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This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 co... See more...
Aliases for LZTS1 Gene
Aliases for LZTS1 Gene
External Ids for LZTS1 Gene
- HGNC: 13861
- Entrez Gene: 11178
- Ensembl: ENSG00000061337
- OMIM: 606551
- UniProtKB: Q9Y250
Previous GeneCards Identifiers for LZTS1 Gene
- GC08M019978
- GC08M020165
- GC08M020113
- GC08M020147
- GC08M018643
Summaries for LZTS1 Gene
-
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]
GeneCards Summary for LZTS1 Gene
LZTS1 (Leucine Zipper Tumor Suppressor 1) is a Protein Coding gene. Diseases associated with LZTS1 include Esophageal Cancer and Ehlers-Danlos Syndrome, Hypermobility Type. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is LZTS2.
UniProtKB/Swiss-Prot Summary for LZTS1 Gene
-
Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.
Additional gene information for LZTS1 Gene
- HGNC(13861)
- Entrez Gene(11178)
- Ensembl(ENSG00000061337)
- OMIM(606551)
- UniProtKB(Q9Y250)
- Open Targets Platform(ENSG00000061337)
- Monarch Initiative
- Search for LZTS1 at DataMed
- Search for LZTS1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LZTS1 Gene
Genomics for LZTS1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LZTS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LZTS1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LZTS1
- Top Transcription factor binding sites by QIAGEN in the LZTS1 gene promoter:
-
- AP-4
- E47
- IRF-2
- MRF-2
- Olf-1
- p53
- PPAR-gamma1
- PPAR-gamma2
- Tal-1
Genomic Locations for LZTS1 Gene
Genomic Locations for LZTS1 Gene
- chr8:20,246,165-20,303,963
- (GRCh38/hg38)
- Size:
- 57,799 bases
- Orientation:
- Minus strand
- chr8:20,103,676-20,161,474
- (GRCh37/hg19)
- Size:
- 57,799 bases
- Orientation:
- Minus strand
Genomic View for LZTS1 Gene
Genes around LZTS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.3 by HGNC
- 8p21.3 by Entrez Gene
- 8p21.3 by Ensembl
LZTS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LZTS1 Gene
Proteins for LZTS1 Gene
-
Protein details for LZTS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y250-LZTS1_HUMAN
- Recommended name:
- Leucine zipper putative tumor suppressor 1
- Protein Accession:
- Q9Y250
- D3DSQ6
- Q9Y5V7
- Q9Y5V8
- Q9Y5V9
- Q9Y5W0
- Q9Y5W1
- Q9Y5W2
Protein attributes for LZTS1 Gene
- Size:
- 596 amino acids
- Molecular mass:
- 66613 Da
- Quaternary structure:
-
- Binds EEF1G, TLK2 and CDK1.
- Miscellaneous:
-
- Defects in LZTS1 are found in many types of tumors.
Protein Expression for LZTS1 Gene
Post-translational modifications for LZTS1 Gene
- Phosphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for LZTS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-LZTS1 (aa 315-585) polyclonal antibody
- Novus Biologicals Antibodies for LZTS1
-
Abcam antibodies for LZTS1
- Invitrogen Antibodies for LZTS1 (AFLGC-Lzts1)
-
Biorbyt antibodies for LZTS1
-
Santa Cruz Biotechnology (SCBT) Antibodies for LZTS1
Protein Products
-
OriGene Purified Proteins for LZTS1
- Search Origene for MassSpec and Protein Over-expression Lysates for LZTS1
- Origene Custom Protein Services for LZTS1
-
Abcam proteins for LZTS1
No data available for DME Specific Peptides for LZTS1 Gene
Domains & Families for LZTS1 Gene
Gene Families for LZTS1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for LZTS1 Gene
- GenScript: Design optimal peptide antigens:
-
- Fez1 (LZTS1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y250- Family:
-
- Belongs to the LZTS family.
Function for LZTS1 Gene
Molecular function for LZTS1 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.
