This gene is closely related to several other genes clustered on chromosome X. These genes may be overexpressed in tumors. Multiple alternatively spliced variants encoding the same protein have been identified. [provided by RefSeq, Jun 2014] See more...

Aliases for MAGEA12 Gene

Aliases for MAGEA12 Gene

  • MAGE Family Member A12 2 3 5
  • Cancer/Testis Antigen Family 1, Member 12 2 3
  • Melanoma-Associated Antigen 12 3 4
  • Melanoma Antigen Family A12 2 3
  • Cancer/Testis Antigen 1.12 3 4
  • MAGE12F Antigen 3 4
  • MAGE12 3 4
  • CT1.12 3 4
  • Melanoma Antigen Family A, 12 3
  • MAGE-12 Antigen 4

External Ids for MAGEA12 Gene

Previous HGNC Symbols for MAGEA12 Gene

  • MAGE12

Previous GeneCards Identifiers for MAGEA12 Gene

  • GC0XM146239
  • GC0XM148556
  • GC0XM149647
  • GC0XM150516
  • GC0XM151476
  • GC0XM151628
  • GC0XM151649
  • GC0XM151899
  • GC0XM140701

Summaries for MAGEA12 Gene

Entrez Gene Summary for MAGEA12 Gene

  • This gene is closely related to several other genes clustered on chromosome X. These genes may be overexpressed in tumors. Multiple alternatively spliced variants encoding the same protein have been identified. [provided by RefSeq, Jun 2014]

GeneCards Summary for MAGEA12 Gene

MAGEA12 (MAGE Family Member A12) is a Protein Coding gene. Diseases associated with MAGEA12 include Melanoma. An important paralog of this gene is MAGEA2B.

UniProtKB/Swiss-Prot Summary for MAGEA12 Gene

  • Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.

Gene Wiki entry for MAGEA12 Gene

Additional gene information for MAGEA12 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAGEA12 Gene

Genomics for MAGEA12 Gene

GeneHancer (GH) Regulatory Elements for MAGEA12 Gene

Promoters and enhancers for MAGEA12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ152733 Promoter 1.3 EPDnew Ensembl 500.7 +0.4 443 1.6 NRF1 SIX5 REST TOE1 NFRKB TAF9B NEUROD1 CREB3L1 POLR2A GABPA CSAG1 CSAG4 MAGEA12 lnc-MAGEA12-3 GABRQ MAGEA6 ENSG00000231447
GH0XJ152714 Promoter 0.7 EPDnew Ensembl 500.4 -19.2 -19157 2.4 CSAG2 MAGEA2B lnc-CSAG2-2 lnc-MAGEA3-1 MAGEA12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAGEA12 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAGEA12

Top Transcription factor binding sites by QIAGEN in the MAGEA12 gene promoter:
  • MyoD
  • p53
  • POU2F1
  • POU2F1a
  • TBP
  • TFIID

Genomic Locations for MAGEA12 Gene

Genomic Locations for MAGEA12 Gene
chrX:152,733,757-152,737,669
(GRCh38/hg38)
Size:
3,913 bases
Orientation:
Plus strand
chrX:151,899,293-151,903,184
(GRCh37/hg19)
Size:
3,892 bases
Orientation:
Minus strand

Genomic View for MAGEA12 Gene

Genes around MAGEA12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA12 Gene

Proteins for MAGEA12 Gene

  • Protein details for MAGEA12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43365-MAGAC_HUMAN
    Recommended name:
    Melanoma-associated antigen 12
    Protein Accession:
    P43365
    Secondary Accessions:
    • Q6FHH8
    • Q9NSD3

    Protein attributes for MAGEA12 Gene

    Size:
    314 amino acids
    Molecular mass:
    34836 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEA12 Gene

Post-translational modifications for MAGEA12 Gene

  • Ubiquitination at Lys244
  • Modification sites at PhosphoSitePlus

Other Protein References for MAGEA12 Gene

No data available for DME Specific Peptides for MAGEA12 Gene

Domains & Families for MAGEA12 Gene

Gene Families for MAGEA12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGEA12 Gene

Blocks:
  • MAGE protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEA12 Gene

