This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are cluster... See more...

Aliases for MAGEA2B Gene

Aliases for MAGEA2B Gene

  • MAGE Family Member A2B 2 3 5
  • Melanoma-Associated Antigen 2 3 4
  • Melanoma Antigen Family A2B 2 3
  • Cancer/Testis Antigen 1.2 3 4
  • MAGE-2 Antigen 3 4
  • CT1.2 3 4
  • MAGE2 3 4
  • Melanoma Antigen, Family A, 2, Copy B 3
  • Melanoma Antigen Family A, 2B 3
  • Melanoma Antigen 2 3
  • MAGEA2A 4
  • MAGEA2 4

External Ids for MAGEA2B Gene

Previous GeneCards Identifiers for MAGEA2B Gene

  • GC0XP150502
  • GC0XP151538
  • GC0XM151670
  • GC0XP151633
  • GC0XP151883

Summaries for MAGEA2B Gene

Entrez Gene Summary for MAGEA2B Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEA2B Gene

MAGEA2B (MAGE Family Member A2B) is a Protein Coding gene. Diseases associated with MAGEA2B include Melanoma and Dyskeratosis Congenita. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and repressing transcription factor binding. An important paralog of this gene is MAGEA2.

UniProtKB/Swiss-Prot Summary for MAGEA2B Gene

  • Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

Additional gene information for MAGEA2B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAGEA2B Gene

Genomics for MAGEA2B Gene

GeneHancer (GH) Regulatory Elements for MAGEA2B Gene

Promoters and enhancers for MAGEA2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ152714 Promoter 0.7 EPDnew Ensembl 500.7 +0.1 98 2.4 CSAG2 MAGEA2B lnc-CSAG2-2 lnc-MAGEA3-1 MAGEA12
GH0XJ152716 Promoter 0.3 EPDnew 500.7 +2.4 2351 0.1 MAGEA2B lnc-CSAG1-1 lnc-MAGEA3-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAGEA2B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAGEA2B

Top Transcription factor binding sites by QIAGEN in the MAGEA2B gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • HNF-1
  • HNF-1A
  • Olf-1
  • p53

Genomic Locations for MAGEA2B Gene

Genomic Locations for MAGEA2B Gene
chrX:152,714,502-152,718,607
(GRCh38/hg38)
Size:
4,106 bases
Orientation:
Plus strand
chrX:151,883,082-151,887,096
(GRCh37/hg19)
Size:
4,015 bases
Orientation:
Plus strand

Genomic View for MAGEA2B Gene

Genes around MAGEA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA2B Gene

Proteins for MAGEA2B Gene

  • Protein details for MAGEA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43356-MAGA2_HUMAN
    Recommended name:
    Melanoma-associated antigen 2
    Protein Accession:
    P43356
    Secondary Accessions:
    • A8K328
    • Q32NC6

    Protein attributes for MAGEA2B Gene

    Size:
    314 amino acids
    Molecular mass:
    35055 Da
    Quaternary structure:
    • Interacts with TRIM28 and UBE2H. Interacts with HDAC3. Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5).

neXtProt entry for MAGEA2B Gene

Post-translational modifications for MAGEA2B Gene

  • Glycosylation at Asn76
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • MAGA2_HUMAN (1497)

No data available for DME Specific Peptides for MAGEA2B Gene

Domains & Families for MAGEA2B Gene

Gene Families for MAGEA2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGEA2B Gene

Blocks:
  • MAGE protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEA2B Gene

GenScript: Design optimal peptide antigens:
  • MAGE-2 antigen (MAGA2_HUMAN)
  • Melanoma antigen family A, 2B (Q6P448_HUMAN)
  • Melanoma antigen family A, 2B (Q96E03_HUMAN)
genes like me logo Genes that share domains with MAGEA2B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MAGEA2B Gene

Function for MAGEA2B Gene

Molecular function for MAGEA2B Gene

UniProtKB/Swiss-Prot Function:
Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

Gene Ontology (GO) - Molecular Function for MAGEA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16847267
GO:0031625 ubiquitin protein ligase binding IDA 20864041
GO:0042826 histone deacetylase binding IDA 16847267
GO:0070491 repressing transcription factor binding IDA 16847267
genes like me logo Genes that share ontologies with MAGEA2B: view
genes like me logo Genes that share phenotypes with MAGEA2B: view

Animal Model Products

CRISPR Products

miRNA for MAGEA2B Gene

miRTarBase miRNAs that target MAGEA2B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEA2B Gene

