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This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
MAGEA11 (MAGE Family Member A11) is a Protein Coding gene. Diseases associated with MAGEA11 include Melanoma and Dyskeratosis Congenita. An important paralog of this gene is MAGEA4.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XJ149712 | Promoter | 0.4 | EPDnew | 250.3 | +23.8 | 23848 | 0.1 | GABPA | MAGEA11 piR-31301-008 HSFX1 | |
GH0XJ149682 | Enhancer | 0.5 | Ensembl ENCODE | 0.4 | -6.2 | -6246 | 1.9 | FEZF1 ZFP91 | TMEM185A piR-31301-007 MAGEA11 | |
GH0XJ149684 | Enhancer | 0.3 | Ensembl | 0.7 | -4.1 | -4092 | 0.2 | ATF4 | MAGEA11 piR-31301-007 TMEM185A | |
GH0XJ149716 | Enhancer | 0.3 | Ensembl | 0.3 | +27.3 | 27308 | 0.6 | EBF1 SPI1 | ENSG00000238039 piR-31301-008 MAGEA11 HSFX1 | |
GH0XJ149640 | Enhancer | 0.3 | Ensembl | 0.3 | -46.4 | -46398 | 0.8 | PRDM6 EP300 | TMEM185A piR-31292-235 ENSG00000229322 MAGEA11 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0016604 | nuclear body | IDA | -- |
This gene was present in the common ancestor of human and mouse.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MAGEA11 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Magea4 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Magea4 30 17 31 |
|
ManyToMany | |
1700080O16Rik 31 |
|
ManyToMany | |||
3830417A13Rik 31 |
|
ManyToMany | |||
Magea10 31 |
|
ManyToMany | |||
Magea5 31 |
|
ManyToMany | |||
Magea6 31 |
|
ManyToMany | |||
Magea1 31 |
|
ManyToMany | |||
Magea8 31 |
|
ManyToMany | |||
Magea3 31 |
|
ManyToMany | |||
Magea2 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1557362265 | - |
p.Ser57Pro |
|||
rs2233049 | - |
p.Ser191Arg |
Disorder | Aliases | PubMed IDs |
---|---|---|
melanoma |
|
|
dyskeratosis congenita |
|
|