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Aliases for MAGEA9 Gene

Aliases for MAGEA9 Gene

  • MAGE Family Member A9 2 3 5
  • MAGE-9 Antigen 2 3 4
  • Cancer/Testis Antigen Family 1, Member 9 2 3
  • Melanoma-Associated Antigen 9 2 3
  • Melanoma Antigen Family A9 2 3
  • Cancer/Testis Antigen 1.9 3 4
  • MAGE9 3 4
  • CT1.9 3 4
  • Melanoma Antigen Family A, 9 3
  • MAGEA9A 4

External Ids for MAGEA9 Gene

Previous HGNC Symbols for MAGEA9 Gene

  • MAGE9

Previous GeneCards Identifiers for MAGEA9 Gene

  • GC0XP143533
  • GC0XP145914
  • GC0XP146754
  • GC0XP147569
  • GC0XP148569
  • GC0XP148671
  • GC0XP148863
  • GC0XM137617

Summaries for MAGEA9 Gene

Entrez Gene Summary for MAGEA9 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEA9 Gene

MAGEA9 (MAGE Family Member A9) is a Protein Coding gene. Diseases associated with MAGEA9 include Terminal Osseous Dysplasia and Melanoma. An important paralog of this gene is MAGEA9B.

UniProtKB/Swiss-Prot for MAGEA9 Gene

  • Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Gene Wiki entry for MAGEA9 Gene

Additional gene information for MAGEA9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA9 Gene

Genomics for MAGEA9 Gene

GeneHancer (GH) Regulatory Elements for MAGEA9 Gene

Promoters and enhancers for MAGEA9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ149781 Promoter 0.5 EPDnew 650.7 +0.0 6 0.1 MAGEA9 MAGEA7P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAGEA9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAGEA9 gene promoter:
  • HNF-3beta
  • GR-beta
  • GR-alpha
  • GR
  • LCR-F1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • Pbx1a
  • Nkx3-1

Genomic Locations for MAGEA9 Gene

Genomic Locations for MAGEA9 Gene
chrX:149,781,921-149,787,739
(GRCh38/hg38)
Size:
5,819 bases
Orientation:
Plus strand
chrX:148,863,584-148,869,399
(GRCh37/hg19)
Size:
5,816 bases
Orientation:
Plus strand

Genomic View for MAGEA9 Gene

Genes around MAGEA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA9 Gene

Proteins for MAGEA9 Gene

  • Protein details for MAGEA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43362-MAGA9_HUMAN
    Recommended name:
    Melanoma-associated antigen 9
    Protein Accession:
    P43362
    Secondary Accessions:
    • A8K8A7
    • Q7Z5K4
    • Q92910
    • A8K8A7
    • Q7Z5K4
    • Q92910

    Protein attributes for MAGEA9 Gene

    Size:
    315 amino acids
    Molecular mass:
    35088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEA9 Gene

Post-translational modifications for MAGEA9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEA9 Gene

No data available for DME Specific Peptides for MAGEA9 Gene

Domains & Families for MAGEA9 Gene

Gene Families for MAGEA9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGEA9 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEA9: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MAGEA9 Gene

Function for MAGEA9 Gene

Molecular function for MAGEA9 Gene

UniProtKB/Swiss-Prot Function:
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
GENATLAS Biochemistry:
human melanoma antigen,family A,member 9,expressed in melanoma,testis

Gene Ontology (GO) - Molecular Function for MAGEA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAGEA9: view
genes like me logo Genes that share phenotypes with MAGEA9: view

Animal Model Products

CRISPR Products

miRNA for MAGEA9 Gene

miRTarBase miRNAs that target MAGEA9

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGEA9

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEA9 Gene

Localization for MAGEA9 Gene

Gene Ontology (GO) - Cellular Components for MAGEA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MAGEA9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MAGEA9 Gene

Pathways & Interactions for MAGEA9 Gene

SuperPathways for MAGEA9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MAGEA9: view

No data available for Pathways by source and SIGNOR curated interactions for MAGEA9 Gene

Drugs & Compounds for MAGEA9 Gene

No Compound Related Data Available

Transcripts for MAGEA9 Gene

mRNA/cDNA for MAGEA9 Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEA9 Gene

