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Aliases for MAGEC1 Gene

Aliases for MAGEC1 Gene

  • MAGE Family Member C1 2 3 5
  • Cancer/Testis Antigen Family 7, Member 1 2 3
  • Melanoma Antigen Family C1 2 3
  • Cancer/Testis Antigen 7.1 3 4
  • MAGE-C1 Antigen 3 4
  • CT7.1 3 4
  • Melanoma-Associated Antigen C1 3
  • Melanoma Antigen Family C, 1 3
  • CT7 3

External Ids for MAGEC1 Gene

Previous GeneCards Identifiers for MAGEC1 Gene

  • GC0XP135521
  • GC0XP137849
  • GC0XP138924
  • GC0XP139685
  • GC0XP140717
  • GC0XP140819
  • GC0XP140991
  • GC0XP130087

Summaries for MAGEC1 Gene

Entrez Gene Summary for MAGEC1 Gene

  • This gene is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This protein contains a large number of unique short repetitive sequences in front of the MAGE-homologous sequence, and therefore is about 800 aa longer than the other MAGE proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEC1 Gene

MAGEC1 (MAGE Family Member C1) is a Protein Coding gene. Diseases associated with MAGEC1 include Melanoma and Mucosal Melanoma. An important paralog of this gene is MAGEC2.

Additional gene information for MAGEC1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEC1 Gene

Genomics for MAGEC1 Gene

GeneHancer (GH) Regulatory Elements for MAGEC1 Gene

Promoters and enhancers for MAGEC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ141903 Promoter 0.9 EPDnew 650.7 +0.0 23 0.1 MEIS2 PKNOX1 ATF1 ZNF740 NFRKB GABPA POLR2A VEZF1 GABPB1 SUPT5H MAGEC1 GC0XP141919
GH0XJ141904 Promoter 0.6 EPDnew 650.7 +0.9 898 0.1 NR2C2 MAGEC1 GC0XP141919
GH0XJ141895 Promoter 0.5 EPDnew 0.4 -8.0 -7990 0.1 MAGEC1 GC0XP141890 GC0XP141889 GC0XP141888 MAGEC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAGEC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAGEC1 gene promoter:

Genomic Locations for MAGEC1 Gene

Genomic Locations for MAGEC1 Gene
chrX:141,903,856-141,909,401
(GRCh38/hg38)
Size:
5,546 bases
Orientation:
Plus strand
chrX:140,991,642-140,997,187
(GRCh37/hg19)

Genomic View for MAGEC1 Gene

Genes around MAGEC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEC1 Gene

Proteins for MAGEC1 Gene

  • Protein details for MAGEC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60732-MAGC1_HUMAN
    Recommended name:
    Melanoma-associated antigen C1
    Protein Accession:
    O60732
    Secondary Accessions:
    • A0PK03
    • O75451
    • Q8TCV4

    Protein attributes for MAGEC1 Gene

    Size:
    1142 amino acids
    Molecular mass:
    123643 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAGEC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAGEC1 Gene

Post-translational modifications for MAGEC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEC1 Gene

Domains & Families for MAGEC1 Gene

Gene Families for MAGEC1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MAGEC1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEC1: view

No data available for UniProtKB/Swiss-Prot for MAGEC1 Gene

Function for MAGEC1 Gene

Molecular function for MAGEC1 Gene

GENATLAS Biochemistry:
melanoma antigen,family C,member 1,expressed in a significant proportion of tumors of various histological types and in normal testis

Gene Ontology (GO) - Molecular Function for MAGEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17137291
genes like me logo Genes that share ontologies with MAGEC1: view
genes like me logo Genes that share phenotypes with MAGEC1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEC1 Gene

Localization for MAGEC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEC1 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGEC1 Gene

Pathways & Interactions for MAGEC1 Gene

SuperPathways for MAGEC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGEC1 Gene

Drugs & Compounds for MAGEC1 Gene

No Compound Related Data Available

Transcripts for MAGEC1 Gene

mRNA/cDNA for MAGEC1 Gene

(32) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEC1 Gene

Melanoma antigen family C, 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEC1 Gene

No ASD Table

Relevant External Links for MAGEC1 Gene

GeneLoc Exon Structure for
MAGEC1
ECgene alternative splicing isoforms for
MAGEC1

Expression for MAGEC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEC1 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEC1 Gene

This gene is overexpressed in Testis (x48.9).

