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Aliases for MAGEB3 Gene

Aliases for MAGEB3 Gene

  • MAGE Family Member B3 2 3 5
  • Cancer/Testis Antigen Family 3, Member 5 2 3
  • Melanoma Antigen Family B3 2 3
  • MAGE-B3 Antigen 3 4
  • Melanoma-Associated Antigen B3 3
  • Melanoma Antigen Family B, 3 3
  • CT3.5 3

External Ids for MAGEB3 Gene

Previous GeneCards Identifiers for MAGEB3 Gene

  • GC0XP028753
  • GC0XP028932
  • GC0XP029450
  • GC0XP029615
  • GC0XP030008
  • GC0XP030158
  • GC0XP027985

Summaries for MAGEB3 Gene

Entrez Gene Summary for MAGEB3 Gene

  • This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEB3 Gene

MAGEB3 (MAGE Family Member B3) is a Protein Coding gene. Diseases associated with MAGEB3 include Melanoma. An important paralog of this gene is MAGEB4.

Additional gene information for MAGEB3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB3 Gene

Genomics for MAGEB3 Gene

GeneHancer (GH) Regulatory Elements for MAGEB3 Gene

Promoters and enhancers for MAGEB3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI030230 Promoter 0.5 EPDnew 550.8 0.0 -2 0.1 MAGEB3 MAGEB2
GH0XI030228 Enhancer 0.2 ENCODE 550.8 -1.7 -1717 0.2 MAGEB3 MAGEB2
GH0XI030219 Enhancer 0.4 ENCODE 0.4 -10.7 -10742 0.9 FOXA2 POU5F1 MAGEB1 MAGEB4 MAGEB2 MAGEB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAGEB3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAGEB3 gene promoter:

Genomic Locations for MAGEB3 Gene

Genomic Locations for MAGEB3 Gene
chrX:30,230,436-30,237,493
(GRCh38/hg38)
Size:
7,058 bases
Orientation:
Plus strand
chrX:30,248,553-30,255,610
(GRCh37/hg19)

Genomic View for MAGEB3 Gene

Genes around MAGEB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB3 Gene

Proteins for MAGEB3 Gene

  • Protein details for MAGEB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15480-MAGB3_HUMAN
    Recommended name:
    Melanoma-associated antigen B3
    Protein Accession:
    O15480
    Secondary Accessions:
    • A0AVE4
    • B3KQ52
    • O75861

    Protein attributes for MAGEB3 Gene

    Size:
    346 amino acids
    Molecular mass:
    39211 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEB3 Gene

Post-translational modifications for MAGEB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEB3 Gene

No data available for DME Specific Peptides for MAGEB3 Gene

Domains & Families for MAGEB3 Gene

Gene Families for MAGEB3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGEB3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEB3: view

No data available for UniProtKB/Swiss-Prot for MAGEB3 Gene

Function for MAGEB3 Gene

Molecular function for MAGEB3 Gene

GENATLAS Biochemistry:
melanoma antigen,family B,member 3,expressed in normal testis and in testicular tumor

Phenotypes for MAGEB3 Gene

genes like me logo Genes that share phenotypes with MAGEB3: view

Animal Model Products

CRISPR Products

miRNA for MAGEB3 Gene

miRTarBase miRNAs that target MAGEB3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEB3 Gene

Localization for MAGEB3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEB3 gene
Compartment Confidence
nucleus 2
mitochondrion 1
peroxisome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MAGEB3 Gene

Pathways & Interactions for MAGEB3 Gene

SuperPathways for MAGEB3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEB3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGEB3 Gene

Drugs & Compounds for MAGEB3 Gene

No Compound Related Data Available

Transcripts for MAGEB3 Gene

Unigene Clusters for MAGEB3 Gene

Melanoma antigen family B, 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB3 Gene

No ASD Table

Relevant External Links for MAGEB3 Gene

GeneLoc Exon Structure for
MAGEB3
ECgene alternative splicing isoforms for
MAGEB3

Expression for MAGEB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEB3 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEB3 Gene

This gene is overexpressed in Testis (x52.1).

Protein differential expression in normal tissues from HIPED for MAGEB3 Gene

This gene is overexpressed in Heart (48.3) and Testis (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEB3 Gene



Protein tissue co-expression partners for MAGEB3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAGEB3 Gene:

MAGEB3

SOURCE GeneReport for Unigene cluster for MAGEB3 Gene:

Hs.113290

mRNA Expression by UniProt/SwissProt for MAGEB3 Gene:

O15480-MAGB3_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with MAGEB3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEB3 Gene

Orthologs for MAGEB3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEB3 33 34
  • 99.13 (n)
cow
(Bos Taurus)
Mammalia MAGEB3 33
  • 74.64 (n)
-- 34
  • 59 (a)
OneToMany
-- 34
  • 59 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mageb3 33
  • 73.54 (n)
Species where no ortholog for MAGEB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB3 Gene

ENSEMBL:
Gene Tree for MAGEB3 (if available)
TreeFam:
Gene Tree for MAGEB3 (if available)

Paralogs for MAGEB3 Gene

Pseudogenes.org Pseudogenes for MAGEB3 Gene

genes like me logo Genes that share paralogs with MAGEB3: view

Variants for MAGEB3 Gene

Sequence variations from dbSNP and Humsavar for MAGEB3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000534614 -- 30,234,211(+) G/A intron_variant
rs1001404124 -- 30,235,758(+) A/C intron_variant
rs1002125262 -- 30,236,153(+) G/T coding_sequence_variant, missense_variant
rs1002431738 -- 30,230,033(+) G/A upstream_transcript_variant
rs1003256405 -- 30,231,960(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEB3 Gene

Variant ID Type Subtype PubMed ID
esv2668620 CNV deletion 23128226
esv2740048 CNV deletion 23290073

Variation tolerance for MAGEB3 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGEB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGEB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEB3 Gene

Disorders for MAGEB3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGEB3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAGEB3

genes like me logo Genes that share disorders with MAGEB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEB3 Gene

Publications for MAGEB3 Gene

  1. Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. (PMID: 9441743) Lurquin C … Boon T (Genomics 1997) 2 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for MAGEB3 Gene

Sources for MAGEB3 Gene

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