Aliases for MAD2L2 Gene
External Ids for MAD2L2 Gene
Previous GeneCards Identifiers for MAD2L2 Gene
The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAD2L2 Gene
MAD2L2 (Mitotic Arrest Deficient 2 Like 2) is a Protein Coding gene. Diseases associated with MAD2L2 include Fanconi Anemia, Complementation Group V and Fanconi Anemia, Complementation Group A. Among its related pathways are Cell cycle and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template. Gene Ontology (GO) annotations related to this gene include RNA polymerase II activating transcription factor binding and JUN kinase binding.
UniProtKB/Swiss-Prot for MAD2L2 Gene
Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.