This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are cluster... See more...

Aliases for MAGEA3 Gene

Aliases for MAGEA3 Gene

  • MAGE Family Member A3 2 3 5
  • Melanoma-Associated Antigen 3 2 3 4
  • MAGE-3 Antigen 2 3 4
  • Antigen MZ2-D 2 3 4
  • CT1.3 2 3 4
  • Cancer/Testis Antigen Family 1, Member 3 2 3
  • Melanoma Antigen Family A3 2 3
  • Cancer/Testis Antigen 1.3 3 4
  • MAGE3 3 4
  • HIP8 2 3
  • HYPD 2 3
  • Melanoma Antigen Family A, 3 3
  • MGC14613 2
  • MAGEA6 3
  • MAGEA3 5

External Ids for MAGEA3 Gene

Previous HGNC Symbols for MAGEA3 Gene

  • MAGE3

Previous GeneCards Identifiers for MAGEA3 Gene

  • GC0XM146274
  • GC0XM148591
  • GC0XM149682
  • GC0XM150552
  • GC0XM151605
  • GC0XM151685
  • GC0XM151934
  • GC0XM140736

Summaries for MAGEA3 Gene

Entrez Gene Summary for MAGEA3 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEA3 Gene

MAGEA3 (MAGE Family Member A3) is a Protein Coding gene. Diseases associated with MAGEA3 include Ocular Melanoma and Melanoma. Among its related pathways are NF-kappaB Signaling. An important paralog of this gene is MAGEA6.

UniProtKB/Swiss-Prot Summary for MAGEA3 Gene

  • Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Gene Wiki entry for MAGEA3 Gene

Additional gene information for MAGEA3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAGEA3 Gene

Genomics for MAGEA3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MAGEA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ152699 Promoter 0.7 EPDnew Ensembl 600.7 -0.1 -141 2 ENSG00000287394 LOC105373370 MAGEA3 GABRA3 RF00017-8796 GABRQ
GH0XJ152637 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 0.2 -60.7 -60741 1.2 ZIC2 POLR2A EZH2 SCRT2 NRF1 SP2 CTBP1 ZBTB26 ZBTB17 SCRT1 GABRQ piR-31199-404 ENSG00000287394 LOC105373370 MAGEA3
GH0XJ152641 Enhancer 0.7 Ensembl ENCODE 0.2 -57.2 -57241 1 TEAD4 RAD21 CTCF POLR2A SMARCA4 NANOG SP1 POU5F1 MAGEA6 GABRQ piR-31199-404 ENSG00000287394 LOC105373370 MAGEA3
GH0XJ152643 Enhancer 0.5 ENCODE 0.2 -56.6 -56607 0.2 CTCF REST RAD21 SMC3 EBF1 ZNF654 GABRQ piR-31199-404 ENSG00000287394 LOC105373370 MAGEA3
GH0XJ152639 Enhancer 0.3 Ensembl 0.2 -59.6 -59641 0.2 NFIC GABRQ piR-31199-404 ENSG00000287394 LOC105373370 MAGEA3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAGEA3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAGEA3

Top Transcription factor binding sites by QIAGEN in the MAGEA3 gene promoter:
  • aMEF-2
  • FOXJ2
  • FOXJ2 (long isoform)
  • MEF-2
  • MEF-2A
  • MyoD
  • p53

Genomic Locations for MAGEA3 Gene

Genomic Locations for MAGEA3 Gene
chrX:152,698,742-152,702,347
(GRCh38/hg38)
Size:
3,606 bases
Orientation:
Plus strand
chrX:151,934,652-151,938,240
(GRCh37/hg19)
Size:
3,589 bases
Orientation:
Minus strand

Genomic View for MAGEA3 Gene

Genes around MAGEA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA3 Gene

Proteins for MAGEA3 Gene

  • Protein details for MAGEA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43357-MAGA3_HUMAN
    Recommended name:
    Melanoma-associated antigen 3
    Protein Accession:
    P43357
    Secondary Accessions:
    • Q6FHI6

    Protein attributes for MAGEA3 Gene

    Size:
    314 amino acids
    Molecular mass:
    34747 Da
    Quaternary structure:
    • Interacts with TRIM28.

    Three dimensional structures from OCA and Proteopedia for MAGEA3 Gene

neXtProt entry for MAGEA3 Gene

Post-translational modifications for MAGEA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEA3 Gene

Antibody Products

  • Abcam antibodies for MAGEA3
  • Boster Bio Antibodies for MAGEA3

No data available for DME Specific Peptides for MAGEA3 Gene

Domains & Families for MAGEA3 Gene

Gene Families for MAGEA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for MAGEA3 Gene

InterPro:
Blocks:
  • MAGE protein
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEA3 Gene

GenScript: Design optimal peptide antigens:
  • MAGE-3 antigen (MAGA3_HUMAN)
genes like me logo Genes that share domains with MAGEA3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MAGEA3 Gene

Function for MAGEA3 Gene

Molecular function for MAGEA3 Gene

UniProtKB/Swiss-Prot Function:
Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
GENATLAS Biochemistry:
human melanoma antigen,family A,member 3,expressed in melanoma,testis,advanced gastric carcinomas and hepatocellular carcinomas

