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MAG Gene(Protein Coding)

Myelin Associated Glycoprotein

GCID:
GC19P035292
GIFtS:
56
Genes Participants
UDN Logo

Aliases for MAG Gene

Aliases for MAG Gene

  • Myelin Associated Glycoprotein 2 3 5
  • Sialic Acid Binding Ig-Like Lectin 4A 2 3
  • SIGLEC-4A 3 4
  • GMA 3 4
  • Sialic Acid-Binding Immunoglobulin-Like Lectin 4A 3
  • Myelin-Associated Glycoprotein 3
  • SIGLEC4A 3
  • S-MAG 3
  • SPG75 3

External Ids for MAG Gene

Previous HGNC Symbols for MAG Gene

  • GMA

Previous GeneCards Identifiers for MAG Gene

  • GC19P036400
  • GC19P036231
  • GC19P040459
  • GC19P040474
  • GC19P035783
  • GC19P032291
  • GC19P035787
  • GC19P035956

Summaries for MAG Gene

Entrez Gene Summary for MAG Gene

  • The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for MAG Gene

MAG (Myelin Associated Glycoprotein) is a Protein Coding gene. Diseases associated with MAG include Spastic Paraplegia 75, Autosomal Recessive and Chronic Polyneuropathy. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Glial Cell Differentiation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC10.

UniProtKB/Swiss-Prot for MAG Gene

  • Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity).

Additional gene information for MAG Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAG Gene

Genomics for MAG Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MAG Gene

Promoters and enhancers for MAG Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I035294 Promoter/Enhancer 1 EPDnew dbSUPER 550.8 +2.1 2118 0.1 ZFHX2 GLIS2 EGR1 EGR2 MAG CD22
GH19I035292 Promoter/Enhancer 0.8 EPDnew dbSUPER 550.8 +0.1 56 0.1 MAZ MAG CD22
GH19I035290 Enhancer 0.6 FANTOM5 dbSUPER 564.4 -1.1 -1086 0.4 ZFHX2 KLF1 ZNF398 MAG USF2 FAM187B KRTDAP DMKN FFAR2 ENSG00000233214 LGI4 HPN FXYD7
GH19I035293 Enhancer 0.5 FANTOM5 dbSUPER 573.8 +1.4 1431 0.2 MAG LGI4 FXYD7 HPN SCN1B FXYD1 ARHGAP33 ZNF30 CD22
GH19I035316 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 35.8 +26.6 26602 5 HDGF PKNOX1 CLOCK FOXA2 MLX NEUROD1 SIN3A ZNF2 ZBTB7B SLC30A9 CD22 MAG TMEM147-AS1 HAUS5 ZNF792 KMT2B ZNF599 U2AF1L4 ZNF146 PROSER3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAG gene promoter:

Genomic Locations for MAG Gene

Genomic Locations for MAG Gene
chr19:35,292,086-35,313,807
(GRCh38/hg38)
Size:
21,722 bases
Orientation:
Plus strand
chr19:35,782,989-35,804,710
(GRCh37/hg19)

Genomic View for MAG Gene

Genes around MAG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAG Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAG Gene

Proteins for MAG Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MAG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20916-MAG_HUMAN
    Recommended name:
    Myelin-associated glycoprotein
    Protein Accession:
    P20916
    Secondary Accessions:
    • B7Z2E5
    • F5GYC0
    • Q15489
    • Q567S4

    Protein attributes for MAG Gene

    Size:
    626 amino acids
    Molecular mass:
    69069 Da
    Quaternary structure:
    • Monomer and homodimer (By similarity). Interacts (via the first three N-terminal Ig-like domains) with RTN4R and RTN4RL2 (By similarity). Interacts with RTN4R (PubMed:19052207).

    Alternative splice isoforms for MAG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAG Gene

Protein Expression for MAG Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MAG Gene

  • N-glycosylated.
  • Phosphorylated on tyrosine residues.
  • Glycosylation at isoforms=2, 399, posLast=106106, posLast=223223, posLast=246246, isoforms=2, 3315, isoforms=2, 3406, isoforms=2, 3450, and posLast=454454

Other Protein References for MAG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAG Gene

Domains & Families for MAG Gene

Gene Families for MAG Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for MAG Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20916

UniProtKB/Swiss-Prot:

MAG_HUMAN :
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with MAG: view

Function for MAG Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MAG Gene

GENATLAS Biochemistry:
myelin associated glycoprotein,expressed on oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system,interacting with neuronal processes,sialoadhesin family,Ig superfamily
UniProtKB/Swiss-Prot Function:
Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity).

Phenotypes From GWAS Catalog for MAG Gene

Gene Ontology (GO) - Molecular Function for MAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0008289 lipid binding IEA --
GO:0019901 protein kinase binding IEA --
GO:0030246 carbohydrate binding IEA --
GO:0033691 sialic acid binding ISS --
genes like me logo Genes that share ontologies with MAG: view
genes like me logo Genes that share phenotypes with MAG: view

Human Phenotype Ontology for MAG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAG Gene

MGI Knock Outs for MAG:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MAG Gene

Localization for MAG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAG Gene

Cell membrane; Single-pass type I membrane protein. Membrane raft.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAG gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MAG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAG Gene

Pathways & Interactions for MAG Gene

genes like me logo Genes that share pathways with MAG: view

Gene Ontology (GO) - Biological Process for MAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion ISS --
GO:0007399 nervous system development IEA --
GO:0010977 negative regulation of neuron projection development ISS --
GO:0022010 central nervous system myelination IEA --
GO:0030517 negative regulation of axon extension ISS --
genes like me logo Genes that share ontologies with MAG: view

No data available for SIGNOR curated interactions for MAG Gene

Drugs & Compounds for MAG Gene

Products:

  1. Drug

(20) Drugs for MAG Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
rituximab Approved Pharma Therapeutic Antibodies 1808
Antibodies Pharma 7224
Antibodies, Monoclonal Pharma 4660
Antirheumatic Agents Pharma 11532
Immunoglobulins Pharma 7224

(24) Additional Compounds for MAG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAG: view

Transcripts for MAG Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MAG Gene

(3) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(286) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAG Gene

Myelin associated glycoprotein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - - - - - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8:

Relevant External Links for MAG Gene

GeneLoc Exon Structure for
MAG
ECgene alternative splicing isoforms for
MAG

Expression for MAG Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAG Gene

mRNA expression in normal human tissues for MAG Gene
mRNA expression by BioGPS for MAG GenemRNA expression by GTEx for MAG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAG Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x17.1), Brain - Substantia nigra (x8.5), Brain - Hippocampus (x4.5), and Brain - Hypothalamus (x4.0).

Protein differential expression in normal tissues from HIPED for MAG Gene

This gene is overexpressed in Frontal cortex (29.9), Spinal cord (27.3), and Brain (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAG Gene



Protein tissue co-expression partners for MAG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAG Gene:

MAG

SOURCE GeneReport for Unigene cluster for MAG Gene:

Hs.643440

mRNA Expression by UniProt/SwissProt for MAG Gene:

P20916-MAG_HUMAN
Tissue specificity: Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures (PubMed:9495552, PubMed:6200494). Detected in optic nerve, in oligodendroglia and in periaxonal myelin sheaths (PubMed:6200494). Detected in compact myelin (at protein level) (PubMed:6200494). Both isoform 1 and isoform 2 are detected in the central and peripheral nervous system (PubMed:9495552).

