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The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this ... See more...
Aliases for MAG Gene
Aliases for MAG Gene
External Ids for MAG Gene
- HGNC: 6783
- Entrez Gene: 4099
- Ensembl: ENSG00000105695
- OMIM: 159460
- UniProtKB: P20916
Previous HGNC Symbols for MAG Gene
- GMA
Previous GeneCards Identifiers for MAG Gene
- GC19P036400
- GC19P036231
- GC19P040459
- GC19P040474
- GC19P035783
- GC19P032291
- GC19P035787
- GC19P035956
Summaries for MAG Gene
-
The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for MAG Gene
MAG (Myelin Associated Glycoprotein) is a Protein Coding gene. Diseases associated with MAG include Spastic Paraplegia 75, Autosomal Recessive and Polyneuropathy. Among its related pathways are Neuroscience and Guidance Cues and Growth Cone Motility. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC11.
UniProtKB/Swiss-Prot Summary for MAG Gene
-
Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity).
Additional gene information for MAG Gene
- HGNC(6783)
- Entrez Gene(4099)
- Ensembl(ENSG00000105695)
- OMIM(159460)
- UniProtKB(P20916)
- Open Targets Platform(ENSG00000105695)
- Monarch Initiative
- Search for MAG at DataMed
- Search for MAG at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAG Gene
Genomics for MAG Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MAG Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH19J035293 | Enhancer | 1 | FANTOM5 Ensembl dbSUPER | 634.4 | +1.8 | 1776 | 1.7 | TEAD4 EGR1 ZEB1 ZBTB17 NFIC ZFHX2 BCOR NFIB ZMYM3 KDM1A | MAG LSR LGI4 CD22 FXYD1 FXYD7 HPN SCN1B ARHGAP33 ZNF30 | |
| GH19J035290 | Enhancer | 0.6 | FANTOM5 dbSUPER | 614.3 | -1.1 | -1086 | 0.4 | ZFHX2 ZNF398 KLF1 | MAG USF2 FAM187B KRTDAP DMKN FFAR2 ENSG00000233214 LGI4 HPN FXYD7 | |
| GH19J035291 | Enhancer | 0.6 | Ensembl dbSUPER | 600.7 | -0.6 | -585 | 0.2 | ZFHX2 ZNF687 EGR2 | MAG USF2 FAM187B KRTDAP DMKN FFAR2 ENSG00000233214 lnc-FAM187B-4 HAMP | |
| GH19J035292 | Promoter/Enhancer | 0.5 | EPDnew dbSUPER | 600.7 | +0.1 | 56 | 0.1 | MAG RF00017-2943 CD22 | ||
| GH19J035304 | Promoter/Enhancer | 1.7 | EPDnew ENCODE CraniofacialAtlas dbSUPER | 41.6 | +15.9 | 15877 | 6.2 | RNF2 CREB1 GATAD2A CTCF TFE3 LEF1 IKZF1 KDM1A JUND DDX20 | CD22 MAG LSR HAMP ENSG00000267049 DMKN FAM187B ZBTB32 KRTDAP ENSG00000233214 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAG on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAG
- Top Transcription factor binding sites by QIAGEN in the MAG gene promoter:
-
- COUP
- COUP-TF
- COUP-TF1
- GATA-2
- HNF-4alpha1
- HNF-4alpha2
- p300
- STAT3
Genomic Locations for MAG Gene
Genomic Locations for MAG Gene
- chr19:35,292,086-35,313,807
- (GRCh38/hg38)
- Size:
- 21,722 bases
- Orientation:
- Plus strand
- chr19:35,782,989-35,804,710
- (GRCh37/hg19)
- Size:
- 21,722 bases
- Orientation:
- Plus strand
Genomic View for MAG Gene
Genes around MAG on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.1 by HGNC
- 19q13.12 by Entrez Gene
- 19q13.12 by Ensembl
MAG Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAG Gene
Proteins for MAG Gene
-
Protein details for MAG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20916-MAG_HUMAN
- Recommended name:
- Myelin-associated glycoprotein
- Protein Accession:
- P20916
- B7Z2E5
- F5GYC0
- Q15489
- Q567S4
Protein attributes for MAG Gene
- Size:
- 626 amino acids
- Molecular mass:
- 69069 Da
- Quaternary structure:
-
- Monomer and homodimer (By similarity). Interacts (via the first three N-terminal Ig-like domains) with RTN4R and RTN4RL2 (By similarity). Interacts with RTN4R (PubMed:19052207).
