Aliases for MACC1 Gene
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]
GeneCards Summary for MACC1 Gene
MACC1 (MACC1, MET Transcriptional Regulator) is a Protein Coding gene. Diseases associated with MACC1 include Renal Pelvis Carcinoma and Klatskin's Tumor. Among its related pathways are PI3K / Akt Signaling and Tyrosine Kinases / Adaptors. Gene Ontology (GO) annotations related to this gene include growth factor activity. An important paralog of this gene is SH3BP4.
UniProtKB/Swiss-Prot for MACC1 Gene
Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.