GenScript: Design optimal peptide antigens:
  • MAGE12F antigen (MAGAC_HUMAN)
  • cDNA, FLJ94880, highly similar to Homo sapiens melanoma antigen, family A, 12 (MAGEA12), mRNA (Q6FHH8_HUMAN)
genes like me logo Genes that share domains with MAGEA12: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MAGEA12 Gene

Function for MAGEA12 Gene

Molecular function for MAGEA12 Gene

UniProtKB/Swiss-Prot Function:
Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.
GENATLAS Biochemistry:
human melanoma antigen,family A,member 12,expressed in melanoma,testis

Gene Ontology (GO) - Molecular Function for MAGEA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAGEA12: view
genes like me logo Genes that share phenotypes with MAGEA12: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEA12 Gene

Localization for MAGEA12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEA12 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for MAGEA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MAGEA12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MAGEA12 Gene

Pathways & Interactions for MAGEA12 Gene

PathCards logo

SuperPathways for MAGEA12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MAGEA12: view

No data available for Pathways by source and SIGNOR curated interactions for MAGEA12 Gene

Drugs & Compounds for MAGEA12 Gene

(1) Drugs for MAGEA12 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MAGE-12 peptide vaccine (emulsified inMontanide ISA-51) Pharma Vaccine Vaccines 0
genes like me logo Genes that share compounds with MAGEA12: view

Transcripts for MAGEA12 Gene

mRNA/cDNA for MAGEA12 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA12 Gene

No ASD Table

Relevant External Links for MAGEA12 Gene

GeneLoc Exon Structure for
MAGEA12

Expression for MAGEA12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAGEA12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEA12 Gene

This gene is overexpressed in Testis (x24.6).

Protein differential expression in normal tissues from HIPED for MAGEA12 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAGEA12 Gene



Protein tissue co-expression partners for MAGEA12 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAGEA12

SOURCE GeneReport for Unigene cluster for MAGEA12 Gene:

Hs.169246

mRNA Expression by UniProt/SwissProt for MAGEA12 Gene:

P43365-MAGAC_HUMAN
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
genes like me logo Genes that share expression patterns with MAGEA12: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEA12 Gene

Orthologs for MAGEA12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEA12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEA12 31 30
  • 99.04 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Magea10 31
  • 40 (a)
ManyToMany
Magea6 31
  • 39 (a)
ManyToMany
Magea3 31
  • 38 (a)
ManyToMany
Magea4 31
  • 38 (a)
ManyToMany
Magea1 31
  • 38 (a)
ManyToMany
3830417A13Rik 31
  • 38 (a)
ManyToMany
Magea5 31
  • 38 (a)
ManyToMany
1700080O16Rik 31
  • 38 (a)
ManyToMany
Magea8 31
  • 38 (a)
ManyToMany
Magea2 31
  • 37 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 31
  • 40 (a)
ManyToMany
Species where no ortholog for MAGEA12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA12 Gene

ENSEMBL:
Gene Tree for MAGEA12 (if available)
TreeFam:
Gene Tree for MAGEA12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAGEA12: view image

Paralogs for MAGEA12 Gene

Pseudogenes.org Pseudogenes for MAGEA12 Gene

genes like me logo Genes that share paralogs with MAGEA12: view

Variants for MAGEA12 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAGEA12 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs16996512 - p.Glu57Asp

Additional dbSNP identifiers (rs#s) for MAGEA12 Gene

Variation tolerance for MAGEA12 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGEA12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGEA12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEA12 Gene

Disorders for MAGEA12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGEA12 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAGEA12

genes like me logo Genes that share disorders with MAGEA12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA12 Gene

Publications for MAGEA12 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. (PMID: 10854409) Mallon AM … Brown SD (Genome research 2000) 3 4 54
  3. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner UC … Poustka A (Genomics 1995) 2 3 54
  4. Cloning and analysis of MAGE-1-related genes. (PMID: 8037761) Ding M … Fenton RG (Biochemical and biophysical research communications 1994) 3 4 54
  5. Overexpression and Implications of Melanoma-associated Antigen A12 in Pathogenesis of Human Cutaneous Squamous Cell Carcinoma. (PMID: 30952725) Zhao G … Jin Z (Anticancer research 2019) 3 54

Products for MAGEA12 Gene

Sources for MAGEA12 Gene