Melanoma antigen family A, 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGEA9

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA9 Gene

No ASD Table

Relevant External Links for MAGEA9 Gene

GeneLoc Exon Structure for
MAGEA9
ECgene alternative splicing isoforms for
MAGEA9

Expression for MAGEA9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEA9 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEA9 Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for MAGEA9 Gene

This gene is overexpressed in Ovary (61.7) and Testis (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAGEA9 Gene



Protein tissue co-expression partners for MAGEA9 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAGEA9 Gene:

MAGEA9

SOURCE GeneReport for Unigene cluster for MAGEA9 Gene:

Hs.512582

mRNA Expression by UniProt/SwissProt for MAGEA9 Gene:

P43362-MAGA9_HUMAN
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.
genes like me logo Genes that share expression patterns with MAGEA9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEA9 Gene

Orthologs for MAGEA9 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAGEA9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Magea10 34
  • 40 (a)
ManyToMany
Magea5 34
  • 40 (a)
ManyToMany
Magea6 34
  • 39 (a)
ManyToMany
Magea8 34
  • 39 (a)
ManyToMany
Magea1 34
  • 39 (a)
ManyToMany
Magea2 34
  • 39 (a)
ManyToMany
3830417A13Rik 34
  • 39 (a)
ManyToMany
1700080O16Rik 34
  • 39 (a)
ManyToMany
Magea3 34
  • 38 (a)
ManyToMany
Magea4 34
  • 38 (a)
ManyToMany
Species where no ortholog for MAGEA9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA9 Gene

ENSEMBL:
Gene Tree for MAGEA9 (if available)
TreeFam:
Gene Tree for MAGEA9 (if available)

Paralogs for MAGEA9 Gene

(37) SIMAP similar genes for MAGEA9 Gene using alignment to 5 proteins:

  • MAGA9_HUMAN
  • E5RFS8_HUMAN
  • E5RH97_HUMAN
  • E5RJ34_HUMAN
  • E5RJI2_HUMAN
genes like me logo Genes that share paralogs with MAGEA9: view

Variants for MAGEA9 Gene

Sequence variations from dbSNP and Humsavar for MAGEA9 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs111482377 -- 149,780,314(+) G/A upstream_transcript_variant
rs113451770 -- 149,785,673(+) T/C intron_variant
rs151339737 -- 149,782,357(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs188883762 -- 149,786,129(+) A/G intron_variant
rs200845078 -- 149,787,093(+) A/G coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEA9 Gene

Variant ID Type Subtype PubMed ID
dgv2521e212 CNV gain 25503493
dgv2522e212 CNV gain 25503493
esv3574968 CNV loss 25503493
esv3574969 CNV loss 25503493
esv3577504 CNV gain 25503493
esv3577519 CNV gain 25503493
nsv1149654 CNV duplication 26484159
nsv1149848 CNV duplication 26484159
nsv508809 CNV insertion 20534489
nsv518742 CNV gain 19592680
nsv525908 CNV gain 19592680
nsv7464 OTHER inversion 18451855
nsv818041 CNV gain 17921354

Additional Variant Information for MAGEA9 Gene

Human Gene Mutation Database (HGMD)
MAGEA9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGEA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MAGEA9 Gene

Disorders for MAGEA9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MAGEA9 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
terminal osseous dysplasia
  • tod
melanoma
  • malignant melanoma
dyskeratosis congenita
  • zinsser-cole-engman syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAGEA9

genes like me logo Genes that share disorders with MAGEA9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA9 Gene

Publications for MAGEA9 Gene

  1. Evidence for the involvement of the proximal copy of the MAGEA9 gene in Xq28-linked CNV67 specific to spermatogenic failure. (PMID: 28339631) Shen Y … Yang Y (Biology of reproduction 2017) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Molecular and phenotypic variation in patients with severe Hunter syndrome. (PMID: 9147653) Timms KM … Gibbs RA (Human molecular genetics 1997) 3 4 58
  4. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner UC … Poustka A (Genomics 1995) 2 3 58
  5. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PMID: 7927540) De Plaen E … Lurquin C (Immunogenetics 1994) 3 4 58

Products for MAGEA9 Gene

Sources for MAGEA9 Gene

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