Aliases for MAGEC2 Gene
External Ids for MAGEC2 Gene
Previous HGNC Symbols for MAGEC2 Gene
Previous GeneCards Identifiers for MAGEC2 Gene
This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]
GeneCards Summary for MAGEC2 Gene
MAGEC2 (MAGE Family Member C2) is a Protein Coding gene. Diseases associated with MAGEC2 include Melanoma and Hepatocellular Carcinoma. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is MAGEC1.
UniProtKB/Swiss-Prot for MAGEC2 Gene
Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.