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Aliases for MAFG Gene

Aliases for MAFG Gene

  • MAF BZIP Transcription Factor G 2 3 5
  • V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog G 2 3
  • Basic Leucine Zipper Transcription Factor MafG 2 3
  • Transcription Factor MafG 2 3
  • HMAF 3 4
  • V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog G 4

External Ids for MAFG Gene

Previous GeneCards Identifiers for MAFG Gene

  • GC17M079241
  • GC17M9I0116
  • GC17M080415
  • GC17M9I0558
  • GC17M9I7469
  • GC17M077469
  • GC17M079877
  • GC17M075277

Summaries for MAFG Gene

Entrez Gene Summary for MAFG Gene

  • Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]

GeneCards Summary for MAFG Gene

MAFG (MAF BZIP Transcription Factor G) is a Protein Coding gene. Diseases associated with MAFG include Fibrosarcoma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Tacrolimus/Cyclosporine Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is MAFK.

UniProtKB/Swiss-Prot for MAFG Gene

  • Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).

Gene Wiki entry for MAFG Gene

Additional gene information for MAFG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAFG Gene

Genomics for MAFG Gene

GeneHancer (GH) Regulatory Elements for MAFG Gene

Promoters and enhancers for MAFG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I081916 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.4 +9.0 8981 13.1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000264769 SIRT7 MAFG TBCD FAAP100 OGFOD3 HGS ENSG00000262663 HEXDC RFNG
GH17I081908 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 13.3 +20.4 20401 6 HDGF FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 PCYT2 MAFG ENSG00000235296 PYCR1 MYADML2 GCGR PIR61559 SIRT7
GH17I081416 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.5 +511.0 511025 7.6 SIN3A FEZF1 GLIS2 KLF7 FOS DEK SP3 SMARCB1 GMEB1 GLIS1 HGS MAFG FSCN2 CCDC137 NPLOC4 MIR4740 GC17M081444 BAHCC1
GH17I082332 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.2 -402.4 -402363 3.7 HDGF PKNOX1 ATF1 FOXA2 ARNT SIN3A ZNF48 TCF12 POLR2B GLIS2 SECTM1 TBCD TEX19 CCDC57 GPS1 ENSG00000263321 ENSG00000265678 ARL16 RFNG ENSG00000260011
GH17I081884 Enhancer 1 ENCODE dbSUPER 11.9 +45.6 45553 3.7 PKNOX1 SIN3A RFX5 ZNF121 SCRT2 ATF7 FOS USF2 CEBPB ZEB2 GC17P081887 P4HB SIRT7 MAFG ENSG00000235296 PYCR1 MYADML2 GC17P081881 ALYREF
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAFG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAFG gene promoter:

Genomic Locations for MAFG Gene

Genomic Locations for MAFG Gene
chr17:81,918,269-81,931,560
(GRCh38/hg38)
Size:
13,292 bases
Orientation:
Minus strand
chr17:79,876,145-79,885,590
(GRCh37/hg19)

Genomic View for MAFG Gene

Genes around MAFG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAFG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAFG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAFG Gene

Proteins for MAFG Gene

  • Protein details for MAFG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15525-MAFG_HUMAN
    Recommended name:
    Transcription factor MafG
    Protein Accession:
    O15525

    Protein attributes for MAFG Gene

    Size:
    162 amino acids
    Molecular mass:
    17850 Da
    Quaternary structure:
    • Homodimer or heterodimer. Homodimerization leads to transcriptional repression. Forms high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3. Interacts with NFE2; the interaction results in transactivation activation. Interacts with CREBBP; the interaction leads to acetylation of the basic region of MAFG and stimulation of NFE2 transcriptional activity through increased DNA binding.

neXtProt entry for MAFG Gene

Post-translational modifications for MAFG Gene

  • Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2.
  • Sumoylation at Lys-14 is required for active transcriptional repression.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAFG Gene

No data available for DME Specific Peptides for MAFG Gene

Domains & Families for MAFG Gene

Gene Families for MAFG Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MAFG Gene

Suggested Antigen Peptide Sequences for MAFG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15525

UniProtKB/Swiss-Prot:

MAFG_HUMAN :
  • Belongs to the bZIP family. Maf subfamily.
Family:
  • Belongs to the bZIP family. Maf subfamily.
genes like me logo Genes that share domains with MAFG: view

Function for MAFG Gene

Molecular function for MAFG Gene

GENATLAS Biochemistry:
small MAF protein G,dimerizing with NFE2 to form an erythroid and megakaryocytic cell specific transcription factor,homolog to v-maf musinloaponeurotic fibrosarcoma (avian) oncogene
UniProtKB/Swiss-Prot Function:
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).

