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Aliases for MAGEB1 Gene

Aliases for MAGEB1 Gene

  • MAGE Family Member B1 2 3 5
  • DSS/AHC Critical Interval MAGE Superfamily 10 2 3
  • Cancer/Testis Antigen Family 3, Member 1 2 3
  • Melanoma Antigen Family B1 2 3
  • Cancer/Testis Antigen 3.1 3 4
  • MAGE-B1 Antigen 3 4
  • MAGE-XP Antigen 3 4
  • MAGEL1 3 4
  • CT3.1 3 4
  • DAM10 3 4
  • DSS-AHC Critical Interval MAGE Superfamily 10 4
  • Melanoma-Associated Antigen B1 3
  • Melanoma Antigen Family B, 1 3
  • MAGE-Xp 3
  • MAGEXP 4

External Ids for MAGEB1 Gene

Previous GeneCards Identifiers for MAGEB1 Gene

  • GC0XP028761
  • GC0XP028944
  • GC0XP029463
  • GC0XP029623
  • GC0XP030021
  • GC0XP030170
  • GC0XP027998

Summaries for MAGEB1 Gene

Entrez Gene Summary for MAGEB1 Gene

  • This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region, and expressed in testis and in a significant fraction of tumors of various histological types. This gene and other MAGEB members are clustered on chromosome Xp22-p21. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene, however, the full length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEB1 Gene

MAGEB1 (MAGE Family Member B1) is a Protein Coding gene. Diseases associated with MAGEB1 include Alternating Hemiplegia Of Childhood. An important paralog of this gene is MAGEB4.

Additional gene information for MAGEB1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB1 Gene

Genomics for MAGEB1 Gene

GeneHancer (GH) Regulatory Elements for MAGEB1 Gene

Promoters and enhancers for MAGEB1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ030247 Promoter 1.1 EPDnew 650.7 +3.4 3446 0.1 PKNOX1 ATF1 TAF9B NFRKB ZBTB40 POLR2B CBX5 ATF7 CREM ZBTB2 MAGEB1 MAGEB2 PLCE1P1
GH0XJ030248 Promoter 0.7 EPDnew 650.4 +5.2 5176 0.1 JUNB IRF4 MAGEB1 MAGEB2 PLCE1P1
GH0XJ030243 Promoter 0.5 EPDnew 650.7 +0.0 33 0.1 MAGEB1 MAGEB4 PLCE1P1
GH0XJ030219 Enhancer 0.4 ENCODE 12.1 -24.0 -24036 0.9 FOXA2 NANOG POU5F1 MAGEB4 MAGEB1 MAGEB2 MAGEB3
GH0XJ030152 Enhancer 0.2 ENCODE 11.8 -91.5 -91467 0.4 MAGEB4 MAGEB1 LOC100420324 PIGFP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAGEB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAGEB1 gene promoter:
  • ARP-1
  • NF-kappaB
  • NF-kappaB1
  • RelA

Genomic Locations for MAGEB1 Gene

Genomic Locations for MAGEB1 Gene
8,309 bases
Plus strand
8,309 bases
Plus strand

Genomic View for MAGEB1 Gene

Genes around MAGEB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB1 Gene

Proteins for MAGEB1 Gene

  • Protein details for MAGEB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen B1
    Protein Accession:
    Secondary Accessions:
    • B2RC79
    • O00601
    • O75862
    • Q6FHJ0
    • Q96CW8

    Protein attributes for MAGEB1 Gene

    347 amino acids
    Molecular mass:
    39037 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEB1 Gene

Post-translational modifications for MAGEB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEB1 Gene

No data available for DME Specific Peptides for MAGEB1 Gene

Domains & Families for MAGEB1 Gene

Gene Families for MAGEB1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGEB1 Gene


Suggested Antigen Peptide Sequences for MAGEB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEB1: view

