Aliases for MAD2L1BP Gene
External Ids for MAD2L1BP Gene
Previous GeneCards Identifiers for MAD2L1BP Gene
The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAD2L1BP Gene
MAD2L1BP (MAD2L1 Binding Protein) is a Protein Coding gene. Diseases associated with MAD2L1BP include Spinal Muscular Atrophy, Type Iii.
UniProtKB/Swiss-Prot Summary for MAD2L1BP Gene
May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.