The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessa... See more...

Aliases for LZTS2 Gene

Aliases for LZTS2 Gene

  • Leucine Zipper Tumor Suppressor 2 2 3 5
  • Leucine Zipper, Putative Tumor Suppressor 2 2 3
  • Leucine Zipper Putative Tumor Suppressor 2 3 4
  • Protein LAPSER1 3 4
  • LAPSER1 3 4
  • KIAA1813 4
  • HLZTS2 4

External Ids for LZTS2 Gene

Previous GeneCards Identifiers for LZTS2 Gene

  • GC10P102424
  • GC10P102746
  • GC10P096386
  • GC10P102756

Summaries for LZTS2 Gene

Entrez Gene Summary for LZTS2 Gene

  • The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for LZTS2 Gene

LZTS2 (Leucine Zipper Tumor Suppressor 2) is a Protein Coding gene. An important paralog of this gene is LZTS1.

UniProtKB/Swiss-Prot Summary for LZTS2 Gene

  • Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.

Additional gene information for LZTS2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LZTS2 Gene

Genomics for LZTS2 Gene

GeneHancer (GH) Regulatory Elements for LZTS2 Gene

Promoters and enhancers for LZTS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LZTS2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LZTS2

Top Transcription factor binding sites by QIAGEN in the LZTS2 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • NF-kappaB1
  • Pax-5
  • Sp1

Genomic Locations for LZTS2 Gene

Genomic Locations for LZTS2 Gene
chr10:100,996,618-101,007,836
(GRCh38/hg38)
Size:
11,219 bases
Orientation:
Plus strand
chr10:102,756,375-102,767,593
(GRCh37/hg19)
Size:
11,219 bases
Orientation:
Plus strand

Genomic View for LZTS2 Gene

Genes around LZTS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LZTS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LZTS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LZTS2 Gene

Proteins for LZTS2 Gene

  • Protein details for LZTS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRK4-LZTS2_HUMAN
    Recommended name:
    Leucine zipper putative tumor suppressor 2
    Protein Accession:
    Q9BRK4
    Secondary Accessions:
    • B1AL14
    • D3DR72
    • Q8N3I0
    • Q96J79
    • Q96JL2

    Protein attributes for LZTS2 Gene

    Size:
    669 amino acids
    Molecular mass:
    72759 Da
    Quaternary structure:
    • Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
    SequenceCaution:
    • Sequence=BAB47442.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LZTS2 Gene

Post-translational modifications for LZTS2 Gene

  • Ubiquitination at Lys615
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LZTS2 Gene

Domains & Families for LZTS2 Gene

Gene Families for LZTS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LZTS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LZTS2 Gene

GenScript: Design optimal peptide antigens:
  • Protein LAPSER1 (LZTS2_HUMAN)
  • LZTS2 protein (Q9BRY6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BRK4

UniProtKB/Swiss-Prot:

LZTS2_HUMAN :
  • Belongs to the LZTS2 family.
Family:
  • Belongs to the LZTS2 family.
genes like me logo Genes that share domains with LZTS2: view

Function for LZTS2 Gene

Molecular function for LZTS2 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
UniProtKB/Swiss-Prot Induction:
By inhibition of NF-kappa-B signaling.

Phenotypes From GWAS Catalog for LZTS2 Gene

Gene Ontology (GO) - Molecular Function for LZTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with LZTS2: view
genes like me logo Genes that share phenotypes with LZTS2: view

Animal Models for LZTS2 Gene

MGI Knock Outs for LZTS2:

Animal Model Products

CRISPR Products

miRNA for LZTS2 Gene

miRTarBase miRNAs that target LZTS2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LZTS2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LZTS2 Gene

Localization for LZTS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LZTS2 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LZTS2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 4
nucleus 3
extracellular 1
endosome 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LZTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with LZTS2: view

