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Aliases for LYZL4 Gene

Aliases for LYZL4 Gene

  • Lysozyme Like 4 2 3 5
  • Lysozyme-4 3 4
  • LYC4 3 4
  • Lysozyme-Like Protein 4 3
  • Lysozyme-Like 4 2
  • Lysozyme A 3
  • LYZA 3

External Ids for LYZL4 Gene

Summaries for LYZL4 Gene

Entrez Gene Summary for LYZL4 Gene

  • Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL4 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]

GeneCards Summary for LYZL4 Gene

LYZL4 (Lysozyme Like 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include lysozyme activity. An important paralog of this gene is SPACA3.

UniProtKB/Swiss-Prot for LYZL4 Gene

  • May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity).

Additional gene information for LYZL4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYZL4 Gene

Genomics for LYZL4 Gene

GeneHancer (GH) Regulatory Elements for LYZL4 Gene

Promoters and enhancers for LYZL4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I042410 Promoter 0.7 EPDnew 550.8 +0.1 73 0.1 MEIS2 PKNOX1 LYZL4 EIF4BP4
GH03I042682 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.9 -274.5 -274487 5 ATF1 FOXA2 ARNT INSM2 ETS1 EGR1 FOS CREM SMARCA5 ZNF362 KLHL40 SEC22C HHATL LYZL4 NKTR CCDC13 CCK KRBOX1 RN7SL567P
GH03I042368 Enhancer 0.7 FANTOM5 ENCODE 11.3 +41.4 41363 1.6 SP1 RFX1 BMI1 CCK LYZL4 HHATL TRAK1 EIF4BP4
GH03I042526 Enhancer 0.7 Ensembl dbSUPER 10.6 -116.4 -116449 0.6 CTCF EGR1 ETV1 E4F1 GABPA EGR2 VIPR1 SS18L2 LYZL4 SEC22C NKTR VIPR1-AS1
GH03I042345 Enhancer 0.6 ENCODE 10.9 +64.5 64503 0.9 TEAD4 TAL1 MAX CBFA2T3 REST GABPA TCF12 ZNF766 CBFA2T2 NFE2 LYZL4 EIF4BP4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LYZL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LYZL4 gene promoter:

Genomic Locations for LYZL4 Gene

Genomic Locations for LYZL4 Gene
49,885 bases
Minus strand

Genomic View for LYZL4 Gene

Genes around LYZL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYZL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYZL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYZL4 Gene

Proteins for LYZL4 Gene

  • Protein details for LYZL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysozyme-like protein 4
    Protein Accession:

    Protein attributes for LYZL4 Gene

    146 amino acids
    Molecular mass:
    16433 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for LYZL4 Gene

Post-translational modifications for LYZL4 Gene

No Post-translational modifications

Other Protein References for LYZL4 Gene

No data available for DME Specific Peptides for LYZL4 Gene

Domains & Families for LYZL4 Gene

Gene Families for LYZL4 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for LYZL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 22 family.
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LYZL4: view

Function for LYZL4 Gene

Molecular function for LYZL4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity).

Phenotypes From GWAS Catalog for LYZL4 Gene

Gene Ontology (GO) - Molecular Function for LYZL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IBA --
genes like me logo Genes that share ontologies with LYZL4: view
genes like me logo Genes that share phenotypes with LYZL4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LYZL4 Gene

Localization for LYZL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYZL4 Gene

Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. Note=Found in the principal piece of sperm tail. {ECO:0000250 UniProtKB:Q9D925}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYZL4 gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for LYZL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle ISS --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA,ISS --
GO:0005634 nucleus IDA,HDA 21630459
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with LYZL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LYZL4 Gene

Pathways & Interactions for LYZL4 Gene

SuperPathways for LYZL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LYZL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization IEA --
GO:0009566 fertilization ISS --
GO:0016998 cell wall macromolecule catabolic process IBA --
GO:0042742 NOT defense response to bacterium ISS --
GO:0050829 defense response to Gram-negative bacterium IBA --
genes like me logo Genes that share ontologies with LYZL4: view

No data available for Pathways by source and SIGNOR curated interactions for LYZL4 Gene

Drugs & Compounds for LYZL4 Gene

No Compound Related Data Available

Transcripts for LYZL4 Gene

Unigene Clusters for LYZL4 Gene

Lysozyme-like 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYZL4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP2: -

Relevant External Links for LYZL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LYZL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LYZL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYZL4 Gene

This gene is overexpressed in Testis (x48.6).

Protein differential expression in normal tissues from HIPED for LYZL4 Gene

This gene is overexpressed in Testis (51.0) and Ovary (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LYZL4 Gene

Protein tissue co-expression partners for LYZL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LYZL4 Gene:


SOURCE GeneReport for Unigene cluster for LYZL4 Gene:


mRNA Expression by UniProt/SwissProt for LYZL4 Gene:

Tissue specificity: Expressed in testis and epididymis.
genes like me logo Genes that share expression patterns with LYZL4: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYZL4 Gene

Orthologs for LYZL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LYZL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LYZL4 33 34
  • 99.32 (n)
(Bos Taurus)
Mammalia LYZL4 33 34
  • 82.07 (n)
(Rattus norvegicus)
Mammalia Lyzl4 33
  • 78.85 (n)
(Mus musculus)
Mammalia Lyzl4 33 16 34
  • 77.24 (n)
(Canis familiaris)
Mammalia LYZL4 34
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia LYZL4 34
  • 49 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
(Danio rerio)
Actinopterygii lyz 34
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7798 34
  • 31 (a)
LysP 34
  • 31 (a)
CG16756 34
  • 30 (a)
LysE 34
  • 30 (a)
LysB 34
  • 29 (a)
LysC 34
  • 29 (a)
LysD 34
  • 29 (a)
LysS 34
  • 29 (a)
CG11159 34
  • 28 (a)
LysX 34
  • 26 (a)
CG30062 34
  • 23 (a)
CG16799 34
  • 22 (a)
CG8492 34
  • 4 (a)
Species where no ortholog for LYZL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LYZL4 Gene

Gene Tree for LYZL4 (if available)
Gene Tree for LYZL4 (if available)

Paralogs for LYZL4 Gene

Paralogs for LYZL4 Gene

(7) SIMAP similar genes for LYZL4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LYZL4: view

Variants for LYZL4 Gene

Sequence variations from dbSNP and Humsavar for LYZL4 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000006560 -- 42,425,550(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000070559 -- 42,379,776(-) C/G genic_downstream_transcript_variant, intron_variant
rs1000072523 -- 42,419,616(-) C/A/T genic_upstream_transcript_variant, intron_variant
rs1000077853 -- 42,385,500(-) G/A/C genic_downstream_transcript_variant, intron_variant
rs1000175253 -- 42,364,803(-) A/G genic_downstream_transcript_variant, intron_variant

Variation tolerance for LYZL4 Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LYZL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LYZL4 Gene

Disorders for LYZL4 Gene

Additional Disease Information for LYZL4

No disorders were found for LYZL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYZL4 Gene

Publications for LYZL4 Gene

  1. Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family. (PMID: 16014814) Zhang K … Yu L (Biology of reproduction 2005) 2 3 4 22 58
  2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay JL … van den Oord EJ (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3 58
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 58

Products for LYZL4 Gene

Sources for LYZL4 Gene

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