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Aliases for MAGEA5 Gene

Aliases for MAGEA5 Gene

  • MAGE Family Member A5 2 3 5
  • Cancer/Testis Antigen Family 1, Member 5 2 3
  • Melanoma Antigen Family A5 2 3
  • Cancer/Testis Antigen 1.5 3 4
  • MAGE-5a Antigen 2 3
  • MAGE-5b Antigen 2 3
  • MAGE-5 Antigen 3 4
  • MAGE5 3 4
  • CT1.5 3 4
  • Melanoma-Associated Antigen 5 3
  • Melanoma Antigen Family A, 5 3
  • MAGEA4 3

External Ids for MAGEA5 Gene

Previous HGNC Symbols for MAGEA5 Gene

  • MAGE5

Previous GeneCards Identifiers for MAGEA5 Gene

  • GC0XM145618
  • GC0XM147941
  • GC0XM149030
  • GC0XM149900
  • GC0XM150953
  • GC0XM151033
  • GC0XM151282
  • GC0XM140136

Summaries for MAGEA5 Gene

Entrez Gene Summary for MAGEA5 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This MAGEA gene encodes a protein that is C-terminally truncated compared to other family members, and this gene can be alternatively interpreted to be a pseudogene. The protein is represented in this Gene record in accordance with the assumed protein-coding status defined in the literature. Read-through transcription exists between this gene and the upstream melanoma antigen family A, 10 (MAGEA10) gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for MAGEA5 Gene

MAGEA5 (MAGE Family Member A5) is a Protein Coding gene. Diseases associated with MAGEA5 include Melanoma and Dyskeratosis Congenita. An important paralog of this gene is MAGEA10-MAGEA5.

UniProtKB/Swiss-Prot for MAGEA5 Gene

  • Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.

Additional gene information for MAGEA5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA5 Gene

Genomics for MAGEA5 Gene

GeneHancer (GH) Regulatory Elements for MAGEA5 Gene

Top Transcription factor binding sites by QIAGEN in the MAGEA5 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • aMEF-2
  • MEF-2A
  • Nkx6-1
  • GR
  • GR-alpha
  • AhR

Genomic Locations for MAGEA5 Gene

Genomic Locations for MAGEA5 Gene
3,891 bases
Minus strand
3,919 bases
Minus strand

Genomic View for MAGEA5 Gene

Genes around MAGEA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA5 Gene

Proteins for MAGEA5 Gene

  • Protein details for MAGEA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen 5
    Protein Accession:
    Secondary Accessions:
    • Q32MD0

    Protein attributes for MAGEA5 Gene

    124 amino acids
    Molecular mass:
    13016 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEA5 Gene

Post-translational modifications for MAGEA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEA5 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for MAGEA5 Gene

Domains & Families for MAGEA5 Gene

Gene Families for MAGEA5 Gene

Protein Domains for MAGEA5 Gene


Suggested Antigen Peptide Sequences for MAGEA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEA5: view

No data available for UniProtKB/Swiss-Prot for MAGEA5 Gene

Function for MAGEA5 Gene

Molecular function for MAGEA5 Gene

UniProtKB/Swiss-Prot Function:
Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.
GENATLAS Biochemistry:
human melanoma antigen,family A,member 5,expressed in melanoma,testis

Gene Ontology (GO) - Molecular Function for MAGEA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MAGEA5: view

Phenotypes for MAGEA5 Gene

genes like me logo Genes that share phenotypes with MAGEA5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEA5 Gene

Localization for MAGEA5 Gene

Gene Ontology (GO) - Cellular Components for MAGEA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MAGEA5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MAGEA5 Gene

Pathways & Interactions for MAGEA5 Gene

SuperPathways for MAGEA5 Gene

No Data Available

Interacting Proteins for MAGEA5 Gene

Selected Interacting proteins: P43359-MAGA5_HUMAN for MAGEA5 Gene via IID

Gene Ontology (GO) - Biological Process for MAGEA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051983 regulation of chromosome segregation IMP 22869527
genes like me logo Genes that share ontologies with MAGEA5: view

No data available for Pathways by source and SIGNOR curated interactions for MAGEA5 Gene

Drugs & Compounds for MAGEA5 Gene

No Compound Related Data Available

Transcripts for MAGEA5 Gene

mRNA/cDNA for MAGEA5 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(48) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEA5 Gene

Melanoma antigen family A, 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA5 Gene

No ASD Table

Relevant External Links for MAGEA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEA5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAGEA5 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAGEA5 Gene:


SOURCE GeneReport for Unigene cluster for MAGEA5 Gene:


mRNA Expression by UniProt/SwissProt for MAGEA5 Gene:

Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
genes like me logo Genes that share expression patterns with MAGEA5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEA5 Gene

Orthologs for MAGEA5 Gene

Evolution for MAGEA5 Gene

Gene Tree for MAGEA5 (if available)
Gene Tree for MAGEA5 (if available)

No data available for Orthologs for MAGEA5 Gene

Paralogs for MAGEA5 Gene

Paralogs for MAGEA5 Gene

(16) SIMAP similar genes for MAGEA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAGEA5: view

Variants for MAGEA5 Gene

Sequence variations from dbSNP and Humsavar for MAGEA5 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000060774 -- 152,117,037(-) A/G intron_variant
rs1000502786 -- 152,115,259(-) C/T coding_sequence_variant, synonymous_variant
rs1001237968 -- 152,117,671(-) T/C intron_variant
rs1001469623 -- 152,114,897(-) A/T 3_prime_UTR_variant
rs1002082920 -- 152,116,322(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEA5 Gene

Variant ID Type Subtype PubMed ID
nsv520971 CNV gain 19592680

Additional Variant Information for MAGEA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MAGEA5 Gene

Disorders for MAGEA5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAGEA5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • malignant melanoma
dyskeratosis congenita
  • zinsser-cole-engman syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAGEA5

genes like me logo Genes that share disorders with MAGEA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA5 Gene

Publications for MAGEA5 Gene

  1. Multiple cancer testis antigens function to support tumor cell mitotic fidelity. (PMID: 22869527) Cappell KM … Whitehurst AW (Molecular and cellular biology 2012) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner UC … Poustka A (Genomics 1995) 2 3 58
  4. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PMID: 7927540) De Plaen E … Lurquin C (Immunogenetics 1994) 3 4 58
  5. MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation analysis in induced sputum from patients with lung cancer and non-malignant lung diseases. (PMID: 22134685) Shin KC … Jeon CH (Oncology reports 2012) 3 58

Products for MAGEA5 Gene

Sources for MAGEA5 Gene

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