No data available for UniProtKB/Swiss-Prot for MAGEB1 Gene

Function for MAGEB1 Gene

Molecular function for MAGEB1 Gene

GENATLAS Biochemistry:
melanoma antigen,family B,member 1,with two alternatively spliced isoforms,expressed in testis,melanoma and lung carcinomas
genes like me logo Genes that share phenotypes with MAGEB1: view

Animal Model Products

miRNA for MAGEB1 Gene

miRTarBase miRNAs that target MAGEB1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEB1 Gene

Localization for MAGEB1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEB1 gene
Compartment Confidence
nucleus 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MAGEB1 Gene

Pathways & Interactions for MAGEB1 Gene

SuperPathways for MAGEB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEB1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAGEB1 Gene

Drugs & Compounds for MAGEB1 Gene

No Compound Related Data Available

Transcripts for MAGEB1 Gene

mRNA/cDNA for MAGEB1 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEB1 Gene

Melanoma antigen family B, 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB1 Gene

No ASD Table

Relevant External Links for MAGEB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEB1 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEB1 Gene

This gene is overexpressed in Testis (x52.0).

Protein differential expression in normal tissues from HIPED for MAGEB1 Gene

This gene is overexpressed in Testis (35.3) and Ovary (27.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAGEB1 Gene

Protein tissue co-expression partners for MAGEB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAGEB1 Gene:


SOURCE GeneReport for Unigene cluster for MAGEB1 Gene:


mRNA Expression by UniProt/SwissProt for MAGEB1 Gene:

Tissue specificity: Expressed only in testis.
genes like me logo Genes that share expression patterns with MAGEB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEB1 Gene

Orthologs for MAGEB1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAGEB1 34 33
  • 99.04 (n)
(Canis familiaris)
Mammalia LOC491795 33
  • 68.82 (n)
-- 34
  • 56 (a)
(Mus musculus)
Mammalia Mageb3 16 33
  • 65.33 (n)
Mageb4 34
  • 32 (a)
(Bos Taurus)
Mammalia -- 34
  • 56 (a)
-- 34
  • 54 (a)
-- 34
  • 50 (a)
-- 34
  • 49 (a)
-- 34
  • 49 (a)
-- 34
  • 48 (a)
  • 47 (a)
-- 34
  • 46 (a)
-- 34
  • 46 (a)
-- 34
  • 44 (a)
MGC133764 34
  • 44 (a)
-- 34
  • 42 (a)
-- 34
  • 40 (a)
Species where no ortholog for MAGEB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB1 Gene

Gene Tree for MAGEB1 (if available)
Gene Tree for MAGEB1 (if available)
Evolutionary constrained regions (ECRs) for MAGEB1: view image

Paralogs for MAGEB1 Gene

Variants for MAGEB1 Gene

Sequence variations from dbSNP and Humsavar for MAGEB1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000880990 -- 30,244,767(+) G/A genic_upstream_transcript_variant, intron_variant
rs1001011777 -- 30,247,676(+) C/T intron_variant
rs1001080251 -- 30,248,313(+) A/G intron_variant
rs1001350459 -- 30,250,338(+) A/G intron_variant
rs1001584787 -- 30,251,515(+) G/T coding_sequence_variant, missense_variant

Variation tolerance for MAGEB1 Gene

Residual Variation Intolerance Score: 18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGEB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEB1 Gene

Disorders for MAGEB1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGEB1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
alternating hemiplegia of childhood
  • ahc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAGEB1

genes like me logo Genes that share disorders with MAGEB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEB1 Gene

Publications for MAGEB1 Gene

  1. Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. (PMID: 9441743) Lurquin C … Boon T (Genomics 1997) 2 3 22 58
  2. A family of rapidly evolving genes from the sex reversal critical region in Xp21. (PMID: 8535061) Dabovic B … Camerino G (Mammalian genome : official journal of the International Mammalian Genome Society 1995) 3 4 22 58
  3. Isolation and characterization of a MAGE gene family in the Xp21.3 region. (PMID: 7761436) Muscatelli F … Monaco AP (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 58
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MAGEB1 Gene

Sources for MAGEB1 Gene

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