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Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]
MAFG (MAF BZIP Transcription Factor G) is a Protein Coding gene. Diseases associated with MAFG include Fibrosarcoma and Ayme-Gripp Syndrome. Among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is MAFK.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IEA,IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0042025 | host cell nucleus | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics | ||
2 | Factors involved in megakaryocyte development and platelet production | ||
3 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
4 | NRF2 pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001701 | in utero embryonic development | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0007596 | blood coagulation | TAS | -- |
GO:0010628 | positive regulation of gene expression | IEA | -- |
GO:0030534 | adult behavior | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MAFG 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MAFG 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MAFG 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mafg 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mafg 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MAFG 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MAFG 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MAFG 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MAFG 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mafg 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mafgb 30 31 |
|
OneToMany | |
mafga 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | maf-S 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | maf-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
fibrosarcoma |
|
|
ayme-gripp syndrome |
|
|