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Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM ... See more...
Aliases for MAFG Gene
Aliases for MAFG Gene
External Ids for MAFG Gene
- HGNC: 6781
- Entrez Gene: 4097
- Ensembl: ENSG00000197063
- OMIM: 602020
- UniProtKB: O15525
Previous GeneCards Identifiers for MAFG Gene
- GC17M079241
- GC17M9I0116
- GC17M080415
- GC17M9I0558
- GC17M9I7469
- GC17M077469
- GC17M079877
- GC17M075277
Summaries for MAFG Gene
-
Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]
GeneCards Summary for MAFG Gene
MAFG (MAF BZIP Transcription Factor G) is a Protein Coding gene. Diseases associated with MAFG include Fibrosarcoma and Ayme-Gripp Syndrome. Among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is MAFK.
UniProtKB/Swiss-Prot Summary for MAFG Gene
-
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+) (By similarity).
Additional gene information for MAFG Gene
- HGNC(6781)
- Entrez Gene(4097)
- Ensembl(ENSG00000197063)
- OMIM(602020)
- UniProtKB(O15525)
- Open Targets Platform(ENSG00000197063)
- Search for MAFG at DataMed
- Search for MAFG at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAFG Gene
Genomics for MAFG Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MAFG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAFG on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAFG
- Top Transcription factor binding sites by QIAGEN in the MAFG gene promoter:
-
- AP-1
- ATF-2
- c-Jun
Genomic Locations for MAFG Gene
Genomic Locations for MAFG Gene
- chr17:81,918,270-81,927,735
- (GRCh38/hg38)
- Size:
- 9,466 bases
- Orientation:
- Minus strand
- chr17:79,876,145-79,885,590
- (GRCh37/hg19)
- Size:
- 9,446 bases
- Orientation:
- Minus strand
Genomic View for MAFG Gene
Genes around MAFG on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by HGNC
- 17q25.3 by Entrez Gene
- 17q25.3 by Ensembl
MAFG Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAFG Gene
Proteins for MAFG Gene
-
Protein details for MAFG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15525-MAFG_HUMAN
- Recommended name:
- Transcription factor MafG
- Protein Accession:
- O15525
Protein attributes for MAFG Gene
- Size:
- 162 amino acids
- Molecular mass:
- 17850 Da
- Quaternary structure:
-
- Homodimer or heterodimer. Homodimerization leads to transcriptional repression. Forms high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3 (PubMed:8932385, PubMed:9421508, PubMed:11154691). Interacts with CREBBP; the interaction leads to acetylation of the basic region of MAFG and stimulation of NFE2 transcriptional activity through increased DNA binding.
Protein Expression for MAFG Gene
Post-translational modifications for MAFG Gene
- Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2.
- Sumoylation at Lys-14 is required for active transcriptional repression.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MAFG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-MAFG monoclonal antibody
- Creative Biolabs Mouse Anti-MAFG Recombinant Antibody (1H7)
- Novus Biologicals Antibodies for MAFG
-
Abcam antibodies for MAFG
- Invitrogen Antibodies for MAFG (AFLGC-MAFG)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAFG
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MAFG
- Origene Custom Protein Services for MAFG
- ProSpec Recombinant Proteins for MAFG
- antibodies-online: Show 9 available Mafg Proteins ranked by validation data
- Compare Top Mafg Proteins
-
Quality Products:
-
Abcam proteins for MAFG
No data available for DME Specific Peptides for MAFG Gene
Domains & Families for MAFG Gene
Gene Families for MAFG Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MAFG Gene
- InterPro:
- Blocks:
-
- Maf transcription factor
- ProtoNet:
Suggested Antigen Peptide Sequences for MAFG Gene
- GenScript: Design optimal peptide antigens:
-
- hMAF (MAFG_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O15525- Family:
-
- Belongs to the bZIP family. Maf subfamily.
Function for MAFG Gene
Molecular function for MAFG Gene
- UniProtKB/Swiss-Prot Function:
- Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+) (By similarity).
