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Aliases for MAGEB4 Gene

Aliases for MAGEB4 Gene

  • MAGE Family Member B4 2 3 5
  • Cancer/Testis Antigen Family 3, Member 6 2 3
  • Melanoma-Associated Antigen B4 2 3
  • Melanoma Antigen Family B4 2 3
  • MAGE-B4 Antigen 3 4
  • Melanoma Antigen Family B, 4 3
  • CT3.6 3

External Ids for MAGEB4 Gene

Previous GeneCards Identifiers for MAGEB4 Gene

  • GC0XP028759
  • GC0XP028943
  • GC0XP029462
  • GC0XP029621
  • GC0XP030019
  • GC0XP030171
  • GC0XP027996

Summaries for MAGEB4 Gene

Entrez Gene Summary for MAGEB4 Gene

  • This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEB genes are clustered on chromosome Xp22-p21. This gene sequence ends in the first intron of MAGEB1, another family member. This gene is expressed in testis. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEB4 Gene

MAGEB4 (MAGE Family Member B4) is a Protein Coding gene. An important paralog of this gene is MAGEB1.

Additional gene information for MAGEB4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB4 Gene

Genomics for MAGEB4 Gene

GeneHancer (GH) Regulatory Elements for MAGEB4 Gene

Promoters and enhancers for MAGEB4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ030243 Promoter 0.5 EPDnew 650.7 +1.8 1823 0.1 MAGEB1 MAGEB4 PLCE1P1
GH0XJ030219 Enhancer 0.4 ENCODE 12.1 -22.2 -22246 0.9 FOXA2 NANOG POU5F1 MAGEB1 MAGEB4 MAGEB2 MAGEB3
GH0XJ030152 Enhancer 0.2 ENCODE 11.8 -89.7 -89677 0.4 MAGEB4 MAGEB1 LOC100420324 PIGFP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAGEB4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAGEB4 gene promoter:
  • ARP-1
  • NF-kappaB2
  • NF-kappaB1
  • NF-kappaB
  • RelA

Genomic Locations for MAGEB4 Gene

Genomic Locations for MAGEB4 Gene
2,254 bases
Plus strand
2,254 bases
Plus strand

Genomic View for MAGEB4 Gene

Genes around MAGEB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB4 Gene

Proteins for MAGEB4 Gene

  • Protein details for MAGEB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen B4
    Protein Accession:
    Secondary Accessions:
    • B2R9G0
    • Q6FHH4
    • Q8IZ00

    Protein attributes for MAGEB4 Gene

    346 amino acids
    Molecular mass:
    38923 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEB4 Gene

Post-translational modifications for MAGEB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEB4 Gene

Domains & Families for MAGEB4 Gene

Gene Families for MAGEB4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGEB4 Gene


Suggested Antigen Peptide Sequences for MAGEB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEB4: view

No data available for UniProtKB/Swiss-Prot for MAGEB4 Gene

Function for MAGEB4 Gene

Molecular function for MAGEB4 Gene

GENATLAS Biochemistry:
melanoma antigen,family B,member 4,expressed in testis

Gene Ontology (GO) - Molecular Function for MAGEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAGEB4: view
genes like me logo Genes that share phenotypes with MAGEB4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGEB4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEB4 Gene

Localization for MAGEB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGEB4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEB4 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAGEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MAGEB4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAGEB4 Gene

Pathways & Interactions for MAGEB4 Gene

SuperPathways for MAGEB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEB4 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAGEB4 Gene

Drugs & Compounds for MAGEB4 Gene

No Compound Related Data Available

Transcripts for MAGEB4 Gene

mRNA/cDNA for MAGEB4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEB4 Gene

Melanoma antigen family B, 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGEB4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for MAGEB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEB4 Gene

Protein differential expression in normal tissues from HIPED for MAGEB4 Gene

This gene is overexpressed in Platelet (34.2), Testis (21.0), Heart (6.9), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAGEB4 Gene

Protein tissue co-expression partners for MAGEB4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAGEB4 Gene:


SOURCE GeneReport for Unigene cluster for MAGEB4 Gene:


mRNA Expression by UniProt/SwissProt for MAGEB4 Gene:

Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with MAGEB4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEB4 Gene

Orthologs for MAGEB4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAGEB4 33
  • 99.13 (n)
(Bos Taurus)
Mammalia LOC101906038 33
  • 73.76 (n)
-- 34
  • 54 (a)
-- 34
  • 52 (a)
-- 34
  • 52 (a)
-- 34
  • 50 (a)
-- 34
  • 50 (a)
-- 34
  • 49 (a)
-- 34
  • 49 (a)
  • 49 (a)
-- 34
  • 48 (a)
-- 34
  • 48 (a)
MGC133764 34
  • 48 (a)
-- 34
  • 42 (a)
-- 34
  • 42 (a)
(Rattus norvegicus)
Mammalia Mageb1 33
  • 66.36 (n)
(Mus musculus)
Mammalia Mageb4 34
  • 33 (a)
Species where no ortholog for MAGEB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB4 Gene

Gene Tree for MAGEB4 (if available)
Gene Tree for MAGEB4 (if available)
Evolutionary constrained regions (ECRs) for MAGEB4: view image

Paralogs for MAGEB4 Gene Pseudogenes for MAGEB4 Gene

genes like me logo Genes that share paralogs with MAGEB4: view

Variants for MAGEB4 Gene

Sequence variations from dbSNP and Humsavar for MAGEB4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1002199287 -- 30,243,615(+) T/C 3_prime_UTR_variant
rs1002902061 -- 30,240,982(+) C/T upstream_transcript_variant
rs1002975656 -- 30,241,447(+) A/T upstream_transcript_variant
rs1003233952 -- 30,243,820(+) G/A 3_prime_UTR_variant
rs1004929009 -- 30,240,829(+) T/C upstream_transcript_variant

Variation tolerance for MAGEB4 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGEB4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEB4 Gene

Disorders for MAGEB4 Gene

Additional Disease Information for MAGEB4

No disorders were found for MAGEB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGEB4 Gene

Publications for MAGEB4 Gene

  1. Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. (PMID: 9441743) Lurquin C … Boon T (Genomics 1997) 2 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A no-stop mutation in MAGEB4 is a possible cause of rare X-linked azoospermia and oligozoospermia in a consanguineous Turkish family. (PMID: 28401488) Okutman O … Viville S (Journal of assisted reproduction and genetics 2017) 3 58

Products for MAGEB4 Gene

Sources for MAGEB4 Gene

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