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The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen ... See more...
Aliases for MAFK Gene
Aliases for MAFK Gene
External Ids for MAFK Gene
- HGNC: 6782
- Entrez Gene: 7975
- Ensembl: ENSG00000198517
- OMIM: 600197
- UniProtKB: O60675
Previous GeneCards Identifiers for MAFK Gene
- GC07P001214
- GC07P001314
- GC07P001343
- GC07P001536
- GC07P001570
Summaries for MAFK Gene
-
The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008]
GeneCards Summary for MAFK Gene
MAFK (MAF BZIP Transcription Factor K) is a Protein Coding gene. Diseases associated with MAFK include Fibrosarcoma and Autosomal Dominant Adult-Onset Proximal Spinal Muscular Atrophy. Among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is MAFG.
UniProtKB/Swiss-Prot Summary for MAFK Gene
-
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:9150357). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9150357, PubMed:8932385). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (PubMed:9150357).
Additional gene information for MAFK Gene
- HGNC(6782)
- Entrez Gene(7975)
- Ensembl(ENSG00000198517)
- OMIM(600197)
- UniProtKB(O60675)
- Open Targets Platform(ENSG00000198517)
- Search for MAFK at DataMed
- Search for MAFK at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAFK Gene
Genomics for MAFK Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MAFK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAFK on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAFK
- Top Transcription factor binding sites by QIAGEN in the MAFK gene promoter:
-
- CREB
- deltaCREB
- GATA-1
- NF-1
- NF-kappaB1
Genomic Locations for MAFK Gene
Genomic Locations for MAFK Gene
- chr7:1,530,702-1,543,043
- (GRCh38/hg38)
- Size:
- 12,342 bases
- Orientation:
- Plus strand
- chr7:1,570,350-1,582,679
- (GRCh37/hg19)
- Size:
- 12,330 bases
- Orientation:
- Plus strand
Genomic View for MAFK Gene
Genes around MAFK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p22.3 by HGNC
- 7p22.3 by Entrez Gene
- 7p22.3 by Ensembl
MAFK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAFK Gene
Proteins for MAFK Gene
-
Protein details for MAFK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60675-MAFK_HUMAN
- Recommended name:
- Transcription factor MafK
- Protein Accession:
- O60675
- A4D214
Protein attributes for MAFK Gene
- Size:
- 156 amino acids
- Molecular mass:
- 17523 Da
- Quaternary structure:
-
- Homodimer or heterodimer. It can form high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3 (PubMed:9150357, PubMed:8932385).
Protein Expression for MAFK Gene
Post-translational modifications for MAFK Gene
Other Protein References for MAFK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- GeneTex Anti-MAFK antibody [AT2F7] and Anti-MAFK antibody
-
Custom Antibody ServicesOriGene Antibodies for MAFK
- Novus Biologicals Antibodies for MAFK
-
Abcam antibodies for MAFK
- Invitrogen Antibodies for MAFK (AFLGC-MAFK)
-
Biorbyt antibodies for MAFK
-
Boster Bio Antibodies for MAFK
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAFK
Protein Products
-
OriGene Purified Proteins for MAFK
- Search Origene for MassSpec and Protein Over-expression Lysates for MAFK
- Origene Custom Protein Services for MAFK
- Novus Biologicals proteins for MAFK
- ProSpec Recombinant Proteins for MAFK
- antibodies-online: Show 6 available MAFK Proteins ranked by validation data
- Compare Top MAFK Proteins
-
Quality Products:
-
Signalway Proteins for MAFK
-
Abcam proteins for MAFK
Assay Products
- antibodies-online: Show 5 available MAFK Elisa Kits ranked by validation data
- Compare Top MAFK Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MAFK Gene
Domains & Families for MAFK Gene
Gene Families for MAFK Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MAFK Gene
- InterPro:
- Blocks:
-
- Maf transcription factor
- ProtoNet:
Suggested Antigen Peptide Sequences for MAFK Gene
- GenScript: Design optimal peptide antigens:
-
- MAFK protein (A2VCQ5_HUMAN)
- MAFK protein (A2VCQ6_HUMAN)
- cDNA FLJ35095 fis, clone PLACE6006186, highly similar to TRANSCRIPTION FACTOR MAFK (A4D214_HUMAN)
- V-maf musculoaponeurotic fibrosarcoma oncogene homolog K (Avian) (A8WFP5_HUMAN)
- Erythroid transcription factor NF-E2 p18 subunit (MAFK_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60675- Family:
-
- Belongs to the bZIP family. Maf subfamily.
