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Aliases for MAGED4 Gene

Aliases for MAGED4 Gene

  • MAGE Family Member D4 2 3 5
  • Melanoma Antigen Family D4 2 3
  • MAGE-D4 Antigen 3 4
  • MAGE-E1 Antigen 3 4
  • MAGEE1 3 4
  • Melanoma-Associated Antigen D4 3
  • Melanoma Antigen Family D, 4 3
  • KIAA1859 4
  • MAGE-D4 3
  • MAGE-E1 3
  • MAGED4A 4
  • MAGE1 3

External Ids for MAGED4 Gene

Previous GeneCards Identifiers for MAGED4 Gene

  • GC0XP049889
  • GC0XP050579
  • GC0XM050721
  • GC0XM051637
  • GC0XM051821
  • GC0XP051949
  • GC0XP051952
  • GC0XP051927

Summaries for MAGED4 Gene

GeneCards Summary for MAGED4 Gene

MAGED4 (MAGE Family Member D4) is a Protein Coding gene. An important paralog of this gene is MAGED4B.

UniProtKB/Swiss-Prot for MAGED4 Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Additional gene information for MAGED4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGED4 Gene

Genomics for MAGED4 Gene

GeneHancer (GH) Regulatory Elements for MAGED4 Gene

Promoters and enhancers for MAGED4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ052184 Promoter 1 EPDnew Ensembl 650.7 +0.5 478 1.8 MAGED4 GC0XP052192
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAGED4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAGED4 gene promoter:
  • STAT5A
  • ZID
  • Meis-1b
  • Meis-1a
  • Meis-1
  • RFX1
  • IRF-7A
  • HNF-4alpha1
  • NF-AT
  • NF-AT1

Genomic Locations for MAGED4 Gene

Genomic Locations for MAGED4 Gene
chrX:52,184,823-52,192,268
(GRCh38/hg38)
Size:
7,446 bases
Orientation:
Plus strand
chrX:51,927,919-51,935,364
(GRCh37/hg19)
Size:
7,446 bases
Orientation:
Plus strand

Genomic View for MAGED4 Gene

Genes around MAGED4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGED4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGED4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGED4 Gene

Proteins for MAGED4 Gene

  • Protein details for MAGED4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JG8-MAGD4_HUMAN
    Recommended name:
    Melanoma-associated antigen D4
    Protein Accession:
    Q96JG8
    Secondary Accessions:
    • A8K093
    • Q5HYN6
    • Q8WXW4
    • Q9BQ84
    • Q9BVH1
    • Q9BYH3
    • Q9BYH4
    • Q9H217
    • A8K093
    • Q5HYN6
    • Q8WXW4
    • Q9BQ84
    • Q9BVH1
    • Q9BYH3
    • Q9BYH4
    • Q9H217

    Protein attributes for MAGED4 Gene

    Size:
    741 amino acids
    Molecular mass:
    81378 Da
    Quaternary structure:
    • Interacts with TRIM27.
    • Interacts with TRIM27.
    SequenceCaution:
    • Sequence=AAH01207.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL50032.1; Type=Frameshift; Positions=186, 219; Evidence={ECO:0000305}; Sequence=BAB47488.2; Type=Erroneous initiation; Evidence={ECO:0000305};
    • Sequence=AAH01207.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL50032.1; Type=Frameshift; Positions=186, 219; Evidence={ECO:0000305}; Sequence=BAB47488.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAGED4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAGED4 Gene

Post-translational modifications for MAGED4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGED4 Gene

No data available for DME Specific Peptides for MAGED4 Gene

Domains & Families for MAGED4 Gene

Gene Families for MAGED4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MAGED4 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGED4: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MAGED4 Gene

Function for MAGED4 Gene

Molecular function for MAGED4 Gene

UniProtKB/Swiss-Prot Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
genes like me logo Genes that share phenotypes with MAGED4: view

Animal Model Products

CRISPR Products

miRNA for MAGED4 Gene

miRTarBase miRNAs that target MAGED4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGED4

