
    Recommended name:
    Protein mago nashi homolog
    Protein Accession:
    P61326
    Secondary Accessions:
    • B1ARP8
    • B2R5A2
    • O35169
    • P50606
    • Q5SW69

    Protein attributes for MAGOH Gene

    Size:
    146 amino acids
    Molecular mass:
    17164 Da
    Quaternary structure:
    • Heterodimer with RBM8A (PubMed:12730685, PubMed:12781131, PubMed:23917022). Core component of the mRNA splicing-dependent exon junction complex (EJC); the core complex contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A (PubMed:11991638, PubMed:16170325, PubMed:16314458, PubMed:23917022, PubMed:16923391, PubMed:16931718, PubMed:19033377, PubMed:20479275). Interacts with PYM1; the interaction is direct and dissociates the EJC from spliced mRNAs (PubMed:14968132, PubMed:18026120, PubMed:19410547). Identified in a complex composed of the EJC core, UPF3B and UPF2. The EJC core can also interact with UPF3A (in vitro) (PubMed:20479275). Identified in the spliceosome C complex (PubMed:11991638).

    Three dimensional structures from OCA and Proteopedia for MAGOH Gene

    Alternative splice isoforms for MAGOH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAGOH Gene

Post-translational modifications for MAGOH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGOH Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGOH Gene

Domains & Families for MAGOH Gene

Gene Families for MAGOH Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for MAGOH Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGOH Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55283, moderately similar to Protein mago nashi homolog (B1ARP8_HUMAN)
  • Protein mago nashi homolog (MGN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61326

UniProtKB/Swiss-Prot:

MGN_HUMAN :
  • Belongs to the mago nashi family.
Family:
  • Belongs to the mago nashi family.
genes like me logo Genes that share domains with MAGOH: view

Function for MAGOH Gene

Molecular function for MAGOH Gene

UniProtKB/Swiss-Prot Function:
Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638). Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway (PubMed:23917022). The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.
GENATLAS Biochemistry:
Drosophila Mago Nashi (grandchildless) homolog,determining the localization and fate of germ cells during Drosophila germ plasm development,expressed ubiquitously adult tissues

Phenotypes From GWAS Catalog for MAGOH Gene

Gene Ontology (GO) - Molecular Function for MAGOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22681889
GO:0005515 protein binding IPI 10662555
genes like me logo Genes that share ontologies with MAGOH: view
genes like me logo Genes that share phenotypes with MAGOH: view

Animal Models for MAGOH Gene

MGI Knock Outs for MAGOH:
  • Magoh Magoh<tm1d(KOMP)Dlsi>
  • Magoh Magoh<tm1a(KOMP)Dlsi>

Animal Model Products

CRISPR Products

miRNA for MAGOH Gene

miRTarBase miRNAs that target MAGOH

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGOH

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAGOH Gene

Localization for MAGOH Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGOH Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles (PubMed:19324961). {ECO:0000250, ECO:0000250 UniProtKB:Q27W02, ECO:0000269 PubMed:19324961}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGOH gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAGOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22720776
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with MAGOH: view

Pathways & Interactions for MAGOH Gene

genes like me logo Genes that share pathways with MAGOH: view

Gene Ontology (GO) - Biological Process for MAGOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP 22203037
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0006405 RNA export from nucleus TAS --
genes like me logo Genes that share ontologies with MAGOH: view

No data available for SIGNOR curated interactions for MAGOH Gene

Drugs & Compounds for MAGOH Gene

No Compound Related Data Available

Transcripts for MAGOH Gene

mRNA/cDNA for MAGOH Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGOH

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGOH Gene

No ASD Table

Relevant External Links for MAGOH Gene

GeneLoc Exon Structure for
MAGOH

Expression for MAGOH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAGOH Gene

Protein differential expression in normal tissues from HIPED for MAGOH Gene

This gene is overexpressed in Pancreas (24.5) and Fetal ovary (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAGOH Gene



Protein tissue co-expression partners for MAGOH Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAGOH

SOURCE GeneReport for Unigene cluster for MAGOH Gene:

Hs.421576

mRNA Expression by UniProt/SwissProt for MAGOH Gene:

P61326-MGN_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for MAGOH Gene

  • Blood(4.1)
genes like me logo Genes that share expression patterns with MAGOH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGOH Gene

Orthologs for MAGOH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAGOH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGOH 31
  • 100 (a)
OneToOne
LOC100613301 30
  • 100 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 99 (a)
ManyToMany
-- 31
  • 98 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia MAGOH 31
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAGOH 31 30
  • 95.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MAGOH 30
  • 95.66 (n)
mouse
(Mus musculus)
Mammalia Magoh 17 31 30
  • 91.1 (n)
rat
(Rattus norvegicus)
Mammalia Magoh 30
  • 90.18 (n)
chicken
(Gallus gallus)
Aves MAGOH 31
  • 99 (a)
OneToMany
MAGOH2 30
  • 83.56 (n)
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 99 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC64274 30
zebrafish
(Danio rerio)
Actinopterygii magoh 31
  • 97 (a)
OneToMany
Dr.13517 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4136 30
fruit fly
(Drosophila melanogaster)
Insecta mago 31 32
  • 88 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mag-1 31
  • 76 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1607 30
wheat
(Triticum aestivum)
Liliopsida Ta.10145 30
corn
(Zea mays)
Liliopsida Zm.4796 30
barley
(Hordeum vulgare)
Liliopsida Hv.275 30
sea squirt
(Ciona savignyi)
Ascidiacea Cin.14815 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14815 30
Species where no ortholog for MAGOH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for MAGOH Gene

ENSEMBL:
Gene Tree for MAGOH (if available)
TreeFam:
Gene Tree for MAGOH (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAGOH: view image

Paralogs for MAGOH Gene

Paralogs for MAGOH Gene

(1) SIMAP similar genes for MAGOH Gene using alignment to 2 proteins:

  • MGN_HUMAN
  • B1ARP8_HUMAN

Pseudogenes.org Pseudogenes for MAGOH Gene

genes like me logo Genes that share paralogs with MAGOH: view

Variants for MAGOH Gene

Additional dbSNP identifiers (rs#s) for MAGOH Gene

Structural Variations from Database of Genomic Variants (DGV) for MAGOH Gene

Variant ID Type Subtype PubMed ID
esv2422213 CNV duplication 17116639
nsv1001535 CNV gain 25217958
nsv1011750 CNV gain 25217958
nsv829871 CNV loss 17160897

Variation tolerance for MAGOH Gene

Residual Variation Intolerance Score: 50.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGOH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGOH

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAGOH Gene

Disorders for MAGOH Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAGOH Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search MAGOH in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAGOH

genes like me logo Genes that share disorders with MAGOH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGOH Gene

Publications for MAGOH Gene

  1. The mammalian homologue of mago nashi encodes a serum-inducible protein. (PMID: 9479507) Zhao XF … Aplan PD (Genomics 1998) 2 3 4 23 54
  2. MAGOH interacts with a novel RNA-binding protein. (PMID: 10662555) Zhao XF … Aplan PD (Genomics 2000) 3 4 23 54
  3. Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay. (PMID: 23917022) Singh KK … Gehring NH (RNA biology 2013) 3 4 54
  4. Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. (PMID: 22203037) Michelle L … Chabot B (Molecular and cellular biology 2012) 3 4 54
  5. Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex. (PMID: 20479275) Buchwald G … Conti E (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 54

Products for MAGOH Gene

Sources for MAGOH Gene