Aliases for LRRC69 Gene

Aliases for LRRC69 Gene

  • Leucine Rich Repeat Containing 69 2 3 5
  • Leucine-Rich Repeat-Containing Protein 69 3 4
  • LRRC69 5

External Ids for LRRC69 Gene

Previous GeneCards Identifiers for LRRC69 Gene

  • GC08U901021
  • GC08P092186
  • GC08P092114
  • GC08P087326

Summaries for LRRC69 Gene

GeneCards Summary for LRRC69 Gene

LRRC69 (Leucine Rich Repeat Containing 69) is a Protein Coding gene.

Additional gene information for LRRC69 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC69 Gene

Genomics for LRRC69 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRRC69 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J091038 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 7.5 -61.7 -61687 4.3 CREB1 PRDM10 TFE3 ZNF512 RFX1 LEF1 IKZF1 KDM1A ZNF692 POLR2A PIP4P2 OTUD6B-AS1 SLC26A7 LRRC69 ENSG00000254251 RF00100-148 C8orf88
GH08J090983 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 9.8 -116.8 -116831 2.4 HNRNPL PRDM10 IKZF1 KDM1A ZNF692 POLR2A BACH1 ZNF143 PHF21A PKNOX1 C8orf88 ENSG00000246792 OTUD6B OTUD6B-AS1 LRRC69 ENSG00000254251 TMEM64 piR-61532-320 NECAB1
GH08J091179 Enhancer 0.8 Ensembl ENCODE 11.5 +78.7 78659 1.4 JUND CEBPB JUN YY1 FOSL1 MAX EP300 FOSL2 CEBPG SPI1 SLC26A7 LRRC69 piR-61532-321 MIR4661
GH08J091068 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 4.4 -31.8 -31831 3.6 SP1 CREB1 PRDM10 REST ZNF629 ZNF512 RFX1 IKZF1 NFKBIZ POLR2A OTUD6B-AS1 OTUD6B PIP4P2 SLC26A7 ENSG00000246792 LRRC69 lnc-OTUD6B-2
GH08J091118 Enhancer 0.5 Ensembl 11.2 +16.5 16469 1.4 CREB1 CEBPB JUND CEBPG ATF3 NFRKB OTUD6B-AS1 SLC26A7 LRRC69 piR-50437-640 lnc-OTUD6B-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC69 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC69

Top Transcription factor binding sites by QIAGEN in the LRRC69 gene promoter:
  • CUTL1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • FOXC1
  • FOXL1
  • HNF-3beta

Genomic Locations for LRRC69 Gene

Genomic Locations for LRRC69 Gene
117,423 bases
Plus strand
117,405 bases
Plus strand

Genomic View for LRRC69 Gene

Genes around LRRC69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC69 Gene

Proteins for LRRC69 Gene

  • Protein details for LRRC69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 69
    Protein Accession:

    Protein attributes for LRRC69 Gene

    347 amino acids
    Molecular mass:
    39592 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC69 Gene


neXtProt entry for LRRC69 Gene

Post-translational modifications for LRRC69 Gene

  • Ubiquitination at Lys24
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC69 Gene

No data available for DME Specific Peptides for LRRC69 Gene

Domains & Families for LRRC69 Gene

Gene Families for LRRC69 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC69 Gene

Suggested Antigen Peptide Sequences for LRRC69 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein 69 (LRC69_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LRRC69 family.
  • Belongs to the LRRC69 family.
genes like me logo Genes that share domains with LRRC69: view

Function for LRRC69 Gene

Phenotypes From GWAS Catalog for LRRC69 Gene

Gene Ontology (GO) - Molecular Function for LRRC69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LRRC69: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC69

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC69 Gene

Localization for LRRC69 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC69 gene
Compartment Confidence
plasma membrane 2
mitochondrion 2
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC69 Gene

Pathways & Interactions for LRRC69 Gene

PathCards logo

SuperPathways for LRRC69 Gene

No Data Available

Interacting Proteins for LRRC69 Gene

Gene Ontology (GO) - Biological Process for LRRC69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA 21873635
genes like me logo Genes that share ontologies with LRRC69: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC69 Gene

Drugs & Compounds for LRRC69 Gene

No Compound Related Data Available

Transcripts for LRRC69 Gene

mRNA/cDNA for LRRC69 Gene

2 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC69

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC69 Gene

No ASD Table

Relevant External Links for LRRC69 Gene

GeneLoc Exon Structure for

Expression for LRRC69 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC69 Gene

Protein differential expression in normal tissues from HIPED for LRRC69 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC69 Gene

Protein tissue co-expression partners for LRRC69 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC69

SOURCE GeneReport for Unigene cluster for LRRC69 Gene:

genes like me logo Genes that share expression patterns with LRRC69: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC69 Gene

Orthologs for LRRC69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC69 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC69 30 31
  • 99.81 (n)
(Canis familiaris)
Mammalia LRRC69 30 31
  • 85.21 (n)
(Bos Taurus)
Mammalia LRRC69 30 31
  • 85.21 (n)
(Rattus norvegicus)
Mammalia Lrrc69 30
  • 76.03 (n)
(Mus musculus)
Mammalia Lrrc69 30 17 31
  • 75.72 (n)
(Ornithorhynchus anatinus)
Mammalia LRRC69 31
  • 55 (a)
(Monodelphis domestica)
Mammalia LRRC69 31
  • 46 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lrrc69 30
  • 57.05 (n)
(Danio rerio)
Actinopterygii si:ch73-302o18.2 30
  • 50.78 (n)
LRRC69 31
  • 37 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5771 31
  • 40 (a)
Species where no ortholog for LRRC69 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LRRC69 Gene

Gene Tree for LRRC69 (if available)
Gene Tree for LRRC69 (if available)
Evolutionary constrained regions (ECRs) for LRRC69: view image

Paralogs for LRRC69 Gene

No data available for Paralogs for LRRC69 Gene

Variants for LRRC69 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC69 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs11785003 - p.Thr64Ile

Additional dbSNP identifiers (rs#s) for LRRC69 Gene

Structural Variations from Database of Genomic Variants (DGV) for LRRC69 Gene

Variant ID Type Subtype PubMed ID
dgv12235n54 CNV loss 21841781
dgv3860n106 CNV deletion 24896259
dgv7268n100 CNV loss 25217958
esv1005988 CNV insertion 20482838
esv2195824 CNV deletion 18987734
esv2523005 CNV deletion 19546169
esv2656822 CNV deletion 23128226
esv2670300 CNV deletion 23128226
esv2737291 CNV deletion 23290073
esv2759629 CNV loss 17122850
esv3325601 CNV insertion 20981092
esv3452204 CNV insertion 20981092
esv35058 CNV loss 17911159
esv3543836 CNV deletion 23714750
esv3572901 CNV loss 25503493
esv3618014 CNV loss 21293372
esv3618015 CNV loss 21293372
esv3618016 CNV loss 21293372
esv3618017 CNV loss 21293372
esv3891440 CNV loss 25118596
esv6601 OTHER inversion 19470904
esv995698 CNV deletion 20482838
nsv1076096 CNV deletion 25765185
nsv1149896 CNV deletion 26484159
nsv398405 CNV insertion 16902084
nsv465736 CNV loss 19166990
nsv524992 CNV loss 19592680
nsv525292 CNV loss 19592680
nsv611721 CNV loss 21841781
nsv6301 CNV insertion 18451855
nsv831390 CNV gain 17160897
nsv957679 CNV deletion 24416366
nsv967617 CNV duplication 23825009

Variation tolerance for LRRC69 Gene

Gene Damage Index Score: 1.78; 33.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC69 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC69 Gene

Disorders for LRRC69 Gene

Additional Disease Information for LRRC69

No disorders were found for LRRC69 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC69 Gene

Publications for LRRC69 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway. (PMID: 30561431) Van Quickelberghe E … Gevaert K (Scientific data 2018) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for LRRC69 Gene

Sources for LRRC69 Gene