Aliases for LZIC Gene

Aliases for LZIC Gene

  • Leucine Zipper And CTNNBIP1 Domain Containing 2 3 5
  • Leucine Zipper And ICAT Homologous Domain-Containing Protein 3 4
  • Leucine Zipper And CTNNBIP1 Domain-Containing Protein 3 4
  • Protein LZIC 3 4
  • Leucine Zipper Domain And ICAT Homologous Domain Containing 3
  • MGC15436 2
  • LZIC 5

External Ids for LZIC Gene

Previous GeneCards Identifiers for LZIC Gene

  • GC01M009951
  • GC01M009832
  • GC01M009591
  • GC01M009699
  • GC01M009924
  • GC01M009148
  • GC01M009982

Summaries for LZIC Gene

GeneCards Summary for LZIC Gene

LZIC (Leucine Zipper And CTNNBIP1 Domain Containing) is a Protein Coding gene. Diseases associated with LZIC include Schnyder Corneal Dystrophy. Gene Ontology (GO) annotations related to this gene include beta-catenin binding. An important paralog of this gene is CTNNBIP1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LZIC Gene

Genomics for LZIC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LZIC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LZIC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LZIC

Top Transcription factor binding sites by QIAGEN in the LZIC gene promoter:
  • CREB
  • GR
  • GR-alpha
  • HOXA5
  • HOXA9
  • HOXA9B
  • ISGF-3
  • Meis-1
  • Meis-1a
  • Sox5

Genomic Locations for LZIC Gene

Latest Assembly
21,295 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
21,274 bases
Minus strand

(GRCh37/hg19 by Ensembl)
21,293 bases
Minus strand

Genomic View for LZIC Gene

Genes around LZIC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LZIC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LZIC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LZIC Gene

Proteins for LZIC Gene

  • Protein details for LZIC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein LZIC
    Protein Accession:
    Secondary Accessions:
    • B2R6F0
    • B4E2N0
    • Q96IU1

    Protein attributes for LZIC Gene

    190 amino acids
    Molecular mass:
    21495 Da
    Quaternary structure:
    • Does not interact with CTNNB1.

    Alternative splice isoforms for LZIC Gene


neXtProt entry for LZIC Gene

Post-translational modifications for LZIC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LZIC Gene

Domains & Families for LZIC Gene

Gene Families for LZIC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LZIC Gene


Suggested Antigen Peptide Sequences for LZIC Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55829, highly similar to Homo sapiens leucine zipper and CTNNBIP1 domain containing (LZIC), mRNA (B4E2N0_HUMAN)
  • Leucine zipper and ICAT homologous domain-containing protein (LZIC_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CTNNBIP1 family.
  • Belongs to the CTNNBIP1 family.
genes like me logo Genes that share domains with LZIC: view

Function for LZIC Gene

Phenotypes From GWAS Catalog for LZIC Gene

Gene Ontology (GO) - Molecular Function for LZIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0008013 beta-catenin binding IEA --
genes like me logo Genes that share ontologies with LZIC: view
genes like me logo Genes that share phenotypes with LZIC: view

miRNA for LZIC Gene

miRTarBase miRNAs that target LZIC

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LZIC

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LZIC Gene

Localization for LZIC Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LZIC gene
Compartment Confidence
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LZIC Gene

Pathways & Interactions for LZIC Gene

PathCards logo

SuperPathways for LZIC Gene

No Data Available

Gene Ontology (GO) - Biological Process for LZIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010212 response to ionizing radiation IEA --
genes like me logo Genes that share ontologies with LZIC: view

No data available for Pathways by source and SIGNOR curated interactions for LZIC Gene

Drugs & Compounds for LZIC Gene

No Compound Related Data Available

Transcripts for LZIC Gene

mRNA/cDNA for LZIC Gene

12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LZIC

Alternative Splicing Database (ASD) splice patterns (SP) for LZIC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: -
SP2: - -
SP3: - - -

Relevant External Links for LZIC Gene

GeneLoc Exon Structure for

Expression for LZIC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LZIC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for LZIC Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LZIC Gene

Protein tissue co-expression partners for LZIC Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LZIC

SOURCE GeneReport for Unigene cluster for LZIC Gene:


mRNA Expression by UniProt/SwissProt for LZIC Gene:

Tissue specificity: Ubiquitously expressed, with highest levels in kidney. Up-regulated in several cases of gastric cancers.

Evidence on tissue expression from TISSUES for LZIC Gene

  • Kidney(4.4)
  • Liver(4.3)
  • Stomach(4.2)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with LZIC: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LZIC Gene

Orthologs for LZIC Gene

This gene was present in the common ancestor of animals.

Orthologs for LZIC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LZIC 29 30
  • 99.82 (n)
(Canis familiaris)
Mammalia LZIC 29 30
  • 95.79 (n)
(Ornithorhynchus anatinus)
Mammalia LZIC 30
  • 92 (a)
(Mus musculus)
Mammalia Lzic 29 16 30
  • 87.54 (n)
(Rattus norvegicus)
Mammalia Lzic 29
  • 86.84 (n)
(Monodelphis domestica)
Mammalia LZIC 30
  • 77 (a)
(Gallus gallus)
Aves LZIC 29 30
  • 81.05 (n)
(Anolis carolinensis)
Reptilia LZIC 30
  • 92 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lzic 29
  • 76.14 (n)
Str.9994 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.9967 29
(Danio rerio)
Actinopterygii lzic 29 30
  • 73.19 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4928 29
(Caenorhabditis elegans)
Secernentea ZK1248.19 29 30
  • 48.72 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2025 30
  • 55 (a)
Species where no ortholog for LZIC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LZIC Gene

Gene Tree for LZIC (if available)
Gene Tree for LZIC (if available)
Evolutionary constrained regions (ECRs) for LZIC: view image
Alliance of Genome Resources:
Additional Orthologs for LZIC

Paralogs for LZIC Gene

Paralogs for LZIC Gene

(1) SIMAP similar genes for LZIC Gene using alignment to 3 proteins:

  • B4E2N0_HUMAN
  • K7ES95_HUMAN
genes like me logo Genes that share paralogs with LZIC: view

Variants for LZIC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LZIC Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs2304778 -- p.Gly104Asp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LZIC Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LZIC Gene

Variant ID Type Subtype PubMed ID
nsv1001742 CNV gain 25217958

Variation tolerance for LZIC Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LZIC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LZIC Gene

Disorders for LZIC Gene

MalaCards: The human disease database

(1) MalaCards diseases for LZIC Gene - From: COP

Disorder Aliases PubMed IDs
schnyder corneal dystrophy
  • sccd
- elite association - COSMIC cancer census association via MalaCards
Search LZIC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LZIC

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LZIC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LZIC Gene

Publications for LZIC Gene

  1. Molecular cloning and characterization of LZIC, a novel gene encoding ICAT homologous protein with leucine zipper domain. (PMID: 11712074) Katoh M (International journal of molecular medicine 2001) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3

Products for LZIC Gene

Sources for LZIC Gene