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Aliases for MAGEA6 Gene

Aliases for MAGEA6 Gene

  • MAGE Family Member A6 2 3 5
  • MAGE-6 Antigen 2 3 4
  • Cancer/Testis Antigen Family 1, Member 6 2 3
  • Melanoma-Associated Antigen 6 2 3
  • Melanoma Antigen Family A6 2 3
  • Cancer/Testis Antigen 1.6 3 4
  • MAGE3B Antigen 3 4
  • MAGE6 3 4
  • CT1.6 3 4
  • Melanoma Antigen Family A, 6 3
  • Melanoma Antigen Family A 6 2
  • MAGE-3b 3
  • MAGE3B 3

External Ids for MAGEA6 Gene

Previous HGNC Symbols for MAGEA6 Gene

  • MAGE6

Previous GeneCards Identifiers for MAGEA6 Gene

  • GC0XU990097
  • GC0XP148524
  • GC0XP149615
  • GC0XM150553
  • GC0XP150484
  • GC0XP151537
  • GC0XP151617
  • GC0XP151867

Summaries for MAGEA6 Gene

Entrez Gene Summary for MAGEA6 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for MAGEA6 Gene

MAGEA6 (MAGE Family Member A6) is a Protein Coding gene. Diseases associated with MAGEA6 include Melanoma and Terminal Osseous Dysplasia. An important paralog of this gene is MAGEA3.

UniProtKB/Swiss-Prot for MAGEA6 Gene

  • Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.

Additional gene information for MAGEA6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA6 Gene

Genomics for MAGEA6 Gene

GeneHancer (GH) Regulatory Elements for MAGEA6 Gene

Promoters and enhancers for MAGEA6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI152769 Promoter 0.5 EPDnew 550.8 +0.0 14 0.1 MAGEA6 GC0XP152763 GC0XP152764 GC0XP152765 GC0XM152591
GH0XI152641 Enhancer 0.4 ENCODE 7.7 +128.4 128351 0.8 SP1 POLR2A POU5F1 MAGEA6 GABRQ LOC100420250 LOC105373370 GC0XM152591
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAGEA6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAGEA6 gene promoter:

Genomic Locations for MAGEA6 Gene

Genomic Locations for MAGEA6 Gene
chrX:152,766,136-152,769,747
(GRCh38/hg38)
Size:
3,612 bases
Orientation:
Minus strand
chrX:151,867,214-151,870,825
(GRCh37/hg19)

Genomic View for MAGEA6 Gene

Genes around MAGEA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA6 Gene

Proteins for MAGEA6 Gene

  • Protein details for MAGEA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43360-MAGA6_HUMAN
    Recommended name:
    Melanoma-associated antigen 6
    Protein Accession:
    P43360
    Secondary Accessions:
    • A8IF93
    • Q6NW44

    Protein attributes for MAGEA6 Gene

    Size:
    314 amino acids
    Molecular mass:
    34891 Da
    Quaternary structure:
    • Interacts with TRIM28.

neXtProt entry for MAGEA6 Gene

Post-translational modifications for MAGEA6 Gene

No Post-translational modifications

Other Protein References for MAGEA6 Gene

No data available for DME Specific Peptides for MAGEA6 Gene

Domains & Families for MAGEA6 Gene

Gene Families for MAGEA6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for MAGEA6 Gene

Suggested Antigen Peptide Sequences for MAGEA6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEA6: view

No data available for UniProtKB/Swiss-Prot for MAGEA6 Gene

Function for MAGEA6 Gene

Molecular function for MAGEA6 Gene

GENATLAS Biochemistry:
human melanoma antigen,family A,member 6,expressed in melanoma,testis
UniProtKB/Swiss-Prot Function:
Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.

