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Aliases for LYZL6 Gene

Aliases for LYZL6 Gene

  • Lysozyme Like 6 2 3 5
  • LYC1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 6a 3
  • Lysozyme-Like Protein 6 3
  • Lysozyme Homolog 3
  • Lysozyme-Like 6 2
  • EC 3.2.1.17 4
  • Lysozyme B 3
  • HEL-S-6a 3
  • PRO1485 3
  • TKAL754 3
  • UNQ754 3
  • LYZB 3

External Ids for LYZL6 Gene

Previous GeneCards Identifiers for LYZL6 Gene

  • GC17M031285
  • GC17M034261
  • GC17M030446

Summaries for LYZL6 Gene

Entrez Gene Summary for LYZL6 Gene

  • This gene encodes a member of the C-type lysozyme/alpha-lactalbumin family. C-type lysozymes are bacteriolytic factors that play a role in host defense, whereas alpha-lactalbumins mediate lactose biosynthesis. The encoded protein contains catalytic residues characteristic of C-type lysozymes and may play a role in male reproduction. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for LYZL6 Gene

LYZL6 (Lysozyme Like 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include lysozyme activity. An important paralog of this gene is SPACA5.

UniProtKB/Swiss-Prot for LYZL6 Gene

  • May be involved sperm-egg plasma membrane adhesion and fusion during fertilization (PubMed:28182716). Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus (PubMed:28182716, PubMed:24013621). Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH (PubMed:28182716). Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6 (PubMed:28182716).

Additional gene information for LYZL6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYZL6 Gene

Genomics for LYZL6 Gene

GeneHancer (GH) Regulatory Elements for LYZL6 Gene

Promoters and enhancers for LYZL6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I035941 Enhancer 0.8 ENCODE 550.8 +0.9 921 1.8 HDAC1 PKNOX1 MZF1 FEZF1 ZNF335 TCF12 GATA2 ATF7 NCOA1 NFIC GC17M036103 LYZL6 CCL5 CCL18 RDM1 C17orf50 RASL10B MMP28
GH17I035943 Promoter 0.7 EPDnew 550.8 0.0 -23 0.1 CREB1 ATF7 ATF2 LYZL6 CCL5 CCL18 ENSG00000273736
GH17I036072 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 8.3 -129.1 -129104 0.4 HDGF CTCF BATF KLF5 IRF4 RAD21 RELA ZFHX2 EGR1 ZNF143 ENSG00000277089 HEATR9 LYZL6 C17orf50 CCL5 MYO19 RDM1 CCL18
GH17I035888 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.2 +52.5 52461 5.5 PKNOX1 SMAD1 RB1 BMI1 BATF IRF4 YY1 ZNF335 ZNF207 ATF7 ENSG00000271394 GC17M035888 CCL3 CCL4 CCL3L3 TAF15 GAS2L2 C17orf50 HEATR9 CCL5
GH17I036148 Enhancer 0.5 FANTOM5 2.3 -205.0 -204987 0 CTCF ZNF362 PRDM6 MLLT1 LOC101927369 CCL3L3 CCL3 CCL4 LYZL6 GC17P036146 ENSG00000276241
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LYZL6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LYZL6 gene promoter:

Genomic Locations for LYZL6 Gene

Genomic Locations for LYZL6 Gene
chr17:35,934,518-35,943,710
(GRCh38/hg38)
Size:
9,193 bases
Orientation:
Minus strand
chr17:34,261,522-34,270,703
(GRCh37/hg19)

Genomic View for LYZL6 Gene

Genes around LYZL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYZL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYZL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYZL6 Gene

Proteins for LYZL6 Gene

  • Protein details for LYZL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75951-LYZL6_HUMAN
    Recommended name:
    Lysozyme-like protein 6
    Protein Accession:
    O75951
    Secondary Accessions:
    • Q6UW30

    Protein attributes for LYZL6 Gene

    Size:
    148 amino acids
    Molecular mass:
    16956 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for LYZL6 Gene

Post-translational modifications for LYZL6 Gene

No Post-translational modifications

Other Protein References for LYZL6 Gene

No data available for DME Specific Peptides for LYZL6 Gene

Domains & Families for LYZL6 Gene

Gene Families for LYZL6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for LYZL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75951

UniProtKB/Swiss-Prot:

LYZL6_HUMAN :
  • Belongs to the glycosyl hydrolase 22 family.
Family:
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LYZL6: view

Function for LYZL6 Gene

Molecular function for LYZL6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
UniProtKB/Swiss-Prot Function:
May be involved sperm-egg plasma membrane adhesion and fusion during fertilization (PubMed:28182716). Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus (PubMed:28182716, PubMed:24013621). Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH (PubMed:28182716). Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6 (PubMed:28182716).

