Aliases for MADCAM1 Gene
External Ids for MADCAM1 Gene
Previous GeneCards Identifiers for MADCAM1 Gene
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for MADCAM1 Gene
MADCAM1 (Mucosal Vascular Addressin Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with MADCAM1 include Ileitis and Cholangitis, Primary Sclerosing. Among its related pathways are Degradation of the extracellular matrix and Innate Immune System. Gene Ontology (GO) annotations related to this gene include integrin binding involved in cell-matrix adhesion.
UniProtKB/Swiss-Prot Summary for MADCAM1 Gene
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.