- GENATLAS Biochemistry:
- small MAF protein G,dimerizing with NFE2 to form an erythroid and megakaryocytic cell specific transcription factor,homolog to v-maf musinloaponeurotic fibrosarcoma (avian) oncogene
Phenotypes From GWAS Catalog for MAFG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IEA,IBA | 21873635 |
Phenotypes for MAFG Gene
- MGI mutant phenotypes for MAFG:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MAFG:
Animal Models for MAFG Gene
- MGI Knock Outs for MAFG:
-
- Mafg Mafg<tm1Jeng>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAFG - Select products 50% OFF >
- * MAFG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAFG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAFG
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAFG
miRNA for MAFG Gene
- miRTarBase miRNAs that target MAFG
-
- hsa-miR-218-5p (MIRT003711)
- hsa-miR-26b-5p (MIRT029000)
- hsa-miR-93-3p (MIRT038855)
- hsa-miR-100-5p (MIRT048503)
- hsa-miR-92a-3p (MIRT049582)
- hsa-miR-204-5p (MIRT198272)
- hsa-miR-211-5p (MIRT198273)
- hsa-miR-623 (MIRT198280)
- hsa-miR-4755-5p (MIRT289736)
- hsa-miR-5006-3p (MIRT289737)
- hsa-miR-5584-3p (MIRT656531)
- hsa-miR-4659b-3p (MIRT656532)
- hsa-miR-4659a-3p (MIRT656533)
- hsa-miR-6875-3p (MIRT656534)
- hsa-miR-6832-3p (MIRT656535)
- hsa-miR-122-5p (MIRT736111)
- hsa-miR-146a-3p (MIRT737639)
- hsa-miR-1914-3p (MIRT738509)
- hsa-miR-301a-5p (MIRT739617)
- hsa-miR-301b-5p (MIRT739627)
- hsa-miR-3179 (MIRT740736)
- hsa-miR-3202 (MIRT741151)
- hsa-miR-363-5p (MIRT741831)
- hsa-miR-3661 (MIRT741991)
- hsa-miR-3921 (MIRT742969)
- hsa-miR-4271 (MIRT743624)
- hsa-miR-4446-3p (MIRT744618)
- hsa-miR-4539 (MIRT746135)
- hsa-miR-4651 (MIRT746556)
- hsa-miR-4653-5p (MIRT746617)
- hsa-miR-4656 (MIRT746656)
- hsa-miR-4685-5p (MIRT746964)
- hsa-miR-4725-3p (MIRT747705)
- hsa-miR-4747-5p (MIRT748248)
- hsa-miR-504-3p (MIRT749551)
- hsa-miR-5194 (MIRT749973)
- hsa-miR-5196-5p (MIRT750032)
- hsa-miR-593-3p (MIRT751588)
- hsa-miR-6077 (MIRT751711)
- hsa-miR-608 (MIRT751993)
- hsa-miR-6132 (MIRT752318)
- hsa-miR-631 (MIRT752654)
- hsa-miR-6738-5p (MIRT754268)
- hsa-miR-6745 (MIRT754458)
- hsa-miR-6780b-5p (MIRT755636)
- hsa-miR-6782-5p (MIRT755704)
- hsa-miR-6783-5p (MIRT755753)
- hsa-miR-6836-5p (MIRT757212)
- hsa-miR-6837-5p (MIRT757246)
- hsa-miR-6880-5p (MIRT758309)
- hsa-miR-6886-5p (MIRT758560)
- hsa-miR-7113-5p (MIRT759113)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAFG
- Browse OriGene Inhibitory RNA Products For MAFG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAFG
Clone Products
- Applied Biological Materials (abm): Clones for MAFG - Select products 50% OFF >
- * MAFG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201268
- MG201284
- MR201268
- MR201268L3
- MR201268L4
- MR201284
- MR201284L3
- MR201284L4
- RC204181
- RC204181L3
- RC204181L4
- RC221486
- RC221486L1
- RC221486L2
- RC221486L3
- RC221486L4
- RG204181
- RG221486
- RR206657
- RR206657L3
- RR206657L4
- MR201268L3V
- MR201268L4V
- MR201284L3V
- MR201284L4V
- RC204181L3V
- RC204181L4V
- RC221486L1V
- RC221486L2V
- RC221486L3V
- RC221486L4V
- RR206657L3V
- RR206657L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAFG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAFG
Cell Line Products
-
Horizon Cell Lines for MAFG
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAFG Gene
Localization for MAFG Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAFG Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IEA,IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0042025 | host cell nucleus | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAFG Gene
Pathways & Interactions for MAFG Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics | ||
| 2 | Factors involved in megakaryocyte development and platelet production | ||
| 3 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 4 | NRF2 pathway | ||
Pathways by source for MAFG Gene
1 BioSystems pathway for MAFG Gene
2 Reactome pathways for MAFG Gene
1 PharmGKB pathway for MAFG Gene
Interacting Proteins for MAFG Gene
Selected Interacting proteins:
O15525-MAFG_HUMAN
ENSP00000350369
for MAFG Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MAFG
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007596 | blood coagulation | TAS | -- |
| GO:0010628 | positive regulation of gene expression | IEA | -- |
| GO:0030534 | adult behavior | IEA | -- |
Transcripts for MAFG Gene
mRNA/cDNA for MAFG Gene
- 2 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000357736 5061 nts (view in UCSC)
- ENST00000392366 1743 nts (view in UCSC)
- ENST00000574686 570 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAFG - Select products 50% OFF >
- * MAFG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAFG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAFG
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAFG
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAFG
- Browse OriGene Inhibitory RNA Products For MAFG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAFG
Clone Products
- Applied Biological Materials (abm): Clones for MAFG - Select products 50% OFF >
- * MAFG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201268
- MG201284
- MR201268
- MR201268L3
- MR201268L4
- MR201284
- MR201284L3
- MR201284L4
- RC204181
- RC204181L3
- RC204181L4
- RC221486
- RC221486L1
- RC221486L2
- RC221486L3
- RC221486L4
- RG204181
- RG221486
- RR206657
- RR206657L3
- RR206657L4
- MR201268L3V
- MR201268L4V
- MR201284L3V
- MR201284L4V
- RC204181L3V
- RC204181L4V
- RC221486L1V
- RC221486L2V
- RC221486L3V
- RC221486L4V
- RR206657L3V
- RR206657L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAFG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAFG
Relevant External Links for MAFG Gene
- GeneLoc Exon Structure for
- MAFG
Expression for MAFG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Eye (Sensory Organs)
- Blood (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for MAFG Gene
This gene is overexpressed in Muscle - Skeletal (x4.1).
