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Aliases for MAGEA4 Gene

Aliases for MAGEA4 Gene

  • MAGE Family Member A4 2 3 5
  • Cancer/Testis Antigen Family 1, Member 4 2 3
  • Melanoma-Associated Antigen 4 2 3
  • Melanoma Antigen Family A4 2 3
  • Cancer/Testis Antigen 1.4 3 4
  • MAGE-41 Antigen 3 4
  • MAGE-X2 Antigen 3 4
  • MAGE-4 Antigen 3 4
  • MAGE4 3 4
  • CT1.4 3 4
  • Melanoma Antigen Family A, 4 3
  • MAGE-41 3
  • MAGE-X2 3
  • MAGE4A 3
  • MAGE4B 3

External Ids for MAGEA4 Gene

Previous HGNC Symbols for MAGEA4 Gene

  • MAGE4

Previous GeneCards Identifiers for MAGEA4 Gene

  • GC0XP145421
  • GC0XP147744
  • GC0XP148829
  • GC0XP149702
  • GC0XP149699
  • GC0XP150752
  • GC0XP150832
  • GC0XP151080
  • GC0XP139939

Summaries for MAGEA4 Gene

Entrez Gene Summary for MAGEA4 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEA4 Gene

MAGEA4 (MAGE Family Member A4) is a Protein Coding gene. Diseases associated with MAGEA4 include Testicular Leukemia and Testicular Cancer. An important paralog of this gene is MAGEA1.

UniProtKB/Swiss-Prot for MAGEA4 Gene

  • Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Gene Wiki entry for MAGEA4 Gene

Additional gene information for MAGEA4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA4 Gene

Genomics for MAGEA4 Gene

GeneHancer (GH) Regulatory Elements for MAGEA4 Gene

Promoters and enhancers for MAGEA4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ151912 Promoter 0.5 EPDnew 650.7 0.0 -38 0.1 MAGEA4-AS1 MAGEA4 PIR56144
GH0XJ151918 Promoter 0.5 EPDnew 650.4 +5.7 5729 0.1 MAGEA4 MAGEA4-AS1 MIR224
GH0XJ151981 Enhancer 1.1 Ensembl ENCODE 12.1 +71.8 71791 6.4 FOXA2 ZNF766 FOS REST ZNF592 MBD2 NFIL3 SMARCA4 ETV4 STAT3 MIR224 MAGEA4 MAGEA4-AS1 GABRE GC0XM152046
GH0XJ151988 Enhancer 0.7 ENCODE 12.1 +76.6 76553 1.6 HDAC1 MEIS2 IRF2 LEF1 ATF1 TEAD4 E4F1 CTBP1 NCOR1 ATF7 MAGEA4-AS1 MAGEA4 GABRE GC0XM152046
GH0XJ151902 Enhancer 0.8 Ensembl ENCODE 0.4 -9.2 -9220 1.7 JUN SIN3A CEBPB ELF1 EP300 RAD21 NR2F2 SP1 FOSL1 JUND MAGEA4 PIR56144
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAGEA4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAGEA4 gene promoter:
  • p53
  • Elk-1
  • Olf-1

Genomic Locations for MAGEA4 Gene

Genomic Locations for MAGEA4 Gene
12,662 bases
Plus strand
12,662 bases
Plus strand

Genomic View for MAGEA4 Gene

Genes around MAGEA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA4 Gene

Proteins for MAGEA4 Gene

  • Protein details for MAGEA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen 4
    Protein Accession:
    Secondary Accessions:
    • Q14798

    Protein attributes for MAGEA4 Gene

    317 amino acids
    Molecular mass:
    34899 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MAGEA4 Gene

neXtProt entry for MAGEA4 Gene

Post-translational modifications for MAGEA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAGEA4 Gene

Domains & Families for MAGEA4 Gene

Gene Families for MAGEA4 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MAGEA4 Gene


Suggested Antigen Peptide Sequences for MAGEA4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEA4: view

No data available for UniProtKB/Swiss-Prot for MAGEA4 Gene

Function for MAGEA4 Gene

Molecular function for MAGEA4 Gene

UniProtKB/Swiss-Prot Function:
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
GENATLAS Biochemistry:
human melanoma antigen,family A,member 4,expressed in melanoma,testis and placenta

Gene Ontology (GO) - Molecular Function for MAGEA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 12525503
genes like me logo Genes that share ontologies with MAGEA4: view
genes like me logo Genes that share phenotypes with MAGEA4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEA4 Gene

Localization for MAGEA4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEA4 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAGEA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MAGEA4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAGEA4 Gene

