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This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be ... See more...
Aliases for MAGED1 Gene
Aliases for MAGED1 Gene
External Ids for MAGED1 Gene
- HGNC: 6813
- Entrez Gene: 9500
- Ensembl: ENSG00000179222
- OMIM: 300224
- UniProtKB: Q9Y5V3
Previous GeneCards Identifiers for MAGED1 Gene
- GC0XU990274
- GC0XP049684
- GC0XP050230
- GC0XP050553
- GC0XP051469
- GC0XP051562
- GC0XP048983
Summaries for MAGED1 Gene
-
This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAGED1 Gene
MAGED1 (MAGE Family Member D1) is a Protein Coding gene. Diseases associated with MAGED1 include Melanoma and Syndromic X-Linked Intellectual Disability. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is MAGED4.
UniProtKB/Swiss-Prot Summary for MAGED1 Gene
-
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
Additional gene information for MAGED1 Gene
- HGNC(6813)
- Entrez Gene(9500)
- Ensembl(ENSG00000179222)
- OMIM(300224)
- UniProtKB(Q9Y5V3)
- Open Targets Platform(ENSG00000179222)
- Search for MAGED1 at DataMed
- Search for MAGED1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAGED1 Gene
Genomics for MAGED1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MAGED1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XJ051891 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 600.2 | +91.3 | 91282 | 5.8 | HNRNPL RFX1 POLR2A RBFOX2 PATZ1 ELF4 GABPA YY1 SCRT2 MNT | NONHSAG054492.2 MAGED1 RNU6-504P CENPVL1 piR-61945-534 RF00017-8442 MAGED4B | |
| GH0XJ051802 | Promoter/Enhancer | 1.5 | Ensembl ENCODE CraniofacialAtlas | 600.7 | +0.7 | 745 | 2.5 | CTCF PRDM10 POLR2A GABPA ZNF143 RBFOX2 PATZ1 ZNF24 ELK1 CEBPB | MAGED1 RNU6-504P CENPVL1 NUDT11 LOC100631242 MAGED4B | |
| GH0XJ051772 | Enhancer | 0.2 | Ensembl | 12.5 | -30.8 | -30798 | 0.4 | GSPT2 MAGED1 piR-41405-173 piR-49097-113 | ||
| GH0XJ051771 | Enhancer | 0.2 | Ensembl | 12.5 | -31.4 | -31397 | 0.4 | GSPT2 MAGED1 piR-41405-173 piR-49097-113 | ||
| GH0XJ051742 | Promoter/Enhancer | 1.4 | Ensembl ENCODE CraniofacialAtlas | 0.2 | -58.7 | -58676 | 3.8 | POLR2A GABPA PATZ1 YY1 ZNF341 SCRT2 ZSCAN29 SP1 MTA3 EGR1 | GSPT2 lnc-CENPVL2-3 NUDT11 MAGED1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAGED1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAGED1
- Top Transcription factor binding sites by QIAGEN in the MAGED1 gene promoter:
-
- AhR
- AML1a
- LyF-1
- MZF-1
- Pax-4a
- POU2F1
- POU2F1a
- Roaz
- RP58
- Zic1
Genomic Locations for MAGED1 Gene
Genomic Locations for MAGED1 Gene
- chrX:51,802,998-51,902,354
- (GRCh38/hg38)
- Size:
- 99,357 bases
- Orientation:
- Plus strand
- chrX:51,546,103-51,645,453
- (GRCh37/hg19)
- Size:
- 99,351 bases
- Orientation:
- Plus strand
Genomic View for MAGED1 Gene
Genes around MAGED1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp11.22 by HGNC
- Xp11.22 by Entrez Gene
- Xp11.22 by Ensembl
MAGED1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAGED1 Gene
Proteins for MAGED1 Gene
-
Protein details for MAGED1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y5V3-MAGD1_HUMAN
- Recommended name:
- Melanoma-associated antigen D1
- Protein Accession:
- Q9Y5V3
- Q5VSH6
- Q8IZ84
- Q8WY92
- Q9H352
- Q9HBT4
- Q9UF36
Protein attributes for MAGED1 Gene
- Size:
- 778 amino acids
- Molecular mass:
- 86161 Da
- Quaternary structure:
-
- Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A. Interacts with TRIM28 and PJA1. Interacts with NGFR/p75NTR and RORA.
- SequenceCaution:
-
- Sequence=AAD31421.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAG35551.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for MAGED1 Gene
Post-translational modifications for MAGED1 Gene
Other Protein References for MAGED1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MAGED1 Antibody
- Creative Diagnostics Anti-MAGED1 (aa 1-130) polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for MAGED1
- Novus Biologicals Antibodies for MAGED1
-
Abcam antibodies for MAGED1
- Invitrogen Antibodies for MAGED1 (AFLGC-MAGED1)
-
Biorbyt antibodies for MAGED1
-
Boster Bio Antibodies for MAGED1
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAGED1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MAGED1
- Origene Custom Protein Services for MAGED1
- ProSpec Recombinant Proteins for MAGED1
-
Signalway Proteins for MAGED1
-
Abcam proteins for MAGED1
Assay Products
- Creative Diagnostics Human MAGED1 ELISA Matched Antibody Pair (ABPR-0543) and Human MAGED1 ELISA Matched Antibody Pair (ABPR-0544)
- antibodies-online: Show 2 available MAGED1 Elisa Kits ranked by validation data
- Compare Top MAGED1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MAGED1 Gene
Domains & Families for MAGED1 Gene
Gene Families for MAGED1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for MAGED1 Gene
Suggested Antigen Peptide Sequences for MAGED1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ53080, highly similar to Melanoma-associated antigen D1 (B4DQ04_HUMAN)
- Neurotrophin receptor-interacting MAGE homolog (MAGD1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MAGED1 Gene
Function for MAGED1 Gene
Molecular function for MAGED1 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
- GENATLAS Biochemistry:
- putative melanoma antigen,family D,member 1,expressed in breast,colon,brain,fetal tissue,tumoral cell (breast,lung,prostate,Wilms),not recognized by T cells but expressed only in tumor and germ-line cells
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003713 | transcription coactivator activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 15930293 |
| GO:0042802 | identical protein binding | IPI | 25416956 |
Phenotypes for MAGED1 Gene
- MGI mutant phenotypes for MAGED1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for MAGED1:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased vaccinia virus (VACV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Increased gamma-H2AX phosphorylation
- Increased nuclear migration speed
Animal Models for MAGED1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAGED1 - Select products 50% OFF >
- * MAGED1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAGED1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAGED1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAGED1
miRNA for MAGED1 Gene
- miRTarBase miRNAs that target MAGED1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAGED1
- Browse OriGene Inhibitory RNA Products For MAGED1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGED1
Clone Products
- Applied Biological Materials (abm): Clones for MAGED1 - Select products 50% OFF >
- * MAGED1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210587
- MR210587
- MR210587L3
- MR210587L4
- RC204088
- RC204088L3
- RC204088L4
- RC207077
- RC207077L3
- RC207077L4
- RC214851
- RC214851L3
- RC214851L4
- RG204088
- RG207077
- RG214851
- RR214811
- RR214811L3
- RR214811L4
- MR210587L3V
- MR210587L4V
- RC204088L3V
- RC204088L4V
- RC207077L3V
- RC207077L4V
- RC214851L3V
- RC214851L4V
- RR214811L3V
- RR214811L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAGED1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAGED1
Cell Line Products
-
Horizon Cell Lines for MAGED1
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAGED1 Gene
Localization for MAGED1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAGED1 Gene
- Cytoplasm. Cell membrane. Peripheral membrane protein. Nucleus. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| nucleus | 4 |
| cytosol | 4 |
| extracellular | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IEA,ISS | -- |
| GO:0005634 | nucleus | ISS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for MAGED1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | p75 NTR receptor-mediated signalling | ||
| 2 | Development HGF signaling pathway |
Development Neurotrophin family signaling
.44
|
|
| 3 | Apoptotic execution phase |
.31
|
|
| 4 | CASP8 activity is inhibited | ||
| 5 | Signaling by GPCR | ||
Pathways by source for MAGED1 Gene
3 BioSystems pathways for MAGED1 Gene
1 KEGG pathway for MAGED1 Gene
1 GeneGo (Thomson Reuters) pathway for MAGED1 Gene
- Development Neurotrophin family signaling
Interacting Proteins for MAGED1 Gene
Selected Interacting proteins:
Q9Y5V3-MAGD1_HUMAN
ENSP00000364847
for MAGED1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MAGED1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | TAS | 15930293 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0032922 | circadian regulation of gene expression | ISS | -- |
| GO:0042752 | regulation of circadian rhythm | IEA | -- |
| GO:0042981 | regulation of apoptotic process | TAS | 15930293 |
Transcripts for MAGED1 Gene
mRNA/cDNA for MAGED1 Gene
- 3 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000326587 2723 nts (view in UCSC)
- ENST00000375695 2875 nts (view in UCSC)
- ENST00000375722 2806 nts (view in UCSC)
- ENST00000375772 2701 nts (view in UCSC)
- ENST00000470461 810 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAGED1 - Select products 50% OFF >
