Aliases for MAGED1 Gene
Aliases for MAGED1 Gene
External Ids for MAGED1 Gene
- HGNC: 6813
- Entrez Gene: 9500
- Ensembl: ENSG00000179222
- OMIM: 300224
- UniProtKB: Q9Y5V3
Previous GeneCards Identifiers for MAGED1 Gene
- GC0XU990274
- GC0XP049684
- GC0XP050230
- GC0XP050553
- GC0XP051469
- GC0XP051562
- GC0XP048983
Summaries for MAGED1 Gene
-
This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAGED1 Gene
MAGED1 (MAGE Family Member D1) is a Protein Coding gene. Diseases associated with MAGED1 include Melanoma and Syndromic X-Linked Intellectual Disability. Among its related pathways are p75 NTR receptor-mediated signalling and Regulation by c-FLIP. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is MAGED4.
UniProtKB/Swiss-Prot for MAGED1 Gene
-
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
Additional gene information for MAGED1 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGED1 Gene
Genomics for MAGED1 Gene
GeneHancer (GH) Regulatory Elements for MAGED1 Gene
Promoters and enhancers for MAGED1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XI051802 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE | 550.8 | +0.4 | 425 | 1.9 | ATF1 MZF1 SIN3A ZBTB40 YY1 ETS1 ZNF335 GLIS2 ELK1 ZNF143 | MAGED1 RNU6-504P CENPVL1 NUDT11 LOC100631242 | |
| GH0XI051891 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE | 550.2 | +90.6 | 90573 | 4.4 | HDGF ARID4B SIN3A DMAP1 YY1 GLIS2 SCRT2 RCOR1 RUNX3 EGR2 | MAGED1 RNU6-504P CENPVL1 ENSG00000228827 | |
| GH0XI051834 | Promoter | 0.8 | EPDnew | 550.3 | +31.3 | 31335 | 0.1 | TCF12 TEAD4 TAL1 CBFA2T3 | MAGED1 RNU6-504P LOC100631242 | |
| GH0XI051742 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE | 0.2 | -59.3 | -59285 | 2.6 | NFRKB ZBTB40 YY1 ZNF335 EGR1 SCRT2 BCLAF1 RUNX3 EGR2 SMARCA5 | GSPT2 NUDT11 MAGED1 | |
| GH0XI051851 | Enhancer | 0.5 | ENCODE | 0.2 | +49.4 | 49369 | 1.5 | ATF4 SOX6 FOS ZEB2 | LOC100631242 MAGED1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MAGED1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MAGED1 Gene
Genomic Locations for MAGED1 Gene
- chrX:51,803,007-51,902,357
- (GRCh38/hg38)
- Size:
- 99,351 bases
- Orientation:
- Plus strand
- chrX:51,546,103-51,645,453
- (GRCh37/hg19)
Genomic View for MAGED1 Gene
Genes around MAGED1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp11.22 by Ensembl
- Xp11.22 by Entrez Gene
- Xp11.22 by HGNC
MAGED1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAGED1 Gene
Proteins for MAGED1 Gene
-
Protein details for MAGED1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y5V3-MAGD1_HUMAN
- Recommended name:
- Melanoma-associated antigen D1
- Protein Accession:
- Q9Y5V3
- Q5VSH6
- Q8IZ84
- Q8WY92
- Q9H352
- Q9HBT4
- Q9UF36
Protein attributes for MAGED1 Gene
- Size:
- 778 amino acids
- Molecular mass:
- 86161 Da
- Quaternary structure:
-
- Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A. Interacts with TRIM28 and PJA1. Interacts with NGFR/p75NTR and RORA.
- SequenceCaution:
-
- Sequence=AAD31421.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAG35551.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for MAGED1 Gene
Post-translational modifications for MAGED1 Gene
- Ubiquitination at posLast=8686, posLast=101101, posLast=141141, posLast=154154, isoforms=2178, isoforms=2182, isoforms=2189, isoforms=2251, isoforms=2493, isoforms=2522, posLast=523523, isoforms=2605, posLast=613613, isoforms=2615, and isoforms=2656
Other Protein References for MAGED1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MAGED1 (NRAGE)
-
Custom Antibody ServicesOriGene Antibodies for MAGED1
- Novus Biologicals Antibodies for MAGED1
-
Abcam antibodies for MAGED1
- Invitrogen Antibodies for MAGED1
- GeneTex MAGED1 antibody for MAGED1
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAGED1
Protein Products
-
OriGene Purified Proteins for MAGED1
- Search Origene for MassSpec and Protein Over-expression Lysates for MAGED1
- Origene Custom Protein Services for MAGED1
- ProSpec Recombinant Proteins for MAGED1
- Search GeneTex for Proteins for MAGED1
-
Abcam proteins for MAGED1
Assay Products
- antibodies-online: Search results for 1 available MAGED1 Elisa Kits ranked by validation data
- Compare Top MAGED1 Elisa Kits
-
Recommended
No data available for DME Specific Peptides for MAGED1 Gene
Domains & Families for MAGED1 Gene
Gene Families for MAGED1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for MAGED1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAGED1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for MAGED1 Gene
Function for MAGED1 Gene
Molecular function for MAGED1 Gene
- GENATLAS Biochemistry:
- putative melanoma antigen,family D,member 1,expressed in breast,colon,brain,fetal tissue,tumoral cell (breast,lung,prostate,Wilms),not recognized by T cells but expressed only in tumor and germ-line cells
- UniProtKB/Swiss-Prot Function:
- Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003713 | transcription coactivator activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 15930293 |
| GO:0042802 | identical protein binding | IPI | 25416956 |
Phenotypes for MAGED1 Gene
- MGI mutant phenotypes for MAGED1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for MAGED1:
Animal Models for MAGED1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAGED1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MAGED1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MAGED1 gene
- Search ViGene Biosciences for MAGED1
CRISPR Products
-
OriGene CRISPR knockouts for MAGED1
- genomics-online: gRNA clones - Search results for available MAGED1 gene related products
- Applied Biological Materials CRISPR for MAGED1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAGED1
- GenScript: Design CRISPR guide RNA sequences for MAGED1
miRNA for MAGED1 Gene
- miRTarBase miRNAs that target MAGED1
miRNA Products
- Search ViGene Biosciences for MAGED1
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for MAGED1
- Browse OriGene Inhibitory RNA Products For MAGED1
- genomics-online: shRNA clones - Search results for available MAGED1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MAGED1 gene
Clone Products
-
OriGene ORF clones in human for MAGED1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAGED1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MAGED1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAGED1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MAGED1 gene related products
- orf clones - Search results for available MAGED1 gene related products
- Applied Biological Materials Clones for MAGED1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MAGED1
-
ViGene Biosciences adenoviral particle packaged cDNA for MAGED1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MAGED1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MAGED1 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAGED1 Gene
Localization for MAGED1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAGED1 Gene
- Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 4 |
| cytosol | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | ISS | -- |
| GO:0005634 | nucleus | ISS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for MAGED1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | p75 NTR receptor-mediated signalling | ||
| 2 | Development HGF signaling pathway | ||
| 3 | CDK-mediated phosphorylation and removal of Cdc6 |
.31
|
|
| 4 | Regulation by c-FLIP | ||
| 5 | A-beta Signaling Pathways | ||
Pathways by source for MAGED1 Gene
3 BioSystems pathways for MAGED1 Gene
9 Reactome pathways for MAGED1 Gene
1 KEGG pathway for MAGED1 Gene
1 GeneGo (Thomson Reuters) pathway for MAGED1 Gene
1 R&D Systems pathway for MAGED1 Gene
Interacting Proteins for MAGED1 Gene
Selected Interacting proteins:
ENSP00000364847
Q9Y5V3-MAGD1_HUMAN
for MAGED1 Gene via
STRING
UniProtKB
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | TAS | 15930293 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0032922 | circadian regulation of gene expression | ISS | -- |
| GO:0042752 | regulation of circadian rhythm | IEA | -- |
| GO:0042981 | regulation of apoptotic process | TAS | 15930293 |
Transcripts for MAGED1 Gene
mRNA/cDNA for MAGED1 Gene
- (7) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (1072) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MAGED1 Gene
- Melanoma antigen family D, 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MAGED1
- genomics-online: gRNA clones - Search results for available MAGED1 gene related products
- Applied Biological Materials CRISPR for MAGED1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAGED1
- GenScript: Design CRISPR guide RNA sequences for MAGED1
miRNA Products
- Search ViGene Biosciences for MAGED1
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for MAGED1
- Browse OriGene Inhibitory RNA Products For MAGED1
- genomics-online: shRNA clones - Search results for available MAGED1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MAGED1 gene
Clone Products
-
OriGene ORF clones in human for MAGED1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAGED1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MAGED1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAGED1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MAGED1 gene related products
- orf clones - Search results for available MAGED1 gene related products
- Applied Biological Materials Clones for MAGED1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for MAGED1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Brain (Nervous System)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Stomach (Gastrointestinal Tract)
-
Ovary (Reproductive System)
This gene is overexpressed in Bone (47.2) and Heart (15.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAGED1 Gene