Protein Expression for MAG Gene
Post-translational modifications for MAG Gene
- N-glycosylated.
- Phosphorylated on tyrosine residues.
- Ubiquitinated, leading to proteasomal degradation.
-
Glycosylation at Asn99, Asn106, Asn223, Asn246, Asn315, Asn406, Asn450, and Asn454
- NX_P20916 (NX_P20916-1)
- Modification sites at PhosphoSitePlus
Other Protein References for MAG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MAG Antibody
- GeneTex Anti-MAG antibody
- NSJ Bioreagents MAG Antibody
- BioLegend Purified anti-MAG (851702) and Purified anti-MAG (851701)
-
Custom Antibody ServicesOriGene Antibodies for MAG
- Novus Biologicals Antibodies for MAG
-
Abcam antibodies for MAG
- Invitrogen Antibodies for MAG (AFLGC-MAG)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAG
- Sino Biological Antibodies for MAG
Protein Products
- G Biosciences Human MAG/Siglec-4a, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for MAG
- Origene Custom Protein Services for MAG
- Sino Biological Recombinant Proteins for MAG
- Sino Biological Cell Lysates for MAG
- antibodies-online: Show 21 available MAG Proteins ranked by validation data
- Compare Top MAG Proteins
-
ProSci Proteins for MAG
-
Abcam proteins for MAG
No data available for DME Specific Peptides for MAG Gene
Domains & Families for MAG Gene
Gene Families for MAG Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for MAG Gene
- InterPro:
- Blocks:
-
- Immunoglobulin C-2 type
- Immunoglobulin V-set
- ProtoNet:
Suggested Antigen Peptide Sequences for MAG Gene
- GenScript: Design optimal peptide antigens:
-
- Siglec-4a (MAG_HUMAN)
- Myelin associated glycoprotein (Q15489_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P20916UniProtKB/Swiss-Prot:
MAG_HUMAN :- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
- Family:
-
- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Function for MAG Gene
Molecular function for MAG Gene
- UniProtKB/Swiss-Prot Function:
- Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity).
- GENATLAS Biochemistry:
- myelin associated glycoprotein,expressed on oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system,interacting with neuronal processes,sialoadhesin family,Ig superfamily
Phenotypes From GWAS Catalog for MAG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IEA | -- |
| GO:0008289 | lipid binding | IEA | -- |
| GO:0019901 | protein kinase binding | IEA | -- |
| GO:0030246 | carbohydrate binding | IEA | -- |
| GO:0033691 | sialic acid binding | IBA,ISS | -- |
Phenotypes for MAG Gene
- MGI mutant phenotypes for MAG:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for MAG:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Reduced mammosphere formation
- Increased viability
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Decreased ionizing radiation sensitivity
Animal Models for MAG Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAG - Select products 50% OFF >
- * MAG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAG
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAG
miRNA for MAG Gene
- miRTarBase miRNAs that target MAG
-
- hsa-miR-3926 (MIRT454594)
- hsa-miR-548s (MIRT454595)
- hsa-miR-3190-5p (MIRT454596)
- hsa-miR-6849-3p (MIRT454597)
- hsa-miR-7106-5p (MIRT499021)
- hsa-miR-766-5p (MIRT499022)
- hsa-miR-3202 (MIRT499023)
- hsa-miR-6130 (MIRT499024)
- hsa-miR-6133 (MIRT499025)
- hsa-miR-6129 (MIRT499026)
- hsa-miR-6127 (MIRT499027)
- hsa-miR-4419a (MIRT499028)
- hsa-miR-4510 (MIRT499029)
- hsa-miR-4756-5p (MIRT499030)
- hsa-miR-4739 (MIRT499031)
- hsa-miR-6876-5p (MIRT499032)
- hsa-miR-1321 (MIRT499033)
- hsa-miR-4476 (MIRT499034)
- hsa-miR-6873-5p (MIRT499035)
- hsa-miR-6758-5p (MIRT499036)
- hsa-miR-6856-5p (MIRT499037)
- hsa-miR-4311 (MIRT499038)
- hsa-miR-4786-5p (MIRT691818)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAG
- Browse OriGene Inhibitory RNA Products For MAG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAG
Clone Products
- Applied Biological Materials (abm): Clones for MAG - Select products 50% OFF >