Function for MAFK Gene
Molecular function for MAFK Gene
- UniProtKB/Swiss-Prot Function:
- Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:9150357). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9150357, PubMed:8932385). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (PubMed:9150357).
- GENATLAS Biochemistry:
- small MAF protein K,interacting with BACH1,heterodimerizing with NFE2 to form an erythroid and megakaryocytic cell specific transcription factor,also expressed in neurones from an alternative promoter at least in mouse,homolog to v-maf fibrosarcoma (avian) oncogene
Phenotypes From GWAS Catalog for MAFK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | ISS | -- |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001221 | transcription cofactor binding | IEA | -- |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 9150357 |
Phenotypes for MAFK Gene
- MGI mutant phenotypes for MAFK:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for MAFK:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased Salmonella enterica Typhimurium invasion
- Strongly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased viability with paclitaxel
- Synthetic lethal with c-Myc after tamoxifen stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAFK - Select products 50% OFF >
- * MAFK CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAFK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAFK
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAFK
miRNA for MAFK Gene
- miRTarBase miRNAs that target MAFK
-
- hsa-miR-92b-3p (MIRT040737)
- hsa-miR-15a-5p (MIRT103092)
- hsa-miR-16-5p (MIRT103093)
- hsa-miR-203a-3p (MIRT103094)
- hsa-miR-15b-5p (MIRT103095)
- hsa-miR-195-5p (MIRT103096)
- hsa-miR-424-5p (MIRT103097)
- hsa-miR-497-5p (MIRT103098)
- hsa-miR-548e-5p (MIRT103099)
- hsa-miR-3613-3p (MIRT103100)
- hsa-miR-4694-3p (MIRT103101)
- hsa-miR-5692a (MIRT103102)
- hsa-miR-6838-5p (MIRT103103)
- hsa-miR-6124 (MIRT239698)
- hsa-miR-671-5p (MIRT409072)
- hsa-miR-4761-5p (MIRT409073)
- hsa-miR-6814-5p (MIRT409074)
- hsa-miR-6880-5p (MIRT409075)
- hsa-miR-122-5p (MIRT473872)
- hsa-miR-504-3p (MIRT473873)
- hsa-miR-4480 (MIRT473874)
- hsa-miR-1909-5p (MIRT473875)
- hsa-miR-3925-3p (MIRT473876)
- hsa-miR-766-3p (MIRT473877)
- hsa-miR-665 (MIRT473878)
- hsa-miR-4763-5p (MIRT499517)
- hsa-miR-4707-3p (MIRT499518)
- hsa-miR-4632-3p (MIRT499519)
- hsa-miR-4485-5p (MIRT499520)
- hsa-miR-4258 (MIRT499521)
- hsa-miR-6083 (MIRT556353)
- hsa-miR-433-3p (MIRT556354)
- hsa-miR-96-3p (MIRT556355)
- hsa-miR-2681-3p (MIRT556356)
- hsa-miR-3074-3p (MIRT556357)
- mmu-miR-1983 (MIRT598401)
- mmu-miR-412-3p (MIRT598402)
- mmu-miR-3473c (MIRT598403)
- mmu-miR-1894-5p (MIRT598404)
- hsa-miR-3667-3p (MIRT610966)
- hsa-miR-6734-3p (MIRT610967)
- hsa-miR-660-3p (MIRT610968)
- hsa-miR-5193 (MIRT610969)
- hsa-miR-1306-5p (MIRT614146)
- hsa-miR-4716-5p (MIRT623352)
- hsa-miR-6749-3p (MIRT717973)
- hsa-miR-1260b (MIRT717975)
- hsa-miR-6829-3p (MIRT717976)
- hsa-miR-1260a (MIRT717977)
- hsa-miR-6791-3p (MIRT717978)
- hsa-miR-532-3p (MIRT717979)
- hsa-miR-1281 (MIRT717980)
- hsa-miR-7108-3p (MIRT717981)
- hsa-miR-1224-3p (MIRT717982)
- hsa-miR-1207-5p (MIRT736033)
- hsa-miR-1268a (MIRT736714)
- hsa-miR-1268b (MIRT736720)
- hsa-miR-1285-3p (MIRT737026)
- hsa-miR-1293 (MIRT737153)
- hsa-miR-1301-3p (MIRT737251)
- hsa-miR-1343-5p (MIRT737472)
- hsa-miR-134-3p (MIRT737501)
- hsa-miR-1539 (MIRT737902)
- hsa-miR-1908-5p (MIRT738322)
- hsa-miR-1909-3p (MIRT738354)
- hsa-miR-3138 (MIRT740157)
- hsa-miR-3187-5p (MIRT740921)
- hsa-miR-3193 (MIRT741046)
- hsa-miR-326 (MIRT741272)
- hsa-miR-330-5p (MIRT741330)
- hsa-miR-363-5p (MIRT741832)
- hsa-miR-3659 (MIRT741954)
- hsa-miR-3665 (MIRT742054)
- hsa-miR-378g (MIRT742762)
- hsa-miR-3944-5p (MIRT743170)
- hsa-miR-4483 (MIRT745150)
- hsa-miR-4486 (MIRT745182)
- hsa-miR-4658 (MIRT746669)
- hsa-miR-4660 (MIRT746685)
