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Aliases for MAGEA8 Gene

Aliases for MAGEA8 Gene

  • MAGE Family Member A8 2 3 5
  • MAGE-8 Antigen 2 3 4
  • Cancer/Testis Antigen Family 1, Member 8 2 3
  • Melanoma Antigen Family A8 2 3
  • Cancer/Testis Antigen 1.8 3 4
  • MAGE8 3 4
  • CT1.8 3 4
  • Melanoma-Associated Antigen 8 3
  • Melanoma Antigen Family A, 8 3

External Ids for MAGEA8 Gene

Previous HGNC Symbols for MAGEA8 Gene

  • MAGE8

Previous GeneCards Identifiers for MAGEA8 Gene

  • GC0XP143633
  • GC0XP146013
  • GC0XP146853
  • GC0XP147668
  • GC0XP148668
  • GC0XP148770
  • GC0XP149009

Summaries for MAGEA8 Gene

Entrez Gene Summary for MAGEA8 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]

GeneCards Summary for MAGEA8 Gene

MAGEA8 (MAGE Family Member A8) is a Protein Coding gene. Diseases associated with MAGEA8 include Melanoma and Dyskeratosis Congenita. An important paralog of this gene is MAGEA4.

UniProtKB/Swiss-Prot for MAGEA8 Gene

  • Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Additional gene information for MAGEA8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA8 Gene

Genomics for MAGEA8 Gene

GeneHancer (GH) Regulatory Elements for MAGEA8 Gene

Promoters and enhancers for MAGEA8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ149881 Promoter 1 EPDnew 650.7 +0.0 23 0.1 ZNF263 ATF1 REST NFXL1 ZEB2 ZBTB40 GABPA CTBP1 MTA3 POLR2A MAGEA8 CXorf40B LINC00894 IDS2 LINC00893 MAGEA8-AS1
GH0XJ150198 Enhancer 1.4 FANTOM5 Ensembl ENCODE 10.6 +319.0 318975 3.4 PKNOX1 ATF1 SIN3A IRF4 BRCA1 GLIS2 ELK1 ATF7 FOS RUNX3 MIR2114 MAGEA8 IDS2 LINC00893 MAMLD1 LOC643015 LINC00894
GH0XJ149828 Enhancer 0.9 Ensembl ENCODE 0.2 -51.5 -51497 2.7 HDGF HDAC1 EBF1 RELA EED ATF7 PRDM10 IKZF2 RUNX3 NRF1 CXorf40A LINC00894 LINC00893 TMEM185A IDS2 LINC00850 MAGEA8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAGEA8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAGEA8 gene promoter:
  • p53

Genomic Locations for MAGEA8 Gene

Genomic Locations for MAGEA8 Gene
4,695 bases
Plus strand
4,669 bases
Plus strand

Genomic View for MAGEA8 Gene

Genes around MAGEA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA8 Gene

Proteins for MAGEA8 Gene

  • Protein details for MAGEA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen 8
    Protein Accession:
    Secondary Accessions:
    • Q9BUN9

    Protein attributes for MAGEA8 Gene

    318 amino acids
    Molecular mass:
    35215 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEA8 Gene

Post-translational modifications for MAGEA8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEA8 Gene

No data available for DME Specific Peptides for MAGEA8 Gene

Domains & Families for MAGEA8 Gene

Gene Families for MAGEA8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGEA8 Gene


Suggested Antigen Peptide Sequences for MAGEA8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEA8: view

No data available for UniProtKB/Swiss-Prot for MAGEA8 Gene

Function for MAGEA8 Gene

Molecular function for MAGEA8 Gene

UniProtKB/Swiss-Prot Function:
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
GENATLAS Biochemistry:
human melanoma antigen,family A,member 8,expressed in melanoma,testis

Gene Ontology (GO) - Molecular Function for MAGEA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAGEA8: view
genes like me logo Genes that share phenotypes with MAGEA8: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEA8 Gene

Localization for MAGEA8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEA8 gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for MAGEA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MAGEA8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MAGEA8 Gene

Pathways & Interactions for MAGEA8 Gene

SuperPathways for MAGEA8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MAGEA8: view

No data available for Pathways by source and SIGNOR curated interactions for MAGEA8 Gene

Drugs & Compounds for MAGEA8 Gene

No Compound Related Data Available

Transcripts for MAGEA8 Gene

Unigene Clusters for MAGEA8 Gene

Melanoma antigen family A, 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3: -

Relevant External Links for MAGEA8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEA8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEA8 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEA8 Gene

This gene is overexpressed in Testis (x15.7).

Protein differential expression in normal tissues from HIPED for MAGEA8 Gene

This gene is overexpressed in Monocytes (62.0) and Platelet (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAGEA8 Gene

Protein tissue co-expression partners for MAGEA8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAGEA8 Gene:


SOURCE GeneReport for Unigene cluster for MAGEA8 Gene:


mRNA Expression by UniProt/SwissProt for MAGEA8 Gene:

Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testis and placenta.
genes like me logo Genes that share expression patterns with MAGEA8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEA8 Gene

Orthologs for MAGEA8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEA8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAGEA8 34 33
  • 99.58 (n)
(Mus musculus)
Mammalia Magea5 34
  • 43 (a)
Magea10 34
  • 43 (a)
Magea1 34
  • 42 (a)
Magea3 34
  • 42 (a)
Magea6 34
  • 42 (a)
Magea8 34
  • 42 (a)
Magea2 34
  • 42 (a)
Magea4 34
  • 42 (a)
1700080O16Rik 34
  • 40 (a)
3830417A13Rik 34
  • 39 (a)
(Canis familiaris)
Mammalia -- 34
  • 42 (a)
(Bos Taurus)
Mammalia -- 34
  • 36 (a)
Species where no ortholog for MAGEA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA8 Gene

Gene Tree for MAGEA8 (if available)
Gene Tree for MAGEA8 (if available)
Evolutionary constrained regions (ECRs) for MAGEA8: view image

Paralogs for MAGEA8 Gene Pseudogenes for MAGEA8 Gene

genes like me logo Genes that share paralogs with MAGEA8: view

Variants for MAGEA8 Gene

Sequence variations from dbSNP and Humsavar for MAGEA8 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000910998 -- 149,880,735(+) G/A upstream_transcript_variant
rs1001364874 -- 149,881,158(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1003477493 -- 149,883,353(+) G/A intron_variant
rs1003828145 -- 149,883,072(+) A/T 5_prime_UTR_variant, intron_variant
rs1004370102 -- 149,881,639(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEA8 Gene

Variant ID Type Subtype PubMed ID
esv22974 CNV gain 19812545
esv3577519 CNV gain 25503493
nsv442819 CNV gain 18776908
nsv515182 CNV gain+loss 21397061
nsv525908 CNV gain 19592680
nsv7464 OTHER inversion 18451855

Variation tolerance for MAGEA8 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGEA8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEA8 Gene

Disorders for MAGEA8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAGEA8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • malignant melanoma
dyskeratosis congenita
  • zinsser-cole-engman syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAGEA8

genes like me logo Genes that share disorders with MAGEA8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA8 Gene

Publications for MAGEA8 Gene

  1. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner UC … Poustka A (Genomics 1995) 2 3 58
  2. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PMID: 7927540) De Plaen E … Lurquin C (Immunogenetics 1994) 3 4 58
  3. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 58
  4. Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. (PMID: 27229929) Daakour S … Twizere JC (BMC cancer 2016) 3 58
  5. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3 58

Products for MAGEA8 Gene

Sources for MAGEA8 Gene

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