- * MAG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223754
- MR223754
- MR223754L3
- MR223754L4
- RC208754
- RC208754L1
- RC208754L2
- RC208754L3
- RC208754L4
- RC215996
- RC215996L1
- RC215996L2
- RC215996L3
- RC215996L4
- RC234527
- RG208754
- RG215996
- RG234527
- RR208763
- RR208763L3
- RR208763L4
- MR223754L3V
- MR223754L4V
- RC208754L1V
- RC208754L2V
- RC208754L3V
- RC208754L4V
- RC215996L1V
- RC215996L2V
- RC215996L3V
- RC215996L4V
- RR208763L3V
- RR208763L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAG
Cell Line Products
-
Horizon Cell Lines for MAG
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MAG Gene
Localization for MAG Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAG Gene
- Cell membrane. Single-pass type I membrane protein. Membrane raft.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 3 |
| extracellular | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | ISS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAG Gene
Pathways & Interactions for MAG Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | p75 NTR receptor-mediated signalling | ||
| 2 | Neuroscience | ||
| 3 | Cell adhesion molecules (CAMs) | ||
| 4 | Guidance Cues and Growth Cone Motility |
Guidance Cues and Growth Cone Motility
-
|
|
| 5 | NgR-p75(NTR)-Mediated Signaling |
NgR-p75(NTR)-Mediated Signaling
-
|
|
Pathways by source for MAG Gene
4 BioSystems pathways for MAG Gene
8 Reactome pathways for MAG Gene
1 KEGG pathway for MAG Gene
1 GeneGo (Thomson Reuters) pathway for MAG Gene
- Development MAG-dependent inhibition of neurite outgrowth
2 Qiagen pathways for MAG Gene
- Guidance Cues and Growth Cone Motility
- NgR-p75(NTR)-Mediated Signaling
1 Cell Signaling Technology pathway for MAG Gene
Interacting Proteins for MAG Gene
GPS-Prot Interaction Network for MAG
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IBA,ISS | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0010977 | negative regulation of neuron projection development | ISS | -- |
| GO:0019226 | transmission of nerve impulse | IEA | -- |
| GO:0022010 | central nervous system myelination | IEA | -- |
Drugs & Compounds for MAG Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- G Biosciences Human MAG/Siglec-4a, Lyophilized
Transcripts for MAG Gene
mRNA/cDNA for MAG Gene
- 3 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000361922 2426 nts (view in UCSC)
- ENST00000392213 2357 nts (view in UCSC)
- ENST00000537831 2341 nts (view in UCSC)
- ENST00000593348 545 nts (view in UCSC)
- ENST00000595791 585 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAG - Select products 50% OFF >
- * MAG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAG
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAG
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAG
- Browse OriGene Inhibitory RNA Products For MAG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAG
Clone Products
- Applied Biological Materials (abm): Clones for MAG - Select products 50% OFF >
- * MAG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223754
- MR223754
- MR223754L3
- MR223754L4
- RC208754
- RC208754L1
- RC208754L2
- RC208754L3
- RC208754L4
- RC215996
- RC215996L1
- RC215996L2
- RC215996L3
- RC215996L4
- RC234527
- RG208754
- RG215996
- RG234527
- RR208763
- RR208763L3
- RR208763L4
- MR223754L3V
- MR223754L4V
- RC208754L1V
- RC208754L2V
- RC208754L3V
- RC208754L4V
- RC215996L1V
- RC215996L2V
- RC215996L3V
- RC215996L4V
- RR208763L3V
- RR208763L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAG
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
Relevant External Links for MAG Gene
- GeneLoc Exon Structure for
- MAG
Expression for MAG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Myelinating Schwann Cells Peripheral Nerve Domain
- Myelinating Oligodendrocyte Cells Spinal Cord White Matter
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Cerebral Cortex
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
-
Peripheral Nervous System (Nervous System)
