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Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM ... See more...
Aliases for MAFG Gene
Aliases for MAFG Gene
External Ids for MAFG Gene
- HGNC: 6781
- Entrez Gene: 4097
- Ensembl: ENSG00000197063
- OMIM: 602020
- UniProtKB: O15525
Previous GeneCards Identifiers for MAFG Gene
- GC17M079241
- GC17M9I0116
- GC17M080415
- GC17M9I0558
- GC17M9I7469
- GC17M077469
- GC17M079877
- GC17M075277
Summaries for MAFG Gene
-
Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]
GeneCards Summary for MAFG Gene
MAFG (MAF BZIP Transcription Factor G) is a Protein Coding gene. Diseases associated with MAFG include Fibrosarcoma. Among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and Factors involved in megakaryocyte development and platelet production. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is MAFK.
UniProtKB/Swiss-Prot Summary for MAFG Gene
-
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+) (By similarity).
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAFG Gene
Genomics for MAFG Gene
GeneHancer (GH) Regulatory Elements for MAFG Gene
Promoters and enhancers for MAFG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAFG on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MAFG gene promoter:
-
- AP-1
- ATF-2
- c-Jun
Genomic Locations for MAFG Gene
Genomic Locations for MAFG Gene
- chr17:81,918,269-81,931,560
- (GRCh38/hg38)
- Size:
- 13,292 bases
- Orientation:
- Minus strand
- chr17:79,876,145-79,885,590
- (GRCh37/hg19)
- Size:
- 9,446 bases
- Orientation:
- Minus strand
Genomic View for MAFG Gene
Genes around MAFG on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by HGNC
- 17q25.3 by Entrez Gene
- 17q25.3 by Ensembl
MAFG Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAFG Gene
Proteins for MAFG Gene
-
Protein details for MAFG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15525-MAFG_HUMAN
- Recommended name:
- Transcription factor MafG
- Protein Accession:
- O15525
Protein attributes for MAFG Gene
- Size:
- 162 amino acids
- Molecular mass:
- 17850 Da
- Quaternary structure:
-
- Homodimer or heterodimer. Homodimerization leads to transcriptional repression. Forms high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3 (PubMed:8932385, PubMed:9421508, PubMed:11154691). Interacts with CREBBP; the interaction leads to acetylation of the basic region of MAFG and stimulation of NFE2 transcriptional activity through increased DNA binding.
Protein Expression for MAFG Gene
Post-translational modifications for MAFG Gene
- Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2.
- Sumoylation at Lys-14 is required for active transcriptional repression.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MAFG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-MAFG monoclonal antibody, Anti-MAFG (aa 1-162) polyclonal antibody, and Anti-MAFG (full length) polyclonal antibody
- GeneTex Anti-MAFG antibody
- Novus Biologicals Antibodies for MAFG
-
Abcam antibodies for MAFG
- Invitrogen Antibodies for MAFG (AFLGC-MAFG)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAFG
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MAFG
- Origene Custom Protein Services for MAFG
- ProSpec Recombinant Proteins for MAFG
- antibodies-online: Show 9 available Mafg Proteins ranked by validation data
- Compare Top Mafg Proteins
-
Quality Products:
-
Abcam proteins for MAFG
No data available for DME Specific Peptides for MAFG Gene
Domains & Families for MAFG Gene
Gene Families for MAFG Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MAFG Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAFG Gene
- GenScript: Design optimal peptide antigens:
-
- hMAF (MAFG_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O15525- Family:
-
- Belongs to the bZIP family. Maf subfamily.
Function for MAFG Gene
Molecular function for MAFG Gene
- UniProtKB/Swiss-Prot Function:
- Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+) (By similarity).
