Aliases for MAGEB18 Gene

Aliases for MAGEB18 Gene

  • MAGE Family Member B18 2 3 5
  • Melanoma-Associated Antigen B18 3 4
  • Melanoma Antigen Family B18 2 3
  • MAGE-B18 Antigen 3 4
  • Melanoma Antigen Family B, 18 3

External Ids for MAGEB18 Gene

Previous GeneCards Identifiers for MAGEB18 Gene

  • GC0XP025917
  • GC0XP026066
  • GC0XP023893
  • GC0XP026156

Summaries for MAGEB18 Gene

GeneCards Summary for MAGEB18 Gene

MAGEB18 (MAGE Family Member B18) is a Protein Coding gene. An important paralog of this gene is MAGEB10.

UniProtKB/Swiss-Prot Summary for MAGEB18 Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Additional gene information for MAGEB18 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAGEB18 Gene

Genomics for MAGEB18 Gene

GeneHancer (GH) Regulatory Elements for MAGEB18 Gene

Promoters and enhancers for MAGEB18 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ025646 Enhancer 0.2 FANTOM5 1.9 -491.9 -491866 0.3 ENSG00000228519 LOC389842 MAGEB18 piR-39858-674
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAGEB18 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAGEB18

Top Transcription factor binding sites by QIAGEN in the MAGEB18 gene promoter:
  • Evi-1
  • HSF1 (long)
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Pax-2
  • Pax-2a
  • Pax-5

Genomic Locations for MAGEB18 Gene

Genomic Locations for MAGEB18 Gene
chrX:26,138,343-26,140,736
(GRCh38/hg38)
Size:
2,394 bases
Orientation:
Plus strand
chrX:26,156,460-26,158,853
(GRCh37/hg19)
Size:
2,394 bases
Orientation:
Plus strand

Genomic View for MAGEB18 Gene

Genes around MAGEB18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEB18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEB18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB18 Gene

Proteins for MAGEB18 Gene

  • Protein details for MAGEB18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M61-MAGBI_HUMAN
    Recommended name:
    Melanoma-associated antigen B18
    Protein Accession:
    Q96M61

    Protein attributes for MAGEB18 Gene

    Size:
    343 amino acids
    Molecular mass:
    38533 Da
    Quaternary structure:
    • Interacts with LNX1.

neXtProt entry for MAGEB18 Gene

Post-translational modifications for MAGEB18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEB18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEB18 Gene

Domains & Families for MAGEB18 Gene

Gene Families for MAGEB18 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGEB18 Gene

Blocks:
  • MAGE protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEB18 Gene

GenScript: Design optimal peptide antigens:
  • MAGE-B18 antigen (MAGBI_HUMAN)
genes like me logo Genes that share domains with MAGEB18: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MAGEB18 Gene

Function for MAGEB18 Gene

Molecular function for MAGEB18 Gene

UniProtKB/Swiss-Prot Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Phenotypes From GWAS Catalog for MAGEB18 Gene

Gene Ontology (GO) - Molecular Function for MAGEB18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MAGEB18: view
genes like me logo Genes that share phenotypes with MAGEB18: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEB18 Gene

Localization for MAGEB18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGEB18 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEB18 gene
Compartment Confidence
nucleus 1
cytosol 1
lysosome 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for MAGEB18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MAGEB18: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAGEB18 Gene

Pathways & Interactions for MAGEB18 Gene

PathCards logo

SuperPathways for MAGEB18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEB18 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGEB18 Gene

Drugs & Compounds for MAGEB18 Gene

No Compound Related Data Available

Transcripts for MAGEB18 Gene

mRNA/cDNA for MAGEB18 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB18 Gene

No ASD Table

Relevant External Links for MAGEB18 Gene

GeneLoc Exon Structure for
MAGEB18

Expression for MAGEB18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAGEB18 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEB18 Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for MAGEB18 Gene

This gene is overexpressed in Placenta (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAGEB18 Gene



Protein tissue co-expression partners for MAGEB18 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAGEB18

SOURCE GeneReport for Unigene cluster for MAGEB18 Gene:

Hs.350683
genes like me logo Genes that share expression patterns with MAGEB18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEB18 Gene

Orthologs for MAGEB18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEB18 31 30
  • 99.42 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MAGEB18 31 30
  • 78.95 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MAGEB18 31 30
  • 77.38 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mageb18 30
  • 71.66 (n)
mouse
(Mus musculus)
Mammalia Mageb18 17 31 30
  • 71.54 (n)
Species where no ortholog for MAGEB18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB18 Gene

ENSEMBL:
Gene Tree for MAGEB18 (if available)
TreeFam:
Gene Tree for MAGEB18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAGEB18: view image

Paralogs for MAGEB18 Gene

Pseudogenes.org Pseudogenes for MAGEB18 Gene

genes like me logo Genes that share paralogs with MAGEB18: view

Variants for MAGEB18 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAGEB18 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs5944317 - p.Pro40Ser

Additional dbSNP identifiers (rs#s) for MAGEB18 Gene

Variation tolerance for MAGEB18 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGEB18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGEB18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEB18 Gene

Disorders for MAGEB18 Gene

Additional Disease Information for MAGEB18

No disorders were found for MAGEB18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGEB18 Gene

Publications for MAGEB18 Gene

  1. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle JM … Potts PR (Molecular cell 2010) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54
  5. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B … Wanker EE (Nucleic acids research 2013) 3 54

Products for MAGEB18 Gene

Sources for MAGEB18 Gene