Aliases for MAGEA1 Gene
External Ids for MAGEA1 Gene
Previous HGNC Symbols for MAGEA1 Gene
Previous GeneCards Identifiers for MAGEA1 Gene
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAGEA1 Gene
MAGEA1 (MAGE Family Member A1) is a Protein Coding gene. Diseases associated with MAGEA1 include Ocular Melanoma and Melanoma. Among its related pathways are Notch Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include histone deacetylase binding. An important paralog of this gene is MAGEA4.
UniProtKB/Swiss-Prot Summary for MAGEA1 Gene
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.