Pathways & Interactions for LZTS2 Gene

PathCards logo

SuperPathways for LZTS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LZTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IEA --
GO:0001822 kidney development IEA --
GO:0007049 cell cycle IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with LZTS2: view

No data available for Pathways by source and SIGNOR curated interactions for LZTS2 Gene

Drugs & Compounds for LZTS2 Gene

No Compound Related Data Available

Transcripts for LZTS2 Gene

mRNA/cDNA for LZTS2 Gene

4 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LZTS2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LZTS2 Gene

No ASD Table

Relevant External Links for LZTS2 Gene

GeneLoc Exon Structure for
LZTS2

Expression for LZTS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LZTS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LZTS2 Gene

This gene is overexpressed in Urine (48.6) and Testis (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LZTS2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LZTS2

SOURCE GeneReport for Unigene cluster for LZTS2 Gene:

Hs.523221

mRNA Expression by UniProt/SwissProt for LZTS2 Gene:

Q9BRK4-LZTS2_HUMAN
Tissue specificity: Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.

Evidence on tissue expression from TISSUES for LZTS2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with LZTS2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LZTS2 Gene

Orthologs for LZTS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LZTS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LZTS2 31 30
  • 99.5 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LZTS2 31 30
  • 90.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LZTS2 31 30
  • 89.27 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lzts2 17 31 30
  • 86.84 (n)
rat
(Rattus norvegicus)
Mammalia Lzts2 30
  • 85.8 (n)
oppossum
(Monodelphis domestica)
Mammalia LZTS2 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LZTS2 31
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves LZTS2 31 30
  • 68.09 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LZTS2 31
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lzts2 30
  • 58.92 (n)
zebrafish
(Danio rerio)
Actinopterygii lzts2a 31 30
  • 58.87 (n)
OneToMany
lzts2b 31
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3837 31
  • 35 (a)
OneToMany
Species where no ortholog for LZTS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LZTS2 Gene

ENSEMBL:
Gene Tree for LZTS2 (if available)
TreeFam:
Gene Tree for LZTS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LZTS2: view image

Paralogs for LZTS2 Gene

Paralogs for LZTS2 Gene

(2) SIMAP similar genes for LZTS2 Gene using alignment to 6 proteins:

  • LZTS2_HUMAN
  • B1AL11_HUMAN
  • B1AL12_HUMAN
  • B1AL13_HUMAN
  • Q9BRY6_HUMAN
  • S4R3W7_HUMAN
genes like me logo Genes that share paralogs with LZTS2: view

Variants for LZTS2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LZTS2 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
736827 Benign: not provided 101,002,682(+) C/T SYNONYMOUS_VARIANT
rs1235690743 A breast cancer sample p.Gly291Arg
rs367898512 A colorectal cancer sample p.Arg121His
rs2275381 - p.Arg299Trp

Additional dbSNP identifiers (rs#s) for LZTS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for LZTS2 Gene

Variant ID Type Subtype PubMed ID
nsv467443 CNV loss 19166990
nsv517698 CNV loss 19592680
nsv831965 CNV loss 17160897

Variation tolerance for LZTS2 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LZTS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LZTS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LZTS2 Gene

Disorders for LZTS2 Gene

Additional Disease Information for LZTS2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LZTS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LZTS2 Gene

Publications for LZTS2 Gene

  1. LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing. (PMID: 18490357) Sudo H … Maru Y (Human molecular genetics 2008) 2 3 4 23 54
  2. LAPSER1: a novel candidate tumor suppressor gene from 10q24.3. (PMID: 11709705) Cabeza-Arvelaiz Y … Chinault AC (Oncogene 2001) 2 3 4 23 54
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 54
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 41 54
  5. Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is mediated by lzts2 in human adipose tissue-derived mesenchymal stem cells. (PMID: 17950943) Hyun Hwa Cho … Jin Sup Jung (Biochimica et biophysica acta 2008) 3 4 54

Products for LZTS2 Gene

Sources for LZTS2 Gene