Evidence on tissue expression from TISSUES for MAG Gene

  • Nervous system(5)
  • Kidney(3.8)
  • Eye(2)
genes like me logo Genes that share expression patterns with MAG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAG Gene

Orthologs for MAG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAG Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia MAG 33 34
  • 92.39 (n)
chimpanzee
(Pan troglodytes)
 Mammalia MAG 34
  • 90 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia MAG 33 34
  • 89.7 (n)
rat
(Rattus norvegicus)
 Mammalia Mag 33
  • 88.66 (n)
mouse
(Mus musculus)
 Mammalia Mag 33 16 34
  • 87.26 (n)
oppossum
(Monodelphis domestica)
 Mammalia MAG 34
  • 86 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 22 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia MAG 34
  • 59 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia mag 33
  • 60.04 (n)
zebrafish
(Danio rerio)
 Actinopterygii mag 33 34
  • 51.97 (n)
Species where no ortholog for MAG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAG Gene

ENSEMBL:
Gene Tree for MAG (if available)
TreeFam:
Gene Tree for MAG (if available)

Paralogs for MAG Gene

Paralogs for MAG Gene

(1) SIMAP similar genes for MAG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MAG: view

Variants for MAG Gene

Sequence variations from dbSNP and Humsavar for MAG Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs140483946 benign, Spastic paraplegia 75, autosomal recessive 35,302,581(+) G/A coding_sequence_variant, synonymous_variant
rs142334011 benign, Spastic paraplegia 75, autosomal recessive 35,295,794(+) G/A/C/T coding_sequence_variant, synonymous_variant
rs142375870 uncertain-significance, Hereditary spastic paraplegia, Spastic paraplegia 75, autosomal recessive 35,302,594(+) A/C coding_sequence_variant, missense_variant
rs144553163 uncertain-significance, likely-benign, Hereditary spastic paraplegia, Spastic paraplegia 75, autosomal recessive 35,299,590(+) C/T coding_sequence_variant, missense_variant
rs147119099 benign, not specified, Spastic paraplegia 75, autosomal recessive 35,295,609(+) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAG Gene

Variant ID Type Subtype PubMed ID
nsv9711 CNV loss 18304495
nsv953283 CNV deletion 24416366
nsv833810 CNV gain 17160897
nsv510765 CNV deletion 20534489
esv2758758 CNV loss 17122850
esv1763084 CNV deletion 17803354
esv1006379 CNV deletion 20482838
dgv2010e59 CNV duplication 20981092

Variation tolerance for MAG Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAG Gene

Human Gene Mutation Database (HGMD)
MAG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAG Gene

Disorders for MAG Gene

MalaCards: The human disease database

(31) MalaCards diseases for MAG Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spastic paraplegia 75, autosomal recessive
  • spg75
chronic polyneuropathy
polyneuropathy
  • polyneuropathies
demyelinating polyneuropathy
  • peripheral demyelinating neuropathy
optic neuritis
- elite association - COSMIC cancer census association via MalaCards
Search MAG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MAG_HUMAN
  • Spastic paraplegia 75, autosomal recessive (SPG75) [MIM:616680]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG75 is characterized by onset in early childhood and is associated with mild to moderate cognitive impairment. {ECO:0000269 PubMed:24482476, ECO:0000269 PubMed:26179919, ECO:0000269 PubMed:27606346}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for MAG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAG: view

No data available for Genatlas for MAG Gene

Publications for MAG Gene

  1. A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia. (PMID: 18496213) Voineskos AN … Kennedy JL (Psychiatric genetics 2008) 3 22 44 58
  2. Identification of the glycosylated sequons of human myelin-associated glycoprotein. (PMID: 7505568) Burger D … Steck AJ (Biochemical and biophysical research communications 1993) 3 4 22 58
  3. cDNA cloning and amino acid sequence for human myelin-associated glycoprotein. (PMID: 2476987) Sato S … Miyatake T (Biochemical and biophysical research communications 1989) 2 3 4 58
  4. Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder. (PMID: 26179919) Lossos A … Peles E (Brain : a journal of neurology 2015) 3 4 58
  5. Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy. (PMID: 19720975) Kuijf ML … Jacobs BC (Neurology 2009) 3 22 58

Products for MAG Gene

Sources for MAG Gene

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