- GENATLAS Biochemistry:
- small MAF protein G,dimerizing with NFE2 to form an erythroid and megakaryocytic cell specific transcription factor,homolog to v-maf musinloaponeurotic fibrosarcoma (avian) oncogene
Phenotypes From GWAS Catalog for MAFG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IBA,IEA | 21873635 |
Phenotypes for MAFG Gene
- MGI mutant phenotypes for MAFG:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MAFG:
Animal Models for MAFG Gene
- MGI Knock Outs for MAFG:
-
- Mafg Mafg<tm1Jeng>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for MAFG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAFG
- genomics-online: gRNA clones - Search for available Mafg gRNA products
- Overview of 129 available Mafg gene related products
- Applied Biological Materials (abm): CRISPR Clones for MAFG - Select products 50% OFF >
- * MAFG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MAFG CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAFG
miRNA for MAFG Gene
- miRTarBase miRNAs that target MAFG
-
- hsa-mir-218-5p (MIRT003711)
- hsa-mir-26b-5p (MIRT029000)
- hsa-mir-93-3p (MIRT038855)
- hsa-mir-100-5p (MIRT048503)
- hsa-mir-92a-3p (MIRT049582)
- hsa-mir-204-5p (MIRT198272)
- hsa-mir-211-5p (MIRT198273)
- hsa-mir-623 (MIRT198280)
- hsa-mir-4755-5p (MIRT289736)
- hsa-mir-5006-3p (MIRT289737)
- hsa-mir-5584-3p (MIRT656531)
- hsa-mir-4659b-3p (MIRT656532)
- hsa-mir-4659a-3p (MIRT656533)
- hsa-mir-6875-3p (MIRT656534)
- hsa-mir-6832-3p (MIRT656535)
- hsa-mir-122-5p (MIRT736111)
- hsa-mir-146a-3p (MIRT737639)
- hsa-mir-1914-3p (MIRT738509)
- hsa-mir-301a-5p (MIRT739617)
- hsa-mir-301b-5p (MIRT739627)
- hsa-mir-3179 (MIRT740736)
- hsa-mir-3202 (MIRT741151)
- hsa-mir-363-5p (MIRT741831)
- hsa-mir-3661 (MIRT741991)
- hsa-mir-3921 (MIRT742969)
- hsa-mir-4271 (MIRT743624)
- hsa-mir-4446-3p (MIRT744618)
- hsa-mir-4539 (MIRT746135)
- hsa-mir-4651 (MIRT746556)
- hsa-mir-4653-5p (MIRT746617)
- hsa-mir-4656 (MIRT746656)
- hsa-mir-4685-5p (MIRT746964)
- hsa-mir-4725-3p (MIRT747705)
- hsa-mir-4747-5p (MIRT748248)
- hsa-mir-504-3p (MIRT749551)
- hsa-mir-5194 (MIRT749973)
- hsa-mir-5196-5p (MIRT750032)
- hsa-mir-593-3p (MIRT751588)
- hsa-mir-6077 (MIRT751711)
- hsa-mir-608 (MIRT751993)
- hsa-mir-6132 (MIRT752318)
- hsa-mir-631 (MIRT752654)
- hsa-mir-6738-5p (MIRT754268)
- hsa-mir-6745 (MIRT754458)
- hsa-mir-6780b-5p (MIRT755636)
- hsa-mir-6782-5p (MIRT755704)
- hsa-mir-6783-5p (MIRT755753)
- hsa-mir-6836-5p (MIRT757212)
- hsa-mir-6837-5p (MIRT757246)
- hsa-mir-6880-5p (MIRT758309)
- hsa-mir-6886-5p (MIRT758560)
- hsa-mir-7113-5p (MIRT759113)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MAFG
- Browse OriGene Inhibitory RNA Products For MAFG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAFG
- genomics-online: shRNA clones - Search for available Mafg shRNA products
- Overview of 129 available Mafg gene related products
Clone Products
-
- MG201268
- MG201284
- MR201268
- MR201268L3
- MR201268L3V
- MR201268L4
- MR201268L4V
- MR201284
- MR201284L3
- MR201284L3V
- MR201284L4
- MR201284L4V
- RC204181
- RC204181L3
- RC204181L3V
- RC204181L4
- RC204181L4V
- RC221486
- RC221486L1
- RC221486L1V
- RC221486L2
- RC221486L2V
- RC221486L3
- RC221486L3V
- RC221486L4
- RC221486L4V
- RG204181
- RG221486
- RR206657
- RR206657L3
- RR206657L3V
- RR206657L4
- RR206657L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAFG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAFG
- genomics-online: cdna clones - Search for available Mafg CDNA products
- Overview of 129 available Mafg gene related products
- orf clones - Search for available Mafg ORF products
- Overview of 129 available Mafg gene related products
- Applied Biological Materials (abm): Clones for MAFG - Select products 50% OFF >
- * MAFG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MAFG tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for MAFG
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAFG Gene
Localization for MAFG Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAFG Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 0 |
| cytosol | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IEA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAFG Gene
Pathways & Interactions for MAFG Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics | ||
| 2 | Factors involved in megakaryocyte development and platelet production | ||
| 3 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 4 | NRF2 pathway | ||
Pathways by source for MAFG Gene
1 BioSystems pathway for MAFG Gene
2 Reactome pathways for MAFG Gene
1 PharmGKB pathway for MAFG Gene
Interacting Proteins for MAFG Gene
Selected Interacting proteins:
O15525-MAFG_HUMAN
ENSP00000350369
for MAFG Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MAFG
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007596 | blood coagulation | TAS | -- |
| GO:0010628 | positive regulation of gene expression | IEA | -- |
| GO:0030534 | adult behavior | IEA | -- |
Transcripts for MAFG Gene
mRNA/cDNA for MAFG Gene
- (2) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (89) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000357736 5061 bps (ENST00000357736.8)
- ENST00000392366 1743 bps (ENST00000392366.7)
- ENST00000574686 570 bps (ENST00000574686.1)
CRISPR Products
-
OriGene CRISPR knockouts for MAFG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAFG
- genomics-online: gRNA clones - Search for available Mafg gRNA products
- Overview of 129 available Mafg gene related products
- Applied Biological Materials (abm): CRISPR Clones for MAFG - Select products 50% OFF >
- * MAFG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MAFG CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAFG
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MAFG
- Browse OriGene Inhibitory RNA Products For MAFG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAFG
- genomics-online: shRNA clones - Search for available Mafg shRNA products
- Overview of 129 available Mafg gene related products
Clone Products
-
- MG201268
- MG201284
- MR201268
- MR201268L3
- MR201268L3V
- MR201268L4
- MR201268L4V
- MR201284
- MR201284L3
- MR201284L3V
- MR201284L4
- MR201284L4V
- RC204181
- RC204181L3
- RC204181L3V
- RC204181L4
- RC204181L4V
- RC221486
- RC221486L1
- RC221486L1V
- RC221486L2
- RC221486L2V
- RC221486L3
- RC221486L3V
- RC221486L4
- RC221486L4V
- RG204181
- RG221486
- RR206657
- RR206657L3
- RR206657L3V
- RR206657L4
- RR206657L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAFG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAFG
- genomics-online: cdna clones - Search for available Mafg CDNA products
- Overview of 129 available Mafg gene related products
- orf clones - Search for available Mafg ORF products
- Overview of 129 available Mafg gene related products
- Applied Biological Materials (abm): Clones for MAFG - Select products 50% OFF >
- * MAFG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MAFG tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for MAFG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Eye (Sensory Organs)
- Blood (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for MAFG Gene
This gene is overexpressed in Muscle - Skeletal (x4.1).
This gene is overexpressed in Heart (51.8) and Fetal Brain (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAFG Gene
NURSA nuclear receptor signaling pathways regulating expression of MAFG Gene:
MAFGSOURCE GeneReport for Unigene cluster for MAFG Gene:
Hs.252229mRNA Expression by UniProt/SwissProt for MAFG Gene:
O15525-MAFG_HUMAN
Tissue specificity:
Highly expressed in skeletal muscle. Also expressed in heart and brain.
Evidence on tissue expression from TISSUES for MAFG Gene
- Lung(4.4)
- Muscle(4.1)
- Nervous system(3.3)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for MAFG
-
OriGene qPCR primer pairs and template standards for MAFG
- genomics-online: primer clones - Search for available Mafg Primer products
- Overview of 129 available Mafg gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAFG Gene
Orthologs for MAFG Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MAFG 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MAFG 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MAFG 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Mafg 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Mafg 17 33 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MAFG 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MAFG 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MAFG 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MAFG 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mafg 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mafgb 33 32 |
|
OneToMany | |
| mafga 33 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | maf-S 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | maf-1 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for MAFG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MAFG Gene
- ENSEMBL:
- Gene Tree for MAFG (if available)
- TreeFam:
- Gene Tree for MAFG (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAFG: view image
Paralogs for MAFG Gene
Variants for MAFG Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000041849 | -- | 81,919,917(-) | A/G | 3_prime_UTR_variant | |
| rs1000195754 | -- | 81,925,763(-) | G/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000195845 | -- | 81,924,020(-) | G/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000360344 | -- | 81,921,536(-) | C/T | 3_prime_UTR_variant | |
| rs1000573932 | -- | 81,923,986(-) | T/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
Residual Variation Intolerance Score:
50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.12;
2.67% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAFG Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MAFG
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAFG Gene
Disorders for MAFG Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fibrosarcoma |
|
|
Search MAFG in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAFG
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MAFG Gene
Publications for MAFG Gene
- Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation. (PMID: 11154691) Hung HL … Blobel GA (The Journal of biological chemistry 2001) 3 4 23 56
- Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription. (PMID: 9421508) Johnsen O … Kolsto AB (Nucleic acids research 1998) 3 4 23 56
- Structure and chromosome mapping of the human small maf-genes MAFG and MAFK. (PMID: 9763667) Iwata T … Ito E (Cytogenetics and cell genetics 1998) 2 3 23 56
- Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. (PMID: 9166829) Blank V … Andrews NC (Blood 1997) 3 4 23 56
- hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2. (PMID: 9195958) Marini MG … Moi P (The Journal of biological chemistry 1997) 3 4 23 56
ExternalLinks
Products for MAFG Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MAFG
- Origene Custom Protein Services for MAFG
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MAFG
- Browse OriGene Inhibitory RNA Products For MAFG
- OriGene qPCR primer pairs for MAFG
- OriGene qPCR primer pairs and template standards for MAFG
- OriGene CRISPR knockouts for MAFG
- MG201268
- MG201284
- MR201268
- MR201268L3
- MR201268L3V
- MR201268L4
- MR201268L4V
- MR201284
- MR201284L3
- MR201284L3V
- MR201284L4
- MR201284L4V
- RC204181
- RC204181L3
- RC204181L3V
- RC204181L4
- RC204181L4V
- RC221486
- RC221486L1
- RC221486L1V
- RC221486L2
- RC221486L2V
- RC221486L3
- RC221486L3V
- RC221486L4
- RC221486L4V
- RG204181
- RG221486
- RR206657
- RR206657L3
- RR206657L3V
- RR206657L4
- RR206657L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MAFG
- Sino Biological Human cDNA Clone for MAFG
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MAFG
- Novus Biologicals proteins and lysates for MAFG
- Browse Antibodies
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- Abcam antibodies for MAFG
- Abcam proteins for MAFG
- Find your target
- Browse Primary Antibodies
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- antibodies-online: Show 14 available Mafg Antibodies ranked by validation data
- Compare Top Mafg Antibodies
- antibodies-online: Search results for available Mafg related products ranked by validation data
- antibodies-online: Show 9 available Mafg Proteins ranked by validation data
- Compare Top Mafg Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for MAFG
- Search Santa Cruz Biotechnology (SCBT) for MAFG siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MAFG
- Horizon Cell Lines for MAFG
- genomics-online: cdna clones - Search for available Mafg CDNA products
- Overview of 129 available Mafg gene related products
- orf clones - Search for available Mafg ORF products
- Overview of 129 available Mafg gene related products
- genomics-online: gRNA clones - Search for available Mafg gRNA products
- Overview of 129 available Mafg gene related products
- genomics-online: primer clones - Search for available Mafg Primer products
- Overview of 129 available Mafg gene related products
- genomics-online: shRNA clones - Search for available Mafg shRNA products
- Overview of 129 available Mafg gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAFG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAFG
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MAFG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAFG
Sources for MAFG Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource