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Aliases for MAGEF1 Gene

Aliases for MAGEF1 Gene

  • MAGE Family Member F1 2 3 5
  • Melanoma Antigen Family F1 2
  • MAGE-F1 Antigen 4

External Ids for MAGEF1 Gene

Previous GeneCards Identifiers for MAGEF1 Gene

  • GC03M181388
  • GC03M185611
  • GC03M185830
  • GC03M185749
  • GC03M185910
  • GC03M184428
  • GC03M181838

Summaries for MAGEF1 Gene

Entrez Gene Summary for MAGEF1 Gene

  • This intronless gene encodes a member of the MAGE superfamily. It is ubiquitously expressed in normal tissues and in tumor cells. This gene includes a microsatellite repeat in the coding region. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEF1 Gene

MAGEF1 (MAGE Family Member F1) is a Protein Coding gene. Diseases associated with MAGEF1 include Melanoma. An important paralog of this gene is NSMCE3.

UniProtKB/Swiss-Prot for MAGEF1 Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Additional gene information for MAGEF1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEF1 Gene

Genomics for MAGEF1 Gene

GeneHancer (GH) Regulatory Elements for MAGEF1 Gene

Promoters and enhancers for MAGEF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I184710 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 565.1 +0.4 420 2.6 HDGF SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B ZNF143 MAGEF1 EPHB3
GH03I184561 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.6 +146.3 146299 9.3 HDGF PKNOX1 CLOCK NEUROD1 SIN3A ZNF2 YY1 SLC30A9 ZNF121 GLIS2 EPHB3 MAGEF1 VPS8 LINC01839
GH03I184524 Enhancer 1 Ensembl ENCODE 22.7 +186.4 186381 1.7 ZNF335 GLIS2 ZNF366 EGR2 SP3 ZNF398 REST ZEB2 ZNF585B GLIS1 MAGEF1 LINC02054 YEATS2 THPO CHRD LINC01840 POLR2H CLCN2 EPHB3 FAM131A
GH03I184655 Enhancer 1.2 Ensembl ENCODE dbSUPER 17.8 +53.6 53596 5.7 ELF3 PKNOX1 ARID4B BATF KLF5 IRF4 ATF7 RCOR1 FOS IKZF2 MAGEF1 YEATS2 EPHB3 LINC01840 FAM131A
GH03I184676 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.9 +33.0 32964 4.4 FOXA2 MZF1 SIN3A FEZF1 ZNF121 ZSCAN5C CEBPB ZNF398 TSHZ1 ZNF843 MAGEF1 EPHB3 LINC01840
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAGEF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAGEF1 gene promoter:

Genomic Locations for MAGEF1 Gene

Genomic Locations for MAGEF1 Gene
chr3:184,710,367-184,712,048
(GRCh38/hg38)
Size:
1,682 bases
Orientation:
Minus strand
chr3:184,428,155-184,429,836
(GRCh37/hg19)

Genomic View for MAGEF1 Gene

Genes around MAGEF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEF1 Gene

Proteins for MAGEF1 Gene

  • Protein details for MAGEF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAY2-MAGF1_HUMAN
    Recommended name:
    Melanoma-associated antigen F1
    Protein Accession:
    Q9HAY2
    Secondary Accessions:
    • Q9H215

    Protein attributes for MAGEF1 Gene

    Size:
    307 amino acids
    Molecular mass:
    35222 Da
    Quaternary structure:
    • Interacts with LNX1, TRIM27 and NSMCE1.

neXtProt entry for MAGEF1 Gene

Post-translational modifications for MAGEF1 Gene

  • Ubiquitination at isoforms=251
  • Modification sites at PhosphoSitePlus

Other Protein References for MAGEF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEF1 Gene

Domains & Families for MAGEF1 Gene

Gene Families for MAGEF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGEF1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEF1: view

