Aliases for MAGI3 Gene
External Ids for MAGI3 Gene
Previous GeneCards Identifiers for MAGI3 Gene
GeneCards Summary for MAGI3 Gene
MAGI3 (Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 3) is a Protein Coding gene. Diseases associated with MAGI3 include Lymphocytic Colitis. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Endometrial cancer. Gene Ontology (GO) annotations related to this gene include frizzled binding and guanylate kinase activity. An important paralog of this gene is MAGI2.
UniProtKB/Swiss-Prot for MAGI3 Gene
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.