Gene Ontology (GO) - Molecular Function for MAGEA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 20864041
genes like me logo Genes that share ontologies with MAGEA6: view
genes like me logo Genes that share phenotypes with MAGEA6: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEA6 Gene

Localization for MAGEA6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEA6 gene
Compartment Confidence
cytosol 2
plasma membrane 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MAGEA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MAGEA6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MAGEA6 Gene

Pathways & Interactions for MAGEA6 Gene

SuperPathways for MAGEA6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MAGEA6: view

No data available for Pathways by source and SIGNOR curated interactions for MAGEA6 Gene

Drugs & Compounds for MAGEA6 Gene

No Compound Related Data Available

Transcripts for MAGEA6 Gene

Unigene Clusters for MAGEA6 Gene

Melanoma antigen family A, 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA6 Gene

No ASD Table

Relevant External Links for MAGEA6 Gene

GeneLoc Exon Structure for
MAGEA6
ECgene alternative splicing isoforms for
MAGEA6

Expression for MAGEA6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEA6 Gene

This gene is overexpressed in Testis (x49.2).

Protein differential expression in normal tissues from HIPED for MAGEA6 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAGEA6 Gene



Protein tissue co-expression partners for MAGEA6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAGEA6 Gene:

MAGEA6

SOURCE GeneReport for Unigene cluster for MAGEA6 Gene:

Hs.441113

mRNA Expression by UniProt/SwissProt for MAGEA6 Gene:

P43360-MAGA6_HUMAN
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.

Evidence on tissue expression from TISSUES for MAGEA6 Gene

  • Skin(2.8)
genes like me logo Genes that share expression patterns with MAGEA6: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEA6 Gene

Orthologs for MAGEA6 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAGEA6 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Magea10 34
  • 40 (a)
ManyToMany
Magea6 34
  • 39 (a)
ManyToMany
1700080O16Rik 34
  • 38 (a)
ManyToMany
3830417A13Rik 34
  • 38 (a)
ManyToMany
Magea1 34
  • 38 (a)
ManyToMany
Magea3 34
  • 38 (a)
ManyToMany
Magea5 34
  • 38 (a)
ManyToMany
Magea8 34
  • 38 (a)
ManyToMany
Magea2 34
  • 37 (a)
ManyToMany
Magea4 34
  • 37 (a)
ManyToMany
Species where no ortholog for MAGEA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA6 Gene

ENSEMBL:
Gene Tree for MAGEA6 (if available)
TreeFam:
Gene Tree for MAGEA6 (if available)

Paralogs for MAGEA6 Gene

Pseudogenes.org Pseudogenes for MAGEA6 Gene

genes like me logo Genes that share paralogs with MAGEA6: view

Variants for MAGEA6 Gene

Sequence variations from dbSNP and Humsavar for MAGEA6 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1047232 -- 152,766,387(-) A/G 3_prime_UTR_variant
rs1047234 -- 152,766,383(-) C/A/G/T 3_prime_UTR_variant
rs138036337 -- 152,766,896(-) T/C coding_sequence_variant, missense_variant
rs138239460 -- 152,767,372(-) C/T coding_sequence_variant, synonymous_variant
rs138558171 -- 152,766,335(-) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEA6 Gene

Variant ID Type Subtype PubMed ID
esv2758901 CNV gain 17122850
nsv1119372 CNV duplication 24896259
nsv1148882 CNV duplication 26484159

Variation tolerance for MAGEA6 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.20; 61.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGEA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGEA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEA6 Gene

Disorders for MAGEA6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MAGEA6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
terminal osseous dysplasia
  • tod
dyskeratosis congenita
  • zinsser-cole-engman syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAGEA6

genes like me logo Genes that share disorders with MAGEA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA6 Gene

Publications for MAGEA6 Gene

  1. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle JM … Potts PR (Molecular cell 2010) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma. (PMID: 12631591) Tatsumi T … Storkus WJ (Clinical cancer research : an official journal of the American Association for Cancer Research 2003) 3 22 58
  4. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner UC … Poustka A (Genomics 1995) 2 3 58
  5. Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens. (PMID: 7642112) Imai Y … Itoh K (Gene 1995) 3 4 58

Products for MAGEA6 Gene

Sources for MAGEA6 Gene

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