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGED4 Gene

Localization for MAGED4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGED4 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MAGED4 Gene

Pathways & Interactions for MAGED4 Gene

SuperPathways for MAGED4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGED4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGED4 Gene

Drugs & Compounds for MAGED4 Gene

No Compound Related Data Available

Transcripts for MAGED4 Gene

mRNA/cDNA for MAGED4 Gene

(4) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGED4 Gene

Melanoma antigen family D, 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGED4

Alternative Splicing Database (ASD) splice patterns (SP) for MAGED4 Gene

No ASD Table

Relevant External Links for MAGED4 Gene

GeneLoc Exon Structure for
MAGED4
ECgene alternative splicing isoforms for
MAGED4

Expression for MAGED4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGED4 Gene

mRNA differential expression in normal tissues according to GTEx for MAGED4 Gene

This gene is overexpressed in Brain - Hypothalamus (x10.7) and Brain - Amygdala (x5.0).

Protein differential expression in normal tissues from HIPED for MAGED4 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (65.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAGED4 Gene



Protein tissue co-expression partners for MAGED4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAGED4 Gene:

MAGED4

SOURCE GeneReport for Unigene cluster for MAGED4 Gene:

Hs.522650

mRNA Expression by UniProt/SwissProt for MAGED4 Gene:

Q96JG8-MAGD4_HUMAN
Tissue specificity: Expressed only in brain and ovary among normal tissues. Isoform 1 and isoform 2 are specifically expressed in glioma cells among cancer cells. Detected in some renal cell carcinoma samples.

Evidence on tissue expression from TISSUES for MAGED4 Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with MAGED4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGED4 Gene

Orthologs for MAGED4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAGED4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC465643 33
  • 99.81 (n)
-- 34
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC480926 33
  • 90.23 (n)
-- 34
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MAGED4B 33
  • 88.48 (n)
-- 34
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 39 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 37 (a)
OneToMany
chicken
(Gallus gallus)
Aves MAGE 34
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ndnl2 34
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToMany
Species where no ortholog for MAGED4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAGED4 Gene

ENSEMBL:
Gene Tree for MAGED4 (if available)
TreeFam:
Gene Tree for MAGED4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAGED4: view image

Paralogs for MAGED4 Gene

Variants for MAGED4 Gene

Sequence variations from dbSNP and Humsavar for MAGED4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs112352914 -- 52,191,946(+) G/A/C intron_variant
rs200366801 -- 52,191,118(+) C/A intron_variant
rs200921001 -- 52,188,670(+) G/A intron_variant
rs201653231 -- 52,186,117(+) C/T coding_sequence_variant, synonymous_variant
rs368363830 -- 52,192,078(+) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for MAGED4 Gene

Variant ID Type Subtype PubMed ID
esv3350872 OTHER inversion 20981092
nsv1125093 CNV duplication 24896259
nsv516643 CNV gain 19592680

Additional Variant Information for MAGED4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGED4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MAGED4 Gene

Disorders for MAGED4 Gene

Additional Disease Information for MAGED4

No disorders were found for MAGED4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGED4 Gene

Publications for MAGED4 Gene

  1. MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma. (PMID: 11406556) Sasaki M … Ikenaka K (Cancer research 2001) 2 3 4 58
  2. Structural characterization and chromosomal localization of the MAGE-E1 gene. (PMID: 11602350) Kawano Y … Ikenaka K (Gene 2001) 3 4 58
  3. [Preparation and application of melanoma-associated antigen D4 polyclonal antibody]. (PMID: 28031124) He S … Xie X (Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2017) 3 58
  4. Detection of serum melanoma-associated antigen D4 in patients with squamous cell carcinoma of the esophagus. (PMID: 25951896) Oya H … Kodera Y (Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 2016) 3 58
  5. Overexpression of melanoma-associated antigen D4 is an independent prognostic factor in squamous cell carcinoma of the esophagus. (PMID: 24147998) Oya H … Kodera Y (Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 2015) 3 58

Products for MAGED4 Gene

Sources for MAGED4 Gene

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