Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with... See more...

Aliases for MACROH2A1 Gene

Aliases for MACROH2A1 Gene

  • MacroH2A.1 Histone 2 3
  • H2A Histone Family Member Y 2 3 5
  • Medulloblastoma Antigen MU-MB-50.205 3 4
  • Core Histone Macro-H2A.1 3 4
  • Histone MacroH2A1 3 4
  • Histone H2A.Y 3 4
  • H2AFY 3 5
  • H2A/Y 3 4
  • MH2A1 3 4
  • H2A Histone Family, Member Y 2
  • Histone MacroH2A1.1 3
  • Histone MacroH2A1.2 3
  • MACROH2A1.1 3
  • MacroH2A1.2 3
  • H2AF12M 3
  • H2A.Y 3

External Ids for MACROH2A1 Gene

Previous HGNC Symbols for MACROH2A1 Gene

  • H2AFY

Summaries for MACROH2A1 Gene

Entrez Gene Summary for MACROH2A1 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

GeneCards Summary for MACROH2A1 Gene

MACROH2A1 (MacroH2A.1 Histone) is a Protein Coding gene. Diseases associated with MACROH2A1 include Liebenberg Syndrome and Medulloblastoma. Among its related pathways are Chromatin Regulation / Acetylation and ATF-2 transcription factor network. An important paralog of this gene is MACROH2A2.

UniProtKB/Swiss-Prot Summary for MACROH2A1 Gene

  • Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16428466, PubMed:16107708).
  • [Isoform 1]: Binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation (PubMed:15902274). Increases the expression of genes involved in redox metabolism, including SOD3 (PubMed:23022728).
  • [Isoform 2]: Represses SOD3 gene expression.

Gene Wiki entry for MACROH2A1 Gene

Additional gene information for MACROH2A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MACROH2A1 Gene

Genomics for MACROH2A1 Gene

GeneHancer (GH) Regulatory Elements for MACROH2A1 Gene

Promoters and enhancers for MACROH2A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MACROH2A1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MACROH2A1

Genomic Locations for MACROH2A1 Gene

Genomic Locations for MACROH2A1 Gene
chr5:135,333,900-135,400,147
(GRCh38/hg38)
Size:
66,248 bases
Orientation:
Minus strand
chr5:134,669,590-134,735,604
(GRCh37/hg19)
Size:
66,015 bases
Orientation:
Minus strand

Genomic View for MACROH2A1 Gene

Genes around MACROH2A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MACROH2A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MACROH2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MACROH2A1 Gene

Proteins for MACROH2A1 Gene

  • Protein details for MACROH2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75367-H2AY_HUMAN
    Recommended name:
    Core histone macro-H2A.1
    Protein Accession:
    O75367
    Secondary Accessions:
    • O75377
    • Q503A8
    • Q7Z5E3
    • Q96D41
    • Q9H8P3
    • Q9UP96

    Protein attributes for MACROH2A1 Gene

    Size:
    372 amino acids
    Molecular mass:
    39617 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with HDAC1 and HDAC2 (By similarity). Interacts with SPOP. Part of a complex consisting of H2AFY, CUL3 and SPOP.
    Miscellaneous:
    • [Isoform 2]: The preferential expression of isoform 2 over that of isoform 1 requires the presence of DDX5/DDX17.
    • [Isoform 1]: Specifically binds ADP-ribose and O-acetyl-ADP-ribose. Important residues for binding are Asp-203, Gly-224, Gly-314 and Phe-348. Preferentially expressed over isoform 2 in the absence of DDX5/DDX17.

    Three dimensional structures from OCA and Proteopedia for MACROH2A1 Gene

    Alternative splice isoforms for MACROH2A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MACROH2A1 Gene

Post-translational modifications for MACROH2A1 Gene

  • Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin.
  • Ubiquitination at Lys117, Lys123, Lys189, Lys251, Lys285, Lys292, Lys295, Lys307, and Lys323
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MACROH2A1 Gene

Domains & Families for MACROH2A1 Gene

Gene Families for MACROH2A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MACROH2A1 Gene

Blocks:
  • Histone H2A
  • Protein of unknown function Appr-1
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MACROH2A1 Gene

GenScript: Design optimal peptide antigens:
  • Histone H2A (B4DJC3_HUMAN)
  • Histone H2A (D6RCF2_HUMAN)
  • Medulloblastoma antigen MU-MB-50.205 (H2AY_HUMAN)
genes like me logo Genes that share domains with MACROH2A1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MACROH2A1 Gene

Function for MACROH2A1 Gene

Molecular function for MACROH2A1 Gene

UniProtKB/Swiss-Prot Function:
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16428466, PubMed:16107708).
UniProtKB/Swiss-Prot Function:
[Isoform 1]: Binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation (PubMed:15902274). Increases the expression of genes involved in redox metabolism, including SOD3 (PubMed:23022728).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Represses SOD3 gene expression.

Phenotypes From GWAS Catalog for MACROH2A1 Gene

Gene Ontology (GO) - Molecular Function for MACROH2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000182 rDNA binding IDA 24071584
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 23595991
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA 25526730
GO:0003677 DNA binding IBA,NAS 9714746
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with MACROH2A1: view
genes like me logo Genes that share phenotypes with MACROH2A1: view

Human Phenotype Ontology for MACROH2A1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MACROH2A1 Gene

MGI Knock Outs for MACROH2A1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MACROH2A1 Gene

Localization for MACROH2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MACROH2A1 Gene

Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin. {ECO:0000269 PubMed:15621527, ECO:0000269 PubMed:15897469, ECO:0000269 PubMed:9634239}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MACROH2A1 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MACROH2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 18936163
GO:0000784 nuclear chromosome, telomeric region HDA 19135898
GO:0000785 chromatin IEA --
GO:0000786 nucleosome NAS 9714746
GO:0000790 nuclear chromatin IDA,IBA 19734898
genes like me logo Genes that share ontologies with MACROH2A1: view

Pathways & Interactions for MACROH2A1 Gene

genes like me logo Genes that share pathways with MACROH2A1: view

Pathways by source for MACROH2A1 Gene

1 BioSystems pathway for MACROH2A1 Gene
3 KEGG pathways for MACROH2A1 Gene
1 Cell Signaling Technology pathway for MACROH2A1 Gene
1 GeneTex pathway for MACROH2A1 Gene

Gene Ontology (GO) - Biological Process for MACROH2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 19734898
GO:0006325 chromatin organization IBA 21873635
GO:0006334 nucleosome assembly NAS 9714746
GO:0007549 dosage compensation IDA 15053874
GO:0019216 regulation of lipid metabolic process IMP 25526730
genes like me logo Genes that share ontologies with MACROH2A1: view

No data available for SIGNOR curated interactions for MACROH2A1 Gene

Drugs & Compounds for MACROH2A1 Gene

No Compound Related Data Available

Transcripts for MACROH2A1 Gene

mRNA/cDNA for MACROH2A1 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MACROH2A1 Gene

No ASD Table

Relevant External Links for MACROH2A1 Gene

GeneLoc Exon Structure for
MACROH2A1

Expression for MACROH2A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MACROH2A1

SOURCE GeneReport for Unigene cluster for MACROH2A1 Gene:

Hs.420272

mRNA Expression by UniProt/SwissProt for MACROH2A1 Gene:

O75367-H2AY_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for MACROH2A1 Gene

  • Blood(4.8)
  • Nervous system(4.5)
  • Bone marrow(4.4)
  • Liver(4.4)
  • Lung(3.7)
  • Pancreas(2.6)
  • Eye(2.4)
  • Skin(2.3)
  • Lymph node(2)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MACROH2A1 Gene

Orthologs for MACROH2A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MACROH2A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia H2AFY 31 30
  • 99.91 (n)
OneToOne
dog
(Canis familiaris)
Mammalia H2AFY 30
  • 93.73 (n)
cow
(Bos Taurus)
Mammalia H2AFY 31 30
  • 93.44 (n)
OneToOne
mouse
(Mus musculus)
Mammalia H2afy 31 30
  • 90.68 (n)
OneToOne
Macroh2a1 17
platypus
(Ornithorhynchus anatinus)
Mammalia H2AFY 31
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia H2afy 30
  • 89.94 (n)
chicken
(Gallus gallus)
Aves H2AFY 31 30
  • 85.39 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia H2AFY 31
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia h2afy 30
  • 75.88 (n)
Str.9088 30
zebrafish
(Danio rerio)
Actinopterygii h2afy 30
  • 70.7 (n)
H2AFY (5 of 16) 31
  • 63 (a)
OneToMany
H2AFY (1 of 16) 31
  • 63 (a)
OneToMany
H2AFY (2 of 16) 31
  • 63 (a)
OneToMany
H2AFY (14 of 16) 31
  • 63 (a)
OneToMany
H2AFY (4 of 16) 31
  • 63 (a)
OneToMany
H2AFY (8 of 16) 31
  • 63 (a)
OneToMany
H2AFY (10 of 16) 31
  • 62 (a)
OneToMany
H2AFY (3 of 16) 31
  • 62 (a)
OneToMany
H2AFY (15 of 16) 31
  • 62 (a)
OneToMany
H2AFY (12 of 16) 31
  • 62 (a)
OneToMany
H2AFY (11 of 16) 31
  • 62 (a)
OneToMany
H2AFY (9 of 16) 31
  • 62 (a)
OneToMany
H2AFY (6 of 16) 31
  • 62 (a)
OneToMany
H2AFY (16 of 16) 31
  • 62 (a)
OneToMany
H2AFY (13 of 16) 31
  • 62 (a)
OneToMany
H2AFY (7 of 16) 31
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta His2A:CG33829 31
  • 64 (a)
OneToMany
His2A:CG33823 31
  • 64 (a)
OneToMany
His2A:CG33838 31
  • 64 (a)
OneToMany
His2A:CG33862 31
  • 64 (a)
OneToMany
His2A:CG33808 31
  • 64 (a)
OneToMany
His2A:CG33832 31
  • 64 (a)
OneToMany
His2A:CG33844 31
  • 64 (a)
OneToMany
His2A:CG33865 31
  • 64 (a)
OneToMany
His2A:CG33817 31
  • 64 (a)
OneToMany
His2A:CG33859 31
  • 64 (a)
OneToMany
His2A:CG33850 31
  • 64 (a)
OneToMany
His2A:CG33847 31
  • 64 (a)
OneToMany
His2A:CG33814 31
  • 64 (a)
OneToMany
His2A:CG33835 31
  • 64 (a)
OneToMany
His2A:CG31618 31
  • 64 (a)
OneToMany
His2A:CG33820 31
  • 64 (a)
OneToMany
His2A:CG33841 31
  • 64 (a)
OneToMany
His2A:CG33853 31
  • 64 (a)
OneToMany
His2A:CG33856 31
  • 64 (a)
OneToMany
His2A:CG33826 31
  • 64 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea his-43 31
  • 63 (a)
OneToMany
his-61 31
  • 63 (a)
OneToMany
his-65 31
  • 63 (a)
OneToMany
his-51 31
  • 63 (a)
OneToMany
his-19 31
  • 63 (a)
OneToMany
his-7 31
  • 63 (a)
OneToMany
his-21 31
  • 63 (a)
OneToMany
his-47 31
  • 63 (a)
OneToMany
his-68 31
  • 63 (a)
OneToMany
his-3 31
  • 63 (a)
OneToMany
his-53 31
  • 63 (a)
OneToMany
his-16 31
  • 63 (a)
OneToMany
his-33 31
  • 63 (a)
OneToMany
his-12 31
  • 63 (a)
OneToMany
his-30 31
  • 63 (a)
OneToMany
his-35 31
  • 62 (a)
OneToMany
his-57 31
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HTA1 31
  • 59 (a)
OneToMany
HTA2 31
  • 59 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 57 (a)
OneToOne
Species where no ortholog for MACROH2A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MACROH2A1 Gene

ENSEMBL:
Gene Tree for MACROH2A1 (if available)
TreeFam:
Gene Tree for MACROH2A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MACROH2A1: view image

Paralogs for MACROH2A1 Gene

Variants for MACROH2A1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MACROH2A1 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
716117 Benign: not provided 135,343,265(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
730304 Benign: not provided 135,369,490(-) G/A SYNONYMOUS_VARIANT
785137 Benign: not provided 135,370,028(-) G/A INTRON_VARIANT
799411 Benign: not provided 135,360,551(-) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for MACROH2A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MACROH2A1 Gene

Variant ID Type Subtype PubMed ID
nsv1112886 CNV deletion 24896259
nsv5015 CNV insertion 18451855
nsv599745 CNV loss 21841781
nsv830496 CNV gain 17160897

Variation tolerance for MACROH2A1 Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MACROH2A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MACROH2A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MACROH2A1 Gene

Disorders for MACROH2A1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MACROH2A1 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
liebenberg syndrome
  • lbnbg
medulloblastoma
  • mdb
alpha thalassemia-x-linked intellectual disability syndrome
  • alpha-thalassemia/mental retardation syndrome, nondeletion type
breast cancer
  • breast cancer, familial
fanconi anemia, complementation group a
  • fanca
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MACROH2A1

genes like me logo Genes that share disorders with MACROH2A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MACROH2A1 Gene

Publications for MACROH2A1 Gene

  1. Isolation of cDNA clones encoding human histone macroH2A1 subtypes. (PMID: 9714746) Lee Y … Choe IS (Biochimica et biophysica acta 1998) 2 3 4 23 54
  2. Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry. (PMID: 16210244) Chu F … Burlingame AL (Molecular & cellular proteomics : MCP 2006) 3 4 23 54
  3. Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. (PMID: 15897469) Hernández-Muñoz I … van Lohuizen M (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 23 54
  4. Splicing regulates NAD metabolite binding to histone macroH2A. (PMID: 15965484) Kustatscher G … Ladurner AG (Nature structural & molecular biology 2005) 3 4 23 54
  5. Histone variant macroH2A1.2 is mono-ubiquitinated at its histone domain. (PMID: 16129414) Ogawa Y … Shibahara KI (Biochemical and biophysical research communications 2005) 3 4 23 54

Products for MACROH2A1 Gene

Sources for MACROH2A1 Gene