This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing... See more...

Aliases for MAEA Gene

Aliases for MAEA Gene

  • Macrophage Erythroblast Attacher 2 3 4 5
  • Cell Proliferation-Inducing Gene 5 Protein 3 4
  • E3 Ubiquitin-Protein Transferase MAEA 3 4
  • Human Lung Cancer Oncogene 10 Protein 3 4
  • Erythroblast Macrophage Protein 3 4
  • P44EMLP 3 4
  • HLC-10 3 4
  • EMP 3 4
  • GID Complex Subunit 9, FYV10 Homolog (S. Cerevisiae) 2
  • GID Complex Subunit 9, FYV10 Homolog 3
  • Lung Cancer-Related Protein 10 3
  • EC 2.3.2.27 4
  • EMLP 3
  • GID9 3
  • PIG5 3

External Ids for MAEA Gene

Previous GeneCards Identifiers for MAEA Gene

  • GC04P001273
  • GC04P001252

Summaries for MAEA Gene

Entrez Gene Summary for MAEA Gene

  • This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for MAEA Gene

MAEA (Macrophage Erythroblast Attacher) is a Protein Coding gene. Diseases associated with MAEA include Plasma Cell Neoplasm and Solitary Osseous Plasmacytoma. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is RMND5B.

UniProtKB/Swiss-Prot Summary for MAEA Gene

  • Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). MAEA is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable).

Additional gene information for MAEA Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAEA Gene

Genomics for MAEA Gene

GeneHancer (GH) Regulatory Elements for MAEA Gene

Promoters and enhancers for MAEA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAEA on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAEA

Top Transcription factor binding sites by QIAGEN in the MAEA gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • NF-Y
  • NF-YA
  • NF-YB
  • RSRFC4

Genomic Locations for MAEA Gene

Genomic Locations for MAEA Gene
chr4:1,289,851-1,340,148
(GRCh38/hg38)
Size:
50,298 bases
Orientation:
Plus strand
chr4:1,283,639-1,333,935
(GRCh37/hg19)
Size:
50,297 bases
Orientation:
Plus strand

Genomic View for MAEA Gene

Genes around MAEA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAEA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAEA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAEA Gene

Proteins for MAEA Gene

  • Protein details for MAEA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L5Y9-MAEA_HUMAN
    Recommended name:
    E3 ubiquitin-protein transferase MAEA
    Protein Accession:
    Q7L5Y9
    Secondary Accessions:
    • O95285
    • Q5JB54
    • Q6ZRD6
    • Q9BQ11
    • Q9H9V6
    • Q9H9Z4
    • Q9NW84

    Protein attributes for MAEA Gene

    Size:
    396 amino acids
    Molecular mass:
    45287 Da
    Quaternary structure:
    • Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5 (PubMed:17467196, PubMed:29911972). Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (PubMed:29911972). Interacts with F-actin (PubMed:16510120).
    Miscellaneous:
    • [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    SequenceCaution:
    • Sequence=AAC67543.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305}; Sequence=AAC67543.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAC67543.1; Type=Miscellaneous discrepancy; Note=Sequence differs at N-terminus.; Evidence={ECO:0000305}; Sequence=AAO85220.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AK128302; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAEA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAEA Gene

Post-translational modifications for MAEA Gene

  • Autoubiquitinated as component of the CTLH E3 ubiquitin-protein ligase complex (in vitro).
  • Ubiquitination at Lys23, Lys31, Lys84, Lys97, Lys100, Lys144, Lys223, Lys186, Lys323, and Lys304
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MAEA Gene

Domains & Families for MAEA Gene

Gene Families for MAEA Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAEA Gene

Blocks:
  • Lissencephaly type-1-like homology motif
  • CTLH, C-terminal to LisH motif
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAEA Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ34632 fis, clone KIDNE2015660, highly similar to Homo sapiens macrophage erythroblast attacher (MAEA), transcript variant 2, mRNA (B3KRN7_HUMAN)
  • cDNA FLJ53639, highly similar to Homo sapiens macrophage erythroblast attacher (MAEA), transcript variant 1, mRNA (B4DQT1_HUMAN)
  • cDNA FLJ54556, highly similar to Homo sapiens macrophage erythroblast attacher (MAEA), transcript variant 1, mRNA (B4DVN3_HUMAN)
  • Macrophage erythroblast attacher, isoform CRA_b (D3DVP1_HUMAN)
  • Macrophage erythroblast attacher, isoform CRA_a (D3DVP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7L5Y9

UniProtKB/Swiss-Prot:

MAEA_HUMAN :
  • The expected RING-type zinc finger domain is highly divergent and most of the expected Cys residues are not conserved (Probable). Still, the protein is required for CTLH complex E3 ubiquitin-protein transferase activity (PubMed:29911972). In addition, the conserved Cys-314 in this highly divergent region is required for ubiquitination by the yeast GID complex, suggesting a direct role in catalyzing ubiquitination (Probable).
Domain:
  • The expected RING-type zinc finger domain is highly divergent and most of the expected Cys residues are not conserved (Probable). Still, the protein is required for CTLH complex E3 ubiquitin-protein transferase activity (PubMed:29911972). In addition, the conserved Cys-314 in this highly divergent region is required for ubiquitination by the yeast GID complex, suggesting a direct role in catalyzing ubiquitination (Probable).
genes like me logo Genes that share domains with MAEA: view

Function for MAEA Gene

Molecular function for MAEA Gene

UniProtKB/Swiss-Prot Function:
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). MAEA is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=. ;.

Enzyme Numbers (IUBMB) for MAEA Gene

Phenotypes From GWAS Catalog for MAEA Gene

Gene Ontology (GO) - Molecular Function for MAEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA,IEA 16510120
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA 21873635
GO:0005515 protein binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MAEA: view
genes like me logo Genes that share phenotypes with MAEA: view

Animal Models for MAEA Gene

MGI Knock Outs for MAEA:
  • Maea Maea<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for MAEA Gene

miRTarBase miRNAs that target MAEA

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAEA Gene

Localization for MAEA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAEA Gene

Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Detected in a nuclear, speckled-like pattern (PubMed:16510120). Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis (PubMed:16510120). Present in cytoplasm, nuclear matrix and at the cell surface in macrophages; predominantly nuclear in immature macrophages and predominantly detected at the cell surface in mature macrophages. Colocalizes with F-actin in macrophages (By similarity). {ECO:0000250 UniProtKB:Q4VC33, ECO:0000269 PubMed:16510120}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAEA gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 4
extracellular 3
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 29911972
GO:0005634 nucleus IDA 17467196
GO:0005654 nucleoplasm IDA 24143168
GO:0005737 cytoplasm IBA 21873635
GO:0005819 spindle IDA 16510120
genes like me logo Genes that share ontologies with MAEA: view

Pathways & Interactions for MAEA Gene

PathCards logo

SuperPathways for MAEA Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IBA 21873635
GO:0007010 cytoskeleton organization IEA --
GO:0007049 cell cycle IEA --
GO:0007155 cell adhesion IDA 9763581
GO:0007346 regulation of mitotic cell cycle NAS 16510120
genes like me logo Genes that share ontologies with MAEA: view

No data available for Pathways by source and SIGNOR curated interactions for MAEA Gene

Drugs & Compounds for MAEA Gene

(1) Drugs for MAEA Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tetrachlorodecaoxide Approved, Investigational Pharma Target 0
genes like me logo Genes that share compounds with MAEA: view

Transcripts for MAEA Gene

mRNA/cDNA for MAEA Gene

6 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAEA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - - - -
SP2:
SP3: - - - - -
SP4:
SP5:
SP6:

Relevant External Links for MAEA Gene

GeneLoc Exon Structure for
MAEA

Expression for MAEA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAEA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAEA Gene

This gene is overexpressed in Lavage (47.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAEA Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAEA

SOURCE GeneReport for Unigene cluster for MAEA Gene:

Hs.139896

mRNA Expression by UniProt/SwissProt for MAEA Gene:

Q7L5Y9-MAEA_HUMAN
Tissue specificity: Detected at macrophage membranes (at protein level). Ubiquitous.

Evidence on tissue expression from TISSUES for MAEA Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Kidney(3.9)
  • Intestine(3.7)
  • Skin(3.5)
  • Blood(3.3)
  • Liver(3.2)
  • Heart(2.9)
  • Bone marrow(2.8)
  • Lymph node(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with MAEA: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAEA Gene