- Pro-myelinating Schwann Cells Peripheral Nerve Domain
- Immature Schwann Cells Peripheral Nerve Domain
- Myelinating Schwann Cells Peripheral Nerve Domain
-
Spinal Cord (Nervous System)
- Myelinating Oligodendrocyte Cells Spinal Cord White Matter
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
mRNA differential expression in normal tissues according to GTEx for MAG Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x17.1), Brain - Substantia nigra (x8.5), Brain - Hippocampus (x4.5), and Brain - Hypothalamus (x4.0).
This gene is overexpressed in Frontal cortex (29.9), Spinal cord (27.3), and Brain (11.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAG Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAG
SOURCE GeneReport for Unigene cluster for MAG Gene:
Hs.643440mRNA Expression by UniProt/SwissProt for MAG Gene:
P20916-MAG_HUMAN
Tissue specificity:
Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures (PubMed:9495552, PubMed:6200494). Detected in optic nerve, in oligodendroglia and in periaxonal myelin sheaths (PubMed:6200494). Detected in compact myelin (at protein level) (PubMed:6200494). Both isoform 1 and isoform 2 are detected in the central and peripheral nervous system (PubMed:9495552).
Evidence on tissue expression from TISSUES for MAG Gene
- Nervous system(5)
- Kidney(4.1)
- Eye(2.5)
- Blood(2.3)
- Skin(2.2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for MAG
-
OriGene qPCR primer pairs and template standards for MAG
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAG Gene
Orthologs for MAG Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | MAG 30 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | MAG 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MAG 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mag 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mag 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MAG 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | MAG 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mag 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mag 30 31 |
|
OneToOne |
- Species where no ortholog for MAG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MAG Gene
- ENSEMBL:
- Gene Tree for MAG (if available)
- TreeFam:
- Gene Tree for MAG (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAG: view image
Paralogs for MAG Gene
Paralogs for MAG Gene
(1) SIMAP similar genes for MAG Gene using alignment to 4 proteins:
- MAG_HUMAN
- M0QZU4_HUMAN
- M0R3B9_HUMAN
- M0R3I4_HUMAN
Variants for MAG Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAG Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 639292 | Uncertain Significance: Spastic paraplegia 75, autosomal recessive | 35,300,333(+) | A/G | MISSENSE_VARIANT | |
| 641864 | Uncertain Significance: Spastic paraplegia 75, autosomal recessive | 35,299,826(+) | G/A | MISSENSE_VARIANT | |
| 654572 | Uncertain Significance: Spastic paraplegia 75, autosomal recessive | 35,302,535(+) | C/T | MISSENSE_VARIANT | |
| 657878 | Uncertain Significance: Spastic paraplegia 75, autosomal recessive | 35,295,894(+) | G/T | NONSENSE | |
| 660792 | Uncertain Significance: Spastic paraplegia 75, autosomal recessive | 35,309,907(+) | C/T | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2010e59 | CNV | duplication | 20981092 |
| esv1006379 | CNV | deletion | 20482838 |
| esv1763084 | CNV | deletion | 17803354 |
| esv2758758 | CNV | loss | 17122850 |
| nsv510765 | CNV | deletion | 20534489 |
| nsv833810 | CNV | gain | 17160897 |
| nsv953283 | CNV | deletion | 24416366 |
| nsv9711 | CNV | loss | 18304495 |
Residual Variation Intolerance Score:
31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.34;
63.21% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAG Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAG Gene
Disorders for MAG Gene
(51) MalaCards diseases for MAG Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spastic paraplegia 75, autosomal recessive |
|
|
| polyneuropathy |
|
|
| demyelinating polyneuropathy |
|
|
| optic neuritis |
|
|
| chronic polyneuropathy |
|
|
Search MAG in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MAG_HUMAN- Spastic paraplegia 75, autosomal recessive (SPG75) [MIM:616680]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG75 is characterized by onset in early childhood and is associated with mild to moderate cognitive impairment. {ECO:0000269 PubMed:24482476, ECO:0000269 PubMed:26179919, ECO:0000269 PubMed:27606346}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for MAG
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for MAG Gene
Publications for MAG Gene
- A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia. (PMID: 18496213) Voineskos AN … Kennedy JL (Psychiatric genetics 2008) 3 23 41
- Identification of the glycosylated sequons of human myelin-associated glycoprotein. (PMID: 7505568) Burger D … Steck AJ (Biochemical and biophysical research communications 1993) 3 4 23
- cDNA cloning and amino acid sequence for human myelin-associated glycoprotein. (PMID: 2476987) Sato S … Miyatake T (Biochemical and biophysical research communications 1989) 2 3 4
- Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder. (PMID: 26179919) Lossos A … Peles E (Brain : a journal of neurology 2015) 3 4
- Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy. (PMID: 19720975) Kuijf ML … Jacobs BC (Neurology 2009) 3 23
ExternalLinks
Products for MAG Gene
- View all 6 R&D Systems MAG (MAG/Siglec-4a) Products
- View all R&D Systems MAG (MAG/Siglec-4a) Proteins and Enzymes
- View all 4 R&D Systems MAG (MAG/Siglec-4a) Primary Antibodies
- View all R&D Systems MAG (MAG/Siglec-4a) cDNA Clones
- Learn more about R&D Systems custom MAG antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for MAG
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MAG
- Origene Custom Protein Services for MAG
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAG
- Browse OriGene Inhibitory RNA Products For MAG
- OriGene qPCR primer pairs for MAG
- OriGene qPCR primer pairs and template standards for MAG
- OriGene CRISPR knockouts for MAG
- MG223754
- MR223754
- MR223754L3
- MR223754L4
- RC208754
- RC208754L1
- RC208754L2
- RC208754L3
- RC208754L4
- RC215996
- RC215996L1
- RC215996L2
- RC215996L3
- RC215996L4
- RC234527
- RG208754
- RG215996
- RG234527
- RR208763
- RR208763L3
- RR208763L4
- MR223754L3V
- MR223754L4V
- RC208754L1V
- RC208754L2V
- RC208754L3V
- RC208754L4V
- RC215996L1V
- RC215996L2V
- RC215996L3V
- RC215996L4V
- RR208763L3V
- RR208763L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MAG
- Sino Biological Human cDNA Clone for MAG
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- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
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- Novus Biologicals proteins and lysates for MAG
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- Invitrogen Antibodies for MAG (AFLGC-MAG)
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- VectorBuilder CRISPR vectors for MAG (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MAG CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MAG
- antibodies-online: Show 26 available MAG Antibodies ranked by validation data
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- antibodies-online: Show 48 available MAG Elisa Kits ranked by validation data
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- antibodies-online: Show 21 available MAG Proteins ranked by validation data
- Compare Top MAG Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for MAG
- Search Santa Cruz Biotechnology (SCBT) for MAG siRNA/shRNA
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- Search for MAG Antibodies at ProSci
- Custom Antibody Services
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- Horizon Cell Lines for MAG
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAG
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MAG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAG
Sources for MAG Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB