LZTS1 Gene (Protein Coding)

Leucine Zipper Tumor Suppressor 1

GC08M020246
GIFtS:
39
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 co... See more...

Aliases for LZTS1 Gene

Aliases for LZTS1 Gene

  • Leucine Zipper Tumor Suppressor 1 2 3 5
  • F37/Esophageal Cancer-Related Gene-Coding Leucine-Zipper Motif 2 3 4
  • FEZ1 2 3 4
  • Leucine Zipper, Putative Tumor Suppressor 1 2 3
  • Leucine Zipper Putative Tumor Suppressor 1 3 4
  • LZTS1 5
  • Fez1 4
  • F37 3

External Ids for LZTS1 Gene

Previous GeneCards Identifiers for LZTS1 Gene

  • GC08M019978
  • GC08M020165
  • GC08M020113
  • GC08M020147
  • GC08M018643

Summaries for LZTS1 Gene

Entrez Gene Summary for LZTS1 Gene

  • This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]

GeneCards Summary for LZTS1 Gene

LZTS1 (Leucine Zipper Tumor Suppressor 1) is a Protein Coding gene. Diseases associated with LZTS1 include Esophageal Cancer and Ehlers-Danlos Syndrome, Hypermobility Type. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is LZTS2.

UniProtKB/Swiss-Prot Summary for LZTS1 Gene

  • Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.

Gene Wiki entry for LZTS1 Gene

Additional gene information for LZTS1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LZTS1 Gene

Genomics for LZTS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for LZTS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08J020302 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +0.9 871 3.8 ZIC2 SIN3A VEZF1 GABPB1 SMARCA4 ZNF189 GLIS1 L3MBTL2 TFAP4 POLR2A LZTS1 piR-45517-008 ATP6V1B2
GH08J020255 Promoter 0.3 EPDnew 261.3 +48.6 48614 0.1 LZTS1 RNU6-892P FJ601678-108 piR-57135-086 ATP6V1B2
GH08J020267 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 25.2 +35.4 35401 2.8 ETS1 ZIC2 SIN3A PRDM1 ETV4 YY1 FOSL1 JUND TAF1 BHLHE40 LZTS1 RNU6-892P piR-57135-086 LZTS1-AS1 ATP6V1B2
GH08J020273 Enhancer 0.6 ENCODE dbSUPER 26.2 +30.0 30027 1.3 VEZF1 GABPA EBF1 GATA2 ZNF639 LZTS1-AS1 LZTS1 RNU6-892P piR-57135-086 ATP6V1B2
GH08J020264 Enhancer 0.6 ENCODE dbSUPER 24.5 +38.7 38693 1.7 ZNF146 CEBPG ATF4 CEBPB NR2F2 piR-57135-086 LZTS1 RNU6-892P FJ601678-108 ATP6V1B2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LZTS1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LZTS1

Top Transcription factor binding sites by QIAGEN in the LZTS1 gene promoter:
  • AP-4
  • E47
  • IRF-2
  • MRF-2
  • Olf-1
  • p53
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1

Genomic Locations for LZTS1 Gene

Latest Assembly
chr8:20,246,165-20,303,963
(GRCh38/hg38)
Size:
57,799 bases
Orientation:
Minus strand

Previous Assembly
chr8:20,103,676-20,161,474
(GRCh37/hg19 by Entrez Gene)
Size:
57,799 bases
Orientation:
Minus strand

chr8:20,103,676-20,161,474
(GRCh37/hg19 by Ensembl)
Size:
57,799 bases
Orientation:
Minus strand

Genomic View for LZTS1 Gene

Genes around LZTS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LZTS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LZTS1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LZTS1 Gene

Proteins for LZTS1 Gene

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  • Protein details for LZTS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y250-LZTS1_HUMAN
    Recommended name:
    Leucine zipper putative tumor suppressor 1
    Protein Accession:
    Q9Y250
    Secondary Accessions:
    • D3DSQ6
    • Q9Y5V7
    • Q9Y5V8
    • Q9Y5V9
    • Q9Y5W0
    • Q9Y5W1
    • Q9Y5W2

    Protein attributes for LZTS1 Gene

    Size:
    596 amino acids
    Molecular mass:
    66613 Da
    Quaternary structure:
    • Binds EEF1G, TLK2 and CDK1.
    Miscellaneous:
    • Defects in LZTS1 are found in many types of tumors.