Gene Ontology (GO) - Molecular Function for MAFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA,NAS 9286713
GO:0005515 protein binding IPI 8932385
genes like me logo Genes that share ontologies with MAFG: view
genes like me logo Genes that share phenotypes with MAFG: view

Animal Models for MAFG Gene

MGI Knock Outs for MAFG:

Animal Model Products

miRNA for MAFG Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAFG Gene

Localization for MAFG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAFG Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAFG gene
Compartment Confidence
nucleus 5
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MAFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with MAFG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAFG Gene

Pathways & Interactions for MAFG Gene

genes like me logo Genes that share pathways with MAFG: view

Pathways by source for MAFG Gene

1 BioSystems pathway for MAFG Gene
1 PharmGKB pathway for MAFG Gene

Gene Ontology (GO) - Biological Process for MAFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with MAFG: view

No data available for SIGNOR curated interactions for MAFG Gene

Drugs & Compounds for MAFG Gene

(1) Drugs for MAFG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MAFG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAFG: view

Transcripts for MAFG Gene

Unigene Clusters for MAFG Gene

V-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAFG Gene

No ASD Table

Relevant External Links for MAFG Gene

GeneLoc Exon Structure for
MAFG
ECgene alternative splicing isoforms for
MAFG

Expression for MAFG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAFG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAFG Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for MAFG Gene

This gene is overexpressed in Heart (51.8) and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAFG Gene



Protein tissue co-expression partners for MAFG Gene

NURSA nuclear receptor signaling pathways regulating expression of MAFG Gene:

MAFG

SOURCE GeneReport for Unigene cluster for MAFG Gene:

Hs.252229

mRNA Expression by UniProt/SwissProt for MAFG Gene:

O15525-MAFG_HUMAN
Tissue specificity: Highly expressed in skeletal muscle. Also expressed in heart and brain.

Evidence on tissue expression from TISSUES for MAFG Gene

  • Lung(4.4)
  • Muscle(4.1)
  • Nervous system(3.5)
  • Skin(2)
genes like me logo Genes that share expression patterns with MAFG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAFG Gene

Orthologs for MAFG Gene

This gene was present in the common ancestor of animals.

Orthologs for MAFG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAFG 34 33
  • 99.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MAFG 33 34
  • 95.27 (n)
cow
(Bos Taurus)
Mammalia MAFG 33 34
  • 94.24 (n)
rat
(Rattus norvegicus)
Mammalia Mafg 33
  • 91.15 (n)
mouse
(Mus musculus)
Mammalia Mafg 16 34 33
  • 90.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAFG 34
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAFG 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAFG 33 34
  • 87.24 (n)
lizard
(Anolis carolinensis)
Reptilia MAFG 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mafg 33
  • 74.07 (n)
zebrafish
(Danio rerio)
Actinopterygii mafgb 33 34
  • 84.57 (n)
mafga 34
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta maf-S 34
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea maf-1 34
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
Species where no ortholog for MAFG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAFG Gene

ENSEMBL:
Gene Tree for MAFG (if available)
TreeFam:
Gene Tree for MAFG (if available)

Paralogs for MAFG Gene

Paralogs for MAFG Gene

(5) SIMAP similar genes for MAFG Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAFG: view

Variants for MAFG Gene

Sequence variations from dbSNP and Humsavar for MAFG Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000041849 -- 81,919,917(-) A/G 3_prime_UTR_variant
rs1000195754 -- 81,925,763(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000195845 -- 81,924,020(-) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000360344 -- 81,921,536(-) C/T 3_prime_UTR_variant
rs1000573932 -- 81,923,986(-) T/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MAFG Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv29964 CNV loss 17803354
esv33468 CNV loss 17666407
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv833569 CNV loss 17160897
nsv833571 CNV loss 17160897
nsv952392 CNV deletion 24416366

Variation tolerance for MAFG Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAFG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAFG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAFG Gene

Disorders for MAFG Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAFG Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fibrosarcoma
  • fibrocytic tumor
- elite association - COSMIC cancer census association via MalaCards
Search MAFG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAFG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAFG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAFG Gene

Publications for MAFG Gene

  1. Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation. (PMID: 11154691) Hung HL … Blobel GA (The Journal of biological chemistry 2001) 3 4 22 58
  2. Structure and chromosome mapping of the human small maf-genes MAFG and MAFK. (PMID: 9763667) Iwata T … Ito E (Cytogenetics and cell genetics 1998) 2 3 22 58
  3. Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif. (PMID: 9150357) Toki T … Ito E (Oncogene 1997) 3 4 22 58
  4. Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. (PMID: 9166829) Blank V … Andrews NC (Blood 1997) 3 4 22 58
  5. hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2. (PMID: 9195958) Marini MG … Moi P (The Journal of biological chemistry 1997) 3 4 22 58

Products for MAFG Gene

Sources for MAFG Gene

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