Enzyme Numbers (IUBMB) for LYZL6 Gene

Gene Ontology (GO) - Molecular Function for LYZL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IBA --
GO:0003824 catalytic activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with LYZL6: view

Phenotypes for LYZL6 Gene

GenomeRNAi human phenotypes for LYZL6:
genes like me logo Genes that share phenotypes with LYZL6: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LYZL6 Gene

Localization for LYZL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYZL6 Gene

Secreted. Cell surface. Cell projection, cilium, flagellum. Note=Detected on the postacrosomal membrane of mature spermatozoa (PubMed:28182716). {ECO:0000269 PubMed:28182716}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYZL6 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for LYZL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0009986 cell surface IEA --
GO:0042995 cell projection IEA --
GO:0097225 sperm midpiece IEA,ISS --
genes like me logo Genes that share ontologies with LYZL6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LYZL6 Gene

Pathways & Interactions for LYZL6 Gene

SuperPathways for LYZL6 Gene

No Data Available

Interacting Proteins for LYZL6 Gene

Selected Interacting proteins: O75951-LYZL6_HUMAN for LYZL6 Gene via IID

Gene Ontology (GO) - Biological Process for LYZL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization IEA --
GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization IMP 24013621
GO:0008152 metabolic process IEA --
GO:0009566 fertilization IMP 28182716
GO:0016998 cell wall macromolecule catabolic process IBA --
genes like me logo Genes that share ontologies with LYZL6: view

No data available for Pathways by source and SIGNOR curated interactions for LYZL6 Gene

Drugs & Compounds for LYZL6 Gene

(1) Drugs for LYZL6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved, Investigational Nutra 0
genes like me logo Genes that share compounds with LYZL6: view

Transcripts for LYZL6 Gene

mRNA/cDNA for LYZL6 Gene

Unigene Clusters for LYZL6 Gene

Lysozyme-like 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYZL6 Gene

No ASD Table

Relevant External Links for LYZL6 Gene

GeneLoc Exon Structure for
LYZL6
ECgene alternative splicing isoforms for
LYZL6

Expression for LYZL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LYZL6 Gene

mRNA differential expression in normal tissues according to GTEx for LYZL6 Gene

This gene is overexpressed in Testis (x52.8).

NURSA nuclear receptor signaling pathways regulating expression of LYZL6 Gene:

LYZL6

SOURCE GeneReport for Unigene cluster for LYZL6 Gene:

Hs.97477

mRNA Expression by UniProt/SwissProt for LYZL6 Gene:

O75951-LYZL6_HUMAN
Tissue specificity: Expressed in testis, epididymis and spermatozoa (at protein level) (PubMed:16014814, PubMed:28182716). Expressed in late-stage spermatocytes and round spermatids (PubMed:28182716).
genes like me logo Genes that share expression patterns with LYZL6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYZL6 Gene

Orthologs for LYZL6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LYZL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYZL6 33
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia LOC480492 33
  • 85.06 (n)
cow
(Bos Taurus)
Mammalia LYZL6 33
  • 84.35 (n)
rat
(Rattus norvegicus)
Mammalia Lyzl6 33
  • 80.95 (n)
mouse
(Mus musculus)
Mammalia Lyzl6 33 16
  • 79.82 (n)
Species where no ortholog for LYZL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LYZL6 Gene

ENSEMBL:
Gene Tree for LYZL6 (if available)
TreeFam:
Gene Tree for LYZL6 (if available)

Paralogs for LYZL6 Gene

Paralogs for LYZL6 Gene

(8) SIMAP similar genes for LYZL6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LYZL6: view

Variants for LYZL6 Gene

Sequence variations from dbSNP and Humsavar for LYZL6 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000050714 -- 35,942,353(-) T/C intron_variant
rs1000403681 -- 35,942,653(-) A/G intron_variant
rs1000406439 -- 35,935,331(-) T/A intron_variant
rs1000796156 -- 35,934,908(-) C/T intron_variant
rs1000853683 -- 35,939,955(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LYZL6 Gene

Variant ID Type Subtype PubMed ID
nsv833424 CNV gain 17160897
nsv1079030 OTHER inversion 25765185
nsv1059795 CNV gain 25217958
esv3554361 CNV deletion 23714750

Variation tolerance for LYZL6 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.75; 78.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LYZL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYZL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYZL6 Gene

Disorders for LYZL6 Gene

Additional Disease Information for LYZL6

No disorders were found for LYZL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYZL6 Gene

Publications for LYZL6 Gene

  1. Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family. (PMID: 16014814) Zhang K … Yu L (Biology of reproduction 2005) 3 4 22 58
  2. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES. (PMID: 10213461) Nomiyama H … Yoshie O (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999) 2 3 4 58
  3. LYZL6, an acidic, bacteriolytic, human sperm-related protein, plays a role in fertilization. (PMID: 28182716) Huang P … Dong X (PloS one 2017) 3 4 58
  4. Characterisation of Lyzls in mice and antibacterial properties of human LYZL6. (PMID: 24013621) Wei J … Li JY (Asian journal of andrology 2013) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for LYZL6 Gene

Sources for LYZL6 Gene

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