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Aliases for MAGED4B Gene

Aliases for MAGED4B Gene

  • MAGE Family Member D4B 2 3 5
  • Melanoma Antigen Family D4B 2 3
  • MAGE-D4 Antigen 3 4
  • MAGE-E1 Antigen 3 4
  • Melanoma-Associated Antigen D4 3
  • Melanoma Antigen Family D, 4B 3
  • KIAA1859 4
  • MAGED4A 4
  • MAGEE1 4

External Ids for MAGED4B Gene

Previous GeneCards Identifiers for MAGED4B Gene

  • GC0XU900705
  • GC0XM051822
  • GC0XM049240
  • GC0XM051805

Summaries for MAGED4B Gene

Entrez Gene Summary for MAGED4B Gene

  • This gene is a member of the MAGED gene family. It is expressed only in brain and ovary, and some transcript variants of this gene are specifically expressed in glioma cells. This gene is clustered with other MAGED genes on chromosome Xp11. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for MAGED4B Gene

MAGED4B (MAGE Family Member D4B) is a Protein Coding gene. Diseases associated with MAGED4B include Glioma. An important paralog of this gene is MAGED4.

UniProtKB/Swiss-Prot for MAGED4B Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Gene Wiki entry for MAGED4B Gene

Additional gene information for MAGED4B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGED4B Gene

Genomics for MAGED4B Gene

GeneHancer (GH) Regulatory Elements for MAGED4B Gene

Promoters and enhancers for MAGED4B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ052068 Promoter 1 EPDnew Ensembl 650.7 +0.4 371 1.4 MAGED4B SNORA11E
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAGED4B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAGED4B gene promoter:
  • STAT5A
  • Meis-1b
  • Meis-1a
  • Meis-1
  • ZID
  • RFX1
  • IRF-7A
  • HNF-4alpha1
  • NF-AT4
  • NF-AT3

Genomic Locations for MAGED4B Gene

Genomic Locations for MAGED4B Gene
chrX:52,061,827-52,069,272
(GRCh38/hg38)
Size:
7,446 bases
Orientation:
Minus strand
chrX:51,804,923-51,812,368
(GRCh37/hg19)
Size:
7,446 bases
Orientation:
Minus strand

Genomic View for MAGED4B Gene

Genes around MAGED4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGED4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGED4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGED4B Gene

Proteins for MAGED4B Gene

  • Protein details for MAGED4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JG8-MAGD4_HUMAN
    Recommended name:
    Melanoma-associated antigen D4
    Protein Accession:
    Q96JG8
    Secondary Accessions:
    • A8K093
    • Q5HYN6
    • Q8WXW4
    • Q9BQ84
    • Q9BVH1
    • Q9BYH3
    • Q9BYH4
    • Q9H217
    • A8K093
    • Q5HYN6
    • Q8WXW4
    • Q9BQ84
    • Q9BVH1
    • Q9BYH3
    • Q9BYH4
    • Q9H217

    Protein attributes for MAGED4B Gene

    Size:
    741 amino acids
    Molecular mass:
    81378 Da
    Quaternary structure:
    • Interacts with TRIM27.
    • Interacts with TRIM27.
    SequenceCaution:
    • Sequence=AAH01207.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL50032.1; Type=Frameshift; Positions=186, 219; Evidence={ECO:0000305}; Sequence=BAB47488.2; Type=Erroneous initiation; Evidence={ECO:0000305};
    • Sequence=AAH01207.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL50032.1; Type=Frameshift; Positions=186, 219; Evidence={ECO:0000305}; Sequence=BAB47488.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAGED4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAGED4B Gene

Post-translational modifications for MAGED4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAGED4B Gene

Domains & Families for MAGED4B Gene

Gene Families for MAGED4B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MAGED4B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGED4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGED4B: view

No data available for UniProtKB/Swiss-Prot for MAGED4B Gene

Function for MAGED4B Gene

Molecular function for MAGED4B Gene

UniProtKB/Swiss-Prot Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
genes like me logo Genes that share phenotypes with MAGED4B: view

Animal Model Products

miRNA for MAGED4B Gene

miRTarBase miRNAs that target MAGED4B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGED4B Gene

Localization for MAGED4B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGED4B gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MAGED4B Gene

Pathways & Interactions for MAGED4B Gene

SuperPathways for MAGED4B Gene

No Data Available

Interacting Proteins for MAGED4B Gene

Gene Ontology (GO) - Biological Process for MAGED4B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGED4B Gene

Drugs & Compounds for MAGED4B Gene

(1) Additional Compounds for MAGED4B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAGED4B: view

Transcripts for MAGED4B Gene

mRNA/cDNA for MAGED4B Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGED4B Gene

No ASD Table

Relevant External Links for MAGED4B Gene

GeneLoc Exon Structure for
MAGED4B
ECgene alternative splicing isoforms for
MAGED4B

Expression for MAGED4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGED4B Gene

mRNA differential expression in normal tissues according to GTEx for MAGED4B Gene

This gene is overexpressed in Brain - Hypothalamus (x9.7) and Brain - Amygdala (x4.3).

Protein differential expression in normal tissues from HIPED for MAGED4B Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (65.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAGED4B Gene



Protein tissue co-expression partners for MAGED4B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAGED4B Gene:

MAGED4B

mRNA Expression by UniProt/SwissProt for MAGED4B Gene:

Q96JG8-MAGD4_HUMAN
Tissue specificity: Expressed only in brain and ovary among normal tissues. Isoform 1 and isoform 2 are specifically expressed in glioma cells among cancer cells. Detected in some renal cell carcinoma samples.

Evidence on tissue expression from TISSUES for MAGED4B Gene

  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with MAGED4B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGED4B Gene

Orthologs for MAGED4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAGED4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
OneToMany
LOC465643 33
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia LOC480926 33
  • 90.23 (n)
-- 34
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MAGED4B 33
  • 88.48 (n)
-- 34
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 39 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 37 (a)
OneToMany
chicken
(Gallus gallus)
Aves MAGE 34
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ndnl2 34
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToMany
Species where no ortholog for MAGED4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAGED4B Gene

ENSEMBL:
Gene Tree for MAGED4B (if available)
TreeFam:
Gene Tree for MAGED4B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAGED4B: view image

Paralogs for MAGED4B Gene

(23) SIMAP similar genes for MAGED4B Gene using alignment to 4 proteins:

  • MAGD4_HUMAN
  • D6RBW3_HUMAN
  • H0Y8Z3_HUMAN
  • H0Y937_HUMAN

Pseudogenes.org Pseudogenes for MAGED4B Gene

genes like me logo Genes that share paralogs with MAGED4B: view

Variants for MAGED4B Gene

Sequence variations from dbSNP and Humsavar for MAGED4B Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs200011554 -- 52,067,978(-) G/A coding_sequence_variant, synonymous_variant
rs200519198 -- 52,065,425(-) C/T intron_variant
rs201915043 -- 52,062,977(-) G/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs373827485 -- 52,062,160(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAGED4B Gene

Variant ID Type Subtype PubMed ID
esv3350872 OTHER inversion 20981092
nsv1125093 CNV duplication 24896259
nsv516643 CNV gain 19592680

Additional Variant Information for MAGED4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGED4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MAGED4B Gene

Disorders for MAGED4B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGED4B Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
glioma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAGED4B

genes like me logo Genes that share disorders with MAGED4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGED4B Gene

Publications for MAGED4B Gene

  1. Structural characterization and chromosomal localization of the MAGE-E1 gene. (PMID: 11602350) Kawano Y … Ikenaka K (Gene 2001) 3 4 22 58
  2. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle JM … Potts PR (Molecular cell 2010) 3 4 58
  3. Expression of MAGE-D4, a novel MAGE family antigen, is correlated with tumor-cell proliferation of non-small cell lung cancer. (PMID: 16225959) Ito S … Tanaka F (Lung cancer (Amsterdam, Netherlands) 2006) 3 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MAGED4B Gene

Sources for MAGED4B Gene

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