This gene is overexpressed in Heart (51.8) and Fetal Brain (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAFG Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAFG
SOURCE GeneReport for Unigene cluster for MAFG Gene:
Hs.252229mRNA Expression by UniProt/SwissProt for MAFG Gene:
O15525-MAFG_HUMAN
Tissue specificity:
Highly expressed in skeletal muscle. Also expressed in heart and brain.
Evidence on tissue expression from TISSUES for MAFG Gene
- Lung(4.5)
- Muscle(4.4)
- Nervous system(3.8)
- Skin(2.9)
- Kidney(2.4)
- Intestine(2.3)
- Liver(2.2)
- Pancreas(2.2)
- Blood(2.2)
- Bone marrow(2.1)
Primer Products
-
OriGene qPCR primer pairs for MAFG
-
OriGene qPCR primer pairs and template standards for MAFG
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAFG Gene
Orthologs for MAFG Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MAFG 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MAFG 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MAFG 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mafg 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mafg 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MAFG 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MAFG 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MAFG 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MAFG 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mafg 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mafgb 30 31 |
|
OneToMany | |
| mafga 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | maf-S 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | maf-1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for MAFG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MAFG Gene
- ENSEMBL:
- Gene Tree for MAFG (if available)
- TreeFam:
- Gene Tree for MAFG (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAFG: view image
Paralogs for MAFG Gene
Variants for MAFG Gene
Residual Variation Intolerance Score:
50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.12;
2.67% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAFG Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MAFG
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAFG Gene
Disorders for MAFG Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fibrosarcoma |
|
|
| ayme-gripp syndrome |
|
|
Search MAFG in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAFG
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MAFG Gene
Publications for MAFG Gene
- Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation. (PMID: 11154691) Hung HL … Blobel GA (The Journal of biological chemistry 2001) 3 4 23
- Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription. (PMID: 9421508) Johnsen O … Kolsto AB (Nucleic acids research 1998) 3 4 23
- Structure and chromosome mapping of the human small maf-genes MAFG and MAFK. (PMID: 9763667) Iwata T … Ito E (Cytogenetics and cell genetics 1998) 2 3 23
- Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. (PMID: 9166829) Blank V … Andrews NC (Blood 1997) 3 4 23
- Molecular characterization and localization of the human MAFG gene. (PMID: 9286713) Blank V … Andrews NC (Genomics 1997) 3 4 23
ExternalLinks
Products for MAFG Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MAFG
- Origene Custom Protein Services for MAFG
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAFG
- Browse OriGene Inhibitory RNA Products For MAFG
- OriGene qPCR primer pairs for MAFG
- OriGene qPCR primer pairs and template standards for MAFG
- OriGene CRISPR knockouts for MAFG
- MG201268
- MG201284
- MR201268
- MR201268L3
- MR201268L4
- MR201284
- MR201284L3
- MR201284L4
- RC204181
- RC204181L3
- RC204181L4
- RC221486
- RC221486L1
- RC221486L2
- RC221486L3
- RC221486L4
- RG204181
- RG221486
- RR206657
- RR206657L3
- RR206657L4
- MR201268L3V
- MR201268L4V
- MR201284L3V
- MR201284L4V
- RC204181L3V
- RC204181L4V
- RC221486L1V
- RC221486L2V
- RC221486L3V
- RC221486L4V
- RR206657L3V
- RR206657L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- VectorBuilder Custom and pre-made DNA vectors for MAFG (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder Stable cell line generation for MAFG
- antibodies-online: Show 14 available Mafg Antibodies ranked by validation data
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- antibodies-online: Show 9 available Mafg Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for MAFG
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Sources for MAFG Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
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- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
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- (109) Disease Ontology
- (110) Genetics Home Reference
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- (115) NCBI Bookshelf
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB