Aliases for MACROD2 Gene
External Ids for MACROD2 Gene
Previous HGNC Symbols for MACROD2 Gene
The protein encoded by this gene is a deacetylase involved in removing ADP-ribose from mono-ADP-ribosylated proteins. The encoded protein has been shown to translocate from the nucleus to the cytoplasm upon DNA damage. [provided by RefSeq, May 2017]
GeneCards Summary for MACROD2 Gene
MACROD2 (MACRO Domain Containing 2) is a Protein Coding gene. Diseases associated with MACROD2 include Kabuki Syndrome 1 and Autism Spectrum Disorder. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on glycosyl bonds and deacetylase activity. An important paralog of this gene is MACROD1.
UniProtKB/Swiss-Prot for MACROD2 Gene
Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.