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This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]
LZTS1 (Leucine Zipper Tumor Suppressor 1) is a Protein Coding gene. Diseases associated with LZTS1 include Esophageal Cancer and Ehlers-Danlos Syndrome, Hypermobility Type. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is LZTS2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH08J020302 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 250.7 | +0.9 | 871 | 3.8 | ZIC2 SIN3A VEZF1 GABPB1 SMARCA4 ZNF189 GLIS1 L3MBTL2 TFAP4 POLR2A | LZTS1 piR-45517-008 ATP6V1B2 | |
GH08J020255 | Promoter | 0.3 | EPDnew | 261.3 | +48.6 | 48614 | 0.1 | LZTS1 RNU6-892P FJ601678-108 piR-57135-086 ATP6V1B2 | ||
GH08J020267 | Promoter/Enhancer | 1.4 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 25.2 | +35.4 | 35401 | 2.8 | ETS1 ZIC2 SIN3A PRDM1 ETV4 YY1 FOSL1 JUND TAF1 BHLHE40 | LZTS1 RNU6-892P piR-57135-086 LZTS1-AS1 ATP6V1B2 | |
GH08J020273 | Enhancer | 0.6 | ENCODE dbSUPER | 26.2 | +30.0 | 30027 | 1.3 | VEZF1 GABPA EBF1 GATA2 ZNF639 | LZTS1-AS1 LZTS1 RNU6-892P piR-57135-086 ATP6V1B2 | |
GH08J020264 | Enhancer | 0.6 | ENCODE dbSUPER | 24.5 | +38.7 | 38693 | 1.7 | ZNF146 CEBPG ATF4 CEBPB NR2F2 | piR-57135-086 LZTS1 RNU6-892P FJ601678-108 ATP6V1B2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 17349584 |
GO:0008017 | microtubule binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0014069 | postsynaptic density | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016324 | apical plasma membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007049 | cell cycle | IEA | -- |
GO:0016242 | negative regulation of macroautophagy | IMP | -- |
GO:0044772 | mitotic cell cycle phase transition | IEA | -- |
GO:0048167 | regulation of synaptic plasticity | IBA | 21873635 |
GO:0048814 | regulation of dendrite morphogenesis | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
cyclic amp | Experimental | Pharma | 0 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||
SP2: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LZTS1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LZTS1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LZTS1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lzts1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Lzts1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | LZTS1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | LZTS1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LZTS1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | LZTS1 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | lzts1 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3837 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs119473032 | Pathogenic: Esophageal squamous cell carcinoma, somatic. - | 20,253,576(-) |
T/Cp.Lys119Glu NM_021020.5(LZTS1):c.355A>G (p.Lys119Glu) |
MISSENSE | |
rs141630311 | Benign: not provided | 20,250,305(-) |
G/A NM_021020.5(LZTS1):c.1208C>T (p.Thr403Met) |
MISSENSE | |
rs149140637 | Benign: not provided | 20,254,844(-) |
A/G NM_021020.5(LZTS1):c.338T>C (p.Leu113Pro) |
MISSENSE | |
rs28937897 | Pathogenic: Esophageal squamous cell carcinoma, somatic. - | 20,255,097(-) |
A/Gp.Ser29Pro NM_021020.5(LZTS1):c.85T>C (p.Ser29Pro) |
MISSENSE | |
rs34620053 | - |
p.Ser50Phe |
Disorder | Aliases | PubMed IDs |
---|---|---|
esophageal cancer |
|
|
ehlers-danlos syndrome, hypermobility type |
|
|
squamous cell carcinoma |
|
|
collecting duct carcinoma |
|
|
bladder cancer |
|
|