Orthologs for MAEA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAEA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAEA 31 30
  • 99.33 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 96 (a)
OneToMany
-- 31
  • 77 (a)
OneToMany
-- 31
  • 75 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MAEA 31 30
  • 91.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MAEA 31 30
  • 90.99 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Maea 30
  • 89.98 (n)
mouse
(Mus musculus)
Mammalia Maea 17 31 30
  • 89.39 (n)
oppossum
(Monodelphis domestica)
Mammalia MAEA 31
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAEA 31 30
  • 80.39 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAEA 31
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia maea 30
  • 81.13 (n)
Str.2513 30
African clawed frog
(Xenopus laevis)
Amphibia maea-prov 30
zebrafish
(Danio rerio)
Actinopterygii maea 31 30
  • 77.66 (n)
OneToOne
wufb20a09 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004332 30
  • 58.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31357 31 30
  • 58.71 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea maea-1 31
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FYV10 33 31
  • 20 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G55070 30
  • 48.3 (n)
rice
(Oryza sativa)
Liliopsida Os05g0160100 30
  • 50.81 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 60 (a)
OneToOne
Cin.4076 30
bread mold
(Neurospora crassa)
Ascomycetes NCU09000 30
  • 49.45 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC106.13 30
  • 40.07 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4076 30
Species where no ortholog for MAEA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAEA Gene

ENSEMBL:
Gene Tree for MAEA (if available)
TreeFam:
Gene Tree for MAEA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAEA: view image

Paralogs for MAEA Gene

Paralogs for MAEA Gene

genes like me logo Genes that share paralogs with MAEA: view

Variants for MAEA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAEA Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
717838 Benign: not provided 1,315,453(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT
787794 Benign: not provided 1,315,477(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT
rs34082974 - p.Arg34Cys

Additional dbSNP identifiers (rs#s) for MAEA Gene

Structural Variations from Database of Genomic Variants (DGV) for MAEA Gene

Variant ID Type Subtype PubMed ID
esv1006767 CNV deletion 20482838
esv1007469 CNV insertion 20482838
esv1011456 CNV deletion 17803354
esv1108812 CNV deletion 17803354
esv1413945 CNV insertion 17803354
esv1714696 CNV insertion 17803354
esv22192 CNV loss 19812545
esv23351 CNV loss 19812545
esv2726778 CNV deletion 23290073
esv2726779 CNV deletion 23290073
esv2726780 CNV deletion 23290073
esv2726781 CNV deletion 23290073
esv2726782 CNV deletion 23290073
esv2726783 CNV deletion 23290073
esv2726785 CNV deletion 23290073
esv2726786 CNV deletion 23290073
esv2726787 CNV deletion 23290073
nsv1073285 CNV deletion 25765185
nsv1073286 CNV deletion 25765185
nsv1118990 CNV deletion 24896259
nsv1145016 CNV deletion 24896259
nsv1151208 CNV deletion 26484159
nsv290178 CNV insertion 16902084
nsv292086 CNV deletion 16902084
nsv461156 CNV loss 19166990
nsv461157 CNV loss 19166990
nsv473257 CNV novel sequence insertion 20440878
nsv508988 CNV insertion 20534489
nsv593278 CNV loss 21841781
nsv593281 CNV loss 21841781
nsv593298 CNV loss 21841781
nsv593299 CNV loss 21841781
nsv593300 CNV loss 21841781
nsv593301 CNV loss 21841781
nsv822425 CNV loss 20364138
nsv829835 CNV gain 17160897
nsv980177 CNV duplication 23825009

Variation tolerance for MAEA Gene

Residual Variation Intolerance Score: 9.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAEA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAEA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAEA Gene

Disorders for MAEA Gene

MalaCards: The human disease database

(14) MalaCards diseases for MAEA Gene - From: DISEASES

Disorder Aliases PubMed IDs
plasma cell neoplasm
  • multiple myeloma
solitary osseous plasmacytoma
  • isolated osseous plasmacytoma
epiglottis neoplasm
  • epiglottic tumor
extramedullary plasmacytoma
  • extraosseous plasmacytoma
schizophrenia 16
  • sczd16
- elite association - COSMIC cancer census association via MalaCards
Search MAEA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAEA

genes like me logo Genes that share disorders with MAEA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAEA Gene

Publications for MAEA Gene

  1. Molecular identification and functional characterization of a novel protein that mediates the attachment of erythroblasts to macrophages. (PMID: 9763581) Hanspal M … Uong Q (Blood 1998) 2 3 4 23 54
  2. The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. (PMID: 29911972) Lampert F … Peter M (eLife 2018) 3 4 54
  3. Molecular phylogeny of a RING E3 ubiquitin ligase, conserved in eukaryotic cells and dominated by homologous components, the muskelin/RanBPM/CTLH complex. (PMID: 24143168) Francis O … Adams JC (PloS one 2013) 3 4 54
  4. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho YS … Seielstad M (Nature genetics 2011) 3 41 54
  5. RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex. (PMID: 17467196) Kobayashi N … Ishigatsubo Y (Gene 2007) 3 4 54

Products for MAEA Gene

Sources for MAEA Gene