- hsa-miR-4688 (MIRT747011)
- hsa-miR-4706 (MIRT747332)
- hsa-miR-4711-3p (MIRT747438)
- hsa-miR-4734 (MIRT747976)
- hsa-miR-4749-5p (MIRT748313)
- hsa-miR-4763-3p (MIRT748542)
- hsa-miR-4767 (MIRT748603)
- hsa-miR-4793-5p (MIRT748946)
- hsa-miR-4800-5p (MIRT748999)
- hsa-miR-486-3p (MIRT749112)
- hsa-miR-5047 (MIRT749567)
- hsa-miR-505-5p (MIRT749585)
- hsa-miR-5189-5p (MIRT749881)
- hsa-miR-541-3p (MIRT750376)
- hsa-miR-574-5p (MIRT751422)
- hsa-miR-6081 (MIRT751764)
- hsa-miR-612 (MIRT752224)
- hsa-miR-654-5p (MIRT753447)
- hsa-miR-663a (MIRT753582)
- hsa-miR-6721-5p (MIRT753807)
- hsa-miR-6722-3p (MIRT753867)
- hsa-miR-6743-5p (MIRT754411)
- hsa-miR-6745 (MIRT754459)
- hsa-miR-6756-5p (MIRT754800)
- hsa-miR-6759-5p (MIRT754901)
- hsa-miR-6766-5p (MIRT755108)
- hsa-miR-6770-5p (MIRT755283)
- hsa-miR-6776-5p (MIRT755369)
- hsa-miR-6777-5p (MIRT755389)
- hsa-miR-6787-5p (MIRT755943)
- hsa-miR-6790-5p (MIRT756025)
- hsa-miR-6815-5p (MIRT756779)
- hsa-miR-6860 (MIRT757854)
- hsa-miR-6865-5p (MIRT757928)
- hsa-miR-6889-5p (MIRT758638)
- hsa-miR-7114-5p (MIRT759144)
- hsa-miR-744-5p (MIRT759362)
- hsa-miR-939-5p (MIRT760763)
Targeted motifs for MAFK Gene
HOMER Transcription Factor Regulatory Elements motif MAFK
- Consensus sequence: GCTGASTCAGCA Submotif: canonical Cell Type: C2C12 GEO ID: GSE36030
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAFK
- Browse OriGene Inhibitory RNA Products For MAFK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAFK
Clone Products
- Applied Biological Materials (abm): Clones for MAFK - Select products 50% OFF >
- * MAFK as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MAFK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAFK
Cell Line Products
-
Horizon Cell Lines for MAFK
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for MAFK Gene
Localization for MAFK Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAFK Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0042025 | host cell nucleus | IEA | -- |
Pathways & Interactions for MAFK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics | ||
| 2 | Factors involved in megakaryocyte development and platelet production | ||
| 3 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
Pathways by source for MAFK Gene
2 Reactome pathways for MAFK Gene
1 PharmGKB pathway for MAFK Gene
Interacting Proteins for MAFK Gene
Selected Interacting proteins:
O60675-MAFK_HUMAN
ENSP00000344903
for MAFK Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MAFK
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 9150357 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0007596 | blood coagulation | TAS | -- |
Drugs & Compounds for MAFK Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Isoniazid | Approved, Investigational | Pharma | 215 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for MAFK Gene
mRNA/cDNA for MAFK Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000343242 3380 nts (view in UCSC)
- ENST00000403150 2773 nts (view in UCSC)
- ENST00000406174 632 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAFK - Select products 50% OFF >
- * MAFK CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAFK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAFK
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAFK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAFK
- Browse OriGene Inhibitory RNA Products For MAFK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAFK
Clone Products
- Applied Biological Materials (abm): Clones for MAFK - Select products 50% OFF >
- * MAFK as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MAFK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAFK
Relevant External Links for MAFK Gene
- GeneLoc Exon Structure for
- MAFK
Expression for MAFK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Stomach (Gastrointestinal Tract)