- * MAGED1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAGED1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAGED1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAGED1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAGED1
- Browse OriGene Inhibitory RNA Products For MAGED1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGED1
Clone Products
- Applied Biological Materials (abm): Clones for MAGED1 - Select products 50% OFF >
- * MAGED1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210587
- MR210587
- MR210587L3
- MR210587L4
- RC204088
- RC204088L3
- RC204088L4
- RC207077
- RC207077L3
- RC207077L4
- RC214851
- RC214851L3
- RC214851L4
- RG204088
- RG207077
- RG214851
- RR214811
- RR214811L3
- RR214811L4
- MR210587L3V
- MR210587L4V
- RC204088L3V
- RC204088L4V
- RC207077L3V
- RC207077L4V
- RC214851L3V
- RC214851L4V
- RR214811L3V
- RR214811L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAGED1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAGED1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
Relevant External Links for MAGED1 Gene
- GeneLoc Exon Structure for
- MAGED1
Expression for MAGED1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Brain (Nervous System)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Stomach (Gastrointestinal Tract)
-
Ovary (Reproductive System)
This gene is overexpressed in Bone (47.2) and Heart (15.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAGED1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAGED1
SOURCE GeneReport for Unigene cluster for MAGED1 Gene:
Hs.5258mRNA Expression by UniProt/SwissProt for MAGED1 Gene:
Q9Y5V3-MAGD1_HUMAN
Tissue specificity:
Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
Evidence on tissue expression from TISSUES for MAGED1 Gene
- Skin(4.9)
- Nervous system(4.8)
- Blood(4.5)
- Bone marrow(4.3)
- Lung(4.3)
- Pancreas(3.6)
- Liver(3.4)
- Eye(3.1)
- Adrenal gland(2.6)
- Intestine(2.5)
- Kidney(2.5)
- Muscle(2.4)
- Heart(2.3)
Primer Products
-
OriGene qPCR primer pairs for MAGED1
-
OriGene qPCR primer pairs and template standards for MAGED1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGED1 Gene
Orthologs for MAGED1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MAGED1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MAGED1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MAGED1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Maged1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Maged1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | MAGE 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | ndnl2 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for MAGED1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MAGED1 Gene
- ENSEMBL:
- Gene Tree for MAGED1 (if available)
- TreeFam:
- Gene Tree for MAGED1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAGED1: view image
Paralogs for MAGED1 Gene
Paralogs for MAGED1 Gene
- MAGED4B 5
- MAGED4 5
- TRO 5
- MAGED2 5
- MAGEL2 5
- MAGEE1 5
- MAGEC1 5
- NSMCE3 5
- MAGEF1 5
- MAGEB18 5
- MAGEB4 5
- MAGEB1 5
- MAGEB16 5
- MAGEE2 5
- MAGEB17 5
- MAGEA11 5
- MAGEA8 5
- MAGEB6B 5
- MAGEB6 5
- MAGEB10 5
- MAGEB2 5
- MAGEB3 5
- NDN 5
- MAGEA10 5
- MAGEA1 5
- MAGEA4 5
- MAGEC2 5
- MAGEA3 5
- MAGEA2B 5
- MAGEA12 5
- MAGEA6 5
- MAGEA2 5
- MAGEA9B 5
- MAGEA9 5
- MAGEB5 5
- MAGEC3 5
- MAGEH1 5
(26) SIMAP similar genes for MAGED1 Gene using alignment to 1 proteins:
- MAGD1_HUMAN
Variants for MAGED1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAGED1 Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 726781 | Likely Benign: not provided | 51,896,549(+) | G/A | SYNONYMOUS_VARIANT | |
| 756007 | Benign: not provided | 51,896,717(+) | G/A | SYNONYMOUS_VARIANT | |
| 787157 | Benign: not provided | 51,901,618(+) | T/C | SYNONYMOUS_VARIANT | |
| 787158 | Benign: not provided | 51,901,900(+) | T/C | SYNONYMOUS_VARIANT | |
| 790239 | Benign: not provided | 51,894,750(+) | G/A | MISSENSE_VARIANT,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2664331 | CNV | deletion | 23128226 |
| esv3350872 | OTHER | inversion | 20981092 |
| esv3558875 | CNV | deletion | 23714750 |
| esv3573968 | CNV | loss | 25503493 |
| nsv516643 | CNV | gain | 19592680 |
| nsv6906 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.68;
14.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAGED1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGED1 Gene
Disorders for MAGED1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| melanoma |
|
|
| syndromic x-linked intellectual disability |
|
|
| prader-willi syndrome |
|
|
Search MAGED1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAGED1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MAGED1 Gene
Publications for MAGED1 Gene
- hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation. (PMID: 15094062) Wen CJ … Li CJ (FEBS letters 2004) 3 4 23
- [A new melanoma antigen-encoding gene subfamily in human chromosome X]. (PMID: 11280991) Zhang CG … He FC (Yi chuan xue bao = Acta genetica Sinica 2001) 3 4 23
- NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis. (PMID: 10985348) Salehi AH … Barker PA (Neuron 2000) 3 4 23
- Identification of a new, unorthodox member of the MAGE gene family. (PMID: 10409427) Põld M … Berenson JR (Genomics 1999) 2 3 4
- MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle JM … Potts PR (Molecular cell 2010) 3 4
ExternalLinks
Products for MAGED1 Gene
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Sources for MAGED1 Gene
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