MAGEA11 Gene (Protein Coding)

MAGE Family Member A11

GC0XP149688
GIFtS:
39
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are cluster... See more...

Aliases for MAGEA11 Gene

Aliases for MAGEA11 Gene

  • MAGE Family Member A11 2 3 5
  • Melanoma-Associated Antigen 11 2 3 4
  • MAGE-11 Antigen 2 3 4
  • CT1.11 2 3 4
  • Cancer/Testis Antigen Family 1, Member 11 2 3
  • Melanoma Antigen Family A11 2 3
  • Cancer/Testis Antigen 1.11 3 4
  • MAGEA-11 2 3
  • MAGE-11 2 3
  • MAGE11 3 4
  • Melanoma Antigen Family A, 11 3
  • MGC10511 2
  • MAGEA11 5

External Ids for MAGEA11 Gene

Previous HGNC Symbols for MAGEA11 Gene

  • MAGE11

Previous GeneCards Identifiers for MAGEA11 Gene

  • GC0XU990099
  • GC0XM146658
  • GC0XM147473
  • GC0XM148473
  • GC0XM148578
  • GC0XP148769
  • GC0XM137720

Summaries for MAGEA11 Gene

Entrez Gene Summary for MAGEA11 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEA11 Gene

MAGEA11 (MAGE Family Member A11) is a Protein Coding gene. Diseases associated with MAGEA11 include Melanoma and Dyskeratosis Congenita. An important paralog of this gene is MAGEA4.

UniProtKB/Swiss-Prot Summary for MAGEA11 Gene

  • Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.

Gene Wiki entry for MAGEA11 Gene

Additional gene information for MAGEA11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAGEA11 Gene

Genomics for MAGEA11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAGEA11 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XJ149712 Promoter 0.4 EPDnew 250.3 +23.8 23848 0.1 GABPA MAGEA11 piR-31301-008 HSFX1
GH0XJ149682 Enhancer 0.5 Ensembl ENCODE 0.4 -6.2 -6246 1.9 FEZF1 ZFP91 TMEM185A piR-31301-007 MAGEA11
GH0XJ149684 Enhancer 0.3 Ensembl 0.7 -4.1 -4092 0.2 ATF4 MAGEA11 piR-31301-007 TMEM185A
GH0XJ149716 Enhancer 0.3 Ensembl 0.3 +27.3 27308 0.6 EBF1 SPI1 ENSG00000238039 piR-31301-008 MAGEA11 HSFX1
GH0XJ149640 Enhancer 0.3 Ensembl 0.3 -46.4 -46398 0.8 PRDM6 EP300 TMEM185A piR-31292-235 ENSG00000229322 MAGEA11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAGEA11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAGEA11

Top Transcription factor binding sites by QIAGEN in the MAGEA11 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • Evi-1
  • MyoD
  • Pbx1a
  • TBP
  • TFIID

Genomic Locations for MAGEA11 Gene

Latest Assembly
chrX:149,688,193-149,717,268
(GRCh38/hg38)
Size:
29,076 bases
Orientation:
Plus strand

Previous Assembly
chrX:148,769,859-148,798,928
(GRCh37/hg19 by Entrez Gene)
Size:
29,070 bases
Orientation:
Plus strand

chrX:148,769,894-148,798,926
(GRCh37/hg19 by Ensembl)
Size:
29,033 bases
Orientation:
Plus strand

Genomic View for MAGEA11 Gene

Genes around MAGEA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA11 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAGEA11 Gene

Proteins for MAGEA11 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for MAGEA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43364-MAGAB_HUMAN
    Recommended name:
    Melanoma-associated antigen 11
    Protein Accession:
    P43364
    Secondary Accessions:
    • Q5ETU4
    • Q6ZRZ5

    Protein attributes for MAGEA11 Gene

    Size:
    429 amino acids
    Molecular mass:
    48129 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA68870.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAGEA11 Gene

    Alternative splice isoforms for MAGEA11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAGEA11 Gene

Protein Expression for MAGEA11 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MAGEA11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEA11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for MAGEA11
  • Boster Bio Antibodies for MAGEA11

No data available for DME Specific Peptides for MAGEA11 Gene

Domains & Families for MAGEA11 Gene

Gene Families for MAGEA11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGEA11 Gene

InterPro:
Blocks:
  • MAGE protein
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEA11 Gene

GenScript: Design optimal peptide antigens:
  • MAGE-11 antigen (MAGAB_HUMAN)
genes like me logo Genes that share domains with MAGEA11: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MAGEA11 Gene

Function for MAGEA11 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for MAGEA11 Gene

UniProtKB/Swiss-Prot Function:
Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.
GENATLAS Biochemistry:
human melanoma antigen,family A,member 11,expressed in testis

Gene Ontology (GO) - Molecular Function for MAGEA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MAGEA11: view
genes like me logo Genes that share phenotypes with MAGEA11: view

Animal Models for research

miRNA for MAGEA11 Gene

miRTarBase miRNAs that target MAGEA11

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGEA11

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEA11 Gene

Localization for MAGEA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGEA11 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEA11 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAGEA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with MAGEA11: view

Pathways & Interactions for MAGEA11 Gene

PathCards logo

SuperPathways for MAGEA11 Gene

No Data Available

SIGNOR curated interactions for MAGEA11 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAGEA11 Gene

None

No data available for Pathways by source for MAGEA11 Gene

Drugs & Compounds for MAGEA11 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for MAGEA11 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for MAGEA11 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAGEA11

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA11 Gene

No ASD Table

Relevant External Links for MAGEA11 Gene

GeneLoc Exon Structure for
MAGEA11

Expression for MAGEA11 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAGEA11 Gene

mRNA expression in normal human tissues for MAGEA11 Gene
mRNA expression by GTEx for MAGEA11 GenemRNA expression by BioGPS for MAGEA11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEA11 Gene

This gene is overexpressed in Testis (x44.0).

Protein differential expression in normal tissues from HIPED for MAGEA11 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAGEA11 Gene



Protein tissue co-expression partners for MAGEA11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAGEA11

SOURCE GeneReport for Unigene cluster for MAGEA11 Gene:

Hs.670252

mRNA Expression by UniProt/SwissProt for MAGEA11 Gene:

P43364-MAGAB_HUMAN
Tissue specificity: Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal tissue.

Evidence on tissue expression from TISSUES for MAGEA11 Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with MAGEA11: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEA11 Gene

Orthologs for MAGEA11 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAGEA11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MAGEA11 30 31
  • 99.41 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Magea4 30
  • 64.04 (n)
Mouse
(Mus musculus)
 Mammalia Magea4 30 17 31
  • 61.37 (n)
 ManyToMany
1700080O16Rik 31
  • 44 (a)
 ManyToMany
3830417A13Rik 31
  • 44 (a)
 ManyToMany
Magea10 31
  • 43 (a)
 ManyToMany
Magea5 31
  • 42 (a)
 ManyToMany
Magea6 31
  • 42 (a)
 ManyToMany
Magea1 31
  • 41 (a)
 ManyToMany
Magea8 31
  • 41 (a)
 ManyToMany
Magea3 31
  • 41 (a)
 ManyToMany
Magea2 31
  • 40 (a)
 ManyToMany
Species where no ortholog for MAGEA11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MAGEA11 Gene

ENSEMBL:
Gene Tree for MAGEA11 (if available)
TreeFam:
Gene Tree for MAGEA11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAGEA11: view image

Paralogs for MAGEA11 Gene

Paralogs for MAGEA11 Gene

(35) SIMAP similar genes for MAGEA11 Gene using alignment to 3 proteins:

  • MAGAB_HUMAN
  • C9J2X2_HUMAN
  • G5E962_HUMAN

Pseudogenes.org Pseudogenes for MAGEA11 Gene

genes like me logo Genes that share paralogs with MAGEA11: view

Variants for MAGEA11 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAGEA11 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs1557362265 - p.Ser57Pro
rs2233049 - p.Ser191Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MAGEA11 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MAGEA11 Gene

Variant ID Type Subtype PubMed ID
esv3577515 CNV gain 25503493
nsv1153438 OTHER inversion 26484159
nsv508000 OTHER sequence alteration 20534489
nsv510566 OTHER sequence alteration 20534489
nsv525908 CNV gain 19592680
nsv7464 OTHER inversion 18451855

Variation tolerance for MAGEA11 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGEA11 Gene

Human Gene Mutation Database (HGMD)
MAGEA11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGEA11

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEA11 Gene

Disorders for MAGEA11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAGEA11 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
dyskeratosis congenita
  • zinsser-cole-engman syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAGEA11

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MAGEA11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA11 Gene

Publications for MAGEA11 Gene

  1. Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation. (PMID: 18048459) Bai S … Wilson EM (Molecular human reproduction 2008) 3 23
  2. Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction. (PMID: 15684378) Bai S … Wilson EM (Molecular and cellular biology 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner UC … Poustka A (Genomics 1995) 2 3

ExternalLinks

View latest publications for MAGEA11 gene in Mastermind

Products for MAGEA11 Gene

Sources for MAGEA11 Gene