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This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]
LZTS1 (Leucine Zipper Tumor Suppressor 1) is a Protein Coding gene. Diseases associated with LZTS1 include Esophageal Cancer and Ehlers-Danlos Syndrome, Hypermobility Type. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is LZTS2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | NAS | -- |
GO:0003700 | DNA-binding transcription factor activity | TAS | -- |
GO:0005515 | protein binding | IPI | 17349584 |
GO:0008017 | microtubule binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0014069 | postsynaptic density | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016324 | apical plasma membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006351 | transcription, DNA-templated | NAS | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0007049 | cell cycle | IEA | -- |
GO:0016242 | negative regulation of macroautophagy | IMP | -- |
GO:0044772 | mitotic cell cycle phase transition | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
cyclic amp | Experimental | Pharma | 0 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||
SP2: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LZTS1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LZTS1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LZTS1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lzts1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Lzts1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | LZTS1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | LZTS1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LZTS1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | LZTS1 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | lzts1 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3837 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
740925 | Benign: not provided | 20,250,305(-) | G/A | MISSENSE_VARIANT | |
778391 | Benign: not provided | 20,254,844(-) | A/G | MISSENSE_VARIANT | |
rs119473032 | Pathogenic: Esophageal squamous cell carcinoma, somatic. - | 20,253,576(-) | T/Cp.Lys119Glu | MISSENSE_VARIANT | |
rs28937897 | Pathogenic: Esophageal squamous cell carcinoma, somatic. - | 20,255,097(-) | A/Gp.Ser29Pro | MISSENSE_VARIANT | |
rs34620053 | - | p.Ser50Phe |
Disorder | Aliases | PubMed IDs |
---|---|---|
esophageal cancer |
|
|
ehlers-danlos syndrome, hypermobility type |
|
|
squamous cell carcinoma |
|
|
collecting duct carcinoma |
|
|
bladder cancer |
|