Protein differential expression in normal tissues from HIPED for MAGEC1 Gene

This gene is overexpressed in Bone (28.1), Testis (25.4), and Ovary (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAGEC1 Gene



Protein tissue co-expression partners for MAGEC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAGEC1 Gene:

MAGEC1

SOURCE GeneReport for Unigene cluster for MAGEC1 Gene:

Hs.132194

mRNA Expression by UniProt/SwissProt for MAGEC1 Gene:

O60732-MAGC1_HUMAN
Tissue specificity: Expressed in testis and in tumors of a wide variety of histologic types.
genes like me logo Genes that share expression patterns with MAGEC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEC1 Gene

Orthologs for MAGEC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEC1 33
  • 88.76 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 43 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia MAGEA11 34
  • 42 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 4933402E13Rik 34
  • 32 (a)
ManyToMany
Species where no ortholog for MAGEC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEC1 Gene

ENSEMBL:
Gene Tree for MAGEC1 (if available)
TreeFam:
Gene Tree for MAGEC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAGEC1: view image

Paralogs for MAGEC1 Gene

Variants for MAGEC1 Gene

Sequence variations from dbSNP and Humsavar for MAGEC1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000480354 -- 141,908,113(+) G/A coding_sequence_variant, synonymous_variant
rs1001973129 -- 141,905,592(+) C/G coding_sequence_variant, missense_variant
rs1003682 -- 141,903,065(+) T/C upstream_transcript_variant
rs1003696313 -- 141,904,296(+) G/A intron_variant
rs1004194234 -- 141,903,497(+) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEC1 Gene

Variant ID Type Subtype PubMed ID
esv1703664 CNV insertion 17803354
esv2740535 CNV deletion 23290073
esv2740536 CNV deletion 23290073
esv2740537 CNV deletion 23290073
esv2740538 CNV deletion 23290073
nsv9985 CNV gain 18304495

Variation tolerance for MAGEC1 Gene

Residual Variation Intolerance Score: 100% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.72; 94.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGEC1 Gene

Human Gene Mutation Database (HGMD)
MAGEC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGEC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEC1 Gene

Disorders for MAGEC1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MAGEC1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
mucosal melanoma
parapsoriasis
  • digitate dermatosis
spermatocytoma
  • spermatocytic seminoma
myeloma, multiple
  • multiple myeloma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAGEC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAGEC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEC1 Gene

Publications for MAGEC1 Gene

  1. Identification of a new MAGE gene with tumor-specific expression by representational difference analysis. (PMID: 9485030) Lucas S … Boon T (Cancer research 1998) 2 3 4 22 58
  2. Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library. (PMID: 9618514) Chen YT … Old LJ (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 58
  3. Cellular immune responses against CT7 (MAGE-C1) and humoral responses against other cancer-testis antigens in multiple myeloma patients. (PMID: 20108890) Lendvai N … Cho HJ (Cancer immunity 2010) 3 22 58
  4. Frequent MAGE mutations in human melanoma. (PMID: 20862285) Caballero OL … Simpson AJ (PloS one 2010) 3 44 58
  5. Expression of cancer-testis antigen CT7 (MAGE-C1) in breast cancer: an immunohistochemical study with emphasis on prognostic utility. (PMID: 17607369) Krüger S … Friedrich M (Pathology oncology research : POR 2007) 3 22 58

Products for MAGEC1 Gene

Sources for MAGEC1 Gene

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