Aliases for M6PR Gene
External Ids for M6PR Gene
Previous GeneCards Identifiers for M6PR Gene
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
GeneCards Summary for M6PR Gene
M6PR (Mannose-6-Phosphate Receptor, Cation Dependent) is a Protein Coding gene. Diseases associated with M6PR include Niemann-Pick Disease and Mucolipidosis Ii Alpha/Beta. Among its related pathways are Clathrin derived vesicle budding and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and mannose transmembrane transporter activity.
UniProtKB/Swiss-Prot for M6PR Gene
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.