Localization for MAGEA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGEA2B Gene

Nucleus. Nucleus, PML body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEA2B gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 3
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MAGEA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16847267
GO:0016605 PML body IEA,IDA 22117195
genes like me logo Genes that share ontologies with MAGEA2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAGEA2B Gene

Pathways & Interactions for MAGEA2B Gene

PathCards logo

SuperPathways for MAGEA2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 16847267
GO:0033234 negative regulation of protein sumoylation IDA 22117195
GO:0044257 cellular protein catabolic process IMP 20864041
GO:0051443 positive regulation of ubiquitin-protein transferase activity IMP 20864041
GO:0072331 signal transduction by p53 class mediator IDA 16847267
genes like me logo Genes that share ontologies with MAGEA2B: view

No data available for Pathways by source and SIGNOR curated interactions for MAGEA2B Gene

Drugs & Compounds for MAGEA2B Gene

No Compound Related Data Available

Transcripts for MAGEA2B Gene

mRNA/cDNA for MAGEA2B Gene

6 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA2B Gene

No ASD Table

Relevant External Links for MAGEA2B Gene

GeneLoc Exon Structure for
MAGEA2B

Expression for MAGEA2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAGEA2B Gene

mRNA differential expression in normal tissues according to GTEx for MAGEA2B Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for MAGEA2B Gene

This gene is overexpressed in Bone (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAGEA2B Gene



Protein tissue co-expression partners for MAGEA2B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAGEA2B

SOURCE GeneReport for Unigene cluster for MAGEA2B Gene:

Hs.534597

mRNA Expression by UniProt/SwissProt for MAGEA2B Gene:

P43356-MAGA2_HUMAN
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.

Evidence on tissue expression from TISSUES for MAGEA2B Gene

  • Blood(4.3)
  • Skin(4)
genes like me logo Genes that share expression patterns with MAGEA2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEA2B Gene

Orthologs for MAGEA2B Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAGEA2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEA2 30
  • 98.73 (n)
mouse
(Mus musculus)
Mammalia Magea10 31
  • 41 (a)
ManyToMany
Magea6 31
  • 40 (a)
ManyToMany
Magea4 31
  • 39 (a)
ManyToMany
Magea5 31
  • 39 (a)
ManyToMany
3830417A13Rik 31
  • 38 (a)
ManyToMany
Magea3 31
  • 38 (a)
ManyToMany
Magea1 31
  • 38 (a)
ManyToMany
Magea8 31
  • 38 (a)
ManyToMany
1700080O16Rik 31
  • 38 (a)
ManyToMany
Magea2 31
  • 38 (a)
ManyToMany
Species where no ortholog for MAGEA2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA2B Gene

ENSEMBL:
Gene Tree for MAGEA2B (if available)
TreeFam:
Gene Tree for MAGEA2B (if available)

Paralogs for MAGEA2B Gene

(35) SIMAP similar genes for MAGEA2B Gene using alignment to 9 proteins:

  • MAGA2_HUMAN
  • B9A060_HUMAN
  • E7ENJ0_HUMAN
  • E7EP80_HUMAN
  • E7EQY6_HUMAN
  • E7ER35_HUMAN
  • E9PC03_HUMAN
  • Q6P448_HUMAN
  • Q96E03_HUMAN
genes like me logo Genes that share paralogs with MAGEA2B: view

Variants for MAGEA2B Gene

Additional dbSNP identifiers (rs#s) for MAGEA2B Gene

Structural Variations from Database of Genomic Variants (DGV) for MAGEA2B Gene

Variant ID Type Subtype PubMed ID
esv2758901 CNV gain 17122850
nsv1150046 CNV duplication 26484159

Additional Variant Information for MAGEA2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGEA2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MAGEA2B Gene

Disorders for MAGEA2B Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAGEA2B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
dyskeratosis congenita
  • zinsser-cole-engman syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAGEA2B

genes like me logo Genes that share disorders with MAGEA2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA2B Gene

Publications for MAGEA2B Gene

  1. MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs. (PMID: 22117195) Peche LY … Schneider C (Cell death and differentiation 2012) 3 4 54
  2. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle JM … Potts PR (Molecular cell 2010) 3 4 54
  3. MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. (PMID: 16847267) Monte M … Schneider C (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. (PMID: 10854409) Mallon AM … Brown SD (Genome research 2000) 3 4 54

Products for MAGEA2B Gene

Sources for MAGEA2B Gene