NURSA nuclear receptor signaling pathways regulating expression of MAGED1 Gene:
MAGED1SOURCE GeneReport for Unigene cluster for MAGED1 Gene:
Hs.5258mRNA Expression by UniProt/SwissProt for MAGED1 Gene:
Q9Y5V3-MAGD1_HUMAN
Tissue specificity:
Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
Evidence on tissue expression from TISSUES for MAGED1 Gene
- Skin(4.9)
- Nervous system(4.8)
- Blood(4.3)
- Bone marrow(4.2)
- Lung(4.2)
- Pancreas(3.4)
- Liver(2.9)
- Eye(2.8)
- Adrenal gland(2.3)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for MAGED1
-
OriGene qPCR primer pairs and template standards for MAGED1
- genomics-online: primer clones - Search results for available MAGED1 gene related products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGED1 Gene
Orthologs for MAGED1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MAGED1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MAGED1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MAGED1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Maged1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Maged1 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | MAGE 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | ndnl2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for MAGED1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MAGED1 Gene
Paralogs for MAGED1 Gene
- MAGED4 5
- MAGED4B 5
- TRO 5
- MAGED2 5
- MAGEL2 5
- MAGEE1 5
- MAGEF1 5
- MAGEB18 5
- MAGEB17 5
- MAGEA11 5
- MAGEA8 5
- MAGEB16 5
- MAGEE2 5
- MAGEB3 5
- MAGEB6B 5
- NSMCE3 5
- MAGEC1 5
- MAGEB4 5
- MAGEB2 5
- MAGEB10 5
- MAGEB6 5
- MAGEB1 5
- NDN 5
- MAGEA4 5
- MAGEA10 5
- MAGEA1 5
- MAGEA3 5
- MAGEC2 5
- MAGEA9 5
- MAGEA12 5
- MAGEA9B 5
- MAGEA6 5
- MAGEA2B 5
- MAGEA2 5
- MAGEB5 5
- MAGEC3 5
(26) SIMAP similar genes for MAGED1 Gene using alignment to 1 proteins:
Variants for MAGED1 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000077883 | -- | 51,811,691(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000214017 | -- | 51,881,458(+) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000275595 | -- | 51,873,296(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000375412 | -- | 51,802,936(+) | A/G | upstream_transcript_variant | |
| rs1000468023 | -- | 51,821,171(+) | T/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv6906 | CNV | deletion | 18451855 |
| nsv516643 | CNV | gain | 19592680 |
| esv3573968 | CNV | loss | 25503493 |
| esv3558875 | CNV | deletion | 23714750 |
| esv3350872 | OTHER | inversion | 20981092 |
| esv2664331 | CNV | deletion | 23128226 |
Residual Variation Intolerance Score:
25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.68;
14.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAGED1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGED1 Gene
Disorders for MAGED1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| melanoma |
|
|
| syndromic x-linked intellectual disability |
|
|
| keratosis, seborrheic |
|
|
| esophageal cancer |
|
|
Search MAGED1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAGED1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MAGED1 Gene
Publications for MAGED1 Gene
- hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation. (PMID: 15094062) Wen CJ … Li CJ (FEBS letters 2004) 3 4 22 58
- [A new melanoma antigen-encoding gene subfamily in human chromosome X]. (PMID: 11280991) Zhang CG … He FC (Yi chuan xue bao = Acta genetica Sinica 2001) 3 4 22 58
- NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis. (PMID: 10985348) Salehi AH … Barker PA (Neuron 2000) 3 4 22 58
- Identification of a new, unorthodox member of the MAGE gene family. (PMID: 10409427) Põld M … Berenson JR (Genomics 1999) 2 3 4 58
- MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle JM … Potts PR (Molecular cell 2010) 3 4 58
Products for MAGED1 Gene
- R&D Systems Antibodies for MAGED1 (NRAGE)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for MAGED1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MAGED1
- Search Origene for MassSpec and Protein Over-expression Lysates for MAGED1
- Origene Custom Protein Services for MAGED1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAGED1
- Browse OriGene Inhibitory RNA Products For MAGED1
- OriGene qPCR primer pairs and template standards for MAGED1
- OriGene qPCR primer pairs for MAGED1
- OriGene CRISPR knockouts for MAGED1
- OriGene ORF clones in human for MAGED1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MAGED1
- GenScript: Next-day shipping of latest version cDNA ORF clones for MAGED1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for MAGED1
- GenScript Custom Assay Services for MAGED1
- GenScript Custom overexpressing Cell Line Services for MAGED1
- GenScript: Design CRISPR guide RNA sequences for MAGED1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MAGED1
- Sino Biological Human cDNA Clone for MAGED1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for MAGED1
- Novus Biologicals lysates and proteins for MAGED1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MAGED1
- Abcam proteins for MAGED1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for MAGED1
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for MAGED1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAGED1
- VectorBuilder custom plasmid, inducible vectors for MAGED1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAGED1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 93 available MAGED1 Antibodies ranked by validation data
- Compare Top MAGED1 Antibodies
- antibodies-online: Search results for 1 available MAGED1 Elisa Kits ranked by validation data
- Compare Top MAGED1 Elisa Kits
- Recommended
- antibodies-online: Search results for 7 available MAGED1 Proteins ranked by validation data
- Compare Top MAGED1 Proteins
- GeneTex MAGED1 antibody for MAGED1
- Search GeneTex for Proteins for MAGED1
- ViGene Biosciences adenoviral particle packaged cDNA for MAGED1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MAGED1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MAGED1 gene
- Search ViGene Biosciences for MAGED1
- Santa Cruz Biotechnology (SCBT) Antibodies for MAGED1
- Search Santa Cruz Biotechnology (SCBT) for MAGED1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MAGED1
- Horizon Cell Lines for MAGED1
- genomics-online: cdna clones - Search results for available MAGED1 gene related products
- orf clones - Search results for available MAGED1 gene related products
- genomics-online: gRNA clones - Search results for available MAGED1 gene related products
- genomics-online: primer clones - Search results for available MAGED1 gene related products
- genomics-online: shRNA clones - Search results for available MAGED1 gene related products
Sources for MAGED1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew