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Aliases for MAB21L3 Gene

Aliases for MAB21L3 Gene

  • Mab-21 Like 3 2 3 5
  • C1orf161 3 4
  • Chromosome 1 Open Reading Frame 161 2
  • Mab-21-Like 3 (C. Elegans) 2
  • Protein Mab-21-Like 3 3

External Ids for MAB21L3 Gene

Previous HGNC Symbols for MAB21L3 Gene

  • C1orf161

Previous GeneCards Identifiers for MAB21L3 Gene

  • GC01P116655
  • GC01P116111

Summaries for MAB21L3 Gene

GeneCards Summary for MAB21L3 Gene

MAB21L3 (Mab-21 Like 3) is a Protein Coding gene. An important paralog of this gene is MAB21L2.

Additional gene information for MAB21L3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAB21L3 Gene

Genomics for MAB21L3 Gene

GeneHancer (GH) Regulatory Elements for MAB21L3 Gene

Promoters and enhancers for MAB21L3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I116109 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.3 +35.5 35482 3.4 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 ARID4B DMAP1 ZNF48 YY1 ATF7 GC01P116110 MAB21L3 CD58 IGSF3 LOC105378918
GH01I116076 Enhancer 0.5 ENCODE 550.8 +0.4 383 0.2 JUND JUN CEBPB EP300 MAB21L3 GC01M116040
GH01I115975 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.1 -98.3 -98312 3.8 PKNOX1 SIN3A YY1 ZNF766 ZNF213 SP3 REST ZSCAN16 HMBOX1 SETDB1 SLC22A15 LOC101928977 ATP1A1-AS1 ENSG00000237993 CASQ2 MAB21L3 IGSF3 ATP1A1
GH01I116150 Enhancer 1.2 Ensembl ENCODE 7 +76.5 76543 3 FOXA2 ARID4B DMAP1 ZNF2 IRF4 YY1 CBX5 ZNF143 SP5 ZHX2 MAB21L3 SLC22A15 ATP1A1 LINC01779 LOC105378918
GH01I116138 Enhancer 1.2 Ensembl ENCODE 5.1 +63.5 63494 1 HDGF ARNT ZFP64 ARID4B DMAP1 ZNF2 IRF4 SLC30A9 ZNF143 ZNF548 ATP1A1 SLC22A15 MAB21L3 LOC105378918 LINC01779
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAB21L3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MAB21L3 Gene

Genomic Locations for MAB21L3 Gene
chr1:116,075,792-116,135,240
(GRCh38/hg38)
Size:
59,449 bases
Orientation:
Plus strand
chr1:116,654,376-116,677,861
(GRCh37/hg19)

Genomic View for MAB21L3 Gene

Genes around MAB21L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAB21L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAB21L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAB21L3 Gene

Proteins for MAB21L3 Gene

  • Protein details for MAB21L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8X9-MB213_HUMAN
    Recommended name:
    Protein mab-21-like 3
    Protein Accession:
    Q8N8X9
    Secondary Accessions:
    • Q5TDL7

    Protein attributes for MAB21L3 Gene

    Size:
    362 amino acids
    Molecular mass:
    42357 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAB21L3 Gene

Post-translational modifications for MAB21L3 Gene

No Post-translational modifications

Other Protein References for MAB21L3 Gene

No data available for DME Specific Peptides for MAB21L3 Gene

Domains & Families for MAB21L3 Gene

Gene Families for MAB21L3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAB21L3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAB21L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N8X9

UniProtKB/Swiss-Prot:

MB213_HUMAN :
  • Belongs to the mab-21 family.
Family:
  • Belongs to the mab-21 family.
genes like me logo Genes that share domains with MAB21L3: view

Function for MAB21L3 Gene

Phenotypes From GWAS Catalog for MAB21L3 Gene

Gene Ontology (GO) - Molecular Function for MAB21L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAB21L3: view
genes like me logo Genes that share phenotypes with MAB21L3: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAB21L3 Gene

Localization for MAB21L3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAB21L3 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAB21L3 Gene

Pathways & Interactions for MAB21L3 Gene

SuperPathways for MAB21L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAB21L3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAB21L3 Gene

Drugs & Compounds for MAB21L3 Gene

No Compound Related Data Available

Transcripts for MAB21L3 Gene

mRNA/cDNA for MAB21L3 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAB21L3 Gene

Mab-21-like 3 (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAB21L3 Gene

No ASD Table

Relevant External Links for MAB21L3 Gene

GeneLoc Exon Structure for
MAB21L3
ECgene alternative splicing isoforms for
MAB21L3

Expression for MAB21L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAB21L3 Gene

mRNA differential expression in normal tissues according to GTEx for MAB21L3 Gene

This gene is overexpressed in Esophagus - Mucosa (x12.2), Liver (x5.9), and Vagina (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of MAB21L3 Gene:

MAB21L3

SOURCE GeneReport for Unigene cluster for MAB21L3 Gene:

Hs.376194
genes like me logo Genes that share expression patterns with MAB21L3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAB21L3 Gene

Orthologs for MAB21L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAB21L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAB21L3 33 34
  • 99.17 (n)
dog
(Canis familiaris)
Mammalia MAB21L3 33 34
  • 85.08 (n)
cow
(Bos Taurus)
Mammalia MAB21L3 33 34
  • 82.4 (n)
rat
(Rattus norvegicus)
Mammalia Mab21l3 33
  • 79.93 (n)
mouse
(Mus musculus)
Mammalia Mab21l3 33 16 34
  • 79.65 (n)
oppossum
(Monodelphis domestica)
Mammalia MAB21L3 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAB21L3 34
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAB21L3 33 34
  • 71.43 (n)
lizard
(Anolis carolinensis)
Reptilia MAB21L3 34
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mab21l3 33 34
  • 61.72 (n)
worm
(Caenorhabditis elegans)
Secernentea mab-21 34
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToOne
Species where no ortholog for MAB21L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAB21L3 Gene

ENSEMBL:
Gene Tree for MAB21L3 (if available)
TreeFam:
Gene Tree for MAB21L3 (if available)

Paralogs for MAB21L3 Gene

Paralogs for MAB21L3 Gene

genes like me logo Genes that share paralogs with MAB21L3: view

Variants for MAB21L3 Gene

Sequence variations from dbSNP and Humsavar for MAB21L3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000013150 -- 116,110,875(+) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000109836 -- 116,132,409(+) G/A intron_variant
rs1000143747 -- 116,089,882(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000198880 -- 116,073,496(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000240759 -- 116,117,285(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAB21L3 Gene

Variant ID Type Subtype PubMed ID
nsv831126 CNV gain 17160897
esv3567898 CNV gain 25503493
esv27976 CNV loss 19812545

Variation tolerance for MAB21L3 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAB21L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAB21L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAB21L3 Gene

Disorders for MAB21L3 Gene

Additional Disease Information for MAB21L3

No disorders were found for MAB21L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAB21L3 Gene

Publications for MAB21L3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for MAB21L3 Gene

Sources for MAB21L3 Gene

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