Gene Ontology (GO) - Molecular Function for MAGEA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20864041
GO:0089720 caspase binding IDA 12097332
genes like me logo Genes that share ontologies with MAGEA3: view

Phenotypes for MAGEA3 Gene

genes like me logo Genes that share phenotypes with MAGEA3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGEA3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEA3 Gene

Localization for MAGEA3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEA3 gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 3
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endosome 2
lysosome 2
mitochondrion 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for MAGEA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 12097332
genes like me logo Genes that share ontologies with MAGEA3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MAGEA3 Gene

Pathways & Interactions for MAGEA3 Gene

PathCards logo

SuperPathways for MAGEA3 Gene

SuperPathway Contained pathways
1 NF-kappaB Signaling
genes like me logo Genes that share pathways with MAGEA3: view

Pathways by source for MAGEA3 Gene

1 Cell Signaling Technology pathway for MAGEA3 Gene

Gene Ontology (GO) - Biological Process for MAGEA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010955 negative regulation of protein processing IDA 12097332
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 12097332
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP 12097332
genes like me logo Genes that share ontologies with MAGEA3: view

No data available for SIGNOR curated interactions for MAGEA3 Gene

Drugs & Compounds for MAGEA3 Gene

(4) Drugs for MAGEA3 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Astuprotimut-R Investigational Pharma Vaccine Vaccines 0
EP-2101 Pharma Vaccine Vaccines 0
GSK1572932A Pharma Vaccine Vaccines 0
MAGE-A3 Pharma 0

(4) Additional Compounds for MAGEA3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAGEA3: view

Transcripts for MAGEA3 Gene

mRNA/cDNA for MAGEA3 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGEA3

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA3 Gene

No ASD Table

Relevant External Links for MAGEA3 Gene

GeneLoc Exon Structure for
MAGEA3

Expression for MAGEA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAGEA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEA3 Gene

This gene is overexpressed in Testis (x49.5).

Protein differential expression in normal tissues from HIPED for MAGEA3 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAGEA3 Gene



Protein tissue co-expression partners for MAGEA3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAGEA3

SOURCE GeneReport for Unigene cluster for MAGEA3 Gene:

Hs.417816

mRNA Expression by UniProt/SwissProt for MAGEA3 Gene:

P43357-MAGA3_HUMAN
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukemias and lymphomas.

Evidence on tissue expression from TISSUES for MAGEA3 Gene

  • Blood(4.5)
  • Skin(4.5)
  • Bone marrow(4.4)
  • Lung(4.3)
  • Lymph node(2.6)
  • Spleen(2.5)
genes like me logo Genes that share expression patterns with MAGEA3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEA3 Gene

Orthologs for MAGEA3 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAGEA3 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Magea10 31
  • 40 (a)
ManyToMany
Magea6 31
  • 39 (a)
ManyToMany
Magea8 31
  • 38 (a)
ManyToMany
1700080O16Rik 31
  • 38 (a)
ManyToMany
Magea5 31
  • 38 (a)
ManyToMany
3830417A13Rik 31
  • 38 (a)
ManyToMany
Magea1 31
  • 38 (a)
ManyToMany
Magea3 31
  • 38 (a)
ManyToMany
Magea2 31
  • 37 (a)
ManyToMany
Magea4 31
  • 37 (a)
ManyToMany
Species where no ortholog for MAGEA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MAGEA3 Gene

ENSEMBL:
Gene Tree for MAGEA3 (if available)
TreeFam:
Gene Tree for MAGEA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAGEA3: view image

Paralogs for MAGEA3 Gene

Variants for MAGEA3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAGEA3 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
720466 Likely Benign: not provided 152,701,298(+) A/G MISSENSE_VARIANT
723373 Likely Benign: not provided 152,701,299(+) G/A MISSENSE_VARIANT
723719 Benign: not provided 152,701,711(+) C/T SYNONYMOUS_VARIANT
726564 Likely Benign: not provided 152,701,175(+) G/A MISSENSE_VARIANT
731289 Benign: not provided 152,701,141(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for MAGEA3 Gene

Variation tolerance for MAGEA3 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGEA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGEA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEA3 Gene

Disorders for MAGEA3 Gene

MalaCards: The human disease database

(14) MalaCards diseases for MAGEA3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ocular melanoma
  • eye melanoma
melanoma
  • malignant melanoma
squamous cell carcinoma
  • epidermoid carcinoma
testicular cancer
  • childhood neoplasm of the testis
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MAGEA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA3 Gene

Publications for MAGEA3 Gene

  1. Cloning and analysis of MAGE-1-related genes. (PMID: 8037761) Ding M … Fenton RG (Biochemical and biophysical research communications 1994) 3 4 23
  2. Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. (PMID: 8113684) Gaugler B … Boon T (The Journal of experimental medicine 1994) 3 4 23
  3. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle JM … Potts PR (Molecular cell 2010) 3 4
  4. Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines. (PMID: 20423514) Zhang S … Yu Y (BMC cancer 2010) 3 23
  5. Melanoma gene expression and clinical course. (PMID: 19326132) Vourc'h-Jourdain M … Dreno B (Archives of dermatological research 2009) 3 23

Products for MAGEA3 Gene

Sources for MAGEA3 Gene