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Aliases for MAGEB6 Gene

Aliases for MAGEB6 Gene

  • MAGE Family Member B6 2 3 5
  • Cancer/Testis Antigen Family 3, Member 4 2 3
  • Melanoma Antigen Family B6 2 3
  • Cancer/Testis Antigen 3.4 3 4
  • MAGE-B6 Antigen 3 4
  • CT3.4 3 4
  • Melanoma-Associated Antigen B6 3
  • Melanoma Antigen Family B, 6 3
  • MAGE-B6 3
  • MAGEB6A 3

External Ids for MAGEB6 Gene

Previous GeneCards Identifiers for MAGEB6 Gene

  • GC0XP024869
  • GC0XP025412
  • GC0XP025571
  • GC0XP025970
  • GC0XP026120
  • GC0XP023949

Summaries for MAGEB6 Gene

Entrez Gene Summary for MAGEB6 Gene

  • This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is expressed in testis, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEB6 Gene

MAGEB6 (MAGE Family Member B6) is a Protein Coding gene. An important paralog of this gene is MAGEB6B.

Additional gene information for MAGEB6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB6 Gene

Genomics for MAGEB6 Gene

GeneHancer (GH) Regulatory Elements for MAGEB6 Gene

Promoters and enhancers for MAGEB6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ026192 Promoter 0.6 EPDnew 650.7 0.0 -30 0.1 GABPB1 MAGEB6 LOC100420245
GH0XJ026320 Enhancer 0.2 Ensembl 5.8 +127.8 127761 0.4 MAGEB6 GC0XP026335 LOC100130052
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAGEB6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAGEB6 gene promoter:
  • E47
  • Hand1
  • PPAR-alpha
  • AhR
  • Arnt
  • C/EBPalpha

Genomic Locations for MAGEB6 Gene

Genomic Locations for MAGEB6 Gene
3,207 bases
Plus strand
3,207 bases
Plus strand

Genomic View for MAGEB6 Gene

Genes around MAGEB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB6 Gene

Proteins for MAGEB6 Gene

  • Protein details for MAGEB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen B6
    Protein Accession:
    Secondary Accessions:
    • Q6GS19
    • Q9H219

    Protein attributes for MAGEB6 Gene

    407 amino acids
    Molecular mass:
    43992 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEB6 Gene

Post-translational modifications for MAGEB6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEB6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEB6 Gene

Domains & Families for MAGEB6 Gene

Gene Families for MAGEB6 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for MAGEB6 Gene


Suggested Antigen Peptide Sequences for MAGEB6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEB6: view

No data available for UniProtKB/Swiss-Prot for MAGEB6 Gene

Function for MAGEB6 Gene

Gene Ontology (GO) - Molecular Function for MAGEB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 23275563
genes like me logo Genes that share ontologies with MAGEB6: view
genes like me logo Genes that share phenotypes with MAGEB6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGEB6

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEB6 Gene

Localization for MAGEB6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEB6 gene
Compartment Confidence
plasma membrane 2
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MAGEB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MAGEB6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MAGEB6 Gene

Pathways & Interactions for MAGEB6 Gene

SuperPathways for MAGEB6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MAGEB6: view

No data available for Pathways by source and SIGNOR curated interactions for MAGEB6 Gene

Drugs & Compounds for MAGEB6 Gene

No Compound Related Data Available

Transcripts for MAGEB6 Gene

mRNA/cDNA for MAGEB6 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEB6 Gene

Melanoma antigen family B, 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGEB6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB6 Gene

No ASD Table

Relevant External Links for MAGEB6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEB6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEB6 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEB6 Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for MAGEB6 Gene

This gene is overexpressed in Plasma (62.8) and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAGEB6 Gene

Protein tissue co-expression partners for MAGEB6 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAGEB6 Gene:


SOURCE GeneReport for Unigene cluster for MAGEB6 Gene:


mRNA Expression by UniProt/SwissProt for MAGEB6 Gene:

Tissue specificity: Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins.
genes like me logo Genes that share expression patterns with MAGEB6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEB6 Gene

Orthologs for MAGEB6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAGEB6 34 33
  • 97.99 (n)
(Mus musculus)
Mammalia Mageb17-ps 33
  • 66.36 (n)
Mageb3 34
  • 44 (a)
Mageb1 34
  • 37 (a)
Mageb2 34
  • 37 (a)
Gm5072 34
  • 35 (a)
Gm8914 34
  • 35 (a)
(Rattus norvegicus)
Mammalia Mageb6 33
  • 65.81 (n)
(Bos Taurus)
Mammalia -- 34
  • 48 (a)
-- 34
  • 48 (a)
-- 34
  • 45 (a)
-- 34
  • 45 (a)
-- 34
  • 45 (a)
-- 34
  • 44 (a)
-- 34
  • 43 (a)
Species where no ortholog for MAGEB6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB6 Gene

Gene Tree for MAGEB6 (if available)
Gene Tree for MAGEB6 (if available)
Evolutionary constrained regions (ECRs) for MAGEB6: view image

Paralogs for MAGEB6 Gene

Variants for MAGEB6 Gene

Sequence variations from dbSNP and Humsavar for MAGEB6 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000354382 -- 26,191,443(+) C/T upstream_transcript_variant
rs1000382548 -- 26,191,734(+) G/T upstream_transcript_variant
rs1003726090 -- 26,191,844(+) G/A upstream_transcript_variant
rs1003778297 -- 26,192,357(+) G/C upstream_transcript_variant
rs1005709267 -- 26,192,395(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEB6 Gene

Variant ID Type Subtype PubMed ID
esv2740023 CNV deletion 23290073
esv2740022 CNV deletion 23290073
esv2740021 CNV deletion 23290073
esv2677789 CNV deletion 23128226

Variation tolerance for MAGEB6 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGEB6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEB6 Gene

Disorders for MAGEB6 Gene

Additional Disease Information for MAGEB6

No disorders were found for MAGEB6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGEB6 Gene

Publications for MAGEB6 Gene

  1. MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (PMID: 10861452) Lucas S … Boon T (International journal of cancer 2000) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for MAGEB6 Gene

Sources for MAGEB6 Gene

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