Pathways & Interactions for MAGEA4 Gene

SuperPathways for MAGEA4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MAGEA4: view

No data available for Pathways by source and SIGNOR curated interactions for MAGEA4 Gene

Drugs & Compounds for MAGEA4 Gene

No Compound Related Data Available

Transcripts for MAGEA4 Gene

Unigene Clusters for MAGEA4 Gene

Melanoma antigen family A, 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA4 Gene

No ASD Table

Relevant External Links for MAGEA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEA4 Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for MAGEA4 Gene

This gene is overexpressed in Ovary (29.1), Lung (21.3), and Testis (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAGEA4 Gene

Protein tissue co-expression partners for MAGEA4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAGEA4 Gene:


SOURCE GeneReport for Unigene cluster for MAGEA4 Gene:


mRNA Expression by UniProt/SwissProt for MAGEA4 Gene:

Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.
genes like me logo Genes that share expression patterns with MAGEA4: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEA4 Gene

Orthologs for MAGEA4 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAGEA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAGEA4 34 33
  • 98.84 (n)
(Mus musculus)
Mammalia Magea10 34
  • 42 (a)
Magea6 34
  • 40 (a)
1700080O16Rik 34
  • 40 (a)
Magea5 34
  • 39 (a)
Magea3 34
  • 39 (a)
Magea8 34
  • 39 (a)
3830417A13Rik 34
  • 38 (a)
Magea2 34
  • 38 (a)
Magea1 34
  • 38 (a)
Magea4 34
  • 38 (a)
Species where no ortholog for MAGEA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA4 Gene

Gene Tree for MAGEA4 (if available)
Gene Tree for MAGEA4 (if available)
Evolutionary constrained regions (ECRs) for MAGEA4: view image

Paralogs for MAGEA4 Gene

(39) SIMAP similar genes for MAGEA4 Gene using alignment to 7 proteins:

  • C9J9C2_HUMAN
  • C9JK50_HUMAN
  • Q1RN33_HUMAN
  • Q4V9T5_HUMAN Pseudogenes for MAGEA4 Gene

genes like me logo Genes that share paralogs with MAGEA4: view

Variants for MAGEA4 Gene

Sequence variations from dbSNP and Humsavar for MAGEA4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
VAR_036582 A breast cancer sample p.Gly153Asp
rs1000372180 -- 151,913,095(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000707115 -- 151,919,897(+) G/A intron_variant
rs1000742114 -- 151,912,674(+) C/T upstream_transcript_variant
rs1000948948 -- 151,923,089(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEA4 Gene

Variant ID Type Subtype PubMed ID
esv1005324 CNV deletion 20482838
esv22619 CNV gain 19812545
esv2656900 CNV deletion 23128226
esv2664390 CNV deletion 23128226
esv2740611 CNV deletion 23290073
nsv1077249 CNV deletion 25765185
nsv1119646 CNV deletion 24896259
nsv1122270 CNV deletion 24896259
nsv510866 CNV deletion 20534489
nsv528228 CNV gain 19592680
nsv953706 CNV deletion 24416366

Variation tolerance for MAGEA4 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGEA4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEA4 Gene

Disorders for MAGEA4 Gene

MalaCards: The human disease database

(9) MalaCards diseases for MAGEA4 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
testicular leukemia
testicular cancer
  • childhood neoplasm of the testis
  • malignant melanoma
  • seminoma, pure
  • spermatocytic seminoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAGEA4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAGEA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA4 Gene

Publications for MAGEA4 Gene

  1. High-resolution structure of HLA-A*0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene. (PMID: 11502003) Hillig RC … Hülsmeyer M (Journal of molecular biology 2001) 3 4 22 58
  2. Frequent MAGE mutations in human melanoma. (PMID: 20862285) Caballero OL … Simpson AJ (PloS one 2010) 3 44 58
  3. Clinical significance of cancer/testis antigens expression in patients with non-small cell lung cancer. (PMID: 19545928) Shigematsu Y … Yasumoto K (Lung cancer (Amsterdam, Netherlands) 2010) 3 22 58
  4. High frequency of MAGE-A4 and MAGE-A9 expression in high-risk bladder cancer. (PMID: 19533752) Bergeron A … Fradet Y (International journal of cancer 2009) 3 22 58
  5. Cancer/testis antigen MAGE-A4 expression pattern differs in epithelial skin tumors of organ-transplant recipients and immunocompetent patients. (PMID: 17214847) Muehleisen B … Hofbauer GF (Journal of cutaneous pathology 2007) 3 22 58

Products for MAGEA4 Gene

Sources for MAGEA4 Gene

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