    Alternative splice isoforms for LZTS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LZTS1 Gene

Protein Expression for LZTS1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LZTS1 Gene

  • Phosphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LZTS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LZTS1 Gene

Domains & Families for LZTS1 Gene

Gene Families for LZTS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for LZTS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LZTS1 Gene

GenScript: Design optimal peptide antigens:
  • Fez1 (LZTS1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y250

UniProtKB/Swiss-Prot:

LZTS1_HUMAN :
  • Belongs to the LZTS family.
Family:
  • Belongs to the LZTS family.
genes like me logo Genes that share domains with LZTS1: view

Function for LZTS1 Gene

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  6. Cell Lines for research

Molecular function for LZTS1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.

Phenotypes From GWAS Catalog for LZTS1 Gene

Gene Ontology (GO) - Molecular Function for LZTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17349584
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with LZTS1: view
genes like me logo Genes that share phenotypes with LZTS1: view

Human Phenotype Ontology for LZTS1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LZTS1 Gene

MGI Knock Outs for LZTS1:

Animal Models for research

miRNA for LZTS1 Gene

miRTarBase miRNAs that target LZTS1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LZTS1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LZTS1 Gene

Localization for LZTS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LZTS1 Gene

Cytoplasm. Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LZTS1 gene
Compartment Confidence
plasma membrane 3
nucleus 3
mitochondrion 2
cytosol 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LZTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with LZTS1: view

Pathways & Interactions for LZTS1 Gene

PathCards logo

SuperPathways for LZTS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LZTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0016242 negative regulation of macroautophagy IMP --
GO:0044772 mitotic cell cycle phase transition IEA --
GO:0048167 regulation of synaptic plasticity IBA 21873635
GO:0048814 regulation of dendrite morphogenesis IBA 21873635
genes like me logo Genes that share ontologies with LZTS1: view

No data available for Pathways by source and SIGNOR curated interactions for LZTS1 Gene

Drugs & Compounds for LZTS1 Gene

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(1) Drugs for LZTS1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with LZTS1: view

Transcripts for LZTS1 Gene

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mRNA/cDNA for LZTS1 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LZTS1

Alternative Splicing Database (ASD) splice patterns (SP) for LZTS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for LZTS1 Gene

GeneLoc Exon Structure for
LZTS1

Expression for LZTS1 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LZTS1 Gene

mRNA expression in normal human tissues for LZTS1 Gene
mRNA expression by BioGPS for LZTS1 GenemRNA expression by GTEx for LZTS1 Gene

mRNA differential expression in normal tissues according to GTEx for LZTS1 Gene

This gene is overexpressed in Brain - Cortex (x5.2), Brain - Nucleus accumbens (basal ganglia) (x4.8), Brain - Amygdala (x4.3), Brain - Frontal Cortex (BA9) (x4.2), Brain - Caudate (basal ganglia) (x4.1), and Brain - Putamen (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for LZTS1 Gene

This gene is overexpressed in Lung (57.5) and Plasma (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LZTS1 Gene



Protein tissue co-expression partners for LZTS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LZTS1

SOURCE GeneReport for Unigene cluster for LZTS1 Gene:

Hs.521432

mRNA Expression by UniProt/SwissProt for LZTS1 Gene:

Q9Y250-LZTS1_HUMAN
Tissue specificity: Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines.