No data available for UniProtKB/Swiss-Prot for MAGEF1 Gene

Function for MAGEF1 Gene

Molecular function for MAGEF1 Gene

UniProtKB/Swiss-Prot Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Phenotypes From GWAS Catalog for MAGEF1 Gene

Gene Ontology (GO) - Molecular Function for MAGEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAGEF1: view
genes like me logo Genes that share phenotypes with MAGEF1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEF1 Gene

Localization for MAGEF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEF1 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAGEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with MAGEF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAGEF1 Gene

Pathways & Interactions for MAGEF1 Gene

SuperPathways for MAGEF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEF1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGEF1 Gene

Drugs & Compounds for MAGEF1 Gene

No Compound Related Data Available

Transcripts for MAGEF1 Gene

mRNA/cDNA for MAGEF1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(316) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEF1 Gene

Melanoma antigen family F, 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEF1 Gene

No ASD Table

Relevant External Links for MAGEF1 Gene

GeneLoc Exon Structure for
MAGEF1
ECgene alternative splicing isoforms for
MAGEF1

Expression for MAGEF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEF1 Gene

Protein differential expression in normal tissues from HIPED for MAGEF1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEF1 Gene



Protein tissue co-expression partners for MAGEF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAGEF1 Gene:

MAGEF1

SOURCE GeneReport for Unigene cluster for MAGEF1 Gene:

Hs.306123

mRNA Expression by UniProt/SwissProt for MAGEF1 Gene:

Q9HAY2-MAGF1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for MAGEF1 Gene

  • Lung(4.4)
  • Kidney(4.3)
  • Nervous system(3.7)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with MAGEF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEF1 Gene

Orthologs for MAGEF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAGEF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEF1 33 34
  • 98.7 (n)
dog
(Canis familiaris)
Mammalia MAGEF1 33 34
  • 88.29 (n)
cow
(Bos Taurus)
Mammalia MAGEF1 33 34
  • 87.81 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 44 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
OneToMany
chicken
(Gallus gallus)
Aves MAGE 34
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 43 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ndnl2 34
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToMany
Species where no ortholog for MAGEF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAGEF1 Gene

ENSEMBL:
Gene Tree for MAGEF1 (if available)
TreeFam:
Gene Tree for MAGEF1 (if available)

Paralogs for MAGEF1 Gene

Variants for MAGEF1 Gene

Sequence variations from dbSNP and Humsavar for MAGEF1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs34995413 benign, not specified 184,711,346(-) TCCTCCTCCTCCTCCTCCTCC/TCCTCCTCCTCCTCC/TCCTCCTCCTCCTCCTCC/TCCTCCTCCTCCTCCTCCTCCTCC/TCCTCCTCCTCCTCCTCCTCCTCCTCC/TCCTCCTCCTCCTCCTCCTCCTCCTCCTCC/TCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCC/TCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCC coding_sequence_variant, inframe_deletion, inframe_insertion
rs1000925168 -- 184,712,047(-) G/T 5_prime_UTR_variant
rs1000955878 -- 184,711,880(-) C/T 5_prime_UTR_variant
rs1002731349 -- 184,711,990(-) G/A 5_prime_UTR_variant
rs1003581129 -- 184,710,154(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEF1 Gene

Variant ID Type Subtype PubMed ID
esv3598946 CNV gain 21293372
nsv508973 CNV insertion 20534489
nsv829816 CNV loss 17160897

Variation tolerance for MAGEF1 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.13; 87.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGEF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGEF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEF1 Gene

Disorders for MAGEF1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGEF1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAGEF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAGEF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEF1 Gene

Publications for MAGEF1 Gene

  1. MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily. (PMID: 11313144) Stone B … Nelson BH (Gene 2001) 2 3 4 58
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  3. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle JM … Potts PR (Molecular cell 2010) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. An overview of the MAGE gene family with the identification of all human members of the family. (PMID: 11454705) Chomez P … Lucas S (Cancer research 2001) 3 4 58

Products for MAGEF1 Gene

Sources for MAGEF1 Gene

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