Phenotypes From GWAS Catalog for LZTS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | NAS | -- |
| GO:0003700 | DNA-binding transcription factor activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 17349584 |
| GO:0008017 | microtubule binding | IEA | -- |
Phenotypes for LZTS1 Gene
- MGI mutant phenotypes for LZTS1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for LZTS1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Resistant to vaccinia virus (VACV-A4L) infection
- Strongly decreased CFP-tsO45G cell surface transport
- Increased ionizing radiation sensitivity
- Decreased IL-8 secretion
- Increased epidermal growth factor (EGF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LZTS1 - Select products 50% OFF >
- * LZTS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for LZTS1
miRNA for LZTS1 Gene
- miRTarBase miRNAs that target LZTS1
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for LZTS1 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LZTS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LZTS1
Cell Line Products
-
Horizon Cell Lines for LZTS1
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LZTS1 Gene
Localization for LZTS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LZTS1 Gene
- Cytoplasm. Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| nucleus | 3 |
| mitochondrion | 2 |
| cytosol | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
- Nucleoli (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0014069 | postsynaptic density | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016324 | apical plasma membrane | IEA | -- |
Pathways & Interactions for LZTS1 Gene
Interacting Proteins for LZTS1 Gene
Selected Interacting proteins:
Q9Y250-LZTS1_HUMAN
ENSP00000370981
for LZTS1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for LZTS1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | NAS | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0016242 | negative regulation of macroautophagy | IMP | -- |
| GO:0044772 | mitotic cell cycle phase transition | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for LZTS1 Gene
Drugs & Compounds for LZTS1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| cyclic amp | Experimental | Pharma | 0 |
Transcripts for LZTS1 Gene
mRNA/cDNA for LZTS1 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000265801 5459 nts (view in UCSC)
- ENST00000381569 5706 nts (view in UCSC)
- ENST00000522290 1614 nts (view in UCSC)
- ENST00000616228 231 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LZTS1 - Select products 50% OFF >
- * LZTS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LZTS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LZTS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for LZTS1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LZTS1
- Browse OriGene Inhibitory RNA Products For LZTS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LZTS1
Clone Products
- Applied Biological Materials (abm): Clones for LZTS1 - Select products 50% OFF >
- * LZTS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LZTS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LZTS1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: |
Relevant External Links for LZTS1 Gene
- GeneLoc Exon Structure for
- LZTS1
Expression for LZTS1 Gene
mRNA differential expression in normal tissues according to GTEx for LZTS1 Gene
This gene is overexpressed in Brain - Cortex (x5.2), Brain - Nucleus accumbens (basal ganglia) (x4.8), Brain - Amygdala (x4.3), Brain - Frontal Cortex (BA9) (x4.2), Brain - Caudate (basal ganglia) (x4.1), and Brain - Putamen (basal ganglia) (x4.1).
This gene is overexpressed in Lung (57.5) and Plasma (9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LZTS1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LZTS1
SOURCE GeneReport for Unigene cluster for LZTS1 Gene:
Hs.521432mRNA Expression by UniProt/SwissProt for LZTS1 Gene:
Q9Y250-LZTS1_HUMAN
Tissue specificity:
Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines.
Evidence on tissue expression from TISSUES for LZTS1 Gene
- Nervous system(4.7)
Phenotype-based relationships between genes and organs from Gene ORGANizer for LZTS1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- integumentary
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- head
- larynx
- neck
- vocal cord
Thorax:
- esophagus
Abdomen:
- stomach
General:
- skin
Primer Products
-
OriGene qPCR primer pairs for LZTS1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LZTS1 Gene
Orthologs for LZTS1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LZTS1 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LZTS1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LZTS1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Lzts1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Lzts1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | LZTS1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | LZTS1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LZTS1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | LZTS1 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | lzts1 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3837 31 |
|
OneToMany |
- Species where no ortholog for LZTS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for LZTS1 Gene
- ENSEMBL:
- Gene Tree for LZTS1 (if available)
- TreeFam:
- Gene Tree for LZTS1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LZTS1: view image
Paralogs for LZTS1 Gene
Variants for LZTS1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LZTS1 Gene
| SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 740925 | Benign: not provided | 20,250,305(-) | G/A | MISSENSE_VARIANT | |
| 778391 | Benign: not provided | 20,254,844(-) | A/G | MISSENSE_VARIANT | |
| rs119473032 | Pathogenic: Esophageal squamous cell carcinoma, somatic. - | 20,253,576(-) | T/Cp.Lys119Glu | MISSENSE_VARIANT | |
| rs28937897 | Pathogenic: Esophageal squamous cell carcinoma, somatic. - | 20,255,097(-) | A/Gp.Ser29Pro | MISSENSE_VARIANT | |
| rs34620053 | - | p.Ser50Phe |
Residual Variation Intolerance Score:
49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.56;
72.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LZTS1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LZTS1 Gene
Disorders for LZTS1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| esophageal cancer |
|
|
| ehlers-danlos syndrome, hypermobility type |
|
|
| squamous cell carcinoma |
|
|
| collecting duct carcinoma |
|
|
| bladder cancer |
|
Search LZTS1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
LZTS1_HUMAN- Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269 PubMed:10097140}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
Additional Disease Information for LZTS1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for LZTS1 Gene
Publications for LZTS1 Gene
- The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. (PMID: 10097140) Ishii H … Croce CM (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 23
- Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. (PMID: 17349584) Vecchione A … Croce CM (Cancer cell 2007) 2 3 23
- Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22. (PMID: 11464283) Cabeza-Arvelaiz Y … Chinault AC (Oncogene 2001) 3 4 23
- Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. (PMID: 20038947) Shyn SI … Hamilton SP (Molecular psychiatry 2011) 3 41
- FEZ1/LZTS1 protein expression in ovarian cancer. (PMID: 19885841) Califano D … Chiappetta G (Journal of cellular physiology 2010) 3 23
ExternalLinks
Products for LZTS1 Gene
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- Browse Antibodies
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- Abcam proteins for LZTS1
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- Browse Primary Antibodies
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- Browse Monoclonal Antibodies
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- Invitrogen Antibodies for LZTS1 (AFLGC-Lzts1)
- VectorBuilder Custom and pre-made DNA vectors for LZTS1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for LZTS1 (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Stable cell line generation for LZTS1
- antibodies-online: Show 15 available LZTS1 Antibodies ranked by validation data
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- antibodies-online: Show 6 available LZTS1 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for LZTS1
- Search Santa Cruz Biotechnology (SCBT) for LZTS1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LZTS1
- Horizon Cell Lines for LZTS1
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for LZTS1
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- Biorbyt antibodies for LZTS1
Sources for LZTS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
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