This gene is overexpressed in Placenta (42.8), Lung (10.9), and NK cells (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAFK Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAFK
SOURCE GeneReport for Unigene cluster for MAFK Gene:
Hs.520612Evidence on tissue expression from TISSUES for MAFK Gene
- Lung(3.2)
- Liver(2.3)
- Skin(2.2)
- Heart(2.2)
- Muscle(2.2)
- Blood(2.2)
- Pancreas(2.1)
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs for MAFK
-
OriGene qPCR primer pairs and template standards for MAFK
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAFK Gene
Orthologs for MAFK Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Oppossum (Monodelphis domestica) |
Mammalia | MAFK 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MAFK 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MAFK 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mafk 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mafk 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MAFK 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MAFK 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MAFK 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mafk 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mafk 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | maf-S 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010405 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | maf-1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for MAFK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MAFK Gene
- ENSEMBL:
- Gene Tree for MAFK (if available)
- TreeFam:
- Gene Tree for MAFK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAFK: view image
Paralogs for MAFK Gene
(18) SIMAP similar genes for MAFK Gene using alignment to 4 proteins:
- MAFK_HUMAN
- A2VCQ5_HUMAN
- A2VCQ6_HUMAN
- A8WFP5_HUMAN
Variants for MAFK Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv11135n54 | CNV | loss | 21841781 |
| dgv11136n54 | CNV | loss | 21841781 |
| esv2759499 | CNV | loss | 17122850 |
| esv3891010 | CNV | loss | 25118596 |
| nsv1017606 | CNV | loss | 25217958 |
| nsv1112920 | CNV | deletion | 24896259 |
| nsv1145122 | CNV | deletion | 24896259 |
| nsv464247 | CNV | loss | 19166990 |
| nsv471182 | CNV | loss | 18288195 |
| nsv482100 | CNV | gain | 20164927 |
| nsv5615 | CNV | deletion | 18451855 |
| nsv605819 | CNV | loss | 21841781 |
| nsv605820 | CNV | loss | 21841781 |
| nsv823970 | CNV | gain | 20364138 |
| nsv823974 | CNV | loss | 20364138 |
| nsv830879 | CNV | gain+loss | 17160897 |
| nsv830880 | CNV | loss | 17160897 |
| nsv950786 | CNV | deletion | 24416366 |
Gene Damage Index Score:
0.80;
16.87% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAFK Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MAFK
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAFK Gene
Disorders for MAFK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fibrosarcoma |
|
|
| autosomal dominant adult-onset proximal spinal muscular atrophy |
|
|
| ayme-gripp syndrome |
|
|
Search MAFK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAFK
No data available for UniProtKB/Swiss-Prot and Genatlas for MAFK Gene
Publications for MAFK Gene
- Structure and chromosome mapping of the human small maf-genes MAFG and MAFK. (PMID: 9763667) Iwata T … Ito E (Cytogenetics and cell genetics 1998) 2 3 23
- Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif. (PMID: 9150357) Toki T … Ito E (Oncogene 1997) 3 4 23
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
ExternalLinks
Products for MAFK Gene
- Custom Antibody ServicesOriGene Antibodies for MAFK
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- antibodies-online: Show 18 available MAFK Antibodies ranked by validation data
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Sources for MAFK Gene
- (1) GeneCards
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- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
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