Aliases for MAB21L4 Gene
Aliases for MAB21L4 Gene
External Ids for MAB21L4 Gene
- HGNC: 26216
- Entrez Gene: 79919
- Ensembl: ENSG00000172478
- UniProtKB: Q08AI8
Previous HGNC Symbols for MAB21L4 Gene
- C2orf54
Summaries for MAB21L4 Gene
GeneCards Summary for MAB21L4 Gene
MAB21L4 (Mab-21 Like 4) is a Protein Coding gene. An important paralog of this gene is MB21D2.
Additional gene information for MAB21L4 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAB21L4 Gene
Genomics for MAB21L4 Gene
GeneHancer (GH) Regulatory Elements for MAB21L4 Gene
Promoters and enhancers for MAB21L4 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J240895 | Promoter/Enhancer | 1.6 | Ensembl ENCODE dbSUPER | 621.5 | -0.7 | -675 | 3.4 | SP1 PPARG KLF14 SP5 ZNF644 KAT8 GLIS2 RXRA ZIC2 GATAD2A | MAB21L4 AGXT CROCC2 | |
| GH02J240892 | Promoter/Enhancer | 0.9 | EPDnew dbSUPER | 618.8 | +4.8 | 4834 | 0.1 | ZIC2 NFIC | MAB21L4 ENSG00000229996 AGXT | |
| GH02J240896 | Promoter/Enhancer | 0.7 | Ensembl dbSUPER | 620.2 | +1.8 | 1788 | 0.2 | MAB21L4 AGXT | ||
| GH02J240818 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE | 14.3 | +76.8 | 76756 | 3.3 | ZNF652 CREB1 GLIS2 ZBTB8A PRDM10 ZIC2 POLR2A PATZ1 ZNF501 ZNF341 | KIF1A NDUFA10 MAB21L4 AGXT MTERF4 GC02P240756 | |
| GH02J240893 | Promoter/Enhancer | 1.1 | Ensembl dbSUPER | 20.3 | +3.1 | 3088 | 1.2 | RXRA ESRRA PKNOX1 NR2F1 ZFHX2 ZNF189 ELF1 MAZ ZFP91 FOS | MAB21L4 AGXT |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAB21L4 on UCSC Golden Path with GeneCards custom track
Genomic Locations for MAB21L4 Gene
Genomic Locations for MAB21L4 Gene
- chr2:240,886,048-240,896,889
- (GRCh38/hg38)
- Size:
- 10,842 bases
- Orientation:
- Minus strand
- chr2:241,825,465-241,836,306
- (GRCh37/hg19)
- Size:
- 10,842 bases
- Orientation:
- Minus strand
Genomic View for MAB21L4 Gene
Genes around MAB21L4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q37.3 by HGNC
- 2q37.3 by Entrez Gene
- 2q37.3 by Ensembl
MAB21L4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAB21L4 Gene
Proteins for MAB21L4 Gene
-
Protein details for MAB21L4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q08AI8-MB214_HUMAN
- Recommended name:
- Protein mab-21-like 4
- Protein Accession:
- Q08AI8
- B3KPP9
- H7BXM3
- Q08AI9
- Q53QU5
- Q9H622
Protein attributes for MAB21L4 Gene
- Size:
- 447 amino acids
- Molecular mass:
- 49565 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for MAB21L4 Gene
Other Protein References for MAB21L4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MAB21L4
- Invitrogen Antibodies for MAB21L4 (AFLGC-C2orf54)
-
Biorbyt antibodies for MAB21L4
Protein Products
-
OriGene Purified Proteins for MAB21L4
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No data available for DME Specific Peptides for MAB21L4 Gene
Domains & Families for MAB21L4 Gene
Gene Families for MAB21L4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MAB21L4 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MAB21L4 Gene
Function for MAB21L4 Gene
Phenotypes From GWAS Catalog for MAB21L4 Gene
Phenotypes for MAB21L4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAB21L4 - Now 50% OFF >
- * MAB21L4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for MAB21L4
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- genomics-online: gRNA clones - Search results for 42 available C2ORF54 gene related products
- Overview of 42 available C2ORF54 gene related products
miRNA Products
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 42 available C2ORF54 gene related products
- Overview of 42 available C2ORF54 gene related products
Clone Products
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- * MAB21L4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MAB21L4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
OriGene ORF clones in human for MAB21L4
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Cell Line Products
-
Horizon Cell Lines for MAB21L4
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAB21L4 Gene
Localization for MAB21L4 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| golgi apparatus | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 0 |
| cytosol | 0 |
- Golgi apparatus (2)
- Nucleoplasm (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAB21L4 Gene
Pathways & Interactions for MAB21L4 Gene
Interacting Proteins for MAB21L4 Gene
GPS-Prot Interaction Network for MAB21L4
No data available for Pathways by source and SIGNOR curated interactions for MAB21L4 Gene
Transcripts for MAB21L4 Gene
mRNA/cDNA for MAB21L4 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (1) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000402775 1958 bps (ENST00000402775.6)
- ENST00000307486 2017 bps (ENST00000307486.12)
- ENST00000388934 2525 bps (ENST00000388934.4)
- ENST00000414499 549 bps (ENST00000414499.1)
- ENST00000454476 371 bps (ENST00000454476.2)
Unigene Clusters for MAB21L4 Gene
- Chromosome 2 open reading frame 54:
- Representative Sequences:
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAB21L4 - Now 50% OFF >
- * MAB21L4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MAB21L4 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for MAB21L4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAB21L4
- genomics-online: gRNA clones - Search results for 42 available C2ORF54 gene related products
- Overview of 42 available C2ORF54 gene related products
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MAB21L4
- Browse OriGene Inhibitory RNA Products For MAB21L4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAB21L4
- genomics-online: shRNA clones - Search results for 42 available C2ORF54 gene related products
- Overview of 42 available C2ORF54 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for MAB21L4 - Now 50% OFF >
- * MAB21L4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MAB21L4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
OriGene ORF clones in human for MAB21L4
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- Sino Biological Human cDNA Clone for MAB21L4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAB21L4
Expression for MAB21L4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
-
Epidermis (Integumentary System)
NURSA nuclear receptor signaling pathways regulating expression of MAB21L4 Gene:
MAB21L4SOURCE GeneReport for Unigene cluster for MAB21L4 Gene:
Hs.193745Primer Products
-
OriGene qPCR primer pairs for MAB21L4
- genomics-online: primer clones - Search results for 42 available C2ORF54 gene related products
- Overview of 42 available C2ORF54 gene related products
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAB21L4 Gene
Orthologs for MAB21L4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C2BH2orf54 34 |
|
||
| C2orf54 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | C25H2orf54 34 |
|
||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | C3H2orf54 34 |
|
||
| C2orf54 35 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | 2310007B03Rik 35 34 |
|
OneToOne | |
| Mab21l4 17 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | RGD1563692 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | C2orf54 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | C2orf54 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | C2ORF54 34 |
|
||
| C2orf54 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | C2orf54 35 |
|
OneToOne |
- Species where no ortholog for MAB21L4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MAB21L4 Gene
Variants for MAB21L4 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000048060 | -- | 240,888,003(-) | G/T | intron_variant | |
| rs1000161998 | -- | 240,887,721(-) | G/C | intron_variant | |
| rs1000189270 | -- | 240,885,755(-) | T/G | downstream_transcript_variant | |
| rs1000197132 | -- | 240,892,415(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000277078 | -- | 240,886,095(-) | G/A | 3_prime_UTR_variant |
Residual Variation Intolerance Score:
83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.20;
69.80% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAB21L4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MAB21L4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAB21L4 Gene
Disorders for MAB21L4 Gene
Additional Disease Information for MAB21L4
No disorders were found for MAB21L4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAB21L4 Gene
Publications for MAB21L4 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
ExternalLinks
Products for MAB21L4 Gene
- Custom Antibody ServicesOriGene Antibodies for MAB21L4
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- Custom Assay Services
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- OriGene qPCR primer pairs for MAB21L4
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Sources for MAB21L4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) HGMD
- (45) GAD
- (46) BGMUT
- (47) HuGE
- (48) Atlas
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) OCA
- (69) Proteopedia
- (70) MOPED
- (71) neXtProt
- (72) Reactome
- (73) GeneGo (Thomson Reuters)
- (74) fRNAdb
- (75) DISEASES
- (76) SIMAP
- (77) GenomeRNAi
- (78) LifeMap
- (79) miRTarBase
- (80) MalaCards
- (81) Invitrogen
- (82) BitterDB
- (83) ESI-BIO
- (84) RefSeq
- (85) BioSystems
- (86) MaxQB
- (87) IUPHAR
- (88) BioGPS
- (89) Illumina
- (90) COMPARTMENTS
- (91) HOMER
- (92) PaxDb
- (93) ApexBio
- (94) Addgene
- (95) antibodies-online
- (96) CYP
- (97) NONCODE
- (98) SwitchGear Genomics
- (99) TreeFam
- (100) PathCards
- (101) GeneReviews
- (102) GeneTex
- (103) Taconic Biosciences
- (104) GTEx
- (105) ProteomicsDB
- (106) SCBT
- (107) DGIdb
- (108) ClinicalTrials
- (109) FDA Approved Drugs
- (110) RVIS
- (111) SIGNOR
- (112) diseasecard
- (113) NIH Rare Diseases
- (114) Orphanet
- (115) UMLS
- (116) GTR
- (117) Disease Ontology
- (118) Genetics Home Reference
- (119) MeSH
- (120) MedlinePlus
- (121) CDC
- (122) NINDS
- (123) NCBI Bookshelf
- (124) ClinVar
- (125) Gene Damage Index
- (126) ViGene Biosciences
- (127) HPO
- (128) UDN
- (129) VISTA
- (130) FANTOM5
- (131) ENCODE
- (132) ProSci
- (133) Horizon
- (134) NURSA
- (135) IID
- (136) Cyagen
- (137) VectorBuilder
- (138) SNPedia
- (139) BRCA Exchange
- (140) St John's Lab
- (141) CIViC
- (142) ProteoGenix
- (143) dbSUPER
- (144) TISSUES
- (145) Gene ORGANizer
- (146) abm
- (147) CrownBio
- (148) Human Protein Atlas
- (149) GWAS Catalog
- (150) Monarch Initiative
- (151) DataMed
- (152) HumanCyc
- (153) genomics-online
- (154) UCNEbase
- (155) EPDnew
- (156) Applied Biosystems
- (157) GlyConnect
- (158) Aminode
- (159) GeneCopoeia
- (160) GPS-Prot
- (161) RNACentral
- (162) LncRNADisease
- (163) LOVD
- (164) miR2Disease
- (165) DiseaseEnhancer
- (166) Boster Bio
- (167) Biorbyt
- (168) Biocompare
- (169) Mastermind