Evidence on tissue expression from TISSUES for LZTS1 Gene

  • Nervous system(4.7)

Phenotype-based relationships between genes and organs from Gene ORGANizer for LZTS1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • head
  • larynx
  • neck
  • vocal cord
Thorax:
  • esophagus
Abdomen:
  • stomach
General:
  • skin
genes like me logo Genes that share expression patterns with LZTS1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LZTS1 Gene

Orthologs for LZTS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LZTS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LZTS1 31
  • 100 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia LZTS1 30 31
  • 89.24 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia LZTS1 30 31
  • 89.1 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Lzts1 30
  • 85.58 (n)
Mouse
(Mus musculus)
 Mammalia Lzts1 30 17 31
  • 85.58 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia LZTS1 31
  • 84 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia LZTS1 31
  • 80 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves LZTS1 30 31
  • 78.98 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia LZTS1 31
  • 69 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii lzts1 30 31
  • 56.97 (n)
 OneToOne
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.3837 31
  • 25 (a)
 OneToMany
Species where no ortholog for LZTS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LZTS1 Gene

ENSEMBL:
Gene Tree for LZTS1 (if available)
TreeFam:
Gene Tree for LZTS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LZTS1: view image

Paralogs for LZTS1 Gene

Paralogs for LZTS1 Gene

(2) SIMAP similar genes for LZTS1 Gene using alignment to 1 proteins:

  • LZTS1_HUMAN
genes like me logo Genes that share paralogs with LZTS1: view

Variants for LZTS1 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LZTS1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs119473032 Pathogenic: Esophageal squamous cell carcinoma, somatic. - 20,253,576(-) T/Cp.Lys119Glu
NM_021020.5(LZTS1):c.355A>G (p.Lys119Glu) 		MISSENSE
rs141630311 Benign: not provided 20,250,305(-) G/A
NM_021020.5(LZTS1):c.1208C>T (p.Thr403Met) 		MISSENSE
rs149140637 Benign: not provided 20,254,844(-) A/G
NM_021020.5(LZTS1):c.338T>C (p.Leu113Pro) 		MISSENSE
rs28937897 Pathogenic: Esophageal squamous cell carcinoma, somatic. - 20,255,097(-) A/Gp.Ser29Pro
NM_021020.5(LZTS1):c.85T>C (p.Ser29Pro) 		MISSENSE
rs34620053 - p.Ser50Phe

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LZTS1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LZTS1 Gene

Variant ID Type Subtype PubMed ID
nsv1033511 CNV gain 25217958
nsv520882 CNV loss 19592680
nsv522185 CNV gain 19592680
nsv819988 CNV gain 19587683

Variation tolerance for LZTS1 Gene

Residual Variation Intolerance Score: 49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.56; 72.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LZTS1 Gene

Human Gene Mutation Database (HGMD)
LZTS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LZTS1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LZTS1 Gene

Disorders for LZTS1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for LZTS1 Gene - From: OMI, CVR, COP, and GCD

Disorder Aliases PubMed IDs
esophageal cancer
  • esophageal cancer, somatic
ehlers-danlos syndrome, hypermobility type
  • edshmb
squamous cell carcinoma
  • epidermoid carcinoma
collecting duct carcinoma
  • carcinoma of renal collecting duct
bladder cancer
  • bladder cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search LZTS1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LZTS1_HUMAN
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269 PubMed:10097140}. Note=The disease may be caused by variants affecting the gene represented in this entry.

Additional Disease Information for LZTS1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LZTS1: view

No data available for Genatlas for LZTS1 Gene

Publications for LZTS1 Gene

  1. The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. (PMID: 10097140) Ishii H … Croce CM (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 23 74
  2. Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. (PMID: 17349584) Vecchione A … Croce CM (Cancer cell 2007) 2 3 23
  3. Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22. (PMID: 11464283) Cabeza-Arvelaiz Y … Chinault AC (Oncogene 2001) 3 4 23
  4. Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. (PMID: 20038947) Shyn SI … Hamilton SP (Molecular psychiatry 2011) 3 41
  5. FEZ1/LZTS1 protein expression in ovarian cancer. (PMID: 19885841) Califano D … Chiappetta G (Journal of cellular physiology 2010) 3 23

ExternalLinks

View latest publications for LZTS1 gene in Mastermind

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