MACROD1 Gene (Protein Coding)

Mono-ADP Ribosylhydrolase 1

GC11M063998
GIFtS:
35
See more...

Aliases for MACROD1 Gene

Aliases for MACROD1 Gene

  • Mono-ADP Ribosylhydrolase 1 2 3 5
  • LRP16 2 3 4
  • [Protein ADP-Ribosylaspartate] Hydrolase MACROD1 3 4
  • [Protein ADP-Ribosylglutamate] Hydrolase MACROD1 3 4
  • O-Acetyl-ADP-Ribose Deacetylase MACROD1 3 4
  • ADP-Ribose Glycohydrolase MACROD1 3 4
  • MACRO Domain-Containing Protein 1 3 4
  • MACRO Domain Containing 1 2 3
  • [Protein ADP-Ribosylglutamate] Hydrolase 3
  • Protein LRP16 4
  • EC 3.1.1.106 4
  • EC 3.2.2.- 4
  • MACROD1 5

External Ids for MACROD1 Gene

Previous GeneCards Identifiers for MACROD1 Gene

  • GC11M063523
  • GC11M063767
  • GC11M060094

Summaries for MACROD1 Gene

GeneCards Summary for MACROD1 Gene

MACROD1 (Mono-ADP Ribosylhydrolase 1) is a Protein Coding gene. Diseases associated with MACROD1 include Hypercholesterolemia, Familial, 4 and Endometrial Cancer. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on glycosyl bonds and deacetylase activity. An important paralog of this gene is MACROD2.

UniProtKB/Swiss-Prot Summary for MACROD1 Gene

  • Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Plays a role in estrogen signaling (PubMed:17893710, PubMed:17914104, PubMed:19403568). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PubMed:19022849). May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PubMed:17893710, PubMed:17914104). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PubMed:17914104). Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PubMed:17893710). Enhances ESR1-mediated transcription activity (PubMed:17914104).

Additional gene information for MACROD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MACROD1 Gene

Genomics for MACROD1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MACROD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MACROD1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MACROD1

Top Transcription factor binding sites by QIAGEN in the MACROD1 gene promoter:
  • Bach2
  • c-Myb
  • NF-kappaB
  • NF-kappaB1
  • POU2F1
  • PPAR-gamma1
  • PPAR-gamma2
  • Sp1

Genomic Locations for MACROD1 Gene

Latest Assembly
chr11:63,998,554-64,166,652
(GRCh38/hg38)
Size:
168,099 bases
Orientation:
Minus strand

Previous Assembly
chr11:63,766,030-63,933,585
(GRCh37/hg19 by Entrez Gene)
Size:
167,556 bases
Orientation:
Minus strand

chr11:63,766,030-63,933,578
(GRCh37/hg19 by Ensembl)
Size:
167,549 bases
Orientation:
Minus strand

Genomic View for MACROD1 Gene

Genes around MACROD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MACROD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MACROD1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MACROD1 Gene

Proteins for MACROD1 Gene

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  • Protein details for MACROD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ69-MACD1_HUMAN
    Recommended name:
    ADP-ribose glycohydrolase MACROD1
    Protein Accession:
    Q9BQ69
    Secondary Accessions:
    • Q9UH96

    Protein attributes for MACROD1 Gene

    Size:
    325 amino acids
    Molecular mass:
    35505 Da
    Quaternary structure:
    • Interacts with ESR1; Interacts in a manner that is estrogen independent but is enhanced by estrogen. Interacts (via macro domain) with AR.
    SequenceCaution:
    • Sequence=AAH03188.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH03188.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • Overexpression may promote MCF-7 cells proliferation. There is an approximate one-third increase of the invasive capacity of MACROD1-overexpressing cells. The expression of CDH1 is repressed by MACROD1. Further analyzes demonstrats that MACROD1 inhibits CDH1 transactivation in a dose dependent manner. Inhibition is abolished by estrogen deprivation, indicating that the down-regulation of CDH1 transcription by MACROD1 requires ESR1 mediation. Binding of ESR1 to the CDH1 promoter is antagonized by MACROD1, suggesting that MACROD1 could interfere with ESR1-mediated transcription. Knockdown of MACROD1 leads to impaired AR function and greatly attenuates the coactivation of AR by other AR coactivators such as UXT and NCOA1. This interference also markedly inhibits the androgen-stimulated proliferation of androgen-sensitive LNCaP prostate cancer cells. MACROD1 knockdown does not significantly affect the growth rate of AR-negative PC-3 prostate cancer cells.

    Three dimensional structures from OCA and Proteopedia for MACROD1 Gene

neXtProt entry for MACROD1 Gene

Protein Expression for MACROD1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MACROD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MACROD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MACROD1 Gene

Domains & Families for MACROD1 Gene

Gene Families for MACROD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for MACROD1 Gene

InterPro:
Blocks:
  • Protein of unknown function Appr-1
ProtoNet:

Suggested Antigen Peptide Sequences for MACROD1 Gene

GenScript: Design optimal peptide antigens:
  • Protein LRP16 (MACD1_HUMAN)
genes like me logo Genes that share domains with MACROD1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MACROD1 Gene

Function for MACROD1 Gene

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  6. Cell Lines for research

Molecular function for MACROD1 Gene

UniProtKB/Swiss-Prot Function:
Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Plays a role in estrogen signaling (PubMed:17893710, PubMed:17914104, PubMed:19403568). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PubMed:19022849). May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PubMed:17893710, PubMed:17914104). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PubMed:17914104). Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PubMed:17893710). Enhances ESR1-mediated transcription activity (PubMed:17914104).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+); Xref=Rhea:RHEA:59244, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57967, ChEBI:CHEBI:142723; EC=3.1.1.106; Evidence={ECO:0000305|PubMed:21257746};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+); Xref=Rhea:RHEA:57060, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57967, ChEBI:CHEBI:83767; EC=3.1.1.106; Evidence={ECO:0000305|PubMed:21257746};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O = ADP-D-ribose + H(+) + L-aspartyl-[protein]; Xref=Rhea:RHEA:54428, Rhea:RHEA-COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29961, ChEBI:CHEBI:57967, ChEBI:CHEBI:138102; Evidence={ECO:0000269|PubMed:23474714};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = ADP-D-ribose + H(+) + L-glutamyl-[protein]; Xref=Rhea:RHEA:58248, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:57967, ChEBI:CHEBI:142540; Evidence={ECO:0000269|PubMed:23474712, ECO:0000269|PubMed:23474714};.
UniProtKB/Swiss-Prot Induction:
Overexpressed by estrogens in breast cancer MCF-7 cells, probably via an activation of nuclear receptors for steroids (ESR1 but not ESR2). Significantly increased by estrogens in ESR1-positive Ishikawa endometrial cancer cells. Up-regulated in 17-beta-estradiol-responsive BG-1 ovarian cancer cells but down-regulated in estrogen-resistant SKOV3 ovarian cancer cells. Induced by androgen.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=373 uM for O-acetyl-ADP-ribose {ECO:0000269|PubMed:21257746};
UniProtKB/Swiss-Prot EnzymeRegulation:
Subject to competitive inhibition by the product ADP-ribose.

Enzyme Numbers (IUBMB) for MACROD1 Gene

Phenotypes From GWAS Catalog for MACROD1 Gene

Gene Ontology (GO) - Molecular Function for MACROD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17914104
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IDA 23474712
GO:0019213 deacetylase activity IDA 21257746
genes like me logo Genes that share ontologies with MACROD1: view

Phenotypes for MACROD1 Gene

MGI mutant phenotypes for MACROD1:
inferred from 1 alleles
GenomeRNAi human phenotypes for MACROD1:
genes like me logo Genes that share phenotypes with MACROD1: view

Animal Models for research

miRNA for MACROD1 Gene

miRTarBase miRNAs that target MACROD1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MACROD1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MACROD1 Gene

Localization for MACROD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MACROD1 Gene

Nucleus. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. {ECO:0000269 PubMed:23474712}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MACROD1 gene
Compartment Confidence
nucleus 5
mitochondrion 3
peroxisome 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MACROD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 23474712
GO:0005654 nucleoplasm IBA,IDA --
genes like me logo Genes that share ontologies with MACROD1: view

Pathways & Interactions for MACROD1 Gene

PathCards logo

SuperPathways for MACROD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MACROD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IBA,IMP 23474712
GO:0042278 purine nucleoside metabolic process IBA,IDA 21257746
GO:0051725 protein de-ADP-ribosylation IDA 23474712
genes like me logo Genes that share ontologies with MACROD1: view

No data available for Pathways by source and SIGNOR curated interactions for MACROD1 Gene

Drugs & Compounds for MACROD1 Gene

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No Compound Related Data Available

Transcripts for MACROD1 Gene

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mRNA/cDNA for MACROD1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MACROD1

Alternative Splicing Database (ASD) splice patterns (SP) for MACROD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: -

Relevant External Links for MACROD1 Gene

GeneLoc Exon Structure for
MACROD1

Expression for MACROD1 Gene

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  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MACROD1 Gene

mRNA expression in normal human tissues for MACROD1 Gene
mRNA expression by BioGPS for MACROD1 GenemRNA expression by GTEx for MACROD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MACROD1 Gene

This gene is overexpressed in Muscle - Skeletal (x10.0) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for MACROD1 Gene

This gene is overexpressed in Skin (10.9), Heart (7.6), and Tonsil (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MACROD1 Gene



Protein tissue co-expression partners for MACROD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MACROD1

SOURCE GeneReport for Unigene cluster for MACROD1 Gene:

Hs.602898

Evidence on tissue expression from TISSUES for MACROD1 Gene

  • Nervous system(4.5)
  • Blood(4.5)
  • Eye(4.2)
  • Kidney(2.8)
  • Lung(2.4)
  • Muscle(2.2)
  • Heart(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with MACROD1: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MACROD1 Gene

Orthologs for MACROD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MACROD1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MACROD1 30 31
  • 99.59 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MACROD1 30 31
  • 89.54 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MACROD1 30 31
  • 89.54 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Macrod1 30 17 31
  • 86.17 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Macrod1 30
  • 86.15 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia MACROD1 31
  • 70 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MACROD1 31
  • 70 (a)
 OneToOne
African clawed frog
(Xenopus laevis)
 Amphibia MGC68697 30
Zebrafish
(Danio rerio)
 Actinopterygii macrod1 30 31
  • 55.79 (n)
 OneToMany
zgc65960 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8510 30
Worm
(Caenorhabditis elegans)
 Secernentea B0035.3 31
  • 43 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 53 (a)
 OneToMany
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.8148 30
Species where no ortholog for MACROD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for MACROD1 Gene

ENSEMBL:
Gene Tree for MACROD1 (if available)
TreeFam:
Gene Tree for MACROD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MACROD1: view image

Paralogs for MACROD1 Gene

Paralogs for MACROD1 Gene

(1) SIMAP similar genes for MACROD1 Gene using alignment to 1 proteins:

  • MACD1_HUMAN
genes like me logo Genes that share paralogs with MACROD1: view

Variants for MACROD1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MACROD1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
835656 Uncertain Significance: Peripheral neuropathy 64,117,913(-) C/T
NM_014067.4(MACROD1):c.517+33326G>A 		MISSENSE_VARIANT,INTRON
840095 Uncertain Significance: Peripheral neuropathy 64,118,059(-) G/A
NM_014067.4(MACROD1):c.517+33180C>T 		MISSENSE_VARIANT,INTRON
842634 Uncertain Significance: Peripheral neuropathy 64,116,738(-) C/A
NM_014067.4(MACROD1):c.517+34501G>T 		MISSENSE_VARIANT,INTRON
845837 Uncertain Significance: Peripheral neuropathy 64,118,042(-) G/A
NM_014067.4(MACROD1):c.517+33197C>T 		MISSENSE_VARIANT,INTRON
857225 Uncertain Significance: Peripheral neuropathy 64,116,518(-) C/T
NM_014067.4(MACROD1):c.517+34721G>A 		MISSENSE_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MACROD1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MACROD1 Gene

Variant ID Type Subtype PubMed ID
dgv15n68 CNV loss 17160897
esv2666053 CNV deletion 23128226
esv2669519 CNV deletion 23128226
esv2744613 CNV deletion 23290073
esv29993 CNV loss 17803354
esv3431264 CNV duplication 20981092
esv3626656 CNV loss 21293372
esv996910 CNV loss 20482838
nsv1042075 CNV loss 25217958
nsv1078325 CNV duplication 25765185
nsv1134139 CNV deletion 24896259
nsv1141196 CNV duplication 24896259
nsv1143685 CNV deletion 24896259
nsv1159904 CNV deletion 26073780
nsv354 CNV insertion 18451855
nsv356 CNV deletion 18451855
nsv469961 CNV loss 18288195
nsv473286 CNV novel sequence insertion 20440878
nsv555181 CNV loss 21841781
nsv555182 CNV loss 21841781
nsv555183 CNV loss 21841781
nsv555184 CNV loss 21841781
nsv951010 CNV deletion 24416366

Variation tolerance for MACROD1 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MACROD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MACROD1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MACROD1 Gene

Disorders for MACROD1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MACROD1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
hypercholesterolemia, familial, 4
  • fhcl4
endometrial cancer
  • endometrial cancer, familial
cardiomyopathy, dilated, 1e
  • cmd1e
familial hypercholesterolemia
  • familial hyperbetalipoproteinaemia
hereditary spastic paraplegia
  • familial spastic paraplegia
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

MACD1_HUMAN
  • Note=A chromosomal aberration involving MACROD1 is found in acute leukemia. Translocation t(11;21)(q13;q22) that forms a RUNX1-MACROD1 fusion protein. {ECO:0000269 PubMed:17532767}.

Additional Disease Information for MACROD1

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MACROD1: view

No data available for Genatlas for MACROD1 Gene

Publications for MACROD1 Gene

  1. Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases. (PMID: 23474714) Rosenthal F … Hottiger MO (Nature structural & molecular biology 2013) 2 3 4
  2. A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. (PMID: 23474712) Jankevicius G … Ladurner AG (Nature structural & molecular biology 2013) 3 4
  3. Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases. (PMID: 21257746) Chen D … Ahel I (The Journal of biological chemistry 2011) 3 4
  4. The single-macro domain protein LRP16 is an essential cofactor of androgen receptor. (PMID: 19022849) Yang J … Han WD (Endocrine-related cancer 2009) 3 4
  5. Differential induction of LRP16 by liganded and unliganded estrogen receptor alpha in SKOV3 ovarian carcinoma cells. (PMID: 19403568) Tian L … Han W (The Journal of endocrinology 2009) 3 4

ExternalLinks

View latest publications for MACROD1 